An animal model of posttraumatic stress disorder and its validity: Effect of paroxetine on a PTSD model in rats

Japanese Journal of Neuropsychopharmacology

Volumn 24, Issue 5, 2004, Pages 283-290

  Shimizu, Kunio ^a   Sawamura, Takehito ^a   Nibuya, Masashi ^a   Nakai, Kanji ^a   Takahashi, Yoshitomo ^a   Nomura, Soichiro ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

Animal model; Bi directional change; Inescapable shock; Paroxetine; Posttraumatic stress disorder

Indexed keywords

PAROXETINE; SEROTONIN UPTAKE INHIBITOR;

ANIMAL BEHAVIOR; ANIMAL MODEL; AVOIDANCE BEHAVIOR; LOCOMOTION; MALE; MENTAL DISEASE; NONHUMAN; POSTTRAUMATIC STRESS DISORDER; RAT; SHORT SURVEY; TASK PERFORMANCE; TREATMENT OUTCOME;

ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; MALE; PAROXETINE; RATS; RATS, WISTAR; SEROTONIN UPTAKE INHIBITORS; STRESS DISORDERS, POST-TRAUMATIC;

EID: 11144326718     PISSN: 13402544     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (37)

1. American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders-IV. American Psychiatric Press, Washington DC.
2. Ballenger, J.C., Davidson, J.R., Lecrubier, Y., Nutt, D.J., Foa, E.B., Kessler, R.C., McFarlane, A.C. and Shalev, A.Y. (2000) Consensus statement on posttraumatic stress disorder from the International Consensus Group on Depression and Anxiety. J Clin Psychiatry, 61 (Suppl 5): 60-66.
3. Brown, A.W., Aldridge, W.N., Street, B.W. and Verschoyle, R.D. (1979) The behavioral and neuropathologic sequelae of intoxication by trimethyltin compounds in the rat. Am J Pathol, 97: 59-82.
4. Desan, P.H., Silbert, L.H. and Maier, S.F. (1988) Long-term effects of inescapable stress on daily running activity and antagonism by desipramine. Pharmacol Biochem Behav, 30: 21-29.
5. Helsley, S., Sheikh, T., Kim, K.Y. and Park, S.K. (1999) ECT therapy in PTSD. Am J Psychiatry, 156: 494-495.
6. Imai, H., Nishimura, T., Sadamatsu, M., Liu, Y., Kabuto, M. and Kato, N. (2001) Type II glucocorticoid receptors are involved in neuronal death and astrocyte activation induced by trimethyltin in the rat hippocampus. Exp Neurol, 171: 22-28.
7. Inoue, T., Hashimoto, S., Tsuchiya, K., Izumi, T., Ohmori, T. and Koyama, T. (1996) Effect of citalopram, a selective serotonin reuptake inhibitor, on the acquisition of conditioned freezing. Eur J Pharmacol, 311: 1-6.
8. Kameyama, T. and Nagasaka, M. (1982) Effects of apomorphine and diazepam on a quickly learned conditioned suppression in rats. Pharmacol Biochem Behav, 17: 59-63.
9. Koba, T., Kodama, Y., Shimizu, K., Nomura, S., Sugawara, M., Kobayashi, Y. and Ogasawara, T. (2001) Persistent behavioral changes in rats following inescapable shock stress: A potential model of posttraumatic stress disorder. World J Biol Psychiatry, 2: 34-37.
10. Kodama, Y., Koba, T., Shimizu, K., Sawamura, T., Nagamine Y., Kobayashi, Y., Sugawara, M., Nomura, S. and Ogasawara, T. (2001) Differential Fos protein induction in rat brain regions after persistent avoidance behavior induced by inescapable shock. J Natl Def Med Coll, 26: 180-187.
11. Koks, S., Beljajev, S., Koovit, I., Abramov, U., Bourin, M. and Vasar, E. (2001) 8-OH-DPAT, but not deramciclane, antagonizes the anxiogenic-like action of paroxetine in an elevated plus-maze. Psychopharmacology, 153: 365-372.
12. Liberzon, I., Lopez, J.F., Flagel, S.B., Vazquez, D.M. and Young, E.A. (1999) Differential regulation of hippocampus glucocorticoid receptors mRNA and fast feedback; Relevance to posttraumatic stress disorder. J Neuroendocrinol, 11: 11-17.
13. Lightowler, S., Kennett, G.A., Williamson, IJ., Blackburn, T.P. and Tulloch, I.F. (1994) Anxiolytic-like effect of paroxetine in a rat social interaction test. Pharmacol Biochem Behav, 49: 281-285.
14. Marshall, R.D., Schneier, F.R., Fallon, B.A., Knight, C.B., Abbate, L.A., Goetz, D., Campeas, R. and Liebowitz, M.R. (1998) An open trial of paroxetine in patients with non-combat-related, chronic posttraumatic stress disorder. J Clin Psychopharmacol, 18: 10-18.
15. Marshall, R.D., Beebe, K.L., Oldham, M. and Zaninelli R. (2001) Efficacy and safety of paroxetine treatment for chronic PTSD: A fix dose, placebo-controlled study. Am J Psychiatry, 158: 1982-1988.
16. Mckinney, W.T. and Bunney, W.E. (1969) Animal model of depression. Arch Gen Psychiatry, 21: 240-248.
17. Pynoos, R.S., Ritzmann, R.F., Steinberg, A.M., Goenjian, A. and Prisecaru, I. (1996) A behavioral animal model of posttraumatic stress disorder featuring repeated exposure to situational reminders. Biol Psychiatry, 39: 129-134.
18. Rasmusson, A.M. and Charney, D.S. (1997) Animal models of relevance to PTSD. Ann NY Acad Sci, 821: 332-351.
19. Sanchez, C. and Meier, E. (1997) Behavioral profiles of SSRIs in an animal models of depression, anxiety and aggression: Are they all alike? Psychopharmacology, 129: 197-205.
20. Sawamura, T., Shimizu, K., Nibuya, M., Wakizono, T., Suzuki, G., Tsunoda, T., Takahashi, Y. and Nomura, S. (2004) Effect of paroxetine on a model of posttraumatic stress disorder in rats. Neurosci Lett, 357: 37-40.
21. Shimizu, K., Sawamura, T., Nibuya, M., Suzuki, G., Wakizono, T., Yamamoto, T., Sugawara, M., Yoshino, A., Takahashi, Y. and Nomura, S. (2003) Effect of chronic paroxetine administration on long-lasting behavioral changes in rats exposed to inescapable electric footshock. Psychiatry Clin Neurosci, 57: S68.
22. Tucker, P., Zaninelli, R., Yehuda, R., Ruggiero, L., Dillingham, K. and Pitts, C.D. (2001) Paroxetine in the treatment of chronic posttraumatic stress disorder: Results of a placebo-controlled, flexible dosage trial. J Clin Psychiatry, 62: 860-868.
23. van der Kolk, B. (1987) The drug treatment of post-traumatic stress disorder. J Affect Disord, 13: 203-213.
24. van Dijken, H.H., van der Heyden, J.A., Mos, J. and Tilders, FJ. (1992) Inescapable footshock induce progressive and long-lasting behavioral changes in male rats. Physiol Behav, 51: 787-794.
25. Willner, P. (1984) The validity of animal models of depression. Psychopharmacology, 83: 1-16.
26. Yehuda, R. and Antelman, S.M. (1993) Criteria for rationally evaluating animal models of posttraumatic stress disorder. Biol Psychiatry, 44: 479-486.