Antagonists and non-toxic variants of the dominant wheat gliadin T cell epitope in coeliac disease

Gut

Volumn 55, Issue 4, 2006, Pages 485-491

  Anderson, R P ^a,b   Van Heel, D A ^c   Tye Din, J A ^b   Jewell, D P ^d   Hill, A V S ^e  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR ANTAGONIST; EPITOPE; GAMMA INTERFERON; GLIADIN; GLUTEN; HLA DQ2 ANTIGEN; INTERLEUKIN 10; PEPTIDE; POLYCLONAL ANTIBODY; PROLYLGLUTAMYLLEUCYLPROLINE; PROLYLPHENYLALANYLPROLYLGLUTAMINYLPROLYLGLUTAMYLLEUCYLPROLYLTYROSYLPROLYLGLUTAMINYLPROLINE; PROTEIN P57; PROTEIN P58; PROTEIN P59; PROTEIN P60; PROTEIN P61; PROTEIN P62; PROTEIN P63; PROTEIN P64; PROTEIN P66; PROTEIN P67; PROTEIN P68; PROTEIN P69; PROTEIN P70; PROTEIN P71; PROTEIN P72; PROTEIN P73; SYNAPTOTAGMIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CELIAC DISEASE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; HUMAN; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; PEPTIDE MAPPING; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE; WHEAT;

ADULT; AGED; AMINO ACIDS; CELIAC DISEASE; CELLS, CULTURED; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES, T-LYMPHOCYTE; FEMALE; GLIADIN; HUMANS; INTERFERON TYPE II; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; T-LYMPHOCYTES; TRITICUM;

EID: 33645122173     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2005.064550     Document Type: Article

References (23)

1. Weiser H. The precipitating factor in coeliac disease. Ballieres Clin Gastroenterol 1995;9:191-207.
2. Klenerman P, Rowland-Jones S, McAdam S, et al. Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants. Nature 1994;369:403-7.
3. Bertoletti A, Sette A, Chisari FV, et al. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells. Nature 1994;369:407-10.
4. Kuchroo VK, Greer JM, Kaul D, et al. A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by diverse T cell repertoire. J Immunol 1994;153:3326-36.
5. Bielekova B, Goodwin B, Richert N, et al. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nat Med 2000;6:1167-75.
6. Kappos L, Comi G, Panitch H, et al. Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomised phase II trial. Nat Med 2000;6:1176-82.
7. Tuohy VK, Yu M, Ling Y, et al. Spontaneous regression of primary autoreactivity during chronic progression of experimental autoimmune encephalitis and multiple sclerosis. J Exp Med 1999;189:1033-42.
8. Bielekova B, Sung M-H, Kadom N, et al. Expansion and functional relevance of high-avidity myelin-specific CD4+ T cells in multiple sclerosis. J Immunol 2004;172:3893-904.
9. Anderson RP, Degano P, Godkin AJ, et al. In vivo antigen challenge in coeliac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope. Nat Med 2000;6:337-42.
10. Arentz-Hansen H, Korner R, Molberg O, et al. The intestinal T-cell response to alpha-gliadin in adult coeliac disease is (ocussed on a single deamidated glutamine targeted by tissue transglutaminase. J Exp Med 2000;191:o03-12.
11. Arentz-Hansen H, McAdam SN, Molberg, et al. Celiac lesion T-cells recognize determinants that cluster in regions of gliadins rich in proline residues. Gastroenterology 2002;123:803-9.
12. Vader W, Kooy Y, van Veelan P, et al. The gluten response in children with celiac disease is directed towards multiple gliadin and glutenin peptides. Gastroenterology 2002;122:1729-37.
13. Anderson RP, van Heel DA, Tye-Din JA, et al. T cells in peripheral blood after gluten challenge in coeliac disease. Gut 2005;54:1217-23.
14. Bunce M, O'Neill CM, Barnardo MC, et al. Phototyping: comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP). Tissue Antigens 1995;46:355-67.
15. Olerup O, Aldener A, Fogdell A. HLA-DQB1 and DQA1 typing by PCR amplification with sequence-specific primers in 2 hours. Tissue Antigens 1993;41:119-34.
16. Mullighan CG, Bunce M, Welsh KI. High-resolution HLA-DQB1 typing using the polymerase chain reaction and sequence-specific primers. Tissue Antigens 1997;50:688-92.
17. Plebanski M, Flanagan KL, Lee EA, et al. Interleukin 10-mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum. Immunity 1999;10:651-60.
18. Kim C-Y, Quarsten H, Bergseng E, et al. Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease. Proc Natl Acad Sci U S A 2004;101:4175-9.
19. Lundin KE, Scott H, Hansen T, et al. Gliadin-specific, HLA-DQ(alphal 1*0501,beta 1*0201) restricted T-cells isolated from the small intestinal mucosa of coeliac disease patients. J Exp Med 1993;178:187-96.
20. Vartdal F, Johansen BH, Friede T, et al. The peptide binding motif of the disease associated HLA-DQ (alpha 1* 0501, beta 1* 0201) molecule. Eur J Immunol 1996;26:2764-72.
21. Fraser JS, Engel W, Ellis HJ, et al. Celiac disease: in vivo toxicity of the putative immunodominant determinant. Gut 2003;52:1698-702.
22. Vader LW, Stepniak DT, Bunnik EM, et al. Characterization of cereal toxicity for celiac disease patients based on protein homology in grains. Gastroenterology 2003;125:1105-13.
23. Vader LW, De Ru A, van de Wal Y, et al. Specificity of tissue transglutaminase explains cereal toxicity in celiac disease. J Exp Med 2002;195:643-9.