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Volumn 29, Issue 1, 2012, Pages 149-182

Drug-loaded PLGA nanoparticles for oral administration: Fundamental issues and challenges ahead

Author keywords

Challenges and issues; Nanoparticle characterization; Nanotechnology; PLGA

Indexed keywords

AMIFOSTINE; ATORVASTATIN; CURCUMIN; CYCLOSPORIN A; DEXAMETHASONE; DOXORUBICIN; ELLAGIC ACID; ESTRADIOL; ETHAMBUTOL PLUS ISONIAZID PLUS PYRAZINAMIDE PLUS RIFAMPICIN; ETHIONAMIDE; HEPARIN; HUMAN GROWTH HORMONE; INSULIN; MIFEPRISTONE; NANOPARTICLE; OCTREOTIDE; PACLITAXEL; POLYCAPROLACTONE; POLYGLACTIN; ROLIPRAM; STREPTOMYCIN; SURODEX; TAMOXIFEN; TRIPTORELIN; UBIDECARENONE; UNCLASSIFIED DRUG; VORICONAZOLE; ALPHA TOCOPHEROL SUCCINATE; POLYMER; TUBERCULOSTATIC AGENT;

EID: 84860365715     PISSN: 07434863     EISSN: None     Source Type: Journal    
DOI: 10.1615/critrevtherdrugcarriersyst.v29.i2.20     Document Type: Review
Times cited : (28)

References (127)
  • 1
    • 51649129933 scopus 로고    scopus 로고
    • Microencapsulation by solvent evaporation: State of the art for process engineering approaches
    • Li M, Rouaud O, Poncelet D. Microencapsulation by solvent evaporation: state of the art for process engineering approaches. Int J Pharm. 2008; 363: 26-39.
    • (2008) Int J Pharm. , vol.363 , pp. 26-39
    • Li, M.1    Rouaud, O.2    Poncelet, D.3
  • 2
    • 70249129749 scopus 로고    scopus 로고
    • An innovative, quick and convenient labeling method for the investigation of pharmacological behavior and the metabolism of poly (DL-lactide-co-glycolide) nanospheres
    • Stevanovic M, Maksin T, Petkovic J, Filipic M, Uskokovic D. An innovative, quick and convenient labeling method for the investigation of pharmacological behavior and the metabolism of poly (DL-lactide-co-glycolide) nanospheres. Nanotechnol. 2009; 20: 1-12.
    • (2009) Nanotechnol. , vol.20 , pp. 1-12
    • Stevanovic, M.1    Maksin, T.2    Petkovic, J.3    Filipic, M.4    Uskokovic, D.5
  • 4
    • 0030993565 scopus 로고    scopus 로고
    • The oral absorption of micro-and nanoparticulates: Neither exceptional nor unusual
    • Florence AT. The oral absorption of micro-and nanoparticulates: neither exceptional nor unusual. Pharm Res. 1997;14: 259-66.
    • (1997) Pharm Res. , vol.14 , pp. 259-266
    • Florence, A.T.1
  • 5
    • 0025674686 scopus 로고
    • Nanoparticle uptake by the rat gastrointestinal mucosa: Quantitation and particle size dependency
    • Jani P, Halbert GW, Langridge J, Florence AT. Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency. J Pharm Pharmacol. 1990; 42: 821-6.
    • (1990) J Pharm Pharmacol. , vol.42 , pp. 821-826
    • Jani, P.1    Halbert, G.W.2    Langridge, J.3    Florence, A.T.4
  • 6
    • 82255175728 scopus 로고    scopus 로고
    • PLGA nanoparticles for oral delivery of hydrophobic drugs: Influence of organic solvent on nanoparticles formation and release behavior in vitro and in vivo using estradiol as a model drug
    • Sahana DK, Mittal G, Bhardwaj V, Ravi Kumar MNV. PLGA nanoparticles for oral delivery of hydrophobic drugs: influence of organic solvent on nanoparticles formation and release behavior in vitro and in vivo using estradiol as a model drug. J Pharm Sci. 2007; 9999:1-13.
    • (2007) J Pharm Sci. , vol.9999 , pp. 1-13
    • Sahana, D.K.1    Mittal, G.2    Bhardwaj, V.3    Ravi Kumar, M.N.V.4
  • 7
    • 17444395135 scopus 로고    scopus 로고
    • Polymer-based drug delivery systems for mycobacterial infections
    • Pandey R, Khuller GK. Polymer-based drug delivery systems for mycobacterial infections. Curr Drug Deliv. 2004; 1: 195-201.
    • (2004) Curr Drug Deliv. , vol.1 , pp. 195-201
    • Pandey, R.1    Khuller, G.K.2
  • 8
    • 27844449247 scopus 로고    scopus 로고
    • PLGA-PEG block copolymers for drug formulations
    • Huh KM, Cho YW, Park K. PLGA-PEG block copolymers for drug formulations. Drug Deliv Technol. 2003; 3: 42-9.
    • (2003) Drug Deliv Technol. , vol.3 , pp. 42-49
    • Huh, K.M.1    Cho, Y.W.2    Park, K.3
  • 9
    • 75549088273 scopus 로고    scopus 로고
    • Nanoparticles: A personal experience for formulating poorly water soluble drugs
    • Cooper ER. Nanoparticles: a personal experience for formulating poorly water soluble drugs. J Control Release. 2010; 141: 300-2.
    • (2010) J Control Release. , vol.141 , pp. 300-302
    • Cooper, E.R.1
  • 10
    • 77955861453 scopus 로고    scopus 로고
    • Assessing the safety and cost-effectiveness of early nanodrugs
    • Vines T, Faunce T. Assessing the safety and cost-effectiveness of early nanodrugs. J Law Med 2009;16: 822-45.
    • (2009) J Law Med , vol.16 , pp. 822-845
    • Vines, T.1    Faunce, T.2
  • 11
    • 0038387390 scopus 로고    scopus 로고
    • The dawning era of polymer therapeutics
    • R. Duncan. The dawning era of polymer therapeutics. Nat Rev Drug Discov. 2003; 2: 347-60.
    • (2003) Nat Rev Drug Discov. , vol.2 , pp. 347-360
    • Duncan, R.1
  • 12
    • 84860381775 scopus 로고    scopus 로고
    • assessed on: 15/03/2011
    • www.USFDA.gov/assessed on: 15/03/2011.
  • 13
    • 67651213676 scopus 로고    scopus 로고
    • Nanomaterials: A challenge for toxicologists
    • Dhawan A, Sharma V, Parmar D. Nanomaterials: a challenge for toxicologists. Nanotoxicol 2009; 3: 1-9.
    • (2009) Nanotoxicol , vol.3 , pp. 1-9
    • Dhawan, A.1    Sharma, V.2    Parmar, D.3
  • 14
    • 33750060454 scopus 로고    scopus 로고
    • Freeze-drying of low molecular weight poly (L-lactic acid) nanoparticles: Effect of cryo-and lyoprotectants
    • Hirsjarvi S, Peltonen L, Kainu L, Hirvonen J. Freeze-drying of low molecular weight poly (L-lactic acid) nanoparticles: effect of cryo-and lyoprotectants. J Nanosci Nanotechnol. 2006; 6: 3110-7.
