Celiac disease in children: An old disease with new features

Minerva Pediatrica

Volumn 64, Issue 1, 2012, Pages 71-81

  Rizkalla Reilly, N ^a   Dixit, R ^a   Simpson, S ^a   Green, P H ^a  

^a Department of Medicine   (United States)

Author keywords

Celiac disease; Diet, gluten free; Pediatrics

Indexed keywords

HEMOGLOBIN A1C; IMMUNOGLOBULIN A;

ABDOMINAL DISTENSION; ADAPTIVE IMMUNITY; AGE; ANEMIA; ARTHRITIS; BREAST FEEDING; CALCIUM INTAKE; CELIAC DISEASE; CHILD; CONSTIPATION; DIARRHEA; DIETARY INTAKE; DIETITIAN; DISEASE ASSOCIATION; DUODENUM BIOPSY; GENETIC SCREENING; GEOGRAPHY; GLUTEN FREE DIET; GROWTH DISORDER; HEMOGLOBIN BLOOD LEVEL; HUMAN; INFERTILITY; INNATE IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; MALABSORPTION; MEDICAL CARE; PAIN; PREVALENCE; REVIEW; TREATMENT OUTCOME; VOMITING;

CELIAC DISEASE; CHILD; HUMANS;

EID: 84860294628     PISSN: 00264946     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (100)

