The abnormal processing of TDP-43 is not an upstream event of reduced ADAR2 activity in ALS motor neurons

Neuroscience Research

Volumn 73, Issue 2, 2012, Pages 153-160

  Yamashita, Takenari ^a,b   Hideyama, Takuto ^a,b   Teramoto, Sayaka ^a,b   Kwak, Shin ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Adenosine deaminase acting on RNA type 2 (ADAR2); AMPA receptor; Amyotrophic lateral sclerosis (ALS); GluA2; RNA editing; TDP 43

Indexed keywords

ADENOSINE DEAMINASE; BETA ACTIN; CASPASE 3; PROTEIN ADAR2; TAR DNA BINDING PROTEIN; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BIOLOGICAL ACTIVITY; BIOTRANSFORMATION; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVE SITE; FEMALE; GENETIC ASSOCIATION; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOTONEURON; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TDP 43 PROTEINOPATHY; WESTERN BLOTTING;

ADENOSINE DEAMINASE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL LINE, TUMOR; DNA-BINDING PROTEINS; ENZYME ACTIVATION; HELA CELLS; HUMANS; MICE; MOTOR NEURONS; PROTEIN MODIFICATION, TRANSLATIONAL; RNA-BINDING PROTEINS;

EID: 84860320548     PISSN: 01680102     EISSN: 18728111     Source Type: Journal    
DOI: 10.1016/j.neures.2012.02.015     Document Type: Article

References (32)

