miR-145 is differentially regulated by TGF-β1 and ischaemia and targets Disabled-2 expression and wnt/β-catenin activity

Journal of Cellular and Molecular Medicine

Volumn 16, Issue 5, 2012, Pages 1106-1113

  Mayorga, Maritza E ^a,b   Penn, Marc S ^a,b,c  

^a LERNER RESEARCH INSTITUTE   (United States)

^b NORTHEAST OHIO MEDICAL UNIVERSITY   (United States)

^c SUMMA HEALTH SYSTEM   (United States)

Author keywords

Gene expression; Growth factors cytokines; Myocardial infarction

Indexed keywords

BETA CATENIN; CATNB PROTEIN, RAT; DAB2 PROTEIN, RAT; MICRORNA; MIRN145 MICRORNA, RAT; TGFB1 PROTEIN, RAT; TRANSFORMING GROWTH FACTOR BETA1; VESICULAR TRANSPORT ADAPTOR PROTEIN; WNT PROTEIN;

3' UNTRANSLATED REGION; ANIMAL; ARTICLE; BINDING SITE; BIOSYNTHESIS; CELL CULTURE; DOWN REGULATION; DRUG EFFECT; HEART MUSCLE; HEART MUSCLE ISCHEMIA; LEWIS RAT; MESENCHYMAL STEM CELL; METABOLISM; PHYSIOLOGY; RAT; UPREGULATION; WNT SIGNALING PATHWAY;

3' UNTRANSLATED REGIONS; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; BETA CATENIN; BINDING SITES; CELLS, CULTURED; DOWN-REGULATION; MESENCHYMAL STEM CELLS; MICRORNAS; MYOCARDIAL ISCHEMIA; MYOCARDIUM; RATS; RATS, INBRED LEW; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84860340295     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2011.01385.x     Document Type: Article

References (42)