    • (2006) J Nanosci Nanotechnol. , vol.6 , pp. 3110-3117
    • Hirsjarvi, S.1    Peltonen, L.2    Kainu, L.3    Hirvonen, J.4
  • 15
    • 33646830139 scopus 로고    scopus 로고
    • Investigation of nanocapsules stabilization by amorphous excipients during freeze-drying and storage
    • Abdelwahed W, Degobert G, Fessi H. Investigation of nanocapsules stabilization by amorphous excipients during freeze-drying and storage. Eur J Pharm Biopharm. 2006; 63: 87-94.
    • (2006) Eur J Pharm Biopharm. , vol.63 , pp. 87-94
    • Abdelwahed, W.1    Degobert, G.2    Fessi, H.3
  • 16
    • 34547800192 scopus 로고    scopus 로고
    • Freeze drying of nanoparticles: Formulation, process and storage considerations
    • Abdelwashed W, Degobert G, Stainmesse S, Fessi H. Freeze drying of nanoparticles: formulation, process and storage considerations. Adv Drug Deliv Rev. 2006; 58: 1688-713.
    • (2006) Adv Drug Deliv Rev. , vol.58 , pp. 1688-1713
    • Abdelwashed, W.1    Degobert, G.2    Stainmesse, S.3    Fessi, H.4
  • 18
    • 71649096560 scopus 로고    scopus 로고
    • Cryoprotectants for freeze drying of drug nano-suspensions: Effect of freezing rate
    • Lee MK, Kim MY, Kim S, Lee J. Cryoprotectants for freeze drying of drug nano-suspensions: effect of freezing rate. J Pharm Sci. 2009; 98: 4808-17.
    • (2009) J Pharm Sci. , vol.98 , pp. 4808-4817
    • Lee, M.K.1    Kim, M.Y.2    Kim, S.3    Lee, J.4
  • 19
    • 33344464389 scopus 로고    scopus 로고
    • Critical freezing rate in freeze drying nanocrystal dispersions
    • Lee J, Cheng Y. Critical freezing rate in freeze drying nanocrystal dispersions. J Control Release. 2006; 111: 185-92.
    • (2006) J Control Release. , vol.111 , pp. 185-192
    • Lee, J.1    Cheng, Y.2
  • 20
    • 0033790335 scopus 로고    scopus 로고
    • Freeze-drying of polycaprolactone and poly (D, L-lactic-glycolic) nanoparticles induce minor particle size changes affecting the oral pharmacokinetics of loaded drugs
    • Saez A, Guzmán M, Molpeceres J, Aberturas MR. Freeze-drying of polycaprolactone and poly (D, L-lactic-glycolic) nanoparticles induce minor particle size changes affecting the oral pharmacokinetics of loaded drugs. Eur J Pharm Biopharm. 2000; 50:379-87.
    • (2000) Eur J Pharm Biopharm. , vol.50 , pp. 379-387
    • Saez, A.1    Guzmán, M.2    Molpeceres, J.3    Aberturas, M.R.4
  • 21
    • 78449242762 scopus 로고    scopus 로고
    • Cyclosporin A loaded PLGA nanoparticle: Preparation, optimization, in vitro characterization and stability studies
    • Jain S, Mittal A, Jain AK, Mahajan RR, Singh D. Cyclosporin A loaded PLGA nanoparticle: preparation, optimization, in vitro characterization and stability studies. Curr Nanosci. 2010; 6: 422-31.
    • (2010) Curr Nanosci. , vol.6 , pp. 422-431
    • Jain, S.1    Mittal, A.2    Jain, A.K.3    Mahajan, R.R.4    Singh, D.5
  • 22
    • 38149103482 scopus 로고    scopus 로고
    • How meaningful are the results of nanotoxicity studies in the absence of adequate material charecterization
    • Warheit DB. How meaningful are the results of nanotoxicity studies in the absence of adequate material charecterization. Toxicol Sci. 2008; 101: 183-5.
    • (2008) Toxicol Sci. , vol.101 , pp. 183-185
    • Warheit, D.B.1
  • 23
    • 77957860448 scopus 로고    scopus 로고
    • Toxicity assessment of nanomaterials: Methods and challenges
    • Dhawan A, Sharma V. Toxicity assessment of nanomaterials: methods and challenges. Anal Bioanal Chem. 2010; 398: 589-605.
    • (2010) Anal Bioanal Chem. , vol.398 , pp. 589-605
    • Dhawan, A.1    Sharma, V.2
  • 25
    • 34147191540 scopus 로고    scopus 로고
    • Characterization of the size, shape, and state of dispersion of nanoparticles for toxicological studies
    • Powers KW, Palazuelos M, Moudgil BM, Roberts SM. Characterization of the size, shape, and state of dispersion of nanoparticles for toxicological studies. Nanotoxicol. 2007; 1: 42-51.
    • (2007) Nanotoxicol. , vol.1 , pp. 42-51
    • Powers, K.W.1    Palazuelos, M.2    Moudgil, B.M.3    Roberts, S.M.4
  • 26
    • 38149135806 scopus 로고    scopus 로고
    • Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique
    • Murdock RC, Braydich-Stolle L, Schrand A M, Schlager JJ, Hussain SM. Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique. Toxicol Sci. 2008; 101: 239-53.
    • (2008) Toxicol Sci. , vol.101 , pp. 239-253
    • Murdock, R.C.1    Braydich-Stolle, L.2    Schrand, A.M.3    Schlager, J.J.4    Hussain, S.M.5
  • 27
    • 0037148662 scopus 로고    scopus 로고
    • Characterization of nanoparticle uptake by endothelial cells
    • Davada J, Labhasetwar V. Characterization of nanoparticle uptake by endothelial cells. Int J Pharm 2002; 233: 51-9.
    • (2002) Int J Pharm , vol.233 , pp. 51-59
    • Davada, J.1    Labhasetwar, V.2
  • 28
    • 4644292567 scopus 로고    scopus 로고
    • WGA-grafted PLGA-nanospheres: Preparation and association with Caco-2 single cells
    • Weissenbock A, Wirth M, Gabor F. WGA-grafted PLGA-nanospheres: preparation and association with Caco-2 single cells. J Control Release. 2004; 99: 383-92.
    • (2004) J Control Release. , vol.99 , pp. 383-392
    • Weissenbock, A.1    Wirth, M.2    Gabor, F.3
  • 29
    • 0037018971 scopus 로고    scopus 로고
    • Investigation of polymeric nanoparticles as carrier of enalaprilat for oral administration
    • Ahlin P, Kristl J, Kristl A, Vrecer F. Investigation of polymeric nanoparticles as carrier of enalaprilat for oral administration. Int J Pharm. 2002; 239: 113-20.
    • (2002) Int J Pharm. , vol.239 , pp. 113-120
    • Ahlin, P.1    Kristl, J.2    Kristl, A.3    Vrecer, F.4
  • 30
    • 59349092521 scopus 로고    scopus 로고
    • Localization and quantification of biodegradable particles in an intestinal cell model: The influence of particle size
    • Gaumet M, Gurny R, Delie F. Localization and quantification of biodegradable particles in an intestinal cell model: the influence of particle size. Eur J Pharm Sci. 2009; 36: 465-73.