1. Ciclitira PJ, Ellis HJ, Evans DJ, Lennox ES. Relation of antigenic structure of cereal proteins to their toxicity in coeliac patients. Br J Nutr 1985;53:39-45. (Pubitemid 15198524)
2. Mamone G, Ferranti P, Rossi M, Roepstorff P, Fierro O, Malorni A et al. Identification of a peptide from α-gliadin resistant to digestive enzymes: Implications for celiac disease. J Chromatography B 2007;855:236-41. (Pubitemid 47212017)
3. Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 1997;3797-801.
4. Sollid LM. Coeliac disease: dissecting a complex inflammatory disorder. Nat Rev Immunol 2002;2:647-55. (Pubitemid 37328722)
5. Nilsen EM, Jahnsen FL, Lundin KE, Johansen FE, Fausa O, Sollid LM et al. Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease. Gastroenterology 1998;115:551-63. (Pubitemid 28397290)
6. Mohamed BM, Feighery C, Kelly J, Coates C, O'Shea U, Barnes L et al. Increased protein expression of matrix metalloproteinases -1, -3, and -9 and TIMP-1 in patients with gluten-sensitive enteropathy. Dig Dis Sci 2006;51:1862-8.
7. Maiuri L, Ciacci C, Ricciardelli I, Vacca L, Raia V, Auricchio S et al. Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. Lancet 2003;362:30-7. (Pubitemid 36835817)
8. Maiuri L, Ciacci C, Auricchio S, Brown V, Quaratino S, Londei M. Interleukin 15 mediates epithelial changes in celiac disease. Gastroenterology 2000;119:996-1006.
9. Zanzi D, Stefanile R, Santagata S, Iaffaldano L, Iaquinto G, Giardullo N et al. IL-15 interferes with suppressive activity of intestinal regulatory T cells expanded in Celiac disease. Am J Gastroenterol 2011;106:1308-17.
10. Sollid LM, Markussen G, Ek J, Gjerde H, Vandal F, Thorsby E. Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer. J Exp Med 1989;169:345-50. (Pubitemid 19035567)
11. Greco L, Romino R, Coto I, Di Cosmo N, Percopo S, Maglio M et al. The first large population based twin study of coeliac disease. Gut 2002;50:624-8. (Pubitemid 34407487)
12. Ivarsson A, Hernell O, Nystrom L, Persson LA. Children born in the summer have increased risk for coeliac disease. J Epidemiol Community Health 2003;57:36-9.
13. Wingren CJ, Bjorck S, Lynch KF, Ohlsson H, Agardh D, Merlo J. Coeliac disease in children: a social epidemiological study in Sweden. Acta Paediatr 2011 [Epub ahead of print],
14. Stene LC, Honeyman MC, Hoffenberg EJ, Haas JE, Sokol RJ, Emery L et al. Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study. Am J Gastroenterol 2006;101:2333-40. (Pubitemid 44477562)
15. Welander A, Tjemberg AR, Montgomery SM, Ludvigsson J, Ludvigsson JF. Infectious disease and risk of later celiac disease in childhood. Pediatrics 2010;125:e530-6.
16. Ivarsson A, Persson LA, Nystrom L, Ascher H, Cavell B, Danielsson L et al. Epidemic of coeliac disease in Swedish children. Acta Paediatr 2000;89:165-71. (Pubitemid 30339587)
17. Ivarsson A, Hernell O, Stenlund H, Persson LA. Breast-feeding protects against celiac disease. Am J Clin Nutr 2002;75:914-21. (Pubitemid 34441261)
18. Akobeng AK, Ramanan AV, Buchan I, Heller RF. Effect of breast feeding on risk of coeliac disease: a systematic review and meta-analysis of observational studies. Arch Dis Child 2006,91:39-43. (Pubitemid 43059171)
19. Norris JM, Barriga K, Hoffenberg EJ, Taki I, Miao D, Haas JE et al. Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease. JAMA 2005;293:2343-51. (Pubitemid 40676756)
20. Decker E, Engelmann G, Findeisen A, Gerner P, Laass M, Ney D et al. Cesarean delivery is associated with celiac disease but not inflammatory bowel disease in children. Pediatrics 2010;125:e1433-40.
21. Penders J, Thijs C, Vink C, Stelma FF, Snijders B, Kummeling I et al. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics 2006;118:511-21. (Pubitemid 46085405)
