Novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase N (APN)

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 23, 2008, Pages 9984-9990

  Shang, Luqing ^a   Wang, Qiang ^a   Fang, Hao ^a   Mu, Jiajia ^a   Wang, Xuejian ^a   Yuan, Yumei ^a   Wang, Binghe ^b   Xu, Wenfang ^a  

^a SHANDONG UNIVERSITY   (China)

^b GEORGIA STATE UNIVERSITY   (United States)

Author keywords

3 Phenylpropane 1,2 diamine derivates; Aminopeptidase N inhibitor; Synthesis

Indexed keywords

2 AMINO 3 HYDROXYL N [(2R) 2 AMINO 3 PHENYLPROPYL]PROPIONAMIDE; 2 AMINO 3 METHYL N [(2R) 2 AMINO 3 PHENYLPROPYL]PROPIONAMIDE; 2 AMINO 3 THIOL N [(2R) 2 AMINO 3 PHENYLPROPYL]PROPIONAMIDE; 2 AMINO 4 METHYL N [(2R) 2 AMINO 3 PHENYLPROPYL]VALERAMIDE; 2 AMINO 4 METHYLTHIO N [(2R) 2 AMINO 3 PHENYLPROPYL]BUTYRAMIDE; 2 AMINO N [(2R) 2 AMINO 3 PHENYLPROPYL] ACETAMIDE; 2 AMINO N [(2R) 2 AMINO 3 PHENYLPROPYL]PROPIONAMIDE; 2,5 AMINO N [(2R) 2 AMINO 3 PHENYLPROPYL]VALERAMIDE; 2,6 AMINO N [(2R) 2 AMINO 3 PHENYLPROPYL]CAPROYLAMIDE; 3 [(TERT BUTOXYCARBONYL)AMINO] N [(2R) 2 [(TERTBUTOXYCARBONYL)AMINO] 3 PHENYLPROPYL]PROPIONAMIDE; 3 AMINO N [(2R) 2 AMINO 3 PHENYLPROPYL]PROPIONAMIDE; 3 PHENYLPROPANE 1,2 DIAMINE; 6 AMINO N [(2R) 2 AMINO 3 PHENYLPROPYL]CAPROYLAMIDE; BESTATIN; DIAMINE DERIVATIVE; LEVO PHENYLALANYL N [(2R) 2 AMINO 3 PHENYLPROPYL] LEVO PHENYLALANINAMIDE; MICROSOMAL AMINOPEPTIDASE; MICROSOMAL AMINOPEPTIDASE INHIBITOR; N [(2R) 2 AMINO 3 PHENYLPROPYL] 2 [2 [(2,6 DICHLOROPHENYL)AMINO]PHENYL]ACETAMIDE; N [(2R) 2 AMINO 3 PHENYLPROPYL] 2 PHENYLACETAMIDE; N [(2R) 2 AMINO 3 PHENYLPROPYL] 3 (3,4 HYDROXY)ACRYLAMIDE; N [(2R) 2 AMINO 3 PHENYLPROPYL] 3 PHENYLACRYLAMIDE; N [(2R) 2 AMINO 3 PHENYLPROPYL] 3 PHENYLPROPANAMIDE; N [(2R) 2 AMINO 3 PHENYLPROPYL] 3,5 DINITROBENZAMIDE; N [(2R) 2 AMINO 3 PHENYLPROPYL] 4 PHENYLBUTANAMIDE; N [(2R) 2 AMINO 3 PHENYLPROPYL]LEVO GLUTAMAMIDE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; IC 50;

ANTIGENS, CD13; CELLS, CULTURED; DIAMINES; HL-60 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MATRIX METALLOPROTEINASE 2; MICROSOMES; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 55749090764     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.10.025     Document Type: Article

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