    • (2009) Eur J Pharm Sci. , vol.36 , pp. 465-473
    • Gaumet, M.1    Gurny, R.2    Delie, F.3
  • 31
    • 41549123975 scopus 로고    scopus 로고
    • Nanoparticles for drug delivery: The need for precision in reporting particle size parameters
    • Gaumet M, Vargas A, Gurny R, Delie F. Nanoparticles for drug delivery: the need for precision in reporting particle size parameters. Eur J Pharm Biopharm. 2008; 69:1-9.
    • (2008) Eur J Pharm Biopharm. , vol.69 , pp. 1-9
    • Gaumet, M.1    Vargas, A.2    Gurny, R.3    Delie, F.4
  • 32
    • 38049103405 scopus 로고    scopus 로고
    • Characterization of nanoparticles for therapeutics
    • Hall JB, Dobrovolskaia MA, McNeil SE. Characterization of nanoparticles for therapeutics. Nanomedicine. 2007; 2: 789-803.
    • (2007) Nanomedicine , vol.2 , pp. 789-803
    • Hall, J.B.1    Dobrovolskaia, M.A.2    McNeil, S.E.3
  • 34
    • 56549108860 scopus 로고    scopus 로고
    • Measuring particle size by light scattering
    • In: Holmberg K, editor, New Jersey: John Wiley
    • Borkovec M. Measuring particle size by light scattering. In: Holmberg K, editor. Handbook of applied surface and colloid chemistry. New Jersey: John Wiley; 2002. p. 357-70.
    • (2002) Handbook of applied surface and colloid chemistry , pp. 357-370
    • Borkovec, M.1
  • 36
    • 65749087491 scopus 로고    scopus 로고
    • In vitro assessment of nanomaterial toxicity
    • Jones C, Grainger DW. In vitro assessment of nanomaterial toxicity. Adv Drug Deliv Reviews. 2009; 61: 438-56.
    • (2009) Adv Drug Deliv Reviews. , vol.61 , pp. 438-456
    • Jones, C.1    Grainger, D.W.2
  • 37
    • 0035993127 scopus 로고    scopus 로고
    • Polymer nanoparticle characterization in aqueous suspensions
    • Duclairoir C, Nakache E. Polymer nanoparticle characterization in aqueous suspensions. Int J Polym Anal Charact. 2002; 7: 284-313.
    • (2002) Int J Polym Anal Charact. , vol.7 , pp. 284-313
    • Duclairoir, C.1    Nakache, E.2
  • 38
    • 74249095160 scopus 로고    scopus 로고
    • Part I: Introduction to nanoparticles characterization with AFM
    • cited 2011, Jan 21, Available from
    • Scalf J, West P. Part I: Introduction to nanoparticles characterization with AFM. Pacific Nanotechnology Inc, Santa Clara; 2006 (cited 2011, Jan 21). Available from: www.nanoparticles.org/pdf/Scalf-West.pdf/assessed.
    • (2006) Pacific Nanotechnology Inc, Santa Clara
    • Scalf, J.1    West, P.2
  • 39
    • 71449119077 scopus 로고    scopus 로고
    • The relationship between pH and zeta potential of ~ 30 nm metal oxide nanoparticle suspensions relevant to in vitro toxicological evaluations
    • Berg JM, Romoser A, Banerjee N, Zebda R, Sayes CM. The relationship between pH and zeta potential of ~ 30 nm metal oxide nanoparticle suspensions relevant to in vitro toxicological evaluations. Nanotoxicol. 2009; 3: 276-83.
    • (2009) Nanotoxicol. , vol.3 , pp. 276-283
    • Berg, J.M.1    Romoser, A.2    Banerjee, N.3    Zebda, R.4    Sayes, C.M.5
  • 40
    • 33748310797 scopus 로고    scopus 로고
    • Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm
    • Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, Yeh JI, Wiesner MR, Nel AE. Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett. 2006; 6: 1794-807.
    • (2006) Nano Lett. , vol.6 , pp. 1794-1807
    • Xia, T.1    Kovochich, M.2    Brant, J.3    Hotze, M.4    Sempf, J.5    Oberley, T.6    Sioutas, C.7    Yeh, J.I.8    Wiesner, M.R.9    Nel, A.E.10
  • 41
    • 55749091647 scopus 로고    scopus 로고
    • Nanoparticle size and surface properties determine the protein corona with possibles implications for biological impacts
    • Lundqvist M, Stigler J, Giuliano E, Lynch I, Cedervall T, Dawson K. Nanoparticle size and surface properties determine the protein corona with possibles implications for biological impacts. PNAS. 2009; 105: 14265-70.
    • (2009) PNAS. , vol.105 , pp. 14265-14270
    • Lundqvist, M.1    Stigler, J.2    Giuliano, E.3    Lynch, I.4    Cedervall, T.5    Dawson, K.6
  • 42
  • 43
    • 33144472491 scopus 로고    scopus 로고
    • Bioaccessibility of arsenic (V) bound to ferrihydrate using a simulated gastrointestinal system
    • Beak DG, Basta NT, Scheckel KG, Traina SJ. Bioaccessibility of arsenic (V) bound to ferrihydrate using a simulated gastrointestinal system. Environ Sci Technol. 2006; 40: 1364-70.
    • (2006) Environ Sci Technol. , vol.40 , pp. 1364-1370
    • Beak, D.G.1    Basta, N.T.2    Scheckel, K.G.3    Traina, S.J.4
  • 44
    • 0033557638 scopus 로고    scopus 로고
    • An in vitro gatrointestinal method to estimate bioavailable arsenic in contaminated soils and solid media
    • Rodriguez R, Basta N, Casteel S, Pace LW. An in vitro gatrointestinal method to estimate bioavailable arsenic in contaminated soils and solid media. Environ Sci Technol. 1999; 33: 642-9.
    • (1999) Environ Sci Technol. , vol.33 , pp. 642-649
    • Rodriguez, R.1    Basta, N.2    Casteel, S.3    Pace, L.W.4
  • 45
    • 2442488710 scopus 로고    scopus 로고
    • Hepatic uptake of negatively charged particles in rats: Possible involvement of serum proteins in recognition by scavenger receptor
    • Furumoto K, Nagayama S, Ogawara K, Takakura Y, Hashida M, Higaki K, Kimura T. Hepatic uptake of negatively charged particles in rats: possible involvement of serum proteins in recognition by scavenger receptor. J Control Release. 2004; 97: 133-41.
    • (2004) J Control Release. , vol.97 , pp. 133-141
    • Furumoto, K.1    Nagayama, S.2    Ogawara, K.3    Takakura, Y.4    Hashida, M.5    Higaki, K.6    Kimura, T.7
  • 46
    • 3042682630 scopus 로고    scopus 로고
    • Interfacial approach to aluminium toxicity: Interactions of Al(III) and Pr (III) with model phospholipid bilayer and monolayer membranes
    • Cael V, Van der Heyden A, Champmartin D, Barzyk W, Rubini P, Rogalska E. Interfacial approach to aluminium toxicity: interactions of Al(III) and Pr (III) with model phospholipid bilayer and monolayer membranes. Langmuir. 2003; 19: 8697-708.
