The recombinant outer surface protein A (lipOspA) of Borrelia burgdorferi: A Lyme disease vaccine

Infection

Volumn 24, Issue 5, 1996, Pages 396-397

  Wallich, R ^a   Kramer, M D ^a   Simon, M M ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BACTERIUM ANTIBODY; RECOMBINANT PROTEIN;

ANTIBODY TITER; BORRELIA BURGDORFERI; CLINICAL TRIAL; DRUG SAFETY; DRUG STABILITY; HUMAN; IMMUNE RESPONSE; INFECTION CONTROL; INJECTION PAIN; LYME DISEASE; NONHUMAN; SHORT SURVEY; VACCINATION;

ADULT; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, SURFACE; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL VACCINES; BORRELIA BURGDORFERI GROUP; CLINICAL TRIALS, PHASE I; CLINICAL TRIALS, PHASE II; CLINICAL TRIALS, PHASE III; HUMANS; LIPOPROTEINS; LYME DISEASE; MICE; MICE, SCID; VACCINES, SYNTHETIC;

EID: 0029959724     PISSN: 03008126     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01716093     Document Type: Short Survey

References (12)

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3. Schaible, U. E., Gay, S., Museteanu, C., Kramer, M. D., Zimmer, G., Eichmann, K., Museteanu, U., Simon, M. M.: Lyme borreliosis in the severe combined immunodeficiency (scid) mouse manifests predominantly in the joints, heart, and liver. Am. J. Pathol. 137 (1990) 811-820.
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5. Schaible, U. E., Kramer, M. D., Justus, C. W. E., Museteanu, C., Simon, M. M. : Demonstration of antigen-specific T cells and histopathological alterations in mice experimentally inoculated with B. burgdorferi. Infect. Immun. 57 (1989) 41-47.
6. Schaible, U. E., Kramer, M. D., Eichmann, K., Modolell, M., Museteanu, C., Simon, M. M.: Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice. Proc. Natl. Acad. Sci. USA 87 (1990) 3768-3772.
7. Schaible, U. E., Wallich, R., Kramer, M. D., Museteanu, C., Rittig, M., Moter, S., Simon, M. M. : Role of the immune response in Lyme disease: Lessons from a mouse model. In: Schutzer, S. E. (ed.): Lyme disease. Molecular and immunologic approaches. Cold Spring Harbour Laboratory Press 1992, pp. 243-262.
8. Simon, M. M., Schaible, U. E., Wallich, R., Kramer, M. D.: A mouse model for Borrelia burgdorferi infection: approach to a possible vaccine against Lyme disease. Immunol Today 12 (1991) 11-16.
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11. Wallich, R., Schaible, U. E., Simon, M. M., Heiberger, A., Kramer, M. D.: Cloning and sequencing of the gene encoding the outer surface protein A (OspA) of an european Borrelia burgdorferi isolate. Nucleic Acids Res. 21 (1989) 8864.
12. Kramer, M. D., Wallich, R., Simon, M. M.: The outer surface protein A (OspA) of Borrelia burgdorferi: a vaccine candidate and bioactive mediator. Infection 24 (1996) 190-194.