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Volumn 54, Issue 1, 2005, Pages 152-161

High frequency of functional anti-YMDD and -mutant cytotoxic T lymphocytes after in vitro expansion correlates with successful response to lamivudine therapy for chronic hepatitis B

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; HLA A2 ANTIGEN; INTERLEUKIN 2; LAMIVUDINE; PROTEIN ANTIBODY; TETRAMER; TYROSYLMETHIONYLASPARTYLASPARTATE ANTIBODY; UNCLASSIFIED DRUG;

EID: 10844242136     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2003.032920     Document Type: Article
Times cited : (24)

References (52)
  • 1
    • 0032499913 scopus 로고    scopus 로고
    • A one-year trial of lamivudine for chronic hepatitis B
    • Lai CL, Chien RH, Leung NWY, et al. A one-year trial of lamivudine for chronic hepatitis B. N Engl J Med 1998;339:61-8.
    • (1998) N Engl J Med , vol.339 , pp. 61-68
    • Lai, C.L.1    Chien, R.H.2    Leung, N.W.Y.3
  • 2
    • 0032783736 scopus 로고    scopus 로고
    • Lamivudine: A review of its therapeutic potential in chronic hepatitis B
    • Jarvis B, Faulds D. Lamivudine: a review of its therapeutic potential in chronic hepatitis B. Drugs 1999;58:101-41.
    • (1999) Drugs , vol.58 , pp. 101-141
    • Jarvis, B.1    Faulds, D.2
  • 3
    • 0033592764 scopus 로고    scopus 로고
    • Lamivudine as initial treatment for chronic hepatitis B
    • Dienstag JL, Schiff ER, Wright TL, et al. Lamivudine as initial treatment for chronic hepatitis B. N Engl J Med 1999;341:1256-63.
    • (1999) N Engl J Med , vol.341 , pp. 1256-1263
    • Dienstag, J.L.1    Schiff, E.R.2    Wright, T.L.3
  • 4
    • 0034235528 scopus 로고    scopus 로고
    • Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B
    • Liaw YF, Leung NWY, Chang TT, et al. Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B. Gastroenterology 2000;119:172-80.
    • (2000) Gastroenterology , vol.119 , pp. 172-180
    • Liaw, Y.F.1    Leung, N.W.Y.2    Chang, T.T.3
  • 5
    • 0037198434 scopus 로고    scopus 로고
    • Clinical trial of lamivudine in children with chronic hepatitis B
    • Jonas MM, Kelley DA, Mizerski J, et al. Clinical trial of lamivudine in children with chronic hepatitis B. N Engl J Med 2002;346:1706-13.
    • (2002) N Engl J Med , vol.346 , pp. 1706-1713
    • Jonas, M.M.1    Kelley, D.A.2    Mizerski, J.3
  • 6
    • 0026058540 scopus 로고
    • Inhibition of the replication of hepatitis B virus in vitro by 2′, 3′-dideoxy-3′-thiacytidine and related analogues
    • Doong SL, Tsai CH, Schinazi RF, et al. Inhibition of the replication of hepatitis B virus in vitro by 2′, 3′-dideoxy-3′-thiacytidine and related analogues. Proc Natl Acad Sci USA 1991;88:8495-99.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 8495-8499
    • Doong, S.L.1    Tsai, C.H.2    Schinazi, R.F.3
  • 7
    • 0029591574 scopus 로고
    • A preliminary trial of lamivudine for chronic hepatitis B infection
    • Dienstag JL, Perillo RP, Schiff ER, et al. A preliminary trial of lamivudine for chronic hepatitis B infection. N Engl J Med 1995;333:1657-61.
    • (1995) N Engl J Med , vol.333 , pp. 1657-1661
    • Dienstag, J.L.1    Perillo, R.P.2    Schiff, E.R.3
  • 8
    • 0028817865 scopus 로고
    • Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis
    • Mckenzie R, Fried MW, Sallie R, et al. Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis. N Engl J Med 1995;333:1099-105.
    • (1995) N Engl J Med , vol.333 , pp. 1099-1105
    • Mckenzie, R.1    Fried, M.W.2    Sallie, R.3
  • 9
    • 0034993211 scopus 로고    scopus 로고
    • Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatitis B e antigen seroconversion rates: Results after 3 years of therapy
    • Leung NWY, Lai CL, Chang TT, et al. Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatitis B e antigen seroconversion rates: results after 3 years of therapy. Hepatology 2001;33:1527-32.
