Design, synthesis, and QSAR studies of novel lysine derives as amino-peptidase N/CD13 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 10, 2008, Pages 5473-5481

  Wang, Qiang ^a   Chen, Maoying ^a   Zhu, Huawei ^a   Zhang, Jie ^a   Fang, Hao ^a   Wang, Binghe ^b   Xu, Wenfang ^a  

^a SHANDONG UNIVERSITY   (China)

^b GEORGIA STATE UNIVERSITY   (United States)

Author keywords

APN CD13; Inhibitor; Lysine derivatives; QSAR; Synthesis

Indexed keywords

BESTATIN; GELATINASE A; LYSINE DERIVATIVE; MICROSOMAL AMINOPEPTIDASE; N 6 [(BENZYLOXY)CARBONYL] N 2 (2,4 DICHLOROBENZOYL) N 1 HYDROXYLYSINAMIDE;

ARTICLE; COMPARATIVE MOLECULAR FIELD ANALYSIS; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; IC 50; MOLECULAR MODEL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STEREOSPECIFICITY;

ANTIGENS, CD13; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; INHIBITORY CONCENTRATION 50; LEUCINE; LYSINE; MATRIX METALLOPROTEINASE 2; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 43749112502     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.04.012     Document Type: Article

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