    • (2003) Langmuir. , vol.19 , pp. 8697-8708
    • Cael, V.1    van der Heyden, A.2    Champmartin, D.3    Barzyk, W.4    Rubini, P.5    Rogalska, E.6
  • 47
    • 34547178393 scopus 로고    scopus 로고
    • Particle shape: A new design parameter for micro-and nanoscale drug delivery carriers
    • Champion JA, Katare YK, Mitragotri S. Particle shape: a new design parameter for micro-and nanoscale drug delivery carriers. J Control Release. 2007; 121: 3-9.
    • (2007) J Control Release. , vol.121 , pp. 3-9
    • Champion, J.A.1    Katare, Y.K.2    Mitragotri, S.3
  • 50
    • 57849113507 scopus 로고    scopus 로고
    • Physical approaches to biomaterial design
    • Mitragotri S, Lahann J. Physical approaches to biomaterial design. Nat Materials. 2009; 8: 15-23.
    • (2009) Nat Materials. , vol.8 , pp. 15-23
    • Mitragotri, S.1    Lahann, J.2
  • 51
    • 57749178400 scopus 로고    scopus 로고
    • Shape induced inhibition of phagocytosis of polymer particles
    • Champion JA, Mitragotri S. Shape induced inhibition of phagocytosis of polymer particles. Pharm Res. 2009; 26: 244-249.
    • (2009) Pharm Res. , vol.26 , pp. 244-249
    • Champion, J.A.1    Mitragotri, S.2
  • 53
    • 34250852415 scopus 로고    scopus 로고
    • Pharmaceutical nanotechnology: More than size ten topics for research
    • Florence AT. Pharmaceutical nanotechnology: more than size ten topics for research. Int J Pharm. 2007; 339: 1-2.
    • (2007) Int J Pharm. , vol.339 , pp. 1-2
    • Florence, A.T.1
  • 54
    • 57749207052 scopus 로고    scopus 로고
    • Intravascular delivery of particulate systems: Does geometry really matter?
    • Decuzzi P, Pasqualini R, Arap W, Ferrari M. Intravascular delivery of particulate systems: does geometry really matter? Pharm Res. 2009; 26: 235-43.
    • (2009) Pharm Res. , vol.26 , pp. 235-243
    • Decuzzi, P.1    Pasqualini, R.2    Arap, W.3    Ferrari, M.4
  • 55
    • 74349124409 scopus 로고    scopus 로고
    • Endocytosis and intracellular distribution of PLGA particles in endothelial cells: Effect of particles geometry
    • Yoo JW, Doshi N, Mitragotri S. Endocytosis and intracellular distribution of PLGA particles in endothelial cells: effect of particles geometry. Macromol Rapid Commun. 2009;31: 142-8.
    • (2009) Macromol Rapid Commun. , vol.31 , pp. 142-148
    • Yoo, J.W.1    Doshi, N.2    Mitragotri, S.3
  • 56
    • 0345084474 scopus 로고    scopus 로고
    • Preparation techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymers
    • Quintanar-Guerrero D, Allemann E, Fessi H, Doelker E. Preparation techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymers. Drug Dev Ind Pharm. 1998; 24: 1113-28.
    • (1998) Drug Dev Ind Pharm. , vol.24 , pp. 1113-1128
    • Quintanar-Guerrero, D.1    Allemann, E.2    Fessi, H.3    Doelker, E.4
  • 57
    • 84860364470 scopus 로고    scopus 로고
    • A novel preparation method for PLGA microspheres using non-halogenated solvents
    • Matsumoto A, Kitazawa T, Murata J, Horikiri Y, Yamahara H. A novel preparation method for PLGA microspheres using non-halogenated solvents. Pharm Res. 1996; 13: 360-7.
    • (1996) Pharm Res. , vol.13 , pp. 360-367
    • Matsumoto, A.1    Kitazawa, T.2    Murata, J.3    Horikiri, Y.4    Yamahara, H.5
  • 58
    • 0037130209 scopus 로고    scopus 로고
    • Residual polyvinyl alcohol associated with poly (d, l-lactide-co-glycolide). Nanoparticles affects their physical properties and cellular uptake
    • Sahoo SK, Panyam J, Prabha S, Labhasetwar V. Residual polyvinyl alcohol associated with poly (d, l-lactide-co-glycolide). Nanoparticles affects their physical properties and cellular uptake. J Control Release. 2002; 82: 105-14.
    • (2002) J Control Release. , vol.82 , pp. 105-114
    • Sahoo, S.K.1    Panyam, J.2    Prabha, S.3    Labhasetwar, V.4
  • 59
    • 0035848417 scopus 로고    scopus 로고
    • Effects of emulsifiers on the controlled release of paclitaxel (Taxol) from nanospheres of biodegradable polymers
    • Feng SS, Huang GF. Effects of emulsifiers on the controlled release of paclitaxel (Taxol) from nanospheres of biodegradable polymers. J Control Release. 2001; 71: 53-69.
    • (2001) J Control Release. , vol.71 , pp. 53-69
    • Feng, S.S.1    Huang, G.F.2
  • 60
    • 0037161315 scopus 로고    scopus 로고
    • Vitamin E TPGS used as emulsifier in the solvent evaporation/extraction technique for fabrication of polymeric nanospheres for controlled release of paclitaxel (Taxol)
    • Mu L, Feng SS. Vitamin E TPGS used as emulsifier in the solvent evaporation/extraction technique for fabrication of polymeric nanospheres for controlled release of paclitaxel (Taxol). J Control Release. 2002; 80: 129-44.
    • (2002) J Control Release. , vol.80 , pp. 129-144
    • Mu, L.1    Feng, S.S.2
  • 61
    • 0037186874 scopus 로고    scopus 로고
    • An EU perspectives on the use of an in vitro methods in regulatory pharmaceutical toxicology
    • Snodin DJ. An EU perspectives on the use of an in vitro methods in regulatory pharmaceutical toxicology. Toxicol Lett 2002; 127: 161-8.
    • (2002) Toxicol Lett , vol.127 , pp. 161-168
    • Snodin, D.J.1
  • 62
    • 67349284747 scopus 로고    scopus 로고
    • Current in vitro methods in nanoparticle risk assessment: Limitations and challenges
    • Kroll A, Pillukat MH, Hahn D, Schnekenburger J. Current in vitro methods in nanoparticle risk assessment: limitations and challenges. Eur J Pharm Biopharm. 2009;72: 370-7.
    • (2009) Eur J Pharm Biopharm. , vol.72 , pp. 370-377
    • Kroll, A.1    Pillukat, M.H.2    Hahn, D.3    Schnekenburger, J.4
  • 63
    • 39449086491 scopus 로고    scopus 로고
    • PLGA/PEG-derivative polymeric matrix for drug delivery system applications: Characterisation and cell viability studies
    • Fernandez-Caballed A, Pastoriza P, Barcia E, Montejo C, Negro S. PLGA/PEG-derivative polymeric matrix for drug delivery system applications: characterisation and cell viability studies. Int J Pharm. 2008; 352: 50-7.