    • (2001) Hepatology , vol.33 , pp. 1527-1532
    • Leung, N.W.Y.1    Lai, C.L.2    Chang, T.T.3
  • 10
    • 0002443164 scopus 로고    scopus 로고
    • Incremental increases in HBeAg seroconversion and continued ALT normalization in Asian chronic HBV patients treated with lamivudine for four years
    • Chang TT, Lai CL, Liaw YF, Guan R, et al. Incremental increases in HBeAg seroconversion and continued ALT normalization in Asian chronic HBV patients treated with lamivudine for four years. Antiviral Ther 2000;5(suppl 1):44.
    • (2000) Antiviral Ther , vol.5 , Issue.SUPPL. 1 , pp. 44
    • Chang, T.T.1    Lai, C.L.2    Liaw, Y.F.3    Guan, R.4
  • 11
    • 0031037065 scopus 로고    scopus 로고
    • Hepatitis-B-virus resistance to lamivudine given for recurrent infection after orthotopic liver transplatation
    • Bartholomew M, Jansen RW, Jeffers LJ, et al. Hepatitis-B-virus resistance to lamivudine given for recurrent infection after orthotopic liver transplatation. Lancet 1997;349:3-4.
    • (1997) Lancet , vol.349 , pp. 3-4
    • Bartholomew, M.1    Jansen, R.W.2    Jeffers, L.J.3
  • 12
    • 0031780935 scopus 로고    scopus 로고
    • Identification and characterization of mutations in hepatitis B virus resistant to lamivudine
    • Allen MI, Deslauriers M, Andrews CW, et al. Identification and characterization of mutations in hepatitis B virus resistant to lamivudine. Hepatology 1998;27:1670-7.
    • (1998) Hepatology , vol.27 , pp. 1670-1677
    • Allen, M.I.1    Deslauriers, M.2    Andrews, C.W.3
  • 13
    • 0033803799 scopus 로고    scopus 로고
    • Efficacy of long-term lamivudine monotherapy in patients with hepatitis B e antigen-negative chronic hepatitis B
    • Hadziyannis SJ, Papatheodoridis GV, Dimou E, et al. Efficacy of long-term lamivudine monotherapy in patients with hepatitis B e antigen-negative chronic hepatitis B. Hepatology 2000;32:847-51.
    • (2000) Hepatology , vol.32 , pp. 847-851
    • Hadziyannis, S.J.1    Papatheodoridis, G.V.2    Dimou, E.3
  • 14
    • 0032783679 scopus 로고    scopus 로고
    • Acute exacerbation and hepatitis B virus clearance after emergence of YMDD motif mutation during lamivudine therapy
    • Liaw YF, Chien RN, Yeh CT, et al. Acute exacerbation and hepatitis B virus clearance after emergence of YMDD motif mutation during lamivudine therapy. Hepatology 1999;30:567-72.
    • (1999) Hepatology , vol.30 , pp. 567-572
    • Liaw, Y.F.1    Chien, R.N.2    Yeh, C.T.3
  • 15
    • 0034919416 scopus 로고    scopus 로고
    • Fatal submassive hepatic necrosis associated with tyrosine-methionine- aspartate-aspartate motif mutation of hepatitis B virus after long-term lamivudine therapy
    • Kim JW, Lee HS, Woo GH, et al. Fatal submassive hepatic necrosis associated with tyrosine-methionine-aspartate-aspartate motif mutation of hepatitis B virus after long-term lamivudine therapy. Clin Infect Dis 2001;33:403-5.
    • (2001) Clin Infect Dis , vol.33 , pp. 403-405
    • Kim, J.W.1    Lee, H.S.2    Woo, G.H.3
  • 16
    • 0036161381 scopus 로고    scopus 로고
    • Selection of hepatitis B virus polymerase mutants with enhanced replication by lamivudine treatment after liver transplation
    • Bock CT, Tillmann HL, Torresi J, et al. Selection of hepatitis B virus polymerase mutants with enhanced replication by lamivudine treatment after liver transplation. Gastroenterology 2002;122:264-73.
    • (2002) Gastroenterology , vol.122 , pp. 264-273
    • Bock, C.T.1    Tillmann, H.L.2    Torresi, J.3
  • 17
    • 0030875066 scopus 로고    scopus 로고
    • Lamivudine resistance in immunocompetent chronic hepatitis B; Incidence and patterns
    • Honkoop P, Niesters HGM, Man RA, et al. Lamivudine resistance in immunocompetent chronic hepatitis B; Incidence and patterns. J Hepatol 1997;26:1393-5.
