Acetyl-L-carnitine activates the peroxisome proliferator-activated receptor-γ coactivators PGC-1α/PGC-1β-dependent signaling cascade of mitochondrial biogenesis and decreases the oxidized peroxiredoxins content in old rat liver

Rejuvenation Research

Volumn 15, Issue 2, 2012, Pages 136-139

  Pesce, Vito ^a   Nicassio, Luigi ^a   Fracasso, Flavio ^a   Musicco, Clara ^b   Cantatore, Palmiro ^a,b   Gadaleta, Maria Nicola ^a,b  

^a UNIVERSITY OF BARI   (Italy)

^b CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CITRATE SYNTHASE; CYTOCHROME C OXIDASE; LEVACECARNINE; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; NUCLEAR RESPIRATORY FACTOR 1; PEROXIREDOXIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE;

AGE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; LIVER; MALE; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ACETYLCARNITINE; AGING; ANIMALS; AUTOPHAGY; DIETARY SUPPLEMENTS; DNA, MITOCHONDRIAL; LIVER; MALE; MITOCHONDRIA; OXIDATIVE STRESS; PEROXIREDOXINS; PPAR GAMMA; RATS; RATS, INBRED F344; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; TIME FACTORS; TRANSCRIPTION FACTORS;

RATTUS;

EID: 84860315495     PISSN: 15491684     EISSN: 15578577     Source Type: Journal    
DOI: 10.1089/rej.2011.1255     Document Type: Article

References (20)

1. Rosca MG, Lemieux H, Hoppel CL. Mitochondria in the elderly: Is acetylcarnitine a rejuvenator?. Adv Drug Deliv Rev 2009;61:1332-1342.
2. Gadaleta MN, Petruzzella V, Renis M, Fracasso F, Cantatore P. Reduced transcription of mitochondrial DNA in the senescent rat. Tissue dependence and effect of L-carnitine. Eur J Biochem 1990;187:501-506.
3. Gadaleta MN, Cormio A, Pesce V, Lezza AMS, Cantatore P. Aging and mitochondria. Biochimie 1998;80:863-870.
4. Cassano P, Sciancalepore AG, Pesce V, Fluck M, Hoppeler H, Calvani M, Mosconi L, Cantatore P, Gadaleta MN. Acetyl-L-carnitine feeding to unloaded rats triggers in soleus muscle the coordinated expression of genes involved in mitochondrial biogenesis. Biochim Biophys Acta 2006;1757: 1421-1428.
5. Pesce V, Fracasso F, Musicco C, Lezza AM, Cantatore P, Gadaleta MN. Acetyl-L-carnitine dietary supplementation to old rats increases mitochondrial transcription factor A content in rat hindlimb skeletal muscles. Ann NY Acad Sci 2004;1019:430-433.
6. Pesce V, Fracasso F, Cassano P, Lezza AM, Cantatore P, Gadaleta MN. Acetyl-L-carnitine supplementation to old rats partially reverts the age-related mitochondrial decay of soleus muscle by activating peroxisome proliferatoractivated receptor gamma coactivator-1alpha-dependent mitochondrial biogenesis. Rejuvenation Res 2010;13:148-151.
7. Mollica MP, Iossa S, Soboll S, Liverini G. Acetyl-L-carnitine treatment stimulates oxygen consumption and biosynthetic function in perfused liver of young and old rats. Cell Mol Life Sci 2001;58:477-484.
8. Hagen TM, Liu J, Lykkesfeldt J, Wehr CM, Ingersoll RT, Vinarsky V, Bartholomew JC, Ames BN. Feeding acetyl-Lcarnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proc Natl Acad Sci USA 2002;99:1870-1875.
9. Musicco C, Capelli V, Pesce V, Timperio AM, Calvani M, Mosconi L, Cantatore P, Gadaleta MN. Rat liver mitochondrial proteome: Changes associated with aging and acetyl-Lcarnitine treatment. J Proteomics 2011;74:2536-2547.
10. Musicco C, Capelli V, Pesce V, Timperio AM, Calvani M, Mosconi L, Zolla L, Cantatore P, Gadaleta MN. Accumulation of overoxidized Peroxiredoxin III in aged rat liver mitochondria. Biochim Biophys Acta 2009;1787:890-896.
11. Scarpulla RC. Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochim Biophys Acta 2011;1813:1269-1278.
12. Lazarou M, Smith SM, Thorburn DR, Ryan MT, McKenzie M. Assembly of nuclear DNA-encoded subunits into mitochondrial complex IV, and their preferential integration into supercomplex forms in patient mitochondria. FEBS J 2009; 276:6701-6713.
13. Srere PA. Citrate synthase. Methods Enzymol 1969;13:3-11.
14. Poon HF, Calabrese V, Calvani M, Butterfield DA. Proteomics analyses of specific protein oxidation and protein expression in aged rat brain and its modulation by L-acetylcarnitine: Insights into the mechanisms of action of this proposed therapeutic agent for CNS disorders associated with oxidative stress. Antioxid Redox Signal 2006;8:381-394.
15. Seo AY, Joseph AM, Dutta D, Hwang JC, Aris JP, Leeuwenburgh. New insights into the role of mitochondria in aging: Mitochondrial dynamics and more. J Cell Sci 2010;123: 2533-2542.
16. Palermo V, Falcone C, Calvani M, Mazzoni C. Acetyl-Lcarnitine protects yeast cells from apoptosis and aging and inhibits mitochondrial fission. Aging Cell 2010;9:570-579.
17. Zorzano A, Liesa M, Sebastián D, Segalés J, Palacín M. Mitochondrial fusion proteins: Dual regulators of morphology and metabolism. Semin Cell Dev Biol 2010;21:566-574.
18. Graef M, Nunnari J. A role for mitochondria in autophagy regulation. Autophagy 2011;7:1-2.
19. Galluzzi L, Kepp O, Kroemer G. Mitochondrial dynamics: A strategy for avoiding autophagy. Curr Biol 2011;21:R478-R480.
20. Madiraju P, Pande SV, Prentki M, Madiraju SR. Mitochondrial acetylcarnitine provides acetyl groups for nuclear histone acetylation. Epigenetics 2009;4:399-403.