    • (2008) Int J Pharm. , vol.352 , pp. 50-57
    • Fernandez-Caballed, A.1    Pastoriza, P.2    Barcia, E.3    Montejo, C.4    Negro, S.5
  • 64
    • 60749093701 scopus 로고    scopus 로고
    • Analytical methods to assess nanoparticle toxicity
    • Marquis BJ, Love SA, Braun KL, Haynes CL. Analytical methods to assess nanoparticle toxicity. Analyst. 2009; 134: 425-39.
    • (2009) Analyst. , vol.134 , pp. 425-439
    • Marquis, B.J.1    Love, S.A.2    Braun, K.L.3    Haynes, C.L.4
  • 65
    • 0036181321 scopus 로고    scopus 로고
    • In vitro phagocytosis and monocyte-macrophage activation with poly (lactide) and poly (lactide-co-glycolide) microspheres
    • Prior S, Gander B, Blarer N, Merkle HP, Subira ML, Irache JM, Gamazo C. In vitro phagocytosis and monocyte-macrophage activation with poly (lactide) and poly (lactide-co-glycolide) microspheres. Eur J Pharm Sci. 2002; 15: 197-207.
    • (2002) Eur J Pharm Sci. , vol.15 , pp. 197-207
    • Prior, S.1    Gander, B.2    Blarer, N.3    Merkle, H.P.4    Subira, M.L.5    Irache, J.M.6    Gamazo, C.7
  • 66
    • 10044225776 scopus 로고    scopus 로고
    • Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs
    • Win KY, Feng SS. Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs. Biomaterials. 2005; 26: 2713-22.
    • (2005) Biomaterials. , vol.26 , pp. 2713-2722
    • Win, K.Y.1    Feng, S.S.2
  • 67
    • 0030787532 scopus 로고    scopus 로고
    • A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption: Advantages and limitations of the Caco-2 model
    • Delie F, Rubas W. A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption: advantages and limitations of the Caco-2 model. Crit Rev Ther Drug Carrier Syst. 1997; 14: 221-86.
    • (1997) Crit Rev Ther Drug Carrier Syst. , vol.14 , pp. 221-286
    • Delie, F.1    Rubas, W.2
  • 68
    • 0025674686 scopus 로고
    • Nanoparticle uptake by the rat gastrointestinal mucosa: Quantitation and particle size dependency
    • Jani P, Halbert GW, Langridge J, Florence AT. Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency. J Pharm Pharmacol. 1990; 42: 821-6.
    • (1990) J Pharm Pharmacol. , vol.42 , pp. 821-826
    • Jani, P.1    Halbert, G.W.2    Langridge, J.3    Florence, A.T.4
  • 69
    • 0027869836 scopus 로고
    • Comparison of poly (d, l-lactide-co-glycolide) and polystyrene microsphere targeting to intestinal M cells
    • Jepson MA, Simmons NL, O'Hagan DT., Hirst BH. Comparison of poly (d, l-lactide-co-glycolide) and polystyrene microsphere targeting to intestinal M cells. J Drug Target. 1993; 1: 245-9.
    • (1993) J Drug Target. , vol.1 , pp. 245-249
    • Jepson, M.A.1    Simmons, N.L.2    O'Hagan, D.T.3    Hirst, B.H.4
  • 70
    • 35348866826 scopus 로고    scopus 로고
    • The reliability and limits of the MTT reduction assay for carbon nanotubes-cell interaction
    • Belyanskaya L, Manser P, Spohn P, Bruinink A, Wick P. The reliability and limits of the MTT reduction assay for carbon nanotubes-cell interaction. Carbon. 2007; 45: 2643-8.
    • (2007) Carbon. , vol.45 , pp. 2643-2648
    • Belyanskaya, L.1    Manser, P.2    Spohn, P.3    Bruinink, A.4    Wick, P.5
  • 72
    • 34249691793 scopus 로고    scopus 로고
    • Spectroscopic analysis confirms the interactions between single walled carbon nanotubes and various dyes commonly used to assess cytotoxicity
    • Casey A, Herzog E, Davoren M, Lyng FM, Byrne HJ, Chambers G. Spectroscopic analysis confirms the interactions between single walled carbon nanotubes and various dyes commonly used to assess cytotoxicity. Carbon. 2007;45: 1425-32.
    • (2007) Carbon. , vol.45 , pp. 1425-1432
    • Casey, A.1    Herzog, E.2    Davoren, M.3    Lyng, F.M.4    Byrne, H.J.5    Chambers, G.6
  • 73
    • 26944487638 scopus 로고    scopus 로고
    • Porous gold nanospheres by controlled transmetalation reaction: A novel material for application in cell imaging
    • Shukla S, Priscilla A, Banerjee M, Bhonde RR, Ghatak J, Satyam PV, Sastry M. Porous gold nanospheres by controlled transmetalation reaction: a novel material for application in cell imaging. Chem Mater. 2005; 17: 5000-5.
    • (2005) Chem Mater. , vol.17 , pp. 5000-5005
    • Shukla, S.1    Priscilla, A.2    Banerjee, M.3    Bhonde, R.R.4    Ghatak, J.5    Satyam, P.V.6    Sastry, M.7
  • 74
    • 33947387572 scopus 로고    scopus 로고
    • Investigations on the adsorption behavior of neutral red on mercaptoethane sulfonate protected gold nanoparticles
    • Shang L, Zoua X, Jianga X, Yanga G, Dong S. Investigations on the adsorption behavior of neutral red on mercaptoethane sulfonate protected gold nanoparticles. J Photochem Photobiol. A: Chem. 2006; 187: 152-9.
    • (2006) J Photochem Photobiol. A: Chem. , vol.187 , pp. 152-159
    • Shang, L.1    Zoua, X.2    Jianga, X.3    Yanga, G.4    Dong, S.5
  • 76
    • 35448948988 scopus 로고    scopus 로고
    • Nanotoxicology: signs of stress
    • Stone V, Donaldson K. Nanotoxicology: signs of stress. Nat Nanotechnol. 2006; 1: 23-4.
    • (2006) Nat Nanotechnol. , vol.1 , pp. 23-24
    • Stone, V.1    Donaldson, K.2
  • 77
    • 1342289237 scopus 로고    scopus 로고
    • Methods for detection of reactive metabolite of oxygen and nitrogen: In vitro and in vivo consideration
    • Tarpey MM, Wink DA, Grisham MB. Methods for detection of reactive metabolite of oxygen and nitrogen: in vitro and in vivo consideration. Am J Physiol Regul Integr Comp Physiol. 2004; 286: R431-R444.
    • (2004) Am J Physiol Regul Integr Comp Physiol. , vol.286
    • Tarpey, M.M.1    Wink, D.A.2    Grisham, M.B.3
  • 79
    • 32044468707 scopus 로고    scopus 로고
    • Challenges for assessing carbon nanomaterial toxicity to the skin
    • Monteiro-Riviere NA, Inman AO. Challenges for assessing carbon nanomaterial toxicity to the skin. Carbon. 2006; 44: 1070-8.
