Effect of paroxetine on a model of posttraumatic stress disorder in rats

Neuroscience Letters

Volumn 357, Issue 1, 2004, Pages 37-40

  Sawamura, Takehito ^a   Shimizu, Kunio ^a   Nibuya, Masashi ^a   Wakizono, Tomoki ^a   Suzuki, Go ^a   Tsunoda, Tomoya ^a   Takahashi, Yoshitomo ^a   Nomura, Soichiro ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

Animal model; Bi directional alteration; Electric foot shock; Inescapable shock; Paroxetine; Post traumatic stress disorder

Indexed keywords

PAROXETINE; SEROTONIN UPTAKE INHIBITOR;

ALERTNESS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AVOIDANCE BEHAVIOR; BEHAVIOR; CONTROLLED STUDY; ELECTRIC SHOCK; ESCAPE BEHAVIOR; HYPERACTIVITY; LOCOMOTION; MALE; NEUROCHEMISTRY; NONHUMAN; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PSYCHOPHARMACOLOGY; RAT; TASK PERFORMANCE;

EID: 0442307855     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2003.12.039     Document Type: Article

References (18)

1. Davidson J.R., Rothbaum B.O., van der Kolk B.A., Sikes C.R., Farfel G.M. Multicenter, double-blind comparison of sertraline and placebo in the treatment of posttraumatic stress disorder. Arch. Gen. Psychiatry. 58:2001;485-492.
2. Geracioti T.D., Baker D.G. Jr, Ekhator N.N., West S.A., Hill K.K., Bruce A.B., Schmidt D., Rounds-Kugler B., Yehuda R., Keck P.E., Kasckow J.W. Jr. CSF norepinephrine concentrations in posttraumatic stress disorder. Am. J. Psychiatry. 158:2001;1227-1230.
3. Heime C., Nemeroff C.B. The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biol. Psychiatry. 49:2001;1023-1039.
4. Herry C., Garcia R. Pre-frontal cortex long-term potentiation, but not long-term depression, is associated with the maintenance of extinction of learned fear in mice. J. Neurosci. 22:2002;577-583.
5. Holsboer F. Stress, hypercortisolism and corticosteroid receptors in depression: implications for therapy. J. Affect. Disorders. 62:2001;77-91.
6. Kametani H., Nomura S., Shimizu J. The reversal effect of antidepressants on the escape deficit induced by inescapable shock in rats. Psychopharmacology. 80:1983;206-208.
7. Koba T., Kodama Y., Shimizu K., Nomura S., Sugawara M., Kobayashi Y., Ogasawara T. Persistent behavioural changes in rats following inescapable shock stress: a potential model of posttraumatic stress disorder. World J. Biol. Psychiatry. 2:2001;34-37.
8. Maier S.F. Exposure to the stressor environment prevents the temporal dissipation of behavioral depression/learned helplessness. Biol. Psychiatry. 49:2001;763-773.
9. Marshall R.D., Beebe K.L., Oldham M., Zaninelli R. Efficacy and safety of paroxetine treatment for chronic PTSD: a fixed-dose, placebo-controlled study. Am. J. Psychiatry. 158:2001;1982-1988.
10. Nibuya M., Morinobu S., Duman R.S. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatment. J. Neurosci. 15:1995;7539-7547.
11. Pynoos R.S., Ritzmann R.F., Steinberg A.M., Goenjian A., Prisecaru I. A behavioral animal model of posttraumatic stress disorder featuring repeated exposure to situational reminders. Biol. Psychiatry. 39:1996;129-134.
12. Seligman M.E.P. Helplessness: on Depression, Development and Death. 1975;Freeman, San Francisco.
13. Sherman A.D., Sacquitne J.L., Petty F. Specificity of the learned helplessness model of depression. Pharmacol. Biochem. Behav. 16:1982;449-454.
14. Shirayama Y., Chen A.C., Nakagawa S., Russell D.S., Duman R.S. Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J. Neurosci. 22:2002;3251-3261.
15. Smith M.A., Marino S., Kvetnansky R., Post R.M. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J. Neurosci. 15:1995;1768-1777.
16. Tucker P., Zaninelli R., Yehuda R., Ruggiero L., Dillingham K., Pitts C.D. Paroxetine in the treatment of chronic posttraumatic stress disorder: results of a placebo-controlled, flexible-dosage trial. J. Clin. Psychiatry. 62:2001;860-868.
17. van der Kolk B., Greenberg M., Boyd H., Krystal J. Inescapable shock, neurotransmitters, and addiction to trauma: toward a psychobiology of posttraumatic stress. Biol. Psychiatry. 20:1985;314-325.
18. Yehuda R., Antelman S.M. Criteria for rationally evaluating animal models of posttraumatic stress. Biol. Psychiatry. 33:1993;479-486.