Identification and characterization of Borrelia antigens as potential vaccine candidates against Lyme borreliosis

Vaccine

Volumn 30, Issue 29, 2012, Pages 4398-4406

  Poljak, Albina ^a   Comstedt, Pär ^a   Hanner, Markus ^a   Schüler, Wolfgang ^a   Meinke, Andreas ^a   Wizel, Benjamin ^a   Lundberg, Urban ^a  

^a INTERCELL AG   (Austria)

Author keywords

Antigen; Borrelia; Genomic screen; Lyme borreliosis

Indexed keywords

BACTERIAL ANTIGEN; LYME DISEASE VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIUM IDENTIFICATION; BAGG ALBINO MOUSE; BORRELIA AFZELII; BORRELIA BURGDORFERI; BORRELIA GARINII; C3H MOUSE; CONTROLLED STUDY; DRUG ANTIGENICITY; DRUG CROSS REACTIVITY; GENETIC HETEROGENEITY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; INFLAMMATION; LYME DISEASE; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SERUM; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BORRELIA BURGDORFERI GROUP; CROSS REACTIONS; CYTOKINES; FEMALE; HUMANS; LYME DISEASE; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; RECOMBINANT PROTEINS; T-LYMPHOCYTE SUBSETS;

EID: 84860326997     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2011.10.073     Document Type: Article

References (65)

1. Steere A.C. Lyme disease. N Engl J Med 1989, 321:586-596.
2. Wilske B. Diagnosis of Lyme borreliosis in Europe. Vector Borne Zoonotic Dis 2003, 3:215-227.
3. Takayama K., Rothenberg R.J., Barbour A.G. Absence of lipopolysaccharide in the Lyme disease spirochete, Borrelia burgdorferi. Infect Immun 1987, 55:2311-2313.
4. Barbour A.G., Hayes S.F. Biology of Borrelia species. Microbiol Rev 1986, 50:381-400.
5. Haake D.A. Spirochaetal lipoproteins and pathogenesis. Microbiology 2000, 146:1491-1504.
6. Coburn J., Fischer J.R., Leong J.M. Solving a sticky problem: new genetic approaches to host cell adhesion by the Lyme disease spirochete. Mol Microbiol 2005, 57:1182-1195.
7. Steere A.C., Glickstein L. Elucidation of Lyme arthritis. Nat Rev Immunol 2004, 4:143-152.
8. Ma Y., Weis J.J. Borrelia burgdorferi outer surface lipoproteins OspA and OspB possess B-cell mitogenic and cytokine-stimulatory properties. Infect Immun 1993, 61:3843-3853.
9. Whitmire W.M., Garon C.F. Specific and nonspecific responses of murine B cells to membrane blebs of Borrelia burgdorferi. Infect Immun 1993, 61:1460-1467.
10. Dong Z., Edelstein M.D., Glickstein L.J. CD8+ T cells are activated during the early Th1 and Th2 immune responses in a murine Lyme disease model. Infect Immun 1997, 65:5334-5337.
11. Keane-Myers A., Nickell S.P. T cell subset-dependent modulation of immunity to Borrelia burgdorferi in mice. J Immunol 1995, 154:1770-1776.
12. Keane-Myers A., Nickell S.P. Role of IL-4 and IFN-gamma in modulation of immunity to Borrelia burgdorferi in mice. J Immunol 1995, 155:2020-2028.
13. Burchill M.A., Nardelli D.T., England D.M., DeCoster D.J., Christopherson J.A., Callister S.M., et al. Inhibition of interleukin-17 prevents the development of arthritis in vaccinated mice challenged with Borrelia burgdorferi. Infect Immun 2003, 71:3437-3442.
14. Zeidner N.S., Schneider B.S., Rutherford J.S., Dolan M.C. Suppression of Th2 cytokines reduces tick-transmitted Borrelia burgdorferi load in mice. J Parasitol 2008, 94:767-769.
15. Etz H., Minh D.B., Henics T., Dryla A., Winkler B., Triska C., et al. Identification of in vivo expressed vaccine candidate antigens from Staphylococcus aureus. Proc Natl Acad Sci U S A 2002, 99:6573-6578.
16. Giefing C., Meinke A.L., Hanner M., Henics T., Bui M.D., Gelbmann D., et al. Discovery of a novel class of highly conserved vaccine antigens using genomic scale antigenic fingerprinting of pneumococcus with human antibodies. J Exp Med 2008, 205:117-131.
17. Barthold S.W., Moody K.D., Terwilliger G.A., Duray P.H., Jacoby R.O., Steere A.C., et al. Lyme arthritis in rats infected with Borrelia burgdorferi. J Infect Dis 1988, 157:842-846.
18. Barthold S.W., Beck D.S., Hansen G.M., Terwilliger G.A., Moody K.D. Lyme borreliosis in selected strains and ages of laboratory mice. J Infect Dis 1990, 162:133-138.
19. Ornstein K., Berglund J., Nilsson I., Norrby R., Bergström S. Characterization of Lyme borreliosis isolates from patients with erythema migrans and neuroborreliosis in southern Sweden. J Clin Microbiol 2001, 39:1294-1298.
20. Marconi R.T., Garon C.F. Development of polymerase chain reaction primer sets for diagnosis of Lyme disease and for species-specific identification of Lyme disease isolates by 16S rRNA signature nucleotide analysis. J Clin Microbiol 1992, 30:2830-2834.
21. Zumstein G., Fuchs R., Hofmann A., Preac-Mursic V., Soutschek E., Wilske B. Genetic polymorphism of the gene encoding the outer surface protein A (OspA) of Borrelia burgdorferi. Med Microbiol Immunol 1992, 181:57-70.
22. Livey I., Gibbs C.P., Schuster R., Dorner F. Evidence for lateral transfer and recombination in OspC variation in Lyme disease Borrelia. Mol Microbiol 1995, 18:257-269.
23. Henics T., Winkler B., Pfeifer U., Gill S.R., Buschle M., von Gabain A., et al. Small-fragment genomic libraries for the display of putative epitopes from clinically significant pathogens. Biotechniques 2003, 35:196-202. 204, 206 passim.
24. Meinke A., Henics T., Hanner M., Minh D.B., Nagy E. Antigenome technology: a novel approach for the selection of bacterial vaccine candidate antigens. Vaccine 2005, 23:2035-2041.
25. Liang F.T., Alvarez A.L., Gu Y., Nowling J.M., Ramamoorthy R., Philipp M.T. An immunodominant conserved region within the variable domain of VlsE, the variable surface antigen of Borrelia burgdorferi. J Immunol 1999, 163:5566-5573.
26. Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R., Lathigra R., et al. Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi. Nature 1997, 390:580-586.
27. Casjens S., Palmer N., van Vugt R., Huang W.M., Stevenson B., Rosa P., et al. A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi. Mol Microbiol 2000, 35:490-516.
28. Glöckner G., Lehmann R., Romualdi A., Pradella S., Schulte-Spechtel U., Schilhabel M., et al. Comparative analysis of the Borrelia garinii genome. Nucleic Acids Res 2004, 32:6038-6046.
29. Schwan T.G., Piesman J., Golde W.T., Dolan M.C., Rosa P.A. Induction of an outer surface protein on Borrelia burgdorferi during tick feeding. Proc Natl Acad Sci U S A 1995, 92:2909-2913.
30. Seinost G., Dykhuizen D.E., Dattwyler R.J., Golde W.T., Dunn J.J., Wang I.N., et al. Four clones of Borrelia burgdorferi sensu stricto cause invasive infection in humans. Infect Immun 1999, 67:3518-3524.
31. Wallich R., Kramer M.D., Simon M.M. The recombinant outer surface protein A (lipOspA) of Borrelia burgdorferi: a Lyme disease vaccine. Infection 1996, 24:396-397.
32. Earnhart C.G., Buckles E.L., Marconi R.T. Development of an OspC-based tetravalent, recombinant, chimeric vaccinogen that elicits bactericidal antibody against diverse Lyme disease spirochete strains. Vaccine 2007, 25:466-480.
33. Hanson M.S., Cassatt D.R., Guo B.P., Patel N.K., McCarthy M.P., Dorward D.W., et al. Active and passive immunity against Borrelia burgdorferi decorin binding protein A (DbpA) protects against infection. Infect Immun 1998, 66:2143-2153.
34. Etz H., Minh D.B., Schellack C., Nagy E., Meinke A. Bacterial phage receptors, versatile tools for display of polypeptides on the cell surface. J Bacteriol 2001, 183:6924-6935.
35. Feng S., Hodzic E., Stevenson B., Barthold S.W. Humoral immunity to Borrelia burgdorferi N40 decorin binding proteins during infection of laboratory mice. Infect Immun 1998, 66:2827-2835.
36. Hellwage J., Meri T., Heikkilä T., Alitalo A., Panelius J., Lahdenne P., et al. The complement regulator factor H binds to the surface protein OspE of Borrelia burgdorferi. J Biol Chem 2001, 276:8427-8435.
37. Fikrig E., Feng W., Barthold S.W., Telford S.R., Flavell R.A. Arthropod- and host-specific Borrelia burgdorferi bbk32 expression and the inhibition of spirochete transmission. J Immunol 2000, 164:5344-5351.
38. Rössler D., Eiffert H., Jauris-Heipke S., Lehnert G., Preac-Mursic V., Teepe J., et al. Molecular and immunological characterization of the p83/100 protein of various Borrelia burgdorferi sensu lato strains. Med Microbiol Immunol 1995, 184:23-32.
39. Heikkilä T., Seppälä I., Saxén H., Panelius J., Peltomaa M., Julin T., et al. Recombinant BBK32 protein in serodiagnosis of early and late Lyme borreliosis. J Clin Microbiol 2002, 40:1174-1180.
40. Lahdenne P., Panelius J., Saxen H., Heikkilä T., Sillanpää H., Peltomaa M., et al. Improved serodiagnosis of erythema migrans using novel recombinant borrelial BBK32 antigens. J Med Microbiol 2003, 52:563-567.
41. Wilske B., Habermann C., Fingerle V., Hillenbrand B., Jauris-Heipke S., Lehnert G., et al. An improved recombinant IgG immunoblot for serodiagnosis of Lyme borreliosis. Med Microbiol Immunol 1999, 188:139-144.
42. Bruckbauer H.R., Preac-Mursic V., Fuchs R., Wilske B. Cross-reactive proteins of Borrelia burgdorferi. Eur J Clin Microbiol Infect Dis 1992, 11:224-232.
43. Hauser U., Lehnert G., Wilske B. Diagnostic value of proteins of three Borrelia species (Borrelia burgdorferi sensu lato) and implications for development and use of recombinant antigens for serodiagnosis of Lyme borreliosis in Europe. Clin Diagn Lab Immunol 1998, 5:456-462.
44. Probert W.S., LeFebvre R.B. Protection of C3H/HeN mice from challenge with Borrelia burgdorferi through active immunization with OspA, OspB, or OspC, but not with OspD or the 83-kilodalton antigen. Infect Immun 1994, 62:1920-1926.
45. Kalish R.A., Leong J.M., Steere A.C. Association of treatment-resistant chronic Lyme arthritis with HLA-DR4 and antibody reactivity to OspA and OspB of Borrelia burgdorferi. Infect Immun 1993, 61:2774-2779.
46. Wilske B., Barbour A.G., Bergström S., Burman N., Restrepo B.I., Rosa P.A., et al. Antigenic variation and strain heterogeneity in Borrelia spp. Res Microbiol 1992, 143:583-596.
47. Wang G., van Dam A.P., Schwartz I., Dankert J. Molecular typing of Borrelia burgdorferi sensu lato: taxonomic, epidemiological, and clinical implications. Clin Microbiol Rev 1999, 12:633-653.
48. Barbour A.G., Jasinskas A., Kayala M.A., Davies D.H., Steere A.C., Baldi P., et al. A genome-wide proteome array reveals a limited set of immunogens in natural infections of humans and white-footed mice with Borrelia burgdorferi. Infect Immun 2008, 76:3374-3389.
49. Nowalk A.J., Nolder C., Clifton D.R., Carroll J.A. Comparative proteome analysis of subcellular fractions from Borrelia burgdorferi by NEPHGE and IPG. Proteomics 2006, 6:2121-2134.
50. Caimano M.J., Iyer R., Eggers C.H., Gonzalez C., Morton E.A., Gilbert M.A., et al. Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle. Mol Microbiol 2007, 65:1193-1217.
51. Brooks C.S., Hefty P.S., Jolliff S.E., Akins D.R. Global analysis of Borrelia burgdorferi genes regulated by mammalian host-specific signals. Infect Immun 2003, 71:3371-3383.
52. Hughes J.L., Nolder C.L., Nowalk A.J., Clifton D.R., Howison R.R., Schmit V.L., et al. Borrelia burgdorferi surface-localized proteins expressed during persistent murine infection are conserved among diverse Borrelia spp. Infect Immun 2008, 76:2498-2511.
53. Ojaimi C., Brooks C., Casjens S., Rosa P., Elias A., Barbour A., et al. Profiling of temperature-induced changes in Borrelia burgdorferi gene expression by using whole genome arrays. Infect Immun 2003, 71:1689-1705.
54. Tokarz R., Anderton J.M., Katona L.I., Benach J.L. Combined effects of blood and temperature shift on Borrelia burgdorferi gene expression as determined by whole genome DNA array. Infect Immun 2004, 72:5419-5432.
55. Johnson R.C., Kodner C., Russell M. Passive immunization of hamsters against experimental infection with the Lyme disease spirochete. Infect Immun 1986, 53:713-714.
56. Zhong W., Stehle T., Museteanu C., Siebers A., Gern L., Kramer M., Simon M.M., et al. Therapeutic passive vaccination against chronic Lyme disease in mice. Proc Natl Acad Sci U S A 1997, 94(23):12533-12538.
57. Codolo G., Amedei A., Steere A.C., Papinutto E., Cappon A., Polenghi A., et al. Borrelia burgdorferi NapA-driven Th17 cell inflammation in lyme arthritis. Arthritis Rheum 2008, 58:3609-3617.
58. Schaible U.E., Kramer M.D., Wallich R., Tran T., Simon M.M. Experimental Borrelia burgdorferi infection in inbred mouse strains: antibody response and association of H-2 genes with resistance and susceptibility to development of arthritis. Eur J Immunol 1991, 21:2397-2405.
59. Keane-Myers A., Maliszewski C.R., Finkelman F.D., Nickell S.P. Recombinant IL-4 treatment augments resistance to Borrelia burgdorferi infections in both normal susceptible and antibody-deficient susceptible mice. J Immunol 1996, 156:2488-2494.
60. Matyniak J.E., Reiner S.L. T helper phenotype and genetic susceptibility in experimental Lyme disease. J Exp Med 1995, 181:1251-1254.
61. Berton M.T., Uhr J.W., Vitetta E.S. Synthesis of germ-line gamma 1 immunoglobulin heavy-chain transcripts in resting B cells: induction by interleukin 4 and inhibition by interferon gamma. Proc Natl Acad Sci U S A 1989, 86:2829-2833.
62. Bergstedt-Lindqvist S., Moon H.B., Persson U., Möller G., Heusser C., Severinson E. Interleukin 4 instructs uncommitted B lymphocytes to switch to IgG1 and IgE. Eur J Immunol 1988, 18:1073-1077.
63. Rennick D., Hunte B., Holland G., Thompson-Snipes L. Cofactors are essential for stem cell factor-dependent growth and maturation of mast cell progenitors: comparative effects of interleukin-3 (IL-3), IL-4, IL-10, and fibroblasts. Blood 1995, 85:57-65.
64. Bluth M.H., Robin J., Ruditsky M., Norowitz K.B., Chice S., Pytlak E., et al. IgE anti-Borrelia burgdorferi components (p18, p31, p34, p41, p45, p60) and increased blood CD8+CD60+T cells in children with Lyme disease. Scand J Immunol 2007, 65:376-382.
65. Christopherson J.A., Munson E.L., England D.M., Croke C.L., Remington M.C., Molitor M.L., et al. Destructive arthritis in vaccinated interferon gamma-deficient mice challenged with Borrelia burgdorferi: modulation by tumor necrosis factor alpha. Clin Diagn Lab Immunol 2003, 10:44-52.