    • (2006) Carbon. , vol.44 , pp. 1070-1078
    • Monteiro-Riviere, N.A.1    Inman, A.O.2
  • 80
    • 33947413465 scopus 로고    scopus 로고
    • Cytokine responses of human lung cells (BEAS-2B) treated with micron-sized and nanoparticles of metal oxides compared to soil dusts
    • Vernath JM, Kaser EG, Vernath MM, Koch M, Yost GS. Cytokine responses of human lung cells (BEAS-2B) treated with micron-sized and nanoparticles of metal oxides compared to soil dusts. Part Fibre Toxicol. 2007; 4: 2.
    • (2007) Part Fibre Toxicol. , vol.4 , pp. 2
    • Vernath, J.M.1    Kaser, E.G.2    Vernath, M.M.3    Koch, M.4    Yost, G.S.5
  • 81
    • 47549090665 scopus 로고    scopus 로고
    • Adsorption of essential micronutrients by carbon nanotubes and the implication of nanotoxicty testing
    • Guo L, Von Dem Bussche A, Buechner M, Yan A, Kane AB, Hurt RH. Adsorption of essential micronutrients by carbon nanotubes and the implication of nanotoxicty testing. Small. 2008; 4: 721-7.
    • (2008) Small. , vol.4 , pp. 721-727
    • Guo, L.1    von dem Bussche, A.2    Buechner, M.3    Yan, A.4    Kane, A.B.5    Hurt, R.H.6
  • 82
    • 70349999917 scopus 로고    scopus 로고
    • Polymeric carriers: Preclinical safety and the regulatory implications for design and development of polymer therapeutics
    • Gaspar R, Duncan R. Polymeric carriers: preclinical safety and the regulatory implications for design and development of polymer therapeutics. Adv Drug Deliv Reviews. 2009; 61: 1220-31.
    • (2009) Adv Drug Deliv Reviews. , vol.61 , pp. 1220-1231
    • Gaspar, R.1    Duncan, R.2
  • 83
    • 0002757004 scopus 로고
    • Study of the interactions between nanoparticles and intestinal mucosa
    • Durrer C, Irache J, Duchene D, Ponchel G. Study of the interactions between nanoparticles and intestinal mucosa. Prog Colloid Polym Sci. 1994; 97: 275-80.
    • (1994) Prog Colloid Polym Sci. , vol.97 , pp. 275-280
    • Durrer, C.1    Irache, J.2    Duchene, D.3    Ponchel, G.4
  • 84
    • 0025674686 scopus 로고
    • Nanoparticle uptake by the rat gastrointestinal mucosa: Quantitation and particle size dependency
    • Jani P, Halbert GW, Langridge J, Florence AT. Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency. J Pharm Pharmacol. 1990; 42: 821-6.
    • (1990) J Pharm Pharmacol. , vol.42 , pp. 821-826
    • Jani, P.1    Halbert, G.W.2    Langridge, J.3    Florence, A.T.4
  • 85
    • 34247645112 scopus 로고    scopus 로고
    • Development of biodegradable nanoparticles for oral delivery of ellagic acid and evaluation of their antoioxidant efficacy against cyclosporine A-induced nephrotoxicity in rats
    • Sonaje K, Italia JL, Sharma G, Bhardwaj V, Tikoo K, Ravi Kumar MNV. Development of biodegradable nanoparticles for oral delivery of ellagic acid and evaluation of their antoioxidant efficacy against cyclosporine A-induced nephrotoxicity in rats. Pharm Res. 2007; 24: 899-908.
    • (2007) Pharm Res. , vol.24 , pp. 899-908
    • Sonaje, K.1    Italia, J.L.2    Sharma, G.3    Bhardwaj, V.4    Tikoo, K.5    Ravi Kumar, M.N.V.6
  • 86
    • 32244438967 scopus 로고    scopus 로고
    • Design of estradiol loaded PLGA nanoparticulate formulations: A potential oral delivery system for hormone therapy
    • Hariharan S, Bhardwaj V, Bala I, Sitterberg J, Bakowsky U, Ravi Kumar MNV. Design of estradiol loaded PLGA nanoparticulate formulations: a potential oral delivery system for hormone therapy. Pharm Res. 2006; 23: 184-95.
    • (2006) Pharm Res. , vol.23 , pp. 184-195
    • Hariharan, S.1    Bhardwaj, V.2    Bala, I.3    Sitterberg, J.4    Bakowsky, U.5    Ravi Kumar, M.N.V.6
  • 87
    • 23244464797 scopus 로고    scopus 로고
    • Poly (lactide-co-glycolide) particles of different physiochemical properties and their uptake by peyer's patches in mice
    • Shakweh M, Besnard M, Nicolas V, Fattal E. Poly (lactide-co-glycolide) particles of different physiochemical properties and their uptake by peyer's patches in mice. Eur J pharm Biopharm. 2005; 61: 1-13.
    • (2005) Eur J pharm Biopharm. , vol.61 , pp. 1-13
    • Shakweh, M.1    Besnard, M.2    Nicolas, V.3    Fattal, E.4
  • 89
    • 0031709640 scopus 로고    scopus 로고
    • Arterial uptake of biodegradable nanoparticles: Effect of surface modifications
    • Labhasetwar V, Song C, Humphrey W, Shebuski R, Levy RJ. Arterial uptake of biodegradable nanoparticles: effect of surface modifications. J Pharm Sci. 2000; 87: 1229-34.
    • (2000) J Pharm Sci. , vol.87 , pp. 1229-1234
    • Labhasetwar, V.1    Song, C.2    Humphrey, W.3    Shebuski, R.4    Levy, R.J.5
  • 90
    • 0030787532 scopus 로고    scopus 로고
    • A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption: Advantages and limitations of the Caco-2 model
    • Delie F, Rubas W. A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption: advantages and limitations of the Caco-2 model. Crit Rev Ther Drug Carrier Syst. 1997; 14: 221-86.
    • (1997) Crit Rev Ther Drug Carrier Syst. , vol.14 , pp. 221-286
    • Delie, F.1    Rubas, W.2
  • 91
    • 77951257204 scopus 로고    scopus 로고
    • Interaction of biodegradable nanoparticles with intestinal cells: The effect of surface hydrophilicity
    • Gaumet M, Gurny R, Delie F. Interaction of biodegradable nanoparticles with intestinal cells: The effect of surface hydrophilicity. Int J Pharm. 2010; 390: 45-52.
    • (2010) Int J Pharm. , vol.390 , pp. 45-52
    • Gaumet, M.1    Gurny, R.2    Delie, F.3
  • 93
    • 0028203956 scopus 로고
    • DLlactide-co-glyolide) nanoparticles after intravenous and oral administration to mice
    • DLlactide-co-glyolide) nanoparticles after intravenous and oral administration to mice. Int J Pharm. 1994; 106: 201-11.