    • (1997) J Hepatol , vol.26 , pp. 1393-1395
    • Honkoop, P.1    Niesters, H.G.M.2    Man, R.A.3
  • 18
    • 13344294407 scopus 로고    scopus 로고
    • Enhanced fidelity of 3TC selected mutant HIV-1 reverse transcriptase
    • Wainberg MA, Drosopoulos WC, Salomon H, et al. Enhanced fidelity of 3TC selected mutant HIV-1 reverse transcriptase. Science 1996;271:1282-5.
    • (1996) Science , vol.271 , pp. 1282-1285
    • Wainberg, M.A.1    Drosopoulos, W.C.2    Salomon, H.3
  • 19
    • 0032499922 scopus 로고    scopus 로고
    • Treatment of chronic hepatitis B infection
    • Omata M. Treatment of chronic hepatitis B infection. N Engl J Med 1998;339:114-15.
    • (1998) N Engl J Med , vol.339 , pp. 114-115
    • Omata, M.1
  • 20
    • 0142244873 scopus 로고    scopus 로고
    • The determinants for sustained HBeAg response to lamivudine therapy
    • Chien RN, Yeh CT, Tsai SL, et al. The determinants for sustained HBeAg response to lamivudine therapy. Hepatology 2003;38:1267-73.
    • (2003) Hepatology , vol.38 , pp. 1267-1273
    • Chien, R.N.1    Yeh, C.T.2    Tsai, S.L.3
  • 21
    • 0028925535 scopus 로고
    • The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis
    • Rehermann B, Fowler P, Sidney J, et al. The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis. J Exp Med 1995;181:1047-58.
    • (1995) J Exp Med , vol.181 , pp. 1047-1058
    • Rehermann, B.1    Fowler, P.2    Sidney, J.3
  • 22
    • 0032169470 scopus 로고    scopus 로고
    • Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B
    • Boni C, Bertoletti A, Penna A, et al. Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B. J Clin Invest 1998;102:968-75.
    • (1998) J Clin Invest , vol.102 , pp. 968-975
    • Boni, C.1    Bertoletti, A.2    Penna, A.3
  • 23
    • 0028916425 scopus 로고
    • Hepatitis B virus immunopathogenesis
    • Chisari FV, Ferrari C. Hepatitis B virus immunopathogenesis. Annu Rev Immunol 1995;13:29-60.
    • (1995) Annu Rev Immunol , vol.13 , pp. 29-60
    • Chisari, F.V.1    Ferrari, C.2
  • 24
    • 0036330580 scopus 로고    scopus 로고
    • Effects of lamivudine on the hepatitis B virus specific CD8+ cytotoxic T lymphocyte response via peptide-MHC terrameric complexes assay
    • Lee TH, Chuang YL, Tsai SL, et al. Effects of lamivudine on the hepatitis B virus specific CD8+ cytotoxic T lymphocyte response via peptide-MHC terrameric complexes assay. Lett Pept Sci 2002;8:179-85.
    • (2002) Lett Pept Sci , vol.8 , pp. 179-185
    • Lee, T.H.1    Chuang, Y.L.2    Tsai, S.L.3
  • 25
    • 0032754504 scopus 로고    scopus 로고
    • Direct ex vivo analysis of hepatitis B virus-specific CD8+ T cells associated with the control of infection
    • Maini MK, Boni C, Ogg GS, et al. Direct ex vivo analysis of hepatitis B virus-specific CD8+ T cells associated with the control of infection. Gastroenterology 1999;117:1386-96.
    • (1999) Gastroenterology , vol.117 , pp. 1386-1396
    • Maini, M.K.1    Boni, C.2    Ogg, G.S.3
  • 26
    • 0034678435 scopus 로고    scopus 로고
    • The role of virus-specific CD8+ cell in liver damage and viral control during persistent hepatitis B virus infection
    • Maini MK, Boni C, Lee CK, et al. The role of virus-specific CD8+ cell in liver damage and viral control during persistent hepatitis B virus infection. J Exp Med 2000;191:1269-80.
    • (2000) J Exp Med , vol.191 , pp. 1269-1280
    • Maini, M.K.1    Boni, C.2    Lee, C.K.3
  • 27
    • 0037029652 scopus 로고    scopus 로고
    • Escaping high viral load exhaustion: CDS cells with altered tetramer binding in chronic hepatitis B virus infection
    • Reignat S, Webster GJM, Brown D, et al. Escaping high viral load exhaustion: CDS cells with altered tetramer binding in chronic hepatitis B virus infection. J Exp Med 2002;195:1089-101.
