Synthetic antibodies designed on natural sequence landscapes

Journal of Molecular Biology

Volumn 412, Issue 1, 2011, Pages 55-71

  Zhai, Wenwu ^a   Glanville, Jacob ^a   Fuhrmann, Markus ^b   Mei, Li ^a   Ni, Irene ^a   Sundar, Purnima D ^a   Van Blarcom, Thomas ^a   Abdiche, Yasmina ^a   Lindquist, Kevin ^a   Strohner, Ralf ^b,d   Telman, Dilduz ^a   Cappuccilli, Guido ^c   Finlay, William J J ^a   Van Den Brulle, Jan ^b,d   Cox, David R ^a   Pons, Jaume ^a   Rajpal, Arvind ^a  

^a PFIZER INC   (United States)

^b Sloning BioTechnology GmbH   (Germany)

^c AREA Science Park   (Italy)

^d MORPHOSYS AG   (Germany)

Author keywords

antibody diversity; antibody repertoire; high throughput sequencing; phage display; synthetic antibody library

Indexed keywords

AMINO ACID; IMMUNOGLOBULIN F(AB) FRAGMENT;

AMINO ACID COMPOSITION; ANTIBODY LIBRARY; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE SEQUENCE; GENE SYNTHESIS; GENETIC VARIABILITY; HEAVY CHAIN; HUMAN; LIGHT CHAIN; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PYROSEQUENCING; SEQUENCE ANALYSIS; SYNTHETIC BIOLOGY;

EID: 84860389926     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2011.07.018     Document Type: Article

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