Peptide inhibitors of botulinum neurotoxin serotype A: Design, inhibition, cocrystal structures, structure-activity relationship and pharmacophore modeling

Acta Crystallographica Section D: Biological Crystallography

Volumn 68, Issue 5, 2012, Pages 511-520

  Kumar, Gyanendra ^a   Kumaran, Desigan ^a   Ahmed, S Ashraf ^b   Swaminathan, Subramanyam ^a  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

Author keywords

botulinum neurotoxins; peptide inhibitors; pharmacophore modeling; structure activity relationship

Indexed keywords

BOTULINUM TOXIN A; NEUROTOXIN; PEPTIDE; PEPTIDE HYDROLASE; PROTEINASE INHIBITOR;

ARTICLE; BOTULISM; CHEMICAL STRUCTURE; CHEMISTRY; CLOSTRIDIUM BOTULINUM; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; ENZYMOLOGY; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BOTULINUM TOXINS, TYPE A; BOTULISM; CLOSTRIDIUM BOTULINUM; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; NEUROTOXINS; PEPTIDE HYDROLASES; PEPTIDES; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

CLOSTRIDIUM BOTULINUM;

EID: 84860304082     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444912003551     Document Type: Article

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