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Volumn 12, Issue 4, 2012, Pages 385-393

Clobazam for patients with Lennox-Gastaut syndrome and epilepsy

Author keywords

1,5 benzodiazepine; clobazam; drop attacks; drop seizures; Lennox Gastaut syndrome; refractory epilepsy; refractory seizures

Indexed keywords

ANTIFUNGAL AGENT; BENZODIAZEPINE; CARBAMAZEPINE; CIMETIDINE; CLARITHROMYCIN; CLOBAZAM; DEXAMETHASONE; DILTIAZEM; ERYTHROMYCIN; FELBAMATE; FLUOXETINