Newly discovered viral E3 ligase pK3 induces endoplasmic reticulum-associated degradation of class I major histocompatibility proteins and their membrane-bound chaperones

Journal of Biological Chemistry

Volumn 287, Issue 18, 2012, Pages 14467-14479

  Herr, Roger A ^a   Wang, Xiaoli ^a   Loh, Joy ^a   Virgin, Herbert W ^a   Hansen, Ted H ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN PROCESSING; CELLULAR QUALITY CONTROL; CLASS I; E3 LIGASE; ENDOPLASMIC RETICULUM; LIGASES; MEMBRANE-BOUND; PEPTIDE BINDING; PEPTIDE-LOADING COMPLEX; RAPID DEGRADATION; SLOW DEGRADATION; TAPASIN; TRANS-MEMBRANE PROTEINS; UBIQUITIN LIGASES;

CELL MEMBRANES; LOADING; PEPTIDES;

DEGRADATION;

MAJOR HISTOCOMPATIBILITY ANTIGEN; MEMBRANE PROTEIN; TAPASIN; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; VIRAL UBIQUITIN LIGASE PK3;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CATALYSIS; CELL SURFACE; COMPLEX FORMATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; HERPES VIRUS; LATENT VIRUS INFECTION; MEMBRANE BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STABILITY; RODENT HERPESVIRUS; UBIQUITINATION;

ANIMALS; ANTIGENS, LY; CELL LINE; ENDOPLASMIC RETICULUM; HERPESVIRIDAE; HERPESVIRIDAE INFECTIONS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; PROTEOLYSIS; UBIQUITIN-PROTEIN LIGASES; VIRAL PROTEINS;

HERPESVIRIDAE; MUS; RODENTIA;

EID: 84860375809     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.325340     Document Type: Article

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