    • (2002) J Exp Med , vol.195 , pp. 1089-1101
    • Reignat, S.1    Webster, G.J.M.2    Brown, D.3
  • 28
    • 0037261447 scopus 로고    scopus 로고
    • Activation of Th1 immunity is a common immune mechanism for the successful treatment of hepatitis B and C: Tetramer assay and therapeutic implications
    • Tsai SL, Sheen IS, Chien RN, et al. Activation of Th1 immunity is a common immune mechanism for the successful treatment of hepatitis B and C: tetramer assay and therapeutic implications. J Biomed Sci 2003;10:120-35.
    • (2003) J Biomed Sci , vol.10 , pp. 120-135
    • Tsai, S.L.1    Sheen, I.S.2    Chien, R.N.3
  • 29
    • 13044313467 scopus 로고    scopus 로고
    • Quantitative analysis of hepatitis C virus-specific CD8+ T cells in peripheral blood and liver using peptide-MHC tetramers
    • He X-S, Rehermann B, López-Labrador FX, et al. Quantitative analysis of hepatitis C virus-specific CD8+ T cells in peripheral blood and liver using peptide-MHC tetramers. Proc Natl Acad Sci USA 1999;96:5692-7.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 5692-5697
    • He, X.-S.1    Rehermann, B.2    López-Labrador, F.X.3
  • 30
    • 0036188008 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1-hepatitis C virus coinfection: Intraindividual comparison of cellular immune responses against two persistent viruses
    • Lauer GM, Nguyen TN, Day CL, et al. Human immunodeficiency virus type 1-hepatitis C virus coinfection: intraindividual comparison of cellular immune responses against two persistent viruses. J Virol 2002;76:2817-26.
    • (2002) J Virol , vol.76 , pp. 2817-2826
    • Lauer, G.M.1    Nguyen, T.N.2    Day, C.L.3
  • 31
    • 0036116355 scopus 로고    scopus 로고
    • +-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities
    • +-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities. J Virol 2002;76:6104-13.
    • (2002) J Virol , vol.76 , pp. 6104-6113
    • Lauer, G.M.1    Ouchi, K.2    Chung, R.T.3
  • 32
    • 0025251613 scopus 로고
    • The arginine-rich domain of hepatitis B virus precore and core protein contains a signal for nuclear transport
    • Yeh CT, Liaw YF, Ou JH. The arginine-rich domain of hepatitis B virus precore and core protein contains a signal for nuclear transport. J Virol 1990;64:6141-7.
    • (1990) J Virol , vol.64 , pp. 6141-6147
    • Yeh, C.T.1    Liaw, Y.F.2    Ou, J.H.3
  • 33
    • 0030045482 scopus 로고    scopus 로고
    • Purification and characterization of a naturally processed hepatitis B virus peptide recognized by CD8+ cytotoxic T lymphocytes
    • Tsai SL, Chen MH, Yeh CT, et al. Purification and characterization of a naturally processed hepatitis B virus peptide recognized by CD8+ cytotoxic T lymphocytes. J Clin Invest 1996;97:577-84.
    • (1996) J Clin Invest , vol.97 , pp. 577-584
    • Tsai, S.L.1    Chen, M.H.2    Yeh, C.T.3
  • 34
    • 84984593057 scopus 로고
    • Characterization of T cell clones specific to a determinant of hepatitis B virus core and e antigens in chronic type B hepatitis: Implication for T cell mechanism of HBV immunopathogenesis
    • Tsai SL, Chen PJ, Liao TH, et al. Characterization of T cell clones specific to a determinant of hepatitis B virus core and e antigens in chronic type B hepatitis: implication for T cell mechanism of HBV immunopathogenesis. J Biomed Sci 1994;1:105-18.
    • (1994) J Biomed Sci , vol.1 , pp. 105-118
    • Tsai, S.L.1    Chen, P.J.2    Liao, T.H.3
  • 35
    • 0030053715 scopus 로고    scopus 로고
    • Analysis of rearranged T cell receptor (TCR) Vβ transcripts in livers of primary biliary cirrhosis: Preferential Vβ usage suggests antigen-driven selection
    • Tsai SL, Lai MY, Chen DS. Analysis of rearranged T cell receptor (TCR) Vβ transcripts in livers of primary biliary cirrhosis: preferential Vβ usage suggests antigen-driven selection. Clin Exp Immunol 1996;103:99-104.
    • (1996) Clin Exp Immunol , vol.103 , pp. 99-104
    • Tsai, S.L.1    Lai, M.Y.2    Chen, D.S.3
  • 36
    • 0023081734 scopus 로고
    • Genes of the T-cell antigen receptor in normal and malignant T cells
    • Toyonaga B, Mak TW. Genes of the T- cell antigen receptor in normal and malignant T cells. Annu Rev Immunol 1987;5:585-620.
    • (1987) Annu Rev Immunol , vol.5 , pp. 585-620
    • Toyonaga, B.1    Mak, T.W.2
  • 37
    • 0029557542 scopus 로고
    • Human T-cell receptor variable gene segment families
    • Arden B, Clark SP, Kabelitz D, et al. Human T-cell receptor variable gene segment families. Immunogenetics 1995;42:455-500.
    • (1995) Immunogenetics , vol.42 , pp. 455-500
    • Arden, B.1    Clark, S.P.2    Kabelitz, D.3
  • 38
    • 17744383748 scopus 로고    scopus 로고
    • Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: New perspectives for immune therapy
    • Boni C, Penna A, Ogg GS, et al. Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: new perspectives for immune therapy. Hepatology 2001;33:963-71.
    • (2001) Hepatology , vol.33 , pp. 963-971
    • Boni, C.1    Penna, A.2    Ogg, G.S.3
  • 39
    • 0037381547 scopus 로고    scopus 로고
    • Durability of serologic response after lamivudine treatment of chronic hepatitis B
    • Dienstag JL, Cianciara J, Karayalcin S, et al. Durability of serologic response after lamivudine treatment of chronic hepatitis B. Hepatology 2003;37:748-55.
    • (2003) Hepatology , vol.37 , pp. 748-755
    • Dienstag, J.L.1    Cianciara, J.2    Karayalcin, S.3
  • 40
    • 0030811688 scopus 로고    scopus 로고
    • Human histocompatibility leucocyte antigen-binding supermotifs predict broadly cross-reactive cytotoxic T lymphocyte respondes in patients with acute hepatitis
    • Bertoni R, Sidney J, Fowler P, et al. Human histocompatibility leucocyte antigen-binding supermotifs predict broadly cross-reactive cytotoxic T lymphocyte respondes in patients with acute hepatitis. J Clin Invest 1997;100:503-13.
    • (1997) J Clin Invest , vol.100 , pp. 503-513
    • Bertoni, R.1    Sidney, J.2    Fowler, P.3
  • 41
    • 0032531164 scopus 로고    scopus 로고
    • Enhanced in vitro potency and in vivo immunogenicity of a CTL epitope from hepatitis C virus core protein following amino acid replacement at secondary HLA-A2.1 binding position
    • Sarobe P, Pendleton CD, Akatsuka T, et al. Enhanced in vitro potency and in vivo immunogenicity of a CTL epitope from hepatitis C virus core protein following amino acid replacement at secondary HLA-A2.1 binding position. J Clin Invest 1998;102:1239-48.
    • (1998) J Clin Invest , vol.102 , pp. 1239-1248
    • Sarobe, P.1    Pendleton, C.D.2    Akatsuka, T.3
  • 42
    • 16044369181 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus DNA polymerase by enantiomers of penciclovir triphosphate and metabolic basis for selective inhibition of HBV replication by penciclovir
    • Shaw T, Mok SS, Locarnini SA. Inhibition of hepatitis B virus DNA polymerase by enantiomers of penciclovir triphosphate and metabolic basis for selective inhibition of HBV replication by penciclovir. Hepatology 1996;24:996-1002.
    • (1996) Hepatology , vol.24 , pp. 996-1002
    • Shaw, T.1    Mok, S.S.2    Locarnini, S.A.3
  • 43
    • 0028360076 scopus 로고
    • Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells
    • Bertoletti A, Sette A, Chisari FV, et al. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells. Nature 1994;369:407-10.
    • (1994) Nature , vol.369 , pp. 407-410
    • Bertoletti, A.1    Sette, A.2    Chisari, F.V.3
  • 44
    • 0031680261 scopus 로고    scopus 로고
    • Hepatitis C virus variants circumventing cytotoxic T lymphocyte activity as a mechanism of chronicity
    • Tsai SL, Chen YM, Chen MH, et al. Hepatitis C virus variants circumventing cytotoxic T lymphocyte activity as a mechanism of chronicity. Gastroenterology 1998;115:954-66.
