Basic tetrapeptides as potent intracellular inhibitors of type a botulinum neurotoxin protease activity

Journal of Biological Chemistry

Volumn 286, Issue 3, 2011, Pages 1802-1811

  Hale, Martha ^a   Oyler, George ^b   Swaminathan, Subramanyam ^c   Ahmed, S Ashraf ^a  

^a UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^b SYNAPTIC RESEARCH LLC   (United States)

^c BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ACTIVITIES; BIOTHREAT AGENTS; BOTULINUM NEUROTOXINS; CEREBELLAR NEURONS; DITHIOTHREITOL; DRUG DEVELOPMENT; FLACCID MUSCLE PARALYSIS; HYDROPHOBIC RESIDUES; INHIBITORY EFFECT; LYSATES; METABOLIC FUNCTION; MOTOR NEURONS; MOUSE BRAIN; MULTIPLE INTERACTIONS; NEURONAL CELL; PEPTIDE INHIBITORS; PEPTIDE SUBSTRATES; POOR INHIBITORS; POTENT INHIBITOR; PROTEASE ACTIVITIES; SUBSTRATE PROTEINS; SYSTEMATIC INVESTIGATIONS; TERMINAL CYSTEINE; TETRAPEPTIDE; TIME-DEPENDENT;

CELL CULTURE; ENZYME ACTIVITY; HYDROPHOBICITY; NEURONS; PEPTIDES; PHOSPHORYLATION; SUBSTRATES;

AMINO ACIDS;

ADENOSINE TRIPHOSPHATE; ARGINYLARGINYLALANYLTHREONYLLYSYLMETHIONINE; ARGINYLARGINYLGYLCYLASPARTYLCYSTEINE; ARGINYLARGINYLGYLCYLCYSTEINE; ARGINYLARGINYLGYLCYLISOLEUCINE; ARGINYLARGINYLGYLCYLLEUCINE; ARGINYLARGINYLGYLCYLMETHIONINE; ARGINYLARGINYLGYLCYLPHENYLALANINE; ARGINYLASPARTYLARGINYLARGINYLGYLCYLCYSTEINE; ASPARTYLARGINYLARGINYLGYLCYLCYSTEINE; BOTULINUM TOXIN A; CYSTEINYLARGINYLALANYLTHREONYLLYSYLMETHIONYLLEUCINE; DITHIOTHREITOL; GLUTAMYLARGINYLALANYLTHREONYLLYSYLMETHIONINE; PROTEIN INHIBITOR; PROTEINASE; SYNAPTOPHYSIN; TETRAPEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHICK; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MOUSE; NERVE CELL INHIBITION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT;

ADENOSINE TRIPHOSPHATE; AMINO ACID SUBSTITUTION; ANIMALS; BOTULINUM TOXINS, TYPE A; CELL LINE; CEREBELLUM; CHICKENS; ENZYME INHIBITORS; HUMANS; MICE; MICE, INBRED BALB C; MUTATION, MISSENSE; NEURONS; OLIGOPEPTIDES; RATS; SYNAPTOSOMAL-ASSOCIATED PROTEIN 25;

RATTUS;

EID: 78751557157     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.146464     Document Type: Article

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