Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells

International Journal of Oncology

Volumn 40, Issue 5, 2012, Pages 1515-1524

  Hwang, Soon Kyung ^a,b   Minai Tehrani, Arash ^a   Yu, Kyeong Nam ^a   Chang, Seung Hee ^a   Kim, Ji Eun ^a,c   Lee, Kee Ho ^e   Park, Jongsun ^f   Beck, George R ^g   Cho, Myung Haing ^a,c,d  

^a Seoul National University   (South Korea)

^b NATIONAL CANCER INSTITUTE   (United States)

^c Seoul National University   (South Korea)

^d Seoul National University   (South Korea)

^e Korea Institute of Radiation and Medical Science   (South Korea)

^f Chungnam National University   (South Korea)

^g EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; CTMP; Lung cancer cells; Mitochondria

Indexed keywords

CARBOXYL TERMINAL MODULATOR PROTEIN; CYTOCHROME C; HEAT SHOCK PROTEIN 27; PROTEIN KINASE B; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CARBOXY TERMINAL SEQUENCE; CELL STRUCTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LUNG CANCER; LUNG CARCINOMA; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; TUMOR GROWTH;

EID: 84860298612     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2011.1319     Document Type: Article

References (28)

1. Densmore CL: Advances in noninvasive pulmonary gene therapy. Curr Drug Deliv 3: 55-63, 2006.
2. Chan DC: Mitochondria: dynamic organelles in disease, aging, and development. Cell 125: 1241-1252, 2006.
3. Karbowski M and Youle RJ: Dynamics of mitochondrial morpho-logy in healthy cells and during apoptosis. Cell Death Differ 10: 870-880, 2003. (Pubitemid 36939697)
4. Lawlor MA and Alessi DR: PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J Cell Sci 114: 2903-2910, 2001. (Pubitemid 32821530)
5. Sasaki K, Sato M and Umezawa Y: Fluorescent indicators for Akt/protein kinase B and dynamics of Akt activity visualized in living cells. J Biol Chem 278: 30945-30951, 2003. (Pubitemid 36994606)
6. Franke TF, Kaplan DR and Cantley LC: PI3K: downstream AKTion blocks apoptosis. Cell 88: 435-437, 1997. (Pubitemid 27154408)
7. Maira SM, Galetic I, Brazil DP, et al: Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane. Science 294: 374-380, 2001. (Pubitemid 32963405)
8. Dryer SE, Chae KS, Martin-Caraballo M and Anderson M: Akt activation is necessary for growth factor-induced trafficking of functional K-Ca channels in developing parasympathetic neurons. J Neurophysiol 93: 1174-1182, 2005. (Pubitemid 40283709)
9. Hwang SK, Kwon JT, Park SJ, et al: Lentivirus-mediated carboxyl-terminal modulator protein gene transfection via aerosol in lungs of K-ras null mice. Gene Ther 14: 1721-1730, 2007.
10. Suen DF, Norris KL and Youle RJ: Mitochondrial dynamics and apoptosis. Genes Dev 22: 1577-1590, 2008. (Pubitemid 351846838)
11. Frezza C, Cipolat S, Martins de Brito O, et al: OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell 126: 177-189, 2006.
12. Scorrano L and Pellegrini L: A cut short to death: Parl and Opa1 in the regulation of mitochondrial morphology and apoptosis. Cell Death Differ 14: 1275-1284, 2007. (Pubitemid 46969865)
13. Pellegrini L and Scorrano L: A cut short to death: Parl and Opa1 in the regulation of mitochondrial morphology and apoptosis. Cell Death Differ 14: 1275-1284, 2007. (Pubitemid 46969865)
14. Arnoult D, Grodet A, Lee YJ, Estaquier J and Blackstone C: Release of OPA1 during apoptosis participates in the rapid and complete release of cytochrome c and subsequent mitochondrial fragmentation. J Biol Chem 280: 35742-35750, 2005. (Pubitemid 41532767)
15. Piao L, Li Y, Yang KJ, et al: Heat shock protein 70-mediated sensitization of cells to apoptosis by carboxyl-terminal modulator protein. BMC Cell Biol 10: 53, 2009.
16. Beere HM: Stressed to death: regulation of apoptotic signaling pathways by the heat shock proteins. Sci STKE 2001: re1, 2001.
17. Takayama S, Reed JC and Homma S: Heat-shock proteins as regulators of apoptosis. Oncogene 22: 9041-9047, 2003. (Pubitemid 38121704)
18. Desagher S and Martinou JC: Mitochondria as the central control point of apoptosis. Trends Cell Biol 10: 369-377, 2000. (Pubitemid 30612469)
19. Hogg PJ and Don AS: Mitochondria as cancer drug targets. Trends Mol Med 10: 372-378, 2004. (Pubitemid 39061138)
20. Hemmings BA, Parcellier A, Tintignac LA and Zhuravleva E: PKB and the mitochondria: AKTing on apoptosis. Cell Signal 20: 21-30, 2008. (Pubitemid 350138366)
21. Vivanco I and Sawyers CL: The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2: 489-501, 2002. (Pubitemid 37328931)
22. Hennessy BT, Smith DL, Ram PT, Lu Y and Mills GB: Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov 4: 988-1004, 2005.
23. Hwang SK, Lim HT, Minai-Tehrani A, et al: Repeated aerosol delivery of carboxyl-terminal modulator protein suppresses tumor in the lungs of K-rasLA1 mice. Am J Respir Crit Care Med 179: 1131-1140, 2009.
24. Lee YJ, Jeong SY, Karbowski M, Smith CL and Youle RJ: Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Mol Biol Cell 15: 5001-5011, 2004. (Pubitemid 39392214)
25. Merkwirth C, Dargazanli S, Tatsuta T, et al: Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria. Genes Dev 22: 476-488, 2008. (Pubitemid 351272755)
26. Wang XD: The expanding role of mitochondria in apoptosis. Gene Dev 15: 2922-2933, 2001.
27. Olichon A, Baricault L, Gas N, et al: Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. J Biol Chem 278: 7743-7746, 2003. (Pubitemid 36800505)
28. Bruey JM, Ducasse C, Bonniaud P, et al: Hsp27 negatively regulates cell death by interacting with cytochrome c. Nat Cell Biol 2: 645-652, 2000.