22. Sjogren YM, Tomicic S, Lundberg A, Bottcher MF, Bjorksten B, Sverremark-Ekstrom E et al. Influence of early gut microbiota on the maturation of childhood mucosal and systemic immune responses. Clin Exp Allergy 2009;39:1842-51.
23. Kau AL, Ahern PP, Griffin NW, Goodman AL, Gordon JI. Human nutrition, the gut microbiome and the immune system. Nature 2011;474:327-36.
24. Mustalahti K, Catassi C, Reunanen A, Fabiani E, Heier M, McMillan S et al. The prevalence of celiac disease in Europe: results of a centralized, international mass screening project. Ann Med 2010;42:587-95.
25. Oliveira RP, Sdepanian VL, Barreto JA, Cortez AJ, Carvalho FO, Bordin JO et al. High prevalence of celiac disease in Brazilian blood donor volunteers based on screening by IgA antitissue transglutaminase antibody. Eur J Gastroenterol Hepatol 2007;19:43-9. (Pubitemid 46066867)
26. Fasano A, Berti I, Gerarduzzi T, Not T, Colletti RB, Drago S et al. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med 2003;163:286-92. (Pubitemid 36183856)
27. Teresi S, Crapisi M, Vallejo MD, Castellaneta SP, Francavilla R, Iacono G et al. Celiac disease seropositivity in Saharawi children: a follow-up and family study. J Pediatr Gastroenterol Nutr 2010;50:506-9.
28. Green PH, Neugut AI, Naiyer AJ, Edwards ZC, Gabinelle S, Chinburapa V. Economic benefits of increased diagnosis of celiac disease in a national managed care population in the United States. J Insur Med 2008;40:218-28.
29. Murray JA, Van Dyke C, Plevak MF, Dierkhising RA, Zinsmeister AR, Melton LJ, 3rd. Trends in the identification and clinical features of celiac disease in a North American community, 1950-2001. Clin Gastroenterol Hepatol 2003;1:19-27. (Pubitemid 37254468)
30. Telega G, Bennet TR, Werlin S. Emerging new clinical patterns in the presentation of celiac disease. Arch Pediatr Adolesc Med 2008;162:164-8. (Pubitemid 351240720)
31. Catassi C, Kryszak D, Bhatti B, Sturgeon C, Helzlsouer K, Clipp SL et al. Natural history of celiac disease autoimmunity in a USA cohort followed since 1974. Ann Med 2010;42:530-8.
32. Lohi S, Mustalahti K, Kaukinen K, Laurila K, Collin P, Rissanen H et al. Increasing prevalence of coeliac disease over time. Aliment Pharmacol Ther 2007;26:1217-25. (Pubitemid 47620425)
33. Rubio-Tapia A, Kyle RA, Kaplan EL, Johnson DR, Page W, Erdtmann F et al. Increased prevalence and mortality in undiagnosed celiac disease. Gastroenterology 2009;137:88-93.
34. Cabrera-Chavez F, Rouzaud-Sandez O, Sotelo-Cruz N, Calderon de la Barca AM. Transglutaminase treatment of wheat and maize prolamins of bread increases the serum IgA reactivity of celiac disease patients. J Agric Food Chem 2008;56:1387-91. (Pubitemid 351364073)
35. Vivas S, Ruiz de Morales JM, Fernandez M, Hernando M, Herrero B, Casqueiro J et al. Age-related clinical, serological, and histopathological features of celiac disease. Am J Gastroenterol 2008;103:2360-5; quiz 6.
36. Ravikumara M, Tuthill DP, Jenkins HR. The changing clinical presentation of coeliac disease. Arch Dis Child 2006;91:969-71. (Pubitemid 44863131)
37. Ludvigsson JF, Ansved P, Falth-Magnusson K, Hammersjo JA, Johansson C, Edvardsson S et al. Symptoms and signs have changed in Swedish children with coeliac disease. J Pediatr Gastroenterol Nutr 2004;38:181-6.
38. Llorente-Alonso MJ, Fernandez-Acenero MJ, Sebastian M. Gluten intolerance: sex and age-related features. Can J Gastroenterol 2006;20:719-22. (Pubitemid 44941818)
39. Rampertab SD, Pooran N, Brar P, Singh P, Green PH. Trends in the presentation of celiac disease. Am J Med 2006;119:355 e9-14.
40. McGowan KE, Castiglione DA, Butzner JD. The changing face of childhood celiac disease in north america: impact of serological testing. Pediatrics 2009;124:1572-8.
41. Garampazzi A, Rapa A, Mura S, Capelli A, Valori A, Boldorini R et al. Clinical pattern of celiac disease is still changing. J Pediatr Gastroenterol Nutr 2007;45:611-4. (Pubitemid 350307151)
