Suppression of Th2 cytokines reduces tick-transmitted Borrelia burgdorferi load in mice

Journal of Parasitology

Volumn 94, Issue 3, 2008, Pages 767-769

  Zeidner, Nordin S ^a   Schneider, Bradley S ^b   Rutherford, Jeremiah S ^c   Dolan, Marc C ^a  

^a NATIONAL CENTER FOR EMERGING AND ZOONOTIC INFECTIOUS DISEASES   (United States)

^b INSTITUT PASTEUR   (France)

^c NEW YORK METHODIST HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN G2A ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 4 ANTIBODY; INTERLEUKIN 5; TUMOR NECROSIS FACTOR ALPHA;

BACTERIUM; IMMUNE RESPONSE; IMMUNITY; NEUTRALIZATION; PARASITE INTENSITY; PARASITE TRANSMISSION; RODENT; SALIVA; TICK;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL TRANSMISSION; BORRELIA BURGDORFERI; BORRELIA INFECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEEDING; IMMUNOMODULATION; KNOCKOUT MOUSE; LYME DISEASE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; SALIVA; TH1 CELL; TH2 CELL; TICK;

ANIMALS; ARACHNID VECTORS; BORRELIA BURGDORFERI; INTERLEUKIN-4; INTERLEUKIN-5; IXODIDAE; LYME DISEASE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, KNOCKOUT; SALIVA; TH2 CELLS; TICK INFESTATIONS;

BORRELIA BURGDORFERI; IXODIDA; MUS; SPIROCHAETALES;

EID: 47349109329     PISSN: 00223395     EISSN: None     Source Type: Journal    
DOI: 10.1645/GE-1416R.1     Document Type: Article

References (29)