1. Aizawa H., Sawada J., Hideyama T., Yamashita T., Katayama T., Hasebe N., Kimura T., Yahara O., Kwak S. TDP-43 pathology in sporadic ALS occurs in motor neurons lacking the RNA editing enzyme ADAR2. Acta Neuropathol. 2010, 120:75-84.
2. Arai T., Hasegawa M., Akiyama H., Ikeda K., Nonaka T., Mori H., Mann D., Tsuchiya K., Yoshida M., Hashizume Y., Oda T. TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem. Biophys. Res. Commun. 2006, 351:602-611.
3. Bhalla T., Rosenthal J.J., Holmgren M., Reenan R. Control of human potassium channel inactivation by editing of a small mRNA hairpin. Nat. Struct. Mol. Biol. 2004, 11:950-956.
4. Chen-Plotkin A.S., Lee V.M., Trojanowski J.Q. TAR DNA-binding protein 43 in neurodegenerative disease. Nat. Rev. Neurol. 2010, 6:211-220.
5. Hasegawa M., Arai T., Nonaka T., Kametani F., Yoshida M., Hashizume Y., Beach T.G., Buratti E., Baralle F., Morita M., Nakano I., Oda T., Tsuchiya K., Akiyama H. Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Ann. Neurol. 2008, 64:60-70.
6. Hideyama T., Kwak S. When does ALS start? ADAR2-GluA2 hypothesis for the etiology of sporadic ALS. Front. Mol. Neurosci. 2011, 4:33.
7. Hideyama T., Yamashita T., Aizawa H., Tsuji S., Kakita A., Takahashi H., Kwak S. Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons. Neurobiol. Dis. 2012, 45:1121-1128.
8. Hideyama T., Yamashita T., Suzuki T., Tsuji S., Higuchi M., Seeburg P.H., Takahashi R., Misawa H., Kwak S. Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2. J. Neurosci. 2010, 30:11917-11925.
9. Higuchi M., Maas S., Single F.N., Hartner J., Rozov A., Burnashev N., Feldmeyer D., Sprengel R., Seeburg P.H. Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2. Nature 2000, 406:78-81.
10. Kawahara Y., Ito K., Sun H., Aizawa H., Kanazawa I., Kwak S. Glutamate receptors: RNA editing and death of motor neurons. Nature 2004, 427:801.
11. Kawahara Y., Ito K., Sun H., Kanazawa I., Kwak S. Low editing efficiency of GluR2 mRNA is associated with a low relative abundance of ADAR2 mRNA in white matter of normal human brain. Eur. J. Neurosci. 2003, 18:23-33.
12. Kawahara Y., Sun H., Ito K., Hideyama T., Aoki M., Sobue G., Tsuji S., Kwak S. Underediting of GluR2 mRNA, a neuronal death inducing molecular change in sporadic ALS, does not occur in motor neurons in ALS1 or SBMA. Neurosci. Res. 2006, 54:11-14.
13. Kwak S., Kawahara Y. Deficient RNA editing of GluR2 and neuronal death in amyotropic lateral sclerosis. J. Mol. Med. 2005, 83:110-120.
14. Kwak S., Weiss J.H. Calcium-permeable AMPA channels in neurodegenerative disease and ischemia. Curr. Opin. Neurobiol. 2006, 16:281-287.
15. Lagier-Tourenne C., Polymenidou M., Cleveland D.W. TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration. Hum. Mol. Genet. 2010, 19:R46-R64.
16. Mackenzie I.R., Bigio E.H., Ince P.G., Geser F., Neumann M., Cairns N.J., Kwong L.K., Forman M.S., Ravits J., Stewart H., Eisen A., McClusky L., Kretzschmar H.A., Monoranu C.M., Highley J.R., Kirby J., Siddique T., Shaw P.J., Lee V.M., Trojanowski J.Q. Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations. Ann. Neurol. 2007, 61:427-434.
17. McKee A.C., Gavett B.E., Stern R.A., Nowinski C.J., Cantu R.C., Kowall N.W., Perl D.P., Hedley-Whyte E.T., Price B., Sullivan C., Morin P., Lee H.S., Kubilus C.A., Daneshvar D.H., Wulff M., Budson A.E. TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy. J. Neuropathol. Exp. Neurol. 2010, 69:918-929.
18. Melcher T., Maas S., Herb A., Sprengel R., Seeburg P.H., Higuchi M. A mammalian RNA editing enzyme. Nature 1996, 379:460-464.
19. Neumann M., Sampathu D.M., Kwong L.K., Truax A.C., Micsenyi M.C., Chou T.T., Bruce J., Schuck T., Grossman M., Clark C.M., McCluskey L.F., Miller B.L., Masliah E., Mackenzie I.R., Feldman H., Feiden W., Kretzschmar H.A., Trojanowski J.Q., Lee V.M. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 2006, 314:130-133.
20. Nishimoto Y., Yamashita T., Hideyama T., Tsuji S., Suzuki N., Kwak S. Determination of editors at the novel A-to-I editing positions. Neurosci. Res. 2008, 61:201-206.
21. Nonaka T., Kametani F., Arai T., Akiyama H., Hasegawa M. Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43. Hum. Mol. Genet. 2009, 18:3353-3364.
22. Polymenidou M., Lagier-Tourenne C., Hutt K.R., Huelga S.C., Moran J., Liang T.Y., Ling S.C., Sun E., Wancewicz E., Mazur C., Kordasiewicz H., Sedaghat Y., Donohue J.P., Shiue L., Bennett C.F., Yeo G.W., Cleveland D.W. Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. Nat. Neurosci. 2011, 14:459-468.
23. Sawada J., Yamashita T., Aizawa H., Aburakawa Y., Hasebe N., Kwak S. Effects of antidepressants on GluR2 Q/R site-RNA editing in modified HeLa cell line. Neurosci. Res. 2009, 64:251-258.
24. Seeburg P.H. A-to-I editing: new and old sites, functions and speculations. Neuron 2002, 35:17-20.
25. Sephton C.F., Cenik C., Kucukural A., Dammer E.B., Cenik B., Han Y., Dewey C.M., Roth F.P., Herz J., Peng J., Moore M.J., Yu G. Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes. J. Biol. Chem. 2011, 286:1204-1215.
26. Suzuki T., Tsuzuki K., Kameyama K., Kwak S. Recent advances in the study of AMPA receptors. Nihon yakurigaku zasshi Folia pharmacologica Japonica 2003, 122:515-526.
27. Tan C.F., Eguchi H., Tagawa A., Onodera O., Iwasaki T., Tsujino A., Nishizawa M., Kakita A., Takahashi H. TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation. Acta Neuropathol. 2007, 113:535-542.
28. Tremblay C., St-Amour I., Schneider J., Bennett D.A., Calon F. Accumulation of transactive response DNA binding protein 43 in mild cognitive impairment and Alzheimer disease. J. Neuropathol. Exp. Neurol. 2011, 70:788-798.
29. Wilson A.C., Dugger B.N., Dickson D.W., Wang D.S. TDP-43 in aging and Alzheimer's disease - a review. Int. J. Clin. Exp. Pathol. 2011, 4:147-155.
30. Winton M.J., Igaz L.M., Wong M.M., Kwong L.K., Trojanowski J.Q., Lee V.M. Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation. J. Biol. Chem. 2008, 283:13302-13309.
31. Yamashita T., Tadami C., Nishimoto Y., Hideyama T., Kimura D., Suzuki T., Kwak S. RNA editing of the Q/R site of GluA2 in different cultured cell lines that constitutively express different levels of RNA editing enzyme ADAR2. Neurosci. Res. 2012, 10.1016/j.neures.2012.02.002.
32. Zhang Y.J., Xu Y.F., Cook C., Gendron T.F., Roettges P., Link C.D., Lin W.L., Tong J., Castanedes-Casey M., Ash P., Gass J., Rangachari V., Buratti E., Baralle F., Golde T.E., Dickson D.W., Petrucelli L. Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:7607-7612.