42. Lo W, Sano K, Lebwohl B, Diamond B, Green PH. Changing presentation of adult celiac disease. Dig Dis Sci 2003;48:395-8. (Pubitemid 36233010)
43. Carlsson AK, Axelsson IE, Borulf SK, Bredberg AC, Lindberg BA, Sjoberg KG et al. Prevalence of IgA-antiendomysium and IgA-antigliadin autoantibodies at diagnosis of insulin-dependent diabetes mellitus in Swedish children and adolescents. Pediatrics 1999;103(6 Pt 1):1248-52. (Pubitemid 29258801)
44. Acerini CL, Ahmed ML, Ross KM, Sullivan PB, Bird G, Dunger DB. Coeliac disease in children and adolescents with IDDM: clinical characteristics and response to gluten-free diet. Diabet Med 1998;15:38-44. (Pubitemid 28113997)
45. Abid N, McGlone O, Cardwell C, McCallion W, Carson D. Clinical and metabolic effects of gluten-free diet in children with type 1 diabetes and coeliac disease. Pediatr Diabetes 2011;12(4 Pt 1):322-5.
46. Sun S, Puttha R, Ghezaiel S, Skae M, Cooper C, Amin R. The effect of biopsy-positive silent coeliac disease and treatment with a gluten-free diet on growth and glycaemic control in children with Type 1 diabetes. Diabet Med 2009;26:1250-4.
47. Amin R, Murphy N, Edge J, Ahmed ML, Acerini CL, Dunger DB. A longitudinal study of the effects of a gluten-free diet on glycemic control and weight gain in subjects with type 1 diabetes and celiac disease. Diabetes Care 2002;25:1117-22. (Pubitemid 41071160)
48. Sattar N, Lazare F, Kacer M, Aguayo-Figueroa L, Desikan V, Garcia M et al. Celiac disease in children, adolescents, and young adults with autoimmune thyroid disease. J Pediatr 2011;158:272-5 e1.
49. Savilahti E, Pelkonen P, Visakorpi JK. IgA deficiency in children. A clinical study with special reference to intestinal findings. Arch Dis Child 1971;46:665-70.
50. Meini A, Pillan NM, Villanacci V, Monafo V, Ugazio AG, Plebani A. Prevalence and diagnosis of celiac disease in IgA-deficient children. Ann Allergy Asthma Immunol 1996;77:333-6. (Pubitemid 27014591)
51. Caprai S, Vajro P, Ventura A, Sciveres M, Maggiore G. Autoimmune liver disease associated with celiac disease in childhood: a multicenter study. Clin Gastroenterol Hepatol 2008;6:803-6.
52. Diamanti A, Basso MS, Pietrobattista A, Nobili V. Prevalence of celiac disease in children with autoimmune hepatitis. Dig Liver Dis 2008;40:965.
53. George EK, Mearin ML, Bouquet J, von Blomberg BM, Stapel SO, van Elburg RM et al. High frequency of celiac disease in Down syndrome. J Pediatr 1996;128:555-7. (Pubitemid 26114096)
54. Bonamico M, Pasquino AM, Mariani P, Danesi HM, Culasso F, Mazzanti L et al. Prevalence and clinical picture of celiac disease in Turner syndrome. J Clin Endocrinol Metab 2002;87:5495-8. (Pubitemid 36034350)
55. Giannotti A, Tiberio G, Castro M, Virgilii F, Colistro F, Ferretti F et al. Coeliac disease in Williams syndrome. J Med Genet 2001;38:767-8. (Pubitemid 33032932)
56. Agardh D. Antibodies against synthetic deamidated gliadin peptides and tissue transglutaminase for the identification of childhood celiac disease. Clin Gastroenterol Hepatol 2007;5:1276-81. (Pubitemid 350019051)
57. Monzani A, Rapa A, Fonio P, Tognato E, Panigati L, Oderda G. Use of deamidated gliadin peptide antibodies to monitor diet compliance in childhood celiac disease. J Pediatr Gastroenterol Nutr 2011;53:55-60.
58. Hojsak I, Mozer-Glassberg Y, Segal Gilboa N, Weinberger R, Hartman C, Shamir R. Celiac disease screening assays for children younger than 3 years of age: The Performance of Three Serological Tests. Dig Dis Sci 2011 [Epub ahead of print].
59. Caristo E, Tognato E, Di Dio G, Rapa A, Fonio P. [Increasing prevalence of celiac children with negative serum antigliadin antibodies]. Minerva Pediatr 2010;62:119-23.
60. Maglio M, Tosco A, Paparo F, Auricchio R, Granata V, Colicchio B et al. Serum and intestinal celiac disease-associated antibodies in children with celiac disease younger than 2 years of age. J Pediatr Gastroenterol Nutr 2010;50:43-8.
