Novel aminopeptidase N (APN/CD13) inhibitors derived from chloramphenicol amine

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 17, 2011, Pages 5190-5198

  Jia, Meirong ^a   Yang, Kanghui ^a   Fang, Hao ^a   Xu, Yingying ^a   Sun, Siwei ^a   Su, Li ^a   Xu, Wenfang ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Aminopeptidase N inhibitors; Chloramphenicol amine derivatives; QSAR; Synthesis

Indexed keywords

2 (3 AMINO 3 HYDROXYPROPANAMIDO) N [2 AMINO 3 HYDROXY 3 (4 NITROPHENYL)PROPYL] 4 METHYLPENTANAMIDE; 2 AMINO N [1 [2 AMINO 3 (4 AMINOPHENYL) 3 HYDROXYPROPYLAMINO] 1 OXO 3 PHENYLPROPAN 2 YL] 3 PHENYLPROPANAMIDE; 2 AMINO N [1 [2 AMINO 3 (4 AMINOPHENYL) 3 HYDROXYPROPYLAMINO] 1 OXO 3 PHENYLPROPAN 2 YL] 4 METHYLPENTANAMIDE; 2 AMINO N [1 [2 AMINO 3 HYDROXY 3 (4 IODOPHENYL)PROPYLAMINO] 1 OXO 3 PHENYLPROPAN 2 YL] 4 METHYLPENTANAMIDE; 2 AMINO N [1 [2 AMINO 3 HYDROXY 3 (4 NITROPHENYL)PROPYLAMINO] 1 OXO 3 PHENYLPROPAN 2 YL] 3 PHENYLPROPANAMIDE; 2 AMINO N [1 [2 AMINO 3 HYDROXY 3 (4 NITROPHENYL)PROPYLAMINO] 1 OXO 3 PHENYLPROPAN 2 YL] 4 METHYLPENTANAMIDE; 2 AMINO N [1 [2 AMINO 3 HYDROXY 3 (4 NITROPHENYL)PROPYLAMINO] 3 HYDROXY 1 OXOPROPAN 2 YL] 3 PHENYLPROPANAMIDE; 2 AMINO N [2 AMINO 3 (4 AMINOPHENYL) 3 HYDROXYPROPYL] 3 (4 HYDROXYPHENYL)PROPANAMIDE; 2 AMINO N [2 AMINO 3 (4 AMINOPHENYL) 3 HYDROXYPROPYL] 3 PHENYLPROPANAMIDE; 2 AMINO N [2 AMINO 3 (4 AMINOPHENYL) 3 HYDROXYPROPYL] 4 METHYLPENTANAMIDE; 2 AMINO N [2 AMINO 3 HYDROXY 3 (4 IODOPHENYL)PROPYL] 4 METHYLPENTANAMIDE; 2 AMINO N [2 AMINO 3 HYDROXY 3 (4 NITROPHENYL)PROPYL] 3 (4 HYDROXYPHENYL)PROPANAMIDE; 2 AMINO N [2 AMINO 3 HYDROXY 3 (4 NITROPHENYL)PROPYL] 3 HYDROXYPROPANAMIDE; 2 AMINO N [2 AMINO 3 HYDROXY 3 (4 NITROPHENYL)PROPYL] 3 MERCAPTOPROPANAMIDE; 2 AMINO N [2 AMINO 3 HYDROXY 3 (4 NITROPHENYL)PROPYL] 3 PHENYLPROPANAMIDE; 2 AMINO N [2 AMINO 3 HYDROXY 3 (4 NITROPHENYL)PROPYL] 4 METHYLPENTANAMIDE; 2 AMINO N [3 [2 AMINO 3 HYDROXY 3 (4 NITROPHENYL)PROPYLAMINO] 2 HYDROXY 3 OXOPROPYL] 3 PHENYLPROPANAMIDE; 2,6 DIAMINO N [2 AMINO 3 (4 AMINOPHENYL) 3 HYDROXYPROPYL]HEXANAMIDE; 2,6 DIAMINO N [2 AMINO 3 HYDROXY 3 (4 NITROPHENYL)PROPYL]HEXANAMIDE; 3 AMINO N [1 [2 AMINO 3 HYDROXY 3 (4 NITROPHENYL)PROPYLAMINO] 1 OXO 3 PHENYLPROPAN 2 YL] 3 HYDROXYPROPANAMIDE; 3 AMINO N [2 AMINO 3 HYDROXY 3 (4 NITROPHENYL)PROPYL] 2 HYDROXYPROPANAMIDE; BESTATIN; CHLORAMPHENICOL AMINE DERIVATIVE; CHLORAMPHENICOL DERIVATIVE; MICROSOMAL AMINOPEPTIDASE; N [2 AMINO 3 (4 AMINOPHENYL) 3 HYDROXYPROPYL] 2 (2 AMINO 3 PHENYLPROPANAMIDO) 4 METHYLPENTANAMIDE; N [2 AMINO 3 HYDROXY 3 (4 NITROPHENYL)PROPYL] 2 (2 AMINO 3 PHENYLPROPANAMIDO) 4 METHYLPENTANAMIDE; N [2 AMINO 3 HYDROXY 3 (4 NITROPHENYL)PROPYL] 7 HYDROXY 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXAMIDE; PEPTIDE HYDROLASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; STRUCTURE ACTIVITY RELATION;

AMINES; ANTIGENS, CD13; ANTINEOPLASTIC AGENTS; BINDING SITES; CHLORAMPHENICOL; COMPUTER SIMULATION; DIPEPTIDES; DRUG SCREENING ASSAYS, ANTITUMOR; PROPANOLAMINES; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84860389873     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.07.008     Document Type: Article

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