Design, synthesis and biological evaluation of novel l-lysine ureido derivatives as aminopeptidase N inhibitors

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 2, 2011, Pages 900-906

  Su, Li ^a   Fang, Hao ^a   Yang, Kanghui ^a   Xu, Yingying ^a   Xu, Wenfang ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Aminopeptidase N inhibitor; l Lysine ureido derivatives; Synthesis

Indexed keywords

6 BENZYLOXYCARBONYLAMINO 2 (3 CARBOXYMETHYL UREIDO) HEXANOIC ACID; 6 BENZYLOXYCARBONYLAMINO 2 (3 METHOXYCARBONYL METHYL UREIDO) HEXANOIC ACID METHYL ESTER; 6 BENZYLOXYCARBONYLAMINO 2 [3 (1 CARBOXY 2 BENZYL) UREIDO] HEXANOIC ACID; 6 BENZYLOXYCARBONYLAMINO 2 [3 (1 CARBOXY 2 BENZYL) UREIDO] HEXANOIC ACID METHYL ESTER; 6 BENZYLOXYCARBONYLAMINO 2 [3 (1 CARBOXY 2 METHYL BUTYL) UREIDO] HEXANOIC ACID METHYL ESTER; 6 BENZYLOXYCARBONYLAMINO 2 [3 (1 CARBOXY 2 METHYL PROPYL) UREIDO] HEXANOIC ACID; 6 BENZYLOXYCARBONYLAMINO 2 [3 (1 CARBOXY 2 METHYL PROPYL) UREIDO] HEXANOIC ACID METHYL ESTER; 6 BENZYLOXYCARBONYLAMINO 2 [3 (1 CARBOXY 2 METHYLBUTYL) UREIDO] HEXANOIC ACID; 6 BENZYLOXYCARBONYLAMINO 2 [3 (1 CARBOXY 3 METHYL BUTYL) UREIDO] HEXANOIC ACID; 6 BENZYLOXYCARBONYLAMINO 2 [3 (1 CARBOXY 3 METHYLBUTYL) UREIDO] HEXANOIC ACID METHYL ESTER; 6 BENZYLOXYCARBONYLAMINO 2 [3 (1 CARBOXY 3 METHYLSULFANYL PROPYL) UREIDO] HEXANOIC ACID; 6 BENZYLOXYCARBONYLAMINO 2 [3 (1 CARBOXY 3 METHYLSULFANYL PROPYL) UREIDO] HEXANOIC ACID METHYL ESTER; 6 BENZYLOXYCARBONYLAMINO 2 [3 (1 CARBOXY ETHYL) UREIDO] HEXANOIC ACID; 6 BENZYLOXYCARBONYLAMINO 2 [3 (1 CARBOXY ETHYL) UREIDO] HEXANOIC ACID METHYL ESTER; [5 HYDROXYCARBAMOYL 5 (3 HYDROXYCARBAMOYLMETHY UREIDO) PENTYL] CARBAMIC ACID BENZYL ESTER; BESTATIN; LYSINE DERIVATIVE; LYSINE UREIDO DERIVATIVE; PEPTIDE HYDROLASE INHIBITOR; UNCLASSIFIED DRUG; {5 HYDROXYCARBAMOYL 5 [3 (1 HYDROXYCARBAMOYL 2 METHYL BUTYL) UREIDO] PENTYL} CARBAMIC ACID BENZYL ESTER; {5 HYDROXYCARBAMOYL 5 [3 (1 HYDROXYCARBAMOYL 2 PHENY ETHYL) UREIDO] PENTYL} CARBAMIC ACID BENZYL ESTER; {5 HYDROXYCARBAMOYL 5 [3 (1 HYDROXYCARBAMOYL 3 METHYL BUTYL) UREIDO] PENTYL} CARBAMIC ACID BENZYL ESTER; {5 HYDROXYCARBAMOYL 5 [3 (1 HYDROXYCARBAMOYL 3 METHYLSULFANYL PROPYL) UREIDO] PENTYL} CARBAMIC ACID BENZYL ESTER; {5 HYDROXYCARBAMOYL 5 [3 (1 HYDROXYCARBAMOYL ETHY) UREIDO] PENTYL} CARBAMIC ACID BENZYL ESTER;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DESIGN; DRUG INHIBITION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL;

ANTIGENS, CD13; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; COMPUTER SIMULATION; DRUG DESIGN; HUMANS; HYDROGEN BONDING; LEUCINE; LYSINE; PHENYLUREA COMPOUNDS; PROTEASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 78651480502     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.11.066     Document Type: Article

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