Vitamin D and cancer: Integration of cellular biology, molecular mechanisms and animal models

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 72, Issue SUPPL. 243, 2012, Pages 103-111

  Welsh, Joellen ^a  

^a STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Cancer; Diet; Prevention; VDR; Vitamin D receptor

Indexed keywords

25 HYDROXYVITAMIN D; CALCITRIOL; ESTROGEN; MICRORNA; SONIC HEDGEHOG PROTEIN; VITAMIN D RECEPTOR; CALCITRIOL RECEPTOR; VITAMIN D;

APOPTOSIS; AUTOCRINE EFFECT; BREAST CARCINOGENESIS; CANCER CELL CULTURE; CANCER GROWTH; CANCER RISK; CANCER SUSCEPTIBILITY; CELL DIFFERENTIATION; CELL FATE; CELL STRESS; COLON CARCINOGENESIS; DIET SUPPLEMENTATION; DNA DAMAGE; EPITHELIUM CELL; G1 PHASE CELL CYCLE CHECKPOINT; GENE DELETION; GENETIC MODEL; GENOME; HUMAN; PRIORITY JOURNAL; PROSTATE CANCER; RECEPTOR GENE; REVIEW; SIGNAL TRANSDUCTION; SKIN CARCINOGENESIS; VITAMIN D METABOLISM; ANIMAL; ANTIBODY SPECIFICITY; ARTICLE; DISEASE MODEL; FEMALE; MALE; NEOPLASM; PHYSIOLOGY;

ANIMALIA; MUS;

ANIMALS; DISEASE MODELS, ANIMAL; DNA DAMAGE; FEMALE; HUMANS; MALE; NEOPLASMS; ORGAN SPECIFICITY; RECEPTORS, CALCITRIOL; VITAMIN D;

EID: 84860375306     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.3109/00365513.2012.682870     Document Type: Review

References (52)