61. Lagerqvist C, Dahlbom I, Hansson T, Jidell E, Juto P, Olcen P et al. Antigliadin immunoglobulin A best in finding celiac disease in children younger than 18 months of age. J Pediatr Gastroenterol Nutr 2008;47:428-35.
62. Barbato M, Maiella G, Di Camillo C, Guida S, Valitutti F, Lastrucci G et al. The anti-deamidated gliadin peptide antibodies unmask celiac disease in small children with chronic diarrhoea. Dig Liver Dis 2011;43:465-9.
63. Basso D, Guariso G, Fogar P, Meneghel A, Zambon CF, Navaglia F et al. Antibodies against synthetic deamidated gliadin peptides for celiac disease diagnosis and follow-up in children. Clin Chem 2009;55:150-7.
64. Korponay-Szabo IR, Dahlbom I, Laurila K, Koskinen S, Woolley N, Partanen J et al. Elevation of IgG antibodies against tissue transglutaminase as a diagnostic tool for coeliac disease in selective IgA deficiency. Gut 2003;52:1567-71. (Pubitemid 37363439)
65. Usby S, Koletzko S, Korponay-Szabo IR, Hearin ML, Philips A, Shamir R et al. European Society for Pediatric Gastroenterology, Hepatology and Nutrition Guidelines for the Diagnosis of Coeliac Disease. J Pediatr Gastroenterol Nutr 2012;54(1):136-60.
66. Lebwohl B, Kapel RC, Neugut AI, Green PH, Genta RM. Adherence to biopsy guidelines increases celiac disease diagnosis. Gastrointest Endosc 2011;74:103-9.
67. Pais WP, Duerksen DR, Pettigrew NM, Bernstein CN. How many duodenal biopsy specimens are required to make a diagnosis of celiac disease? Gastrointest Endosc 2008,67:1082-7.
68. Bonamico M, Thanasi E, Mariani P, Nenna R, Luparia RP, Barbera C et al. Duodenal bulb biopsies in celiac disease: a multicenter study. J Pediatr Gastroenterol Nutr 2008;47:618-22.
69. Gonzalez S, Gupta A, Cheng J, Tennyson C, Lewis SK, Bhagat G et al. Prospective study of the role of duodenal bulb biopsies in the diagnosis of celiac disease. Gastrointest Endosc 2010;72:758-65.
70. Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). Gastroenterology 1992;102:330-54.
71. Tosco A, Salvati VM, Auricchio R, Maglio M, Borrelli M, Coruzzo A et al. Natural history of potential celiac disease in children. Clin Gastroenterol Hepatol 2011;9:320-5; quiz e36.
72. Kaukinen K, Partanen J, Maki M, Collin P. HLA-DQ typing in the diagnosis of celiac disease. Am J Gastroenterol 2002,97:695-9. (Pubitemid 34245900)
73. Cohen SA, Ephrath H, Lewis JD, Klevens A, Bergwerk A, Liu S et al. Pediatric Capsule Endoscopy: A Single Center, 5 Year Retrospective Review of The Small Bowel And Patency Capsules. J Pediatr Gastroenterol Nutr 2011 [Epub ahead of print].
74. Petroniene R, Dubcenco E, Baker JP, Ottaway CA, Tang SJ, Zanati SA et al. Given capsule endoscopy in celiac disease: evaluation of diagnostic accuracy and interobserver agreement. Am J Gastroenterol 2005;100:685-94. (Pubitemid 40487570)
75. Lidums I, Cummins AG, Teo E. The role of capsule endoscopy in suspected celiac disease patients with positive celiac serology. Dig Dis Sci 2011;56:499-505.
76. Ciaccio EJ, Bhagat G, Tennyson CA, Lewis SK, Hernandez L, Green PH. Quantitative assessment of endoscopic images for degree of villous atrophy in celiac disease. Dig Dis Sci 2011;56:805-11.
77. Lee AR, Ng DL, Zivin J, Green PH. Economic burden of a gluten-free diet. J Hum Nutr Diet 2007;20:423-30. (Pubitemid 47382299)
78. Singh J, Whelan K. Limited availability and high-er cost of gluten-free foods. J Hum Nutr Diet 2011;24:479-86.
79. Wild D, Robins GG, Burley VJ, Howdle PD. Evidence of high sugar intake, and low fibre and mineral intake, in the gluten-free diet. Aliment Pharmacol Ther 2010;32:573-81.
80. Ohlund K, Olsson C, Hernell O, Ohlund I. Dietary shortcomings in children on a gluten-free diet. J Hum Nutr Diet 2010;23:294-300.
