Structural analysis of botulinum neurotoxin serotype F light chain: Implications on substrate binding and inhibitor design

Biochemistry

Volumn 44, Issue 35, 2005, Pages 11758-11765

  Agarwal, Rakhi ^a   Binz, Thomas ^b   Swaminathan, Subramanyam ^a  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL BONDS; DRUG PRODUCTS; ENZYMES; PROTEINS; SUBSTRATES; TOXIC MATERIALS;

METALLOPEPTIDASES; SEROLOGICALLY DISTINCT CLOSTRIDIUM BOTULINUM NEUROTOXINS (BONTS A-G); SUBSTRATE BINDING;

BIOCHEMISTRY;

BOTULINUM ANTISERUM; BOTULINUM TOXIN A; BOTULINUM TOXIN B; BOTULINUM TOXIN E; BOTULINUM TOXIN F; BOTULINUM TOXIN G; EXOENZYME C3; MERCURY DERIVATIVE; METALLOPROTEINASE; NEUROTRANSMITTER; PEPTIDE; PROTEINASE; SNARE PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; CHEMICAL STRUCTURE; CLOSTRIDIUM BOTULINUM; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIMERIZATION; ENZYME ACTIVITY; ENZYME SPECIFICITY; LIGHT CHAIN; MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SEROTYPE;

BINDING SITES; BOTULINUM TOXINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DRUG DESIGN; MEMBRANE PROTEINS; MERCURY COMPOUNDS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN FOLDING; VESICULAR TRANSPORT PROTEINS;

CLOSTRIDIUM BOTULINUM;

EID: 24344470084     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0510072     Document Type: Article

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