Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein

BMC Cell Biology

Volumn 10, Issue , 2009, Pages

  Piao, Longzhen ^a,g   Li, Yuwen ^a   Yang, Keum Jin ^a   Park, Kyeong Ah ^a   Byun, Hee Sun ^a   Won, Minho ^a   Hong, Janghee ^a   Kim, Jeong Lan ^a   Kweon, Gi Ryang ^a   Hur, Gang Min ^a   Seok, Jeong Ho ^a   Cho, Jae Youl ^b   Chun, Taehoon ^c   Hess, Daniel ^d   Sack, Ragna ^d   Maira, Sauveur Michel ^e   Brazil, Derek P ^f   Hemmings, Brian A ^d   Park, Jongsun ^a  

^a Chungnam National University   (South Korea)

^b Kangwon National University   (South Korea)

^c Korea University   (South Korea)

^d FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^e NOVARTIS PHARMA AG   (Switzerland)

^f UNIVERSITY COLLEGE DUBLIN   (Ireland)

^g YANBIAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CARBOXY TERMINAL MODULATOR PROTEIN; CASPASE; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; PERVANADATE; PROTEIN KINASE B; REGULATOR PROTEIN; SERINE; STAUROSPORINE; UNCLASSIFIED DRUG; APAF1 PROTEIN, HUMAN; ENZYME INHIBITOR; MEMBRANE PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; THEM4 PROTEIN, HUMAN; VANADIC ACID;

AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MITOCHONDRION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SENSITIZATION; CELL LINE; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; HELA CELL; METABOLISM; PHOSPHORYLATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CELL LINE; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HELA CELLS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MEMBRANE PROTEINS; MITOCHONDRIA; PHOSPHORYLATION; STAUROSPORINE; VANADATES;

EID: 69249171372     PISSN: None     EISSN: 14712121     Source Type: Journal    
DOI: 10.1186/1471-2121-10-53     Document Type: Article

References (44)