    • (1994) Int J Pharm. , vol.106 , pp. 201-211
    • le Ray, A.M.1    Vert, M.2    Gautier, J.C.3    Benoit, J.P.4
  • 97
    • 0037331856 scopus 로고    scopus 로고
    • Dynamics of endocytosis and exocytosis of poly (D, L-lactide-co-glycolide) nanoparticles in vascular smooth muscle cells
    • Panyam J, Labhasetwar V. Dynamics of endocytosis and exocytosis of poly (D, L-lactide-co-glycolide) nanoparticles in vascular smooth muscle cells. Pharm Res. 2003; 20: 212-20.
    • (2003) Pharm Res. , vol.20 , pp. 212-220
    • Panyam, J.1    Labhasetwar, V.2
  • 98
    • 1842450748 scopus 로고    scopus 로고
    • The characteristics and mechanisms of uptake of PLGA nanoparticles in rabbit conjunctival epithelial cell layers
    • Qaddoumi MG, Ueda H, Yang J, Davada J, Labhasetwar V, Lee VH. The characteristics and mechanisms of uptake of PLGA nanoparticles in rabbit conjunctival epithelial cell layers. Pharm Res. 2004; 21: 641-8.
    • (2004) Pharm Res. , vol.21 , pp. 641-648
    • Qaddoumi, M.G.1    Ueda, H.2    Yang, J.3    Davada, J.4    Labhasetwar, V.5    Lee, V.H.6
  • 100
    • 0345863541 scopus 로고    scopus 로고
    • Mechanistic study of the uptake of wheat germ agglutinin-conjugated PLGA nanoparticles by A549 cells
    • Mo Y, Lim LY. Mechanistic study of the uptake of wheat germ agglutinin-conjugated PLGA nanoparticles by A549 cells. J Pharm Sci. 2004; 93: 20-8.
    • (2004) J Pharm Sci. , vol.93 , pp. 20-28
    • Mo, Y.1    Lim, L.Y.2
  • 101
    • 84934436076 scopus 로고    scopus 로고
    • Pharmacological inhibition of endocytic pathways: Is it specific enough to be useful?
    • In: Ivanov AI, Walker JM, editors, USA: Humanna Press
    • Ivanov AI. Pharmacological inhibition of endocytic pathways: is it specific enough to be useful? In: Ivanov AI, Walker JM, editors. Methods in molecular biology. USA: Humanna Press; 2008. p. 15-33.
    • (2008) Methods in molecular biology , pp. 15-33
    • Ivanov, A.I.1
  • 102
    • 30344486984 scopus 로고    scopus 로고
    • Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells
    • Glebov OO, Bright NA, Nichols BJ. Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells. Nat Cell Biol. 2006; 8: 46-54.
    • (2006) Nat Cell Biol. , vol.8 , pp. 46-54
    • Glebov, O.O.1    Bright, N.A.2    Nichols, B.J.3
  • 103
    • 13444273098 scopus 로고    scopus 로고
    • Clathrin-and caveolin-1-independent endocytosis: Entry of smian virus 40 into cells devoid of caveolae
    • Damm E-M, Pelkmans L, Kartenbeck J, Mezzacasa A, Kurzchalia T, Helenius A. clathrin-and caveolin-1-independent endocytosis: entry of smian virus 40 into cells devoid of caveolae. J Cell Biol. 2005; 168: 477-88.
    • (2005) J Cell Biol. , vol.168 , pp. 477-488
    • Damm, E-M.1    Pelkmans, L.2    Kartenbeck, J.3    Mezzacasa, A.4    Kurzchalia, T.5    Helenius, A.6
  • 105
    • 0031845276 scopus 로고    scopus 로고
    • Controlled drug delivery by biodegradable poly(ester) devices: Different preparative approaches
    • Jain R, Shah NH, Malick AW, Rhodes CT. Controlled drug delivery by biodegradable poly(ester) devices: different preparative approaches. Drug Dev Ind Pharm. 1998; 24: 703-27.
    • (1998) Drug Dev Ind Pharm. , vol.24 , pp. 703-727
    • Jain, R.1    Shah, N.H.2    Malick, A.W.3    Rhodes, C.T.4
  • 107
    • 60049090585 scopus 로고    scopus 로고
    • Design of biodegradable nanoparticles for oral delivery of doxorubicin: In vivo pharmacokinetics and toxicity studies in rats
    • Kalaria DR, Sharma G, Beniwal V, Ravi Kumar MNV. Design of biodegradable nanoparticles for oral delivery of doxorubicin: in vivo pharmacokinetics and toxicity studies in rats. Pharm Res. 2009; 26: 492-501.
    • (2009) Pharm Res. , vol.26 , pp. 492-501
    • Kalaria, D.R.1    Sharma, G.2    Beniwal, V.3    Ravi Kumar, M.N.V.4
  • 108
    • 33745041084 scopus 로고    scopus 로고
    • Oral poly (lactide-co-glycolide) nanoparticle based antituberculosis drug delivery: Toxicological and chemotherapeutic implications
    • Pandey R, Sharma S, Khuller GK. Oral poly (lactide-co-glycolide) nanoparticle based antituberculosis drug delivery: Toxicological and chemotherapeutic implications. Ind J Exp Biol. 2006; 44: 459-67.
    • (2006) Ind J Exp Biol. , vol.44 , pp. 459-467
    • Pandey, R.1    Sharma, S.2    Khuller, G.K.3
  • 109
    • 78650096718 scopus 로고    scopus 로고
    • Pharmacokinetics and tissue distribution studies of orally administered nanoparticles encapsulated ethionamide used as potential drug delivery system in management of multi-drug resistant tuberculosis
    • Kumar G, Sharma S, Shafiq N, Pandhi P, Khuller GK, Malhotra S. Pharmacokinetics and tissue distribution studies of orally administered nanoparticles encapsulated ethionamide used as potential drug delivery system in management of multi-drug resistant tuberculosis. Drug Deliv. 2011; 18: 65-73.
    • (2011) Drug Deliv. , vol.18 , pp. 65-73
    • Kumar, G.1    Sharma, S.2    Shafiq, N.3    Pandhi, P.4    Khuller, G.K.5    Malhotra, S.6
  • 111
    • 33847666114 scopus 로고    scopus 로고
    • Preparation of insulin loaded PLGA-Hp55 nanoparticles for oral delivery
    • Cui F, Tao A, Cun D, Zhang L, Shi K. Preparation of insulin loaded PLGA-Hp55 nanoparticles for oral delivery. J Pharm Sci. 2007; 96: 421-7.
    • (2007) J Pharm Sci. , vol.96 , pp. 421-427
    • Cui, F.1    Tao, A.2    Cun, D.3    Zhang, L.4    Shi, K.5
  • 114
    • 1842525943 scopus 로고    scopus 로고
    • Preparation of biodegradable cyclosporine nanoparticles by high-pressure emulsification-solvent evaporation process
    • Jaiswal J, Gupta SK, Kreuter J. Preparation of biodegradable cyclosporine nanoparticles by high-pressure emulsification-solvent evaporation process. J Control Release. 2004; 96: 169-78.
    • (2004) J Control Release. , vol.96 , pp. 169-178
    • Jaiswal, J.1    Gupta, S.K.2    Kreuter, J.3
  • 115
    • 34249087392 scopus 로고    scopus 로고
    • PLGA nanoparticles for oral delivery of cyclosporine: Nephrotoxicity and pharmacokinetic studies in comparison to sand immune Neoral
    • Italia JL, Bhatt DK, Bhardwaj V, Tikoo K, Kumar MN. PLGA nanoparticles for oral delivery of cyclosporine: Nephrotoxicity and pharmacokinetic studies in comparison to sand immune Neoral. J Control Release. 2007; 119: 197-206.