1. Barandon L, Couffinhal T, Ezan J, et al. Reduction of infarct size and prevention of cardiac rupture in transgenic mice overexpressing FrzA. Circulation. 2003; 108: 2282-9.
2. Zelarayan LC, Noack C, Sekkali B, et al. Beta-catenin downregulation attenuates ischaemic cardiac remodeling through enhanced resident precursor cell differentiation. Proc Natl Acad Sci U S A. 2008; 105: 19762-7.
3. Saraswati S, Alfaro MP, Thorne CA, et al. Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling. PLoS ONE. 2010; 5: e15521.
4. Templin C, Kotlarz D, Faulhaber J, et al. Ex vivo expanded hematopoietic progenitor cells improve cardiac function after myocardial infarction: role of beta-catenin transduction and cell dose. J Mol Cell Cardiol. 2008; 45: 394-403.
5. Hahn JY, Cho HJ, Bae JW, et al. Beta-catenin overexpression reduces myocardial infarct size through differential effects on cardiomyocytes and cardiac fibroblasts. J Biol Chem. 2006; 281: 30979-89.
6. Mok SC, Wong KK, Chan RK, et al. Molecular cloning of differentially expressed genes in human epithelial ovarian cancer. Gynecol Oncol. 1994; 52: 247-52.
7. Schwahn DJ, Medina D. p96, a MAPK-related protein, is consistently downregulated during mouse mammary carcinogenesis. Oncogene. 1998; 17: 1173-8.
8. Tseng CP, Ely BD, Li Y, et al. Regulation of rat DOC-2 gene during castration-induced rat ventral prostate degeneration and its growth inhibitory function in human prostatic carcinoma cells. Endocrinology. 1998; 139: 3542-53.
9. Huang Y, Friess H, Kleeff J, et al. Doc-2/hDab2 expression is up-regulated in primary pancreatic cancer but reduced in metastasis. Lab Invest. 2001; 81: 863-73.
10. Mok SC, Chan WY, Wong KK, et al. DOC-2, a candidate tumour suppressor gene in human epithelial ovarian cancer. Oncogene. 1998; 16: 2381-7.
11. Hocevar BA, Smine A, Xu XX, et al. The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway. EMBO J. 2001; 20: 2789-801.
12. Mayorga ME, Dong F, Sundararaman S, et al. Central role for Disabled-2 in mesenchymal stem cardiac protein expression and functional consequences after engraftment in acute myocardial infarction. Stem Cells Dev. 2010; 20: 681-93.
13. Cliffe A, Hamada F, Bienz M. A role of dishevelled in relocating axin to the plasma membrane during wingless signaling. Curr Biol. 2003; 13: 960-6.
14. Wong HC, Bourdelas A, Krauss A, et al. Direct binding of the PDZ domain of dishevelled to a conserved internal sequence in the C-terminal region of frizzled. Mol Cell. 2003; 12: 1251-60.
15. Hocevar BA, Mou F, Rennolds JL, et al. Regulation of the Wnt signaling pathway by Disabled-2 (Dab2). EMBO J. 2003; 22: 3084-94.
16. Tong H, Imahashi K, Steenbergen C, et al. Phosphorylation of glycogen synthase kinase-3beta during preconditioning through a phosphatidylinositol-3-kinase-dependent pathway is cardioprotective. Circ Res. 2002; 90: 377-9.
17. Barandon L, Dufourcq P, Costet P, et al. Involvement of FrzA/sFRP-1 and the Wnt/frizzled pathway in ischaemic preconditioning. Circ Res. 2005; 96: 1299-306.
18. Wong N, Hui AB, Fan B, et al. Molecular cytogenetic characterization of nasopharyngeal carcinoma cell lines and xenografts by comparative genomic hybridization and spectral karyotyping. Cancer Genet Cytogenet. 2003; 140: 124-32.
19. Lo KW, Teo PM, Hui AB, et al. High resolution allelotype of microdissected primary nasopharyngeal carcinoma. Cancer Res. 2000; 60: 3348-53.
20. Zhang M, Mal N, Kiedrowski M, et al. SDF-1 expression by mesenchymal stem cells results in trophic support of cardiac myocytes after myocardial infarction. FASEB J. 2007; 21: 3197-207.
21. Akiyama Y, Watkins N, Suzuki H, et al. GATA-4 and GATA-5 transcription factor genes and potential downstream antitumour target genes are epigenetically silenced in colorectal and gastric cancer. Mol Cell Biol. 2003; 23: 8429-39.
22. Jiang Y, Prunier C, Howe PH. The inhibitory effects of Disabled-2 (Dab2) on Wnt signaling are mediated through Axin. Oncogene. 2008; 27: 1865-75.
23. Sheng Z, Sun W, Smith E, et al. Restoration of positioning control following Disabled-2 expression in ovarian and breast tumour cells. Oncogene. 2000; 19: 4847-54.
24. Rosenbauer F, Kallies A, Scheller M, et al. Disabled-2 is transcriptionally regulated by ICSBP and augments macrophage spreading and adhesion. EMBO J. 2002; 21: 211-20.
25. Morris SM, Arden SD, Roberts RC, et al. Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton. Traffic. 2002; 3: 331-41.
26. Morris SM, Tallquist MD, Rock CO, et al. Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport. EMBO J. 2002; 21: 1555-64.
27. Inoue A, Sato O, Homma K, et al. DOC-2/DAB2 is the binding partner of myosin VI. Biochem Biophys Res Commun. 2002; 292: 300-7.
28. Smith ER, Capochichi CD, He J, et al. Disabled-2 mediates c-Fos suppression and the cell growth regulatory activity of retinoic acid in embryonic carcinoma cells. J Biol Chem. 2001; 276: 47303-10.
29. Zhou J, Hsieh JT. The inhibitory role of DOC-2/DAB2 in growth factor receptor-mediated signal cascade. DOC-2/DAB2-mediated inhibition of ERK phosphorylation via binding to Grb2. J Biol Chem. 2001; 276: 27793-8.
30. Prunier C, Howe PH. Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT). J Biol Chem. 2005; 280: 17540-8.
31. Xu XX, Yang W, Jackowski S, et al. Cloning of a novel phosphoprotein regulated by colony-stimulating factor 1 shares a domain with the Drosophila disabled gene product. J Biol Chem. 1995; 270: 14184-91.
32. Howell BW, Gertler FB, Cooper JA. Mouse disabled (mDab1): a Src binding protein implicated in neuronal development. EMBO J. 1997; 16: 121-32.
33. Chaudhury A, Hussey GS, Ray PS, et al. TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI. Nat Cell Biol. 2010; 12: 286-93.
34. Kent OA, Chivukula RR, Mullendore M, et al. Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumour-promoting feed-forward pathway. Genes Dev. 2010; 24: 2754-9.
35. Gao P, Wong, CC, Tung, EK, et al. Deregulation of microRNA expression occurs early and accumulates in early stages of HBV-associated multistep hepatocarcinogenesis. J Hepatol. 2011; 54: 1177-84.
36. Song T, Xia W, Shao N, et al. Differential miRNA expression profiles in bladder urothelial carcinomas. Asian Pac J Cancer Prev. 2010; 11: 905-11.
37. Chen Z, Zeng H, Guo Y, et al. miRNA-145 inhibits non-small cell lung cancer cell proliferation by targeting c-Myc. J Exp Clin Cancer Res. 2010; 29: 151-60.
38. Xu N, Papagiannakopoulos T, Pan G, et al. MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell. 2009; 137: 647-58.
39. Chivukula RR, Mendell JT. Abate and switch: miR-145 in stem cell differentiation. Cell. 2009; 137: 606-8.
40. Cordes KR, Sheehy NT, White MP, et al. miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature. 2009; 460: 705-10.
41. Sachdeva M, Zhu S, Wu F, et al. p53 represses c-Myc through induction of the tumour suppressor miR-145. Proc Natl Acad Sci U S A. 2009; 106: 3207-12.
42. Fichtlscherer S, De RS, Fox H, et al. Circulating microRNAs in patients with coronary artery disease. Circ Res. 2010; 107: 677-84.