1. Parcellier A Tintignac LA Zhuravleva E Hemmings BA PKB and the mitochondria: AKTing on apoptosis Cell Signal 2008, 20(1):21-30. 17716864
2. Dummler B Hemmings BA Physiological roles of PKB/Akt isoforms in development and disease Biochem Soc Trans 2007, 35(Pt 2):231-235. 17371246
3. Cameron AJ De Rycker M Calleja V Alcor D Kjaer S Kostelecky B Saurin A Faisal A Laguerre M Hemmings BA et al Protein kinases, from B to C Biochem Soc Trans 2007, 35(Pt 5):1013-1017. 17956266
4. Lawlor MA Alessi DR PKB/Akt: A key mediator of cell proliferation, survival and insulin responses? J Cell Sci 2001, 114(Pt 16):2903-2910. 11686294
5. Alessi DR Andjelkovic M Caudwell B Cron P Morrice N Cohen P Hemmings BA Mechanism of activation of protein kinase B by insulin and IGF-1 EMBO J 1996, 15(23):6541-6551. 452479 8978681
6. Sarbassov DD Guertin DA Ali SM Sabatini DM Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex Science 2005, 307(5712):1098-1101. 15718470
7. Feng J Park J Cron P Hess D Hemmings BA Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase J Biol Chem 2004, 279(39):41189-41196. 15262962
8. Yang J Cron P Thompson V Good VM Hess D Hemmings BA Barford D Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation Mol Cell 2002, 9(6):1227-1240. 12086620
9. Yang J Cron P Good VM Thompson V Hemmings BA Barford D Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP Nat Struct Biol 2002, 9(12):940-944. 12434148
10. Maira SM Galetic I Brazil DP Kaech S Ingley E Thelen M Hemmings BA Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/ Akt and v-Akt at the plasma membrane Science 2001, 294(5541):374-380. 11598301
11. Chae KS Martin-Caraballo M Anderson M Dryer SE Akt activation is necessary for growth factor-induced trafficking of functional K(Ca) channels in developing parasympathetic neurons J Neurophysiol 2005, 93(3):1174-1182. 15509648
12. Hwang SK Kwon JT Park SJ Chang SH Lee ES Chung YS Beck GR Jr Lee KH Piao L Park J et al Lentivirus-mediated carboxyl-terminal modulator protein gene transfection via aerosol in lungs of K-ras null mice Gene Ther 2007, 14(24):1721-1730. 17960162
13. Knobbe CB Reifenberger J Blaschke B Reifenberger G Hypermethylation and transcriptional downregulation of the carboxyl-terminal modulator protein gene in glioblastomas J Natl Cancer Inst 2004, 96(6):483-486. 15026474
14. Ryan MT Hoogenraad NJ Mitochondrial-nuclear communications Annu Rev Biochem 2007, 76:701-722. 17227225
15. Mihara K Omura T Cytoplasmic chaperones in precursor targeting to mitochondria: The role of MSF and hsp 70 Trends Cell Biol 1996, 6(3):104-108. 15157486
16. Young JC Hoogenraad NJ Hartl FU Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70 Cell 2003, 112(1):41-50. 12526792
17. Parcellier A Tintignac LA Zhuravleva E Cron P Schenk S Bozulic L Hemmings BA Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis Cell Signal 2009, 21(4):639-650. 19168129
18. Carr SA Huddleston MJ Annan RS Selective detection and sequencing of phosphopeptides at the femtomole level by mass spectrometry Anal Biochem 1996, 239(2):180-192. 8811904
19. Papayannopoulos IA The Interpretation of collosion-induced dissociation tandem mass spectra of peptides Mass Spectrometry Reviews 1995, 14:49-73.
20. Nakai K Horton P PSORT: A program for detecting sorting signals in proteins and predicting their subcellular localization Trends Biochem Sci 1999, 24(1):34-36. 10087920
21. Emanuelsson O Nielsen H Brunak S von Heijne G Predicting subcellular localization of proteins based on their N-terminal amino acid sequence J Mol Biol 2000, 300(4):1005-1016. 10891285
22. Claros MG Vincens P Computational method to predict mitochondrially imported proteins and their targeting sequences Eur J Biochem 1996, 241(3):779-786. 8944766
23. Neupert W Herrmann JM Translocation of proteins into mitochondria Annu Rev Biochem 2007, 76:723-749. 17263664
24. Beere HM Stressed to death: Regulation of apoptotic signaling pathways by the heat shock proteins Sci STKE 2001, 2001(93):RE1. 11752668
25. Beere HM Wolf BB Cain K Mosser DD Mahboubi A Kuwana T Tailor P Morimoto RI Cohen GM Green DR Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome Nat Cell Biol 2000, 2(8):469-475. 10934466
26. Saleh A Srinivasula SM Balkir L Robbins PD Alnemri ES Negative regulation of the Apaf-1 apoptosome by Hsp70 Nat Cell Biol 2000, 2(8):476-483. 10934467
27. Zhang Y Chan DC New insights into mitochondrial fusion FEBS Lett 2007, 581(11):2168-2173. 1941839 17331506
28. Jin S DiPaola RS Mathew R White E Metabolic catastrophe as a means to cancer cell death J Cell Sci 2007, 120(Pt 3):379-383. 17251378
29. Fayard E Tintignac LA Baudry A Hemmings BA Protein kinase B/Akt at a glance J Cell Sci 2005, 118(Pt 24):5675-5678. 16339964
30. Brazil DP Yang ZZ Hemmings BA Advances in protein kinase B signalling: AKTion on multiple fronts Trends Biochem Sci 2004, 29(5):233-242. 15130559
31. Hanada M Feng J Hemmings BA Structure, regulation and function of PKB/ AKT - a major therapeutic target Biochim Biophys Acta 2004, 1697(1-2):3-16. 15023346
32. Sasaki K Sato M Umezawa Y Fluorescent indicators for Akt/protein kinase B and dynamics of Akt activity visualized in living cells J Biol Chem 2003, 278(33):30945-30951. 12773546
33. Gutierrez-Barrera AM Menter DG Abbruzzese JL Reddy SA Establishment of three-dimensional cultures of human pancreatic duct epithelial cells Biochem Biophys Res Commun 2007, 358(3):698-703. 2562614 17512909
34. Braun HP Schmitz UK The mitochondrial processing peptidase Int J Biochem Cell Biol 1997, 29(8-9):1043-1045. 9415998
35. Gakh O Cavadini P Isaya G Mitochondrial processing peptidases Biochim Biophys Acta 2002, 1592(1):63-77. 12191769
36. Arretz M Schneider H Guiard B Brunner M Neupert W Characterization of the mitochondrial processing peptidase of Neurospora crassa J Biol Chem 1994, 269(7):4959-4967. 8106471
37. Nett JH Denke E Trumpower BL Two-step processing is not essential for the import and assembly of functionally active iron-sulfur protein into the cytochrome bc1 complex in Saccharomyces cerevisiae J Biol Chem 1997, 272(4):2212-2217. 8999925
38. Xanthoudakis S Nicholson DW Heat-shock proteins as death determinants Nat Cell Biol 2000, 2(9):E163-165. 10980714
39. Miyawaki T Ofengeim D Noh KM Latuszek-Barrantes A Hemmings BA Follenzi A Zukin RS The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death Nat Neurosci 2009, 12(5):618-626. 19349976
40. Hwang SK Lim HT Minai-Tehrani A Lee ES Park J Park SB Beck GR Jr Cho MH Repeated aerosol delivery of carboxyl-terminal modulator protein suppresses tumor in the lungs of K-rasLA1 mice Am J Respir Crit Care Med 2009, 179(12):1131-1140. 19286625
41. Lieber A He CY Kirillova I Kay MA Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo J Virol 1996, 70(12):8944-8960. 190992 8971024
42. Posner BI Faure R Burgess JW Bevan AP Lachance D Zhang-Sun G Fantus IG Ng JB Hall DA Lum BS et al Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics J Biol Chem, 1994, 269(6):4596-4604. 8308031
43. Park J Hill MM Hess D Brazil DP Hofsteenge J Hemmings BA Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity J Biol Chem 2001, 276(40):37459-37471. 11481331
44. Duclos B Marcandier S Cozzone AJ Chemical properties and separation of phosphoamino acids by thin-layer chromatography and/or electrophoresis Methods Enzymol 1991, 201:10-21. 1943759