81. McNeish AS, Sweet EM. Lactose intolerance in childhood coeliac disease. Assessment of its incidence and importance. Arch Dis Child 1968;43:433-7.
82. Ojetti V, Nucera G, Migneco A, Gabrielli M, Lauritano C, Danese S et al. High prevalence of celiac disease in patients with lactose intolerance. Digestion 2005;71:106-10. (Pubitemid 40674578)
83. Blazina S, Bratanic N, Campa AS, Blagus R, Orel R. Bone mineral density and importance of strict gluten-free diet in children and adolescents with celiac disease. Bone 2010;47:598-603.
84. Ferrara P, Cicala M, Tiberi E, Spadaccio C, Marcella L, Gatto A et al. High fat consumption in children with celiac disease. Acta Gastroenterol Belg 2009;72:296-300.
85. Venkatasubramani N, Telega G, Werlin SL. Obesity in pediatric celiac disease. J Pediatr Gastroenterol Nutr 2010;51:295-7.
86. Reilly NR, Aguilar K, Hassid BG, Cheng J, Defelice AR, Kazlow P et al. Celiac disease in normalweight and overweight children: clinical features and growth outcomes following a gluten-free diet. J Pediatr Gastroenterol Nutr 2011;53:528-31.
87. Cheng J, Brar PS, Lee AR, Green PH. Body mass index in celiac disease: beneficial effect of a glutenfree diet. J Clin Gastroenterol 2010;44:267-71.
88. Hoffenberg EJ, Haas J, Drescher A, Barnhurst R, Osberg I, Bao F et al. A trial of oats in children with newly diagnosed celiac disease. J Pediatr 2000;137:361-6.
89. Hogberg L, Laurin P, Falth-Magnusson K, Grant C, Grodzinsky E, Jansson G et al. Oats to children with newly diagnosed coeliac disease: a randomised double blind study. Gut 2004;53:649-54. (Pubitemid 38561441)
90. Dickey W, Ward M, Whittle CR, Kelly MT, Pentieva K, Horigan G et al. Homocysteine and related B-vitamin status in coeliac disease: Effects of gluten exclusion and histological recovery. Scand J Gastroenterol 2008;43:682-8. (Pubitemid 351868700)
91. Hallert C, Grant C, Grehn S, Granno C, Hulten S, Midhagen G et al. Evidence of poor vitamin status in coeliac patients on a gluten-free diet for 10 years. Aliment Pharmacol Ther 2002;16:1333-9.
92. Lerner A, Shapira Y, Agmon-Levin N, Pacht A, Ben-Ami Shor D, Lopez HM et al. The clinical significance of 25oh-vitamin D status in celiac disease. Clin Rev Allergy Immunol 2011 [Epub ahead of print].
93. Nemes E, Lefler E, Szegedi L, Kapitany A, Kovacs JB, Balogh M et al. Gluten intake interferes with the humoral immune response to recombinant hepatitis B vaccine in patients with celiac disease. Pediatrics 2008;121:e1570-6.
94. Aziz I, Evans KE, Papageorgiou V, Sanders DS. Are patients with coeliac disease seeking alternative therapies to a gluten-free diet? J Gastrointestin Liver Dis 2011;20:27-31.
95. Spaenij-Dekking L, Kooy-Winkelaar Y, van Veelen P, Drijfhout JW, Jonker H, van Soest L et al. Natural variation in toxicity of wheat: potential for selection of nontoxic varieties for celiac disease patients. Gastroenterology 2005;129:797-806. (Pubitemid 41242672)
96. Anderson RP, van Heel DA, Tye-Din JA, Jewell DP, Hill AV. Antagonists and non-toxic variants of the dominant wheat gliadin T cell epitope in coeliac disease. Gut 2006;55:485-91.
97. Mitea C, Havenaar R, Drijfhout JW, Edens L, Dekking L, Koning F. Efficient degradation of gluten by a prolyl endoprotease in a gastrointestinal model: implications for coeliac disease. Gut 2008;57:25-32.
98. Pinier M, Verdu EF, Nasser-Eddine M, David CS, Vezina A, Rivard N et al. Polymeric binders suppress gliadin-induced toxicity in the intestinal epithelium. Gastroenterology 2009;136:288-98.
99. Duerksen DR, Wilhelm-Boyles C, Veitch R, Kryszak D, Parry DM. A comparison of antibody testing, permeability testing, and zonulin levels with small-bowel biopsy in celiac disease patients on a gluten-free diet. Dig Dis Sci 2010;55:1026-31.
100. Sollid LM, Khosla C. Novel therapies for coeliac disease. J Intern Med 2011;269:604-13.