    • (1998) Gastroenterology , vol.115 , pp. 954-966
    • Tsai, S.L.1    Chen, Y.M.2    Chen, M.H.3
  • 45
    • 0034940480 scopus 로고    scopus 로고
    • Emergence of YMDD motif mutant of hepatitis B virus during short-term lamivudine therapy in South Korea
    • Paik YH, Chung HY, Ryu WS, et al. Emergence of YMDD motif mutant of hepatitis B virus during short-term lamivudine therapy in South Korea. J Hepatol 2001;35:92-8.
    • (2001) J Hepatol , vol.35 , pp. 92-98
    • Paik, Y.H.1    Chung, H.Y.2    Ryu, W.S.3
  • 46
    • 17344373482 scopus 로고    scopus 로고
    • Emergence and takeover of YMDD motif mutant hepatitis B virus during long-term lamivudine therapy and re-takeover by wild type after cessation of therapy
    • Nafa S, Ahmed S, Chayama D, et al. Emergence and takeover of YMDD motif mutant hepatitis B virus during long-term lamivudine therapy and re-takeover by wild type after cessation of therapy. Hepatology 1998;27:1711-16.
    • (1998) Hepatology , vol.27 , pp. 1711-1716
    • Nafa, S.1    Ahmed, S.2    Chayama, D.3
  • 47
    • 0035056086 scopus 로고    scopus 로고
    • Detection of YMDD mutations in some lamivudine-untreated asymptomatic hepatitis B virus carriers
    • Kobayashi S, Ide T, Sata H. Detection of YMDD mutations in some lamivudine-untreated asymptomatic hepatitis B virus carriers. J Hepatol 2001;34:584-6.
    • (2001) J Hepatol , vol.34 , pp. 584-586
    • Kobayashi, S.1    Ide, T.2    Sata, H.3
  • 48
    • 0032835661 scopus 로고    scopus 로고
    • Extended lamivudine retreatment for chronic nepatitis B: Maintenance of viral suppression after discontinuation of therapy
    • Dienstag JL, Schiff ER, Mitchell M, et al. Extended lamivudine retreatment for chronic nepatitis B: maintenance of viral suppression after discontinuation of therapy. Hepatology 1999;30:1082-7.
    • (1999) Hepatology , vol.30 , pp. 1082-1087
    • Dienstag, J.L.1    Schiff, E.R.2    Mitchell, M.3
  • 49
    • 0033797827 scopus 로고    scopus 로고
    • Hepatitis B e antigen seroconversion after lamivudine therapy is not durable in patients with chronic hepatitis B in Korea
    • Song BC, Suh DJ, Lee HC, et al. Hepatitis B e antigen seroconversion after lamivudine therapy is not durable in patients with chronic hepatitis B in Korea. Hepatology 2000;32:803-6.
    • (2000) Hepatology , vol.32 , pp. 803-806
    • Song, B.C.1    Suh, D.J.2    Lee, H.C.3
  • 50
    • 0036906811 scopus 로고    scopus 로고
    • Effect of virological response on post-treatment durability of lamivudine-induced HBeAg seroconversion
    • Lee KM, Cho SW, Kim SW, et al. Effect of virological response on post-treatment durability of lamivudine-induced HBeAg seroconversion. J Viral Hepat 2002;9:208-12.
    • (2002) J Viral Hepat , vol.9 , pp. 208-212
    • Lee, K.M.1    Cho, S.W.2    Kim, S.W.3
  • 51
    • 0036019518 scopus 로고    scopus 로고
    • Hepatitis B viral genotypes: Clinical relevance and molecular characteristics
    • Kaa JH. Hepatitis B viral genotypes: Clinical relevance and molecular characteristics. J Gastroenterol Hepatol 2002;17:643-50.
    • (2002) J Gastroenterol Hepatol , vol.17 , pp. 643-650
    • Kaa, J.H.1
  • 52
    • 0038045176 scopus 로고    scopus 로고
    • YSDD: A novel mutation in HBV DNA polymerase confers clinical resistance to lamivudine
    • Bozdayi AM, Uzunalimoglu O, Turkyilmaz AR, et al. YSDD: a novel mutation in HBV DNA polymerase confers clinical resistance to lamivudine. J Viral Hepat 2003;10:256-65.
    • (2003) J Viral Hepat , vol.10 , pp. 256-265
    • Bozdayi, A.M.1    Uzunalimoglu, O.2    Turkyilmaz, A.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.