1. Zinser GM, McEleney K, Welsh J. Characterization of mammary tumor cell lines from wild type and vitamin D(3) receptor knockout mice. Mol Cell Endocrinol 2003; 200:67-80.
2. Maund SL, Barclay WW, Hover LD, Axanova LS, Sui G, Hipp JD, Fleet JC, Thorburn A, Cramer SD. Interleukin-1-{alpha} mediates the antiproliferative effects of 1,25-dihydroxyvitamin D in prostate progenitor/stem cells. Cancer Res 2011;71:5276-86.
3. Bijlsma MF, Spek CA, Zivkovic D, van de Water S, Rezaee F, Peppelenbosch MP. Repression of smoothened by patched-dependent (pro-)vitamin D secretion. PLoS Biol 2006;8:e232.
4. Tang JY, Xiao TZ, Oda Y, Chang KS, E Shpall, Wu A, So PL, Hebert J, Bikle D, Epstein EH, Jr. Vitamin D inhibits hedgehog signaling and proliferation in murine Basal cell carcinomas. Cancer Prev Res (Phila) 2011;5:744-51.
5. Mason RS, Dixon KM, Sequeira VB, Gordon-Thomson C. Sunlight protection by vitamin D compounds. 3rd edn. Feldman D, Pike JW, Adams JS, editors: Elsevier; 2011.
6. Wong G, Gupta R, Dixon KM, Deo SS, Choong SM, Halliday GM, Bishop JE, Ishizuka S, Norman AW, Posner GH, Mason RS 1,25-Dihydroxyvitamin D and three lowcalcemic analogs decrease UV-induced DNA damage via the rapid response pathway. J Steroid Biochem Mol Biol 2004;89-90:567-70.
7. Byers SW, Rowlands T, Beildeck M, Bong YS. Mechanism of action of vitamin D and the vitamin D receptor in colorectal cancer prevention and treatment. Rev Endocr Metab Disord 2011.
8. Shah S, Islam MN, Dakshanamurthy S, Rizvi I, Rao M, Herrell R, Zinser G, Valrance M, Aranda A, Moras D, Norman A, Welsh J, Byers SW. The molecular basis of vitamin D receptor and beta-catenin crossregulation. Mol Cell 2006;21:799-809.
9. Egan JB, Thompson PA, Vitanov MV, Bartik L, Jacobs ET, Haussler MR, Gerner EW, Jurutka PW. Vitamin D receptor ligands, adenomatous polyposis coli, and the vitamin D receptor FokI polymorphism collectively modulate betacatenin activity in colon cancer cells. Mol Carcinog. 2010;49:337-52.
10. Alvarez-Diaz S, Larriba MJ, Lopez-Otin C, Munoz A. Vitamin D: Proteases, protease inhibitors and cancer. Cell Cycle. 2010;9:32-7.
11. Ordonez-Moran P, Alvarez-Diaz S, Valle N, Larriba MJ, Bonilla F, Munoz A. The effects of 1,25-dihydroxyvitamin D on colon cancer cells depend on RhoA-ROCK-p38MAPKMSK signaling. J Steroid Biochem Mol Biol. 2010 ;121: 355-61.
12. Kaler P, Augenlicht L, Klampfer L. Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3. Oncogene. 2009;28:3892-902.
13. Palmer HG, Larriba MJ, Garcia JM, Ordonez-Moran P, Pena C, Peiro S, Puig I, Rodriguez R, de la Fuente R, Bernad A, Pollan M, Bonilla F, Gamallo C, de Herreros AG, Munoz A The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer. Nat Med 2004;10:917-9.
14. Larriba MJ, Martin-Villar E, Garcia JM, Pereira, Pena FC, de Herreros AG, Bonilla F, Munoz A. Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer. Carcinogenesis. 2009;30:1459-68.
15. Horvath HC, Khabir Z, Nittke T, Gruber S, Speer G, Manhardt T, Bonner E, Kallay E, J CYP24A1 splice variants-implications for the antitumorigenic actions of 1,25-(OH)2D in colorectal cancer. J Steroid Biochem Mol Biol 2010;121:76-9.
16. Horvath HC, Lakatos P, Kosa JP, Bacsi K, Borka K, Bises G, Nittke T, Hershberger PA, Speer G, Kallay E. The candidate oncogene CYP24A1: A potential biomarker for colorectal tumorigenesis. J Histochem Cytochem 2010; 58:277-85.
17. Matthews D, LaPorta E, Zinser GM, Narvaez CJ, Welsh J. Genomic vitamin D signaling in breast cancer: Insights from animal models and human cells. J Steroid Biochem Mol Biol. 2010;121:362-7.
18. Kemmis CM, Salvador SM, Smith KM, Welsh J. Human mammary epithelial cells express CYP27B1 and are growth inhibited by 25-hydroxyvitamin D-3, the major circulating form of vitamin D-3. J Nutr. 2006;136:887-92.
19. Rowling MJ, Kemmis CM, Taffany DA, Welsh J. Megalinmediated endocytosis of vitamin D binding protein correlates with 25-hydroxycholecalciferol actions in human mammary cells. J Nutr. 2006;136:2754-9.
20. Townsend K, Banwell CM, Guy M, Colston KW, Mansi JL, Stewart PM, Campbell MJ, Hewison M. Autocrine metabolism of vitamin D in normal and malignant breast tissue. Clin Cancer Res. 2005;11:3579-86.
21. Peng X, Vaishnav A, Murillo G, Alimirah F, Torres KE, Mehta RG. Protection against cellular stress by 25-hydroxyvitamin D in breast epithelial cells. J Cell Biochem 2010;110:1324-33.
22. Ching S, Kashinkunti S, Niehaus MD, Zinser GM. Mammary adipocytes bioactivate 25-hydroxyvitamin D(3) and signal via vitamin D(3) receptor, modulating mammary epithelial cell growth. J Cell Biochem 2011.
23. Lopes N, Sousa B, Martins D, Gomes M, Vieira D, Veronese LA, Milanezi F, Paredes J, Costa JL, Schmitt F. Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions. BMC Cancer 2010;10:483.
24. K emmis CM, Welsh J. Mammary epithelial cell transformation is associated with deregulation of the vitamin D pathway. J Cell Biochem 2008;105:980-8.
25. Mathiasen IS, Lademann U, Jaattela M. Apoptosis induced by vitamin D compounds in breast cancer cells is inhibited by Bcl-2 but does not involve known caspases or p53. Cancer Res 1999;59:4848-56.
26. Krishnan AV, Feldman D. Mechanisms of the anti-cancer and anti-inflammatory actions of vitamin D. Annu Rev Pharmacol Toxicol. 2011;51:311-36.
27. Kovalenko PL, Zhang Z, Cui M, Clinton SK, Fleet JC. 1,25 dihydroxyvitamin D-mediated orchestration of anticancer, transcript-level effects in the immortalized, non-transformed prostate epithelial cell line, RWPE1. BMC Genomics. 2010; 11:26.
28. Wang WL, Chatterjee N, Chittur SV, Welsh J, Tenniswood MP. Effects of 1alpha,25 dihydroxyvitamin D and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer 2011;10:58.
29. Quigley DA, To MD, Perez-Losada J, Pelorosso FG, Mao JH, Nagase H, Ginzinger DG, Balmain A. Genetic architecture of mouse skin inflammation and tumour susceptibility. Nature 2009;26:505-8.
30. Zinser GM, Sundberg JP, Welsh J. Vitamin D(3) receptor ablation sensitizes skin to chemically induced tumorigenesis. Carcinogenesis 2002;23:2103-9.
31. Ellison TI, Smith MK, Gilliam AC, MacDonald PN. Inactivation of the vitamin D receptor enhances susceptibility of murine skin to UV-induced tumorigenesis. J Invest Dermatol 2008;128:2508-17.
32. Oda Y, Uchida Y, Moradian S, Crumrine D, Elias PM, Bikle DD. Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation. J Invest Dermatol 2009;129: 1367-78.
33. Teichert AE, Elalieh H, Elias PM, Welsh J, Bikle DD. Overexpression of Hedgehog signaling is associated with epidermal tumor formation in vitamin D receptor-null mice. J Invest Dermatol 2011.
34. Bikle DD, Chang S, Crumrine D, Elalieh H, Man MQ, Choi EH, Dardenne, O Xie Z, Arnaud RS, Feingold K, Elias PM. 25 Hydroxyvitamin D1 alpha-hydroxylase is required for optimal epidermal differentiation and permeability barrier homeostasis. J Invest Dermatol 2004;122: 984-92.
35. Dixon KM, Norman AW, Sequeira VB, Mohan R, Rybchyn MS, Reeve VE, Halliday GM, Mason RS. 1{alpha},25(OH)2-vitamin D and a non-genomic vitamin D analog inhibit ultraviolet radiation-induced skin carcinogenesis. Cancer Prev Res (Phila) 2011.
36. Biggs L, Yu C, Fedoric B, Lopez AF, Galli SJ, Grimbaldeston MA. Evidence that vitamin D(3) promotes mast cell-dependent reduction of chronic UVB-induced skin pathology in mice. J Exp Med 2010;207:455-63.
37. Raman M, Milestone AN, Walters JR, Hart AL, Ghosh S. Vitamin D and gastrointestinal diseases: inflammatory bowel disease and colorectal cancer. Therap Adv Gastroenterol 2011;4:49-62.
38. Newmark HL, Yang K, Kurihara N, Fan K, Augenlicht LH, Lipkin M. Western-style diet-induced colonic tumors and their modulation by calcium and vitamin D in C57Bl/6 mice: a preclinical model for human sporadic colon cancer. Carcinogenesis 2009;30:88-92.
39. Froicu M, Weaver V, Wynn TA, McDowell MA, Welsh JE, Cantorna MT. A crucial role for the vitamin D receptor in experimental inflammatory bowel diseases. Mol Endocrinol 2003;17:2386-92.
40. Murillo G, Nagpal V, Tiwari N, Benya RV, Mehta RG. Actions of vitamin D are mediated by the TLR4 pathway in inflammation-induced colon cancer. J Steroid Biochem Mol Biol 2010;121:403-7.
41. Huerta S, Irwin RW, Heber D, Go VL, Koeffler HP, Uskokovic MR, Harris DM 1alpha,25-(OH)(2)-D(3) and its synthetic analogue decrease tumor load in the Apc(min) Mouse. Cancer Res 2002;62:741-6.
42. Xu H, Posner GH, Stevenson M, Campbell FC. Apc(MIN) modulation of vitamin D secosteroid growth control. Carcinogenesis 2010;8:1434-41.
43. Zheng W, Wong KE, Zhang Z, Dougherty U, MustafiR, Kong J, Deb DK, Zheng H, Bissonnette M, Li YC. Inactivation of the vitamin D receptor in APC(min/-) mice reveals a critical role for the vitamin D receptor in intestinal tumor growth. Int J Cancer 2011.
44. Zheng W, Wong KE, Zhang Z, Dougherty U, MustafiR, Kong J, Deb DK, Zheng H, Bissonnette M, Li YC. Vitamin D receptor deficiency enhances Wnt/beta-Catenin signaling and tumor burden in colon cancer. PLoS One 2011; 6:e23524.
45. James SY, Mercer E, Brady M, Binderup L, Colston KW. EB1089, a synthetic analogue of vitamin D, induces apoptosis in breast cancer cells in vivo and in vitro. Br J Pharmacol 1998;125:953-62.
46. VanWeelden K, Flanagan L, Binderup L, Tenniswood M, Welsh J. Apoptotic regression of MCF-7 xenografts in nude mice treated with the vitamin D analog, EB1089. Endocrinology 1998;139:2102-10.
47. Valrance ME, Brunet AH, Acosta A, Welsh J. Dissociation of growth arrest and CYP24 induction by VDR ligands in mammary tumor cells. J Cell Biochem 2007.
48. El Abdaimi K, Dion N, Papavasiliou V, Cardinal, PE Binderup L, Goltzman D, Ste-Marie LG, Kremer R. The vitamin D analogue EB1089 prevents skeletal metastasis and prolongs survival time in nude mice transplanted with human breast cancer cells. Cancer Res 2000;60:4412-8.
49. Ooi LL, Zheng Y, Zhou H, Trivedi T, Conigrave AD, Seibel MJ, Dunstan CR. Vitamin D deficiency promotes growth of MCF-7 human breast cancer in a rodent model of osteosclerotic bone metastasis. Bone 2010;47:795-803.
50. Ooi LL, Zhou H, Kalak R, Zheng Y, Conigrave AD, Seibel MJ, Dunstan CR. Vitamin D deficiency promotes human breast cancer growth in a murine model of bone metastasis. Cancer Res 2010;70:1835-44.
51. Mordan-McCombs S, Brown T, Wang WL, Gaupel AC, Welsh J, Tenniswood M. Tumor progression in the LPB-Tag transgenic model of prostate cancer is altered by vitamin D receptor and serum testosterone status. J Steroid Biochem Mol Biol 2010;121:368-71.
52. Kovalenko PL, Zhang Z, Yu JG, Li Y, Clinton SK, Fleet JC. Dietary vitamin D and vitamin D receptor level modulate epithelial cell proliferation and apoptosis in the prostate. Cancer Prev Res (Phila) 2011.