    • (2007) J Control Release. , vol.119 , pp. 197-206
    • Italia, J.L.1    Bhatt, D.K.2    Bhardwaj, V.3    Tikoo, K.4    Kumar, M.N.5
  • 117
    • 33645758753 scopus 로고    scopus 로고
    • Sustained release nanoparticulate formulation containing antioxidant-ellagic acid as potential prophylaxis system for oral administration
    • Bala I, Bhardwaj V, Hariharan S, Kharade SV, Roy N, Ravi Kumar MN. Sustained release nanoparticulate formulation containing antioxidant-ellagic acid as potential prophylaxis system for oral administration. J Drug Target. 2006; 14: 27-34.
    • (2006) J Drug Target. , vol.14 , pp. 27-34
    • Bala, I.1    Bhardwaj, V.2    Hariharan, S.3    Kharade, S.V.4    Roy, N.5    Ravi Kumar, M.N.6
  • 118
    • 33749189634 scopus 로고    scopus 로고
    • Oral nanoparticle-based antituberculosis drug delivery to the brain in experimental model
    • Pandey R, Khuller GK. Oral nanoparticle-based antituberculosis drug delivery to the brain in experimental model. J Antimicrob Chemother. 2006; 57: 1146-52.
    • (2006) J Antimicrob Chemother. , vol.57 , pp. 1146-1152
    • Pandey, R.1    Khuller, G.K.2
  • 119
    • 34547700397 scopus 로고    scopus 로고
    • Development of potent oral nanoparticulate formulation of coenzyme Q10 for treatment of hypertension: Can the simple nutritional suppliments be used as first line therapeutic agents for prophylaxsis/therapy?
    • Ankola D, Viswanad B, Bhardwaj V, Ramarao P, Ravi Kumar MNV. Development of potent oral nanoparticulate formulation of coenzyme Q10 for treatment of hypertension: can the simple nutritional suppliments be used as first line therapeutic agents for prophylaxsis/therapy? Eur J Pharm Biopharm. 2007; 67: 361-9.
    • (2007) Eur J Pharm Biopharm. , vol.67 , pp. 361-369
    • Ankola, D.1    Viswanad, B.2    Bhardwaj, V.3    Ramarao, P.4    Ravi Kumar, M.N.V.5
  • 120
    • 33947148323 scopus 로고    scopus 로고
    • Improved bioavailability of orally administered mifepristone from PLGA nanoparticles
    • He W, Horn SW, Hussain MD. Improved bioavailability of orally administered mifepristone from PLGA nanoparticles. Int J Pharm. 2007; 334: 173-8.
    • (2007) Int J Pharm. , vol.334 , pp. 173-178
    • He, W.1    Horn, S.W.2    Hussain, M.D.3
  • 121
    • 36049001769 scopus 로고    scopus 로고
    • Evaluation in a murine tuberculosis model. Nanoparticles-based oral drug delivery system for an injectable antibiotic-streptomycin
    • Pandey R, Khuller GK. Nanoparticles-based oral drug delivery system for an injectable antibiotic-streptomycin. Evaluation in a murine tuberculosis model. Chemother. 2007; 53: 437-41.
    • (2007) Chemother. , vol.53 , pp. 437-441
    • Pandey, R.1    Khuller, G.K.2
  • 123
    • 41249101628 scopus 로고    scopus 로고
    • Oral nanoparticulate atorvastatin calcium is more efficient and safe in comparison to lipicure in treating hyperlipidemia
    • Meena AK, Venkat Ratnam D, Chandraiah G, Ankola DD, Rama Rao P, Ravi Kumar MNV. Oral nanoparticulate atorvastatin calcium is more efficient and safe in comparison to lipicure in treating hyperlipidemia. Lipids. 2008; 43: 231-41.
    • (2008) Lipids. , vol.43 , pp. 231-241
    • Meena, A.K.1    Venkat Ratnam, D.2    Chandraiah, G.3    Ankola, D.D.4    Rama Rao, P.5    Ravi Kumar, M.N.V.6
  • 124
    • 70350244685 scopus 로고    scopus 로고
    • PLGA nanoparticles stabilized with cationic surfactant: Safety studies and application in oral delivery of paclitaxel to treat chemical-induced breast cancer in rat
    • Bhardwaj V, Ankola DD, Gupta SC, Schneider M, Lehr C-M, Ravi Kumar MNV. PLGA nanoparticles stabilized with cationic surfactant: safety studies and application in oral delivery of paclitaxel to treat chemical-induced breast cancer in rat. Pharm Res. 2009; 26: 2495-503.
    • (2009) Pharm Res. , vol.26 , pp. 2495-2503
    • Bhardwaj, V.1    Ankola, D.D.2    Gupta, S.C.3    Schneider, M.4    Lehr, C-M.5    Ravi Kumar, M.N.V.6
  • 125
    • 57749182425 scopus 로고    scopus 로고
    • Pharmacodynamic evaluation of oral estradiol nanoparticles in estrogen deficient (ovariectomized) high fat diet induced hyperlipidemic rat model
    • Mittal G, Chandraiah G, Ramarao P, Ravi Kumar MN. Pharmacodynamic evaluation of oral estradiol nanoparticles in estrogen deficient (ovariectomized) high fat diet induced hyperlipidemic rat model. Pharm Res. 2009; 26: 218-23.
    • (2009) Pharm Res. , vol.26 , pp. 218-223
    • Mittal, G.1    Chandraiah, G.2    Ramarao, P.3    Ravi Kumar, M.N.4
  • 126
    • 78449233395 scopus 로고    scopus 로고
    • The effect of the oral administration of polymeric nanoparticles on the efficacy and toxicity of tamoxifen
    • Jain AK, Swarnakar NK, Godugu C, Singh RP, Jain S. The effect of the oral administration of polymeric nanoparticles on the efficacy and toxicity of tamoxifen. Biomaterials. 2011; 32: 503-15.
    • (2011) Biomaterials. , vol.32 , pp. 503-515
    • Jain, A.K.1    Swarnakar, N.K.2    Godugu, C.3    Singh, R.P.4    Jain, S.5
  • 127
    • 80052594404 scopus 로고    scopus 로고
    • PLGA nanoparticles improve the oral bioavailability of curcumin in rats: Characterizations and mechanisms
    • 9280-2309
    • Xie X, Tao Q, Zou Y, Zhang F, Guo M, Wang Y, Wang H, Zhou Q, Yu S. PLGA nanoparticles improve the oral bioavailability of curcumin in rats: characterizations and mechanisms. J Agric Food Chem. 2011; 59: 9280-9. t
    • (2011) J Agric Food Chem. , vol.59
    • Xie, X.1    Tao, Q.2    Zou, Y.3    Zhang, F.4    Guo, M.5    Wang, Y.6    Wang, H.7    Zhou, Q.8    Yu, S.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.