SNAP-25 substrate peptide (Residues 180-183) binds to but bypasses cleavage by catalytically active Clostridium botulinum neurotoxin E

Journal of Biological Chemistry

Volumn 283, Issue 38, 2008, Pages 25944-25951

  Agarwal, Rakhi ^a   Swaminathan, Subramanyam ^a  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; DOCKING; DRUG PRODUCTS; ENZYMES; HIGHWAY BRIDGES; OXYGEN; SUBSTRATES; ZINC;

ACTIVE SITES; AMINO GROUPS; BOTULINUM; CARBONYL OXYGENS; CATALYTIC DOMAINS; CLOSTRIDIUM BOTULINUM NEUROTOXINS; COMPLEX STRUCTURES; DRUG DESIGNS; ELECTRON DENSITIES; HYDROPHOBIC POCKETS; INHIBITORY PEPTIDES; MAIN CHAINS; PEPTIDE SPANNING; SCISSILE BONDS; SEROTYPE; SIDE CHAINS; SNAP-25; SNARE PROTEINS; SUBSTRATE PEPTIDES; SUBSTRATE RECOGNITIONS;

CRYSTAL STRUCTURE;

ARGININE; BOTULINUM TOXIN; CARBONYL DERIVATIVE; GLUTAMINE; ISOLEUCINE; METHIONINE; NEUROTOXIN; NEUROTOXIN E; OXYGEN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; TYROSINE; UNCLASSIFIED DRUG; ZINC; BOTULINUM TOXIN E; PEPTIDE; RECOMBINANT PROTEIN;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DATA BANK; PROTEIN INTERACTION; BINDING SITE; CHEMISTRY; CLOSTRIDIUM BOTULINUM TYPE E; CONFORMATION; HUMAN; HYDROGEN BOND; KINETICS; METABOLISM; PROTEIN CONFORMATION; PROTEIN FOLDING;

CLOSTRIDIUM BOTULINUM;

ARGININE; BINDING SITES; BOTULINUM TOXINS; CATALYTIC DOMAIN; CLOSTRIDIUM BOTULINUM TYPE E; HUMANS; HYDROGEN BONDING; KINETICS; MOLECULAR CONFORMATION; NEUROTOXINS; PEPTIDES; PROTEIN CONFORMATION; PROTEIN FOLDING; RECOMBINANT PROTEINS; SYNAPTOSOMAL-ASSOCIATED PROTEIN 25;

EID: 54449085769     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M803756200     Document Type: Article

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