1. ANGUITA, J., N. RAMAMOORTHI, J. W. HOVIUS, S. DAS, V. THOMAS, R. PERSINSKI, D. CONZE, P. W. ASKENASE, M. RINCON, F. S. KANTOR, ET AL. 2002. Salp15, an Ixodes scapularis salivary protein, inhibits CD4(+) T cell activation. Immunity 16: 849-859.
2. BOCKENSTEDT, L. K., C. KANG, C. CHANG, D. PERSING, A. HAYDAY, AND S. W. BARTHOLD. 2001. CD4+ T helper cells facilitate regression of murine Lyme carditis. Infection and Immunity 69: 5264-5269.
3. BROSSARD, M., AND S. K. WIKEL. 1997. Immunology of interactions between ticks and hosts. Medical and Veterinary Entomology 11: 270-276.
4. CENTERS FOR DISEASE CONTROL AND PREVENTION. 2004. Lyme disease-United States, 2001-2002. Morbidity and Mortality Weekly Report 3: 365-369.
5. CLOVER, J. R., AND R. S. LANE. 1995. Evidence implicating nymphal Ixodes pacificus (Acari: Ixodidae) in the epidemiology of Lyme disease in California. Morbidity and Mortality Weekly Report 53: 237-240.
6. DENNIS, D. T. 1995. Lyme disease. Dermatology Clinics 13: 537-551.
7. ESPEVIK T., I. S. FIGARI, M. R. SHALABY, G. A. LACKIDES, G. D. LEWIS, H. M. SHEPARD, AND M. A. PALLADINO. 1987. Inhibition of cytokine production by cyclosporin A and transforming growth factor β. Journal of Experimental Medicine 166: 571-576.
8. FERREIRA, B. R., AND J. S. SILVA. 1999. Successive tick infestations selectively promote a T-helper 2 cytokine profile in mice. Immunology 96: 434-439.
9. GANAPAMO, F., B. RUTTI, AND M. BROSSARD. 1997. Identification of an Ixodes ricinus salivary gland fraction through its ability to stimulate CD4+ T cells present in BALB/c mice lymph nodes draining the tick fixation site. Parasitology 115: 91-96.
10. GILLESPIE, R. D., M. C. DOLAN, J. PIESMAN, AND R. G. TITUS. 2001. Identification of an IL-2 binding protein in the saliva of the Lyme disease vector tick, Ixodes scapularis. Journal of Immunology 166: 4319-4326.
11. KOPECKY, J., M. KUTHEJLOVA, AND J. PECHOVA. 1999. Salivary gland extract from Ixodes ricinus ticks inhibits production of interferon-gamma by the upregulation of interleukin-10. Parasite Immunology 21: 351-356.
12. KOPF, M. F., P. D. BROMBACHER, P. D. HODGKIN, A. J. RAMSAY, E. A. MILBOURNE, W. J. DAI, K. S. OVINGTON, C. A. BEHM, G. KOHLER, I. G. YOUNG, ET AL. 1996. IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell reponses. Immunity 4: 15-24.
13. KOTSYFAKIS, M., A. SA-NUNES, I. M. FRANCISCHETTI, T. N. MATHER, J. F. ANDERSEN, AND J. M. RIBEIRO. 2006. Antiinflammatory and immunosuppressive activity of sialostatin L, a salivary cystatin from the tick Ixodes scapularis. Journal of Biological Chemistry 281: 26298-26307.
14. KUTHEJLOVA, M., J. KOPECKY, G. STEPANOVA, AND A. MACELA. 2001. Tick salivary gland extract inhibits killing of Borrelia afzelii spirochetes by mouse macrophages. Infection and Immunity 69: 575-578.
15. LABUDA, M., L. D. JONES, T. WILLIAMS, AND P. A. NUTTALL. 1993. Enhancement of tick-borne encephalitis virus transmission by tick salivary gland extracts. Medical and Veterinary Entomology 7: 193-196.
16. MA, Y., K. P. SEILER, E. J. EICHWALD, J. H. WEISS, C. TEUSCHER, AND J. J. WEISS. 1998. Distinct characteristics of resistance to Borrelia burgdorferi-induced arthritis in C57BL/6N mice. Infection and Immunity 66: 161-168.
17. PELEMAN, R., J. WU, C. FARGEAS, AND G. DELESPESSE. 1989. Recombinant interleukin-4 suppresses the production of interferon-γ by human mononuclear cells. Journal of Experimental Medicine 170: 1751-1756.
18. PIESMAN, J., AND R. J. SINSKY. 1988. Ability of Ixodes scapularis, Dermacentor variabilis, and Amblyomma americanum (Acari: Ixodidae) to acquire, maintain and transmit Lyme disease spirochetes. Journal of Medical Entomology 25: 336-339.
19. RIBEIRO, J. M. C. 1987. Role of saliva in blood-feeding by arthropods. Annual Review of Entomology 32: 463-478.
20. _, AND I. M. FRANCISHETTI. 2003. Role of arthropod saliva in blood feeding: Sialome and post-sialome perspectives. Annual Review of Entomology 48: 73-88.
21. _, G. T. MAKOUL, J. LEVINE, D. R. ROBINSON, AND A. SPIELMAN. 1985. Antihemostatic, antiinflammatory, and immunosuppressive properties of the saliva of a tick, Ixodes dammini. Journal of Experimental Medicine 161: 332-344.
22. SCHOELER, G. B., S. A. MANWEILER, AND S. K. WIKEL. 1999. Ixodes scapularis: Effects of repeated infestations with pathogen-free nymphs on macrophage and T lymphocyte cytokine responses of BALB/c and C3H/HeN mice. Experimental Parasitology 92: 239-248.
23. SEDER, R. A., R. GAZZINELLI, A. SHER, AND W. E. PAUL. 1993. Interleukin-12 acts directly on CD4+ T cells to enhance priming for interferon γ production and diminishes interleukin-4 inhibition of such priming. Proceedings of the National Academy of Science USA 90: 10188-10192.
24. STEERE, A. C. 1989. Lyme disease. New England Journal of Medicine 131: 586-596.
25. WIKEL, S. K. 1999. Immunology of the tick-host interface. In The immunology of host-ectoparasitic arthropod relationships, S. K. Wikel (ed.). CAB International, Wallingford, U.K., p. 204-231.
26. ZEIDNER, N. S., M. C. DOLAN, R. MASSUNG, J. PIESMAN, AND D. FISH. 2000. Coinfection with Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis suppresses IL-2 and IFN-γ production and promotes an IL-4 response in C3H/HeJ mice. Parasite Immunology 22: 581-588.
27. _, M. J. DREITZ, D. BELASCO, AND D. FISH. 1996. Suppression of Ixodes scapularis-induced Borrelia burgdorferi infection using tumor necrosis factor-α, interleukin-2, and interferon-γ. Journal of Infectious Diseases 173: 187-195.
28. _, M. L. MBOW, M. C. DOLAN, R. MASSUNG, E. BACA, AND J. PIESMAN. 1997. Effects of Ixodes, scapularis and Borrelia burgdorferi on modulation of the host immune response: Induction of a Th2 cytokine response in Lyme disease-susceptible (C3H/HeJ) mice but not in disease-resistant (BALB/c) mice. Infection and Immunity 65: 3100-3106.
29. _, B. S. SCHNEIDER, M. C. DOLAN, AND J. PIESMAN. 2001. An analysis of spirochete load, strain, and pathology in a model of Lyme borreliosis. Journal of Vector-Borne and Zoonotic Diseases 1: 33-42.