Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice

Journal of Medicinal Chemistry

Volumn 54, Issue 15, 2011, Pages 5444-5453

  Pasquini, Serena ^a   De Rosa, Maria ^a   Pedani, Valentina ^a   Mugnaini, Claudia ^a   Guida, Francesca ^b   Luongo, Livio ^b   De Chiaro, Maria ^b   Maione, Sabatino ^b   Dragoni, Stefania ^a   Frosini, Maria ^a   Ligresti, Alessia ^c   Di Marzo, Vincenzo ^c   Corelli, Federico ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; ANALGESIC AGENT; CANNABINOID 2 RECEPTOR; FORMALDEHYDE; N (ADAMANTAN 1 YL) 3 ETHYL 3,7 DIHYDRO 7 OXO 2H [1,4] OXAZINO[2,3,4 IJ]QUINOLINE 6 CARBOXAMIDE; N (ADAMANTAN 1 YL) 6 (FURAN 2 YL) 8 METHOXY 4 OXO 1 PENTYL 1,4 DIHYDROQUINOLINE 3 CARBOXAMIDE; N (ADAMANTAN 1 YL) 6 BROMO 1,2 DIHYDRO 4 HYDROXY 2 OXO 1 PENTYLQUINOLINE 3 CARBOXAMIDE; N (ADAMANTAN 1 YL) 6 BROMO 2 BUTYL 1,4 DIHYDRO 4 OXOQUINOLINE 3 CARBOXAMIDE; N (ADAMANTAN 1 YL) 8 METHOXY 4 OXO 1 PENTYL 1,4 DIHYDROQUINOLINE 3 CARBOXAMIDE; RIMONABANT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NOCICEPTION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

4-QUINOLONES; ADAMANTANE; ANALGESICS; ANIMALS; CELL SURVIVAL; HEP G2 CELLS; HUMANS; LIGANDS; MICE; QUINOLONES; RATS; RECEPTOR, CANNABINOID, CB2;

EID: 79961211884     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200476p     Document Type: Article

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