Opioid receptor antagonists attenuate heat stress-induced reduction in cerebral blood flow, increased blood-brain barrier permeability, vasogenic edema and cell changes in the rat

Annals of the New York Academy of Sciences

Volumn 813, Issue , 1997, Pages 559-571

  Sharma, H S ^a,b   Westman, J ^a   Cervos Navarro J ^c   Dey, P K ^d   Nyberg, F ^b  

^a Laboratory of Neuroanatomy   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

^d BANARAS HINDU UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

DYNORPHIN; OPIATE ANTAGONIST; OPIATE PEPTIDE; PROSTAGLANDIN; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; BLOOD BRAIN BARRIER; BODY TEMPERATURE; BRAIN BLOOD FLOW; BRAIN INJURY; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE SEVERITY; EDEMA; HEAT STRESS; HYPERTHERMIA; MALE; MORTALITY; NEUROCHEMISTRY; NONHUMAN; PATHOPHYSIOLOGY; PERMEABILITY; RAT;

ANIMALIA;

EID: 0030929628     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1997.tb51747.x     Document Type: Conference Paper

References (38)

1. AKIL, H., S. J. WATSON, E. YOUNG, M. E. LEWIS, H. KHACHATURIAN & J. M. WALKER. 1984. Endogenous opioids: biology and function. Annu Rev. Neurosci. 7: 223-255.
2. AUSTIN, M. G. & J. W. BERRY. 1956. Observation on one hundred cases of heatstroke. JAMA 161: 1525-1529.
3. BASKIN, D. S., R. K. SIMPSON, JR., J. L. BROWNING, A. W. DUDLEY, F. ROTHENBERG & L. BOUGE. 1993. The effect of long-term high-dose naloxone infusion in experimental blunt spinal cord injury. J. Spinal Disord. 6: 38-43.
4. BLACK, P., R. S. MARKOWITZ, J. A. GILLESPIE & S. D. FINKELSTEIN. 1991. Naloxone and experimental spinal cord injury: effect of varying dose and intensity of injury. J. Neurotrauma 8: 157-171.
5. BLACKWELL, R. P. & R. D. SAUNDERS. 1986. The effects of low-level radio frequency and microwave radiation on brain tissue and animal behaviour. Int. J. Radiat. Biol. 50: 761-787.
6. BRACKEN, M. B. & T. R. HOLFORD. 1993. Effects of timing of methylprednisolone or naloxone administration on recovery of segmental and long-tract neurological function in NASCIS 2. J. Neurosurg. 79: 500-507.
7. CHAO, T. C., R. SINNIAH & J. E. PAKIM. 1981. Acute heat stroke deaths. Pathology 13: 145-156.
8. DUGGAN, A. W. & S. M. FLEETWOOD-WALKER. 1996. Opioids and sensory processing in the central nervous system. Handb. Exp. Pharmacol. 104(11): 731-771.
9. FADEN, A. I. 1990. Opioid and nonopioid mechanisms may contribute to dynorphin's pathophysiological actions in spinal cord injury. Ann. Neurol. 27: 67-74.
10. FADEN, A. I. 1993. Role of endogenous opioids and opioid receptors in central nervous system injury. Handb. Exp. Pharmacol. 104(1): 325-341.
11. FADEN, A. I., A. E. TAKEMORI & T. S. PORTOGHESE. 1987. k-Selective opiate antagonist norbinaltorphimine improves outcome after traumatic spinal cord injury in rats. CNS Trauma 4: 227-237.
12. GLOWES, G. H. A., JR. & T. F. O'DONNELL, JR. 1974. Heat stroke - current concepts. N. Engl. J. Med. 291: 564-566.
13. HAYES, R. L., B. J. GALINET, P. KULKARNE & D. P. BECKER. 1983. Effects of naloxone on systemic and cerebral responses to experimental concussive brain injury;in cats. J. Neurosurg. 58: 720-728.
14. HAYES, R. L., L. W. JENKINS & B. G. LYETH. 1992. Neurotransmitter-mediated mechanisms of traumatic brain injury: acetylcholine and excitatory amino acids. J. Neurotrauma 9(Suppl. 1): S173-S187.
15. HEILBRUNN, L. V. 1954. Heat death. Sci. Am. 190: 4-70.
16. HERZ, A., H. AKIL & E. J. SIMON. 1993. Opioids. Handb. Exp. Pharmacol. 104(I/II). Springer-Verlag. Heidelberg.
17. HUBBARD, R. W., W. D. BOWERS, W. T. MATHER, F. C. CURTIS, R. E. L. CRISS, G. M. SCHELDON & J. W. RATTEREE. 1977. Rat model of acute heat stroke mortality. J. Appl. Physiol. 42: 809-817.
18. HYNYNEN, K. & B. A. LULU. 1990. Hyperthermia and cancer treatment. Invest. Radiol. 25: 824-834.
19. HÖKFELT, T., R. ELDE, O. JOHANSSON, Å. LJUNGDAHL, M. SCHULTZBERG, K. FUXE, M. GOLDSTEIN, G. NlLSSON, B. PERNOW, L. TERENIUS, D. GANTEN, S. L. JEFFO-CATE, J. REHFELD & S. SAID. 1978. Distribution of peptide containing neurons. In Psychopharmacology: A Generation of Progress. M. A. Lipton, A. DiMascio & K. F. Killam, Eds. 39-66. Raven Press. New York.
20. HÖKFELT, T., O. JOHANSSON, Y. HOLETS, B. MEISTER & T. MELANDER. 1987. Distribution of neuropeptides with special reference to their coexistence with classical neurotransmitters. In Psychopharmacology: The Third Generation of Progress. M. H. Y. Meltzer, Ed. 401-416. Raven Press. New York.
21. KONCHEL, J. P. 1989. Heat stroke and heat stress disorders. Dis. Mon. 35: 301-377.
22. MALAMUD, N., W. HAYMAKER & R. P. CUSTER. 1946. Heat stroke: a clinicopathologic study of 125 fatal strokes. Mil. Surg. 99: 397-449.
23. MARTIN, W. R. 1983. Pharmacology of opioids. Pharmacol. Rec. 35: 283-323.
24. MISRA, A. L. 1978. Metabolism of opiates. In Factors Affecting the Action of Narcotics. M. L. Adler, L. Manara & R. Samanin, Eds. 297-343. Raven Press. New York.
25. NORTH, A. R. 1993. Opioid actions in membrane channels. Handb. Exp. Pharmacol. 104(11): 773-797.
26. OLSSON, Y., H. S. SHARMA, F. NYBERG & J. WESTMAN. 1995. The opioid receptor antagonist naloxone influences the pathophysiology of spinal cord injury. In Neuropeptides in the Spinal Cord. F. Nyberg, H. S. Sharma & Z. Wiesenfeld-Hallin, Eds. Prog. Brain Res. 104: 381-399. Elsevier, Amsterdam.
27. SHARMA, H. S., Y. OLSSON & F. NYBERG. 1995. Influence of dynorphin A antibodies on the formation of edema and cell changes in spinal cord trauma. In Neuropeptides in the Spinal Cord. F. Nyberg, H. S. Sharma & Z. Wiesenfeld-Hallin, Eds. Prog. Brain Res. 104: 401-416. Elsevier, Amsterdam.
28. SHARMA, H. S., J. WESTMAN, F. NYBERG, J. CERVÓS-NAVARRO & P. K. DEY. 1994. Opioid peptides participate in the pathophysiology of heat stress in the rat. Neuropeptides 26: 44-45.
29. SHARMA, H. S., J. CERVÓS-NAVARRO & P. K. DEY. 1991. Rearing at high ambient temperature during later phase of the brain development enhances functional plasticity of the CNS and induces tolerance to heat stress. An experimental study in the conscious normotensive young rats. Brain Dysfunct. 4: 104-124.
30. SHARMA, H. S. & J. CERVÓS-NAVARRO. 1990. Brain oedema and cellular changes induced by acute heat stress in young rats. Acta Neurochir. (Wien) Suppl. 51: 383-386.
31. SHARMA, H. S. & P. K. DEY. 1987. Influence of long-term acute heat exposure on regional blood-brain barrier permeability, cerebral blood flow and 5-HT level in conscious normotensive young rats. Brain Res. 424: 153-162.
32. SHARMA, H. S. 1987. Effect of captopril (a converting enzyme inhibitor) on blood-brain barrier permeability and cerebral blood flow in normotensive rats. Neuropharmacology 26: 85-92.
33. SHARMA, H. S. & P. K. DEY. 1986. Probable involvement of 5-hydroxytryptamine in increased permeability of blood-brain barrier under heat stress. Neuropharmacology 25: 161-167.
34. SMINIA, P., J. VAN DER ZEE, J. WONDERGEM & J. HAVEMAN. 1994. Effect of hyperthermia on the central nervous system: a review. Int. J. Hypertherm. 10: 1-30.
35. STERNER, S. 1990. Summer heat illnesses. Conditions that range from mild to fatal. Postgrad. Med. 87: 215-217.
36. WIJSMAN, J. A. & R. R. SHIVERS. 1993. Heat stress affects blood-brain barrier permeability to horseradish peroxidase in mice. Acta Neuropathol. 86: 49-54.
37. WINKLER, T., H. S. SHARMA, E. STÅLBERG, Y. OLSSON & F. NYBERG. 1994. Opioid receptors influence spinal cord electrical activity and edema formation following spinal cord injury. Experimental observations using naloxone in the rat. Neurosci. Res. 21: 91-101.
38. ZEISBURGER, E., E. SCHÖNBAUM & P. LOMAX. 1994. Thermal Balance in Health and Diseases. Recent Basic Research and Clinical Progress. Adv. Pharmacol. Sci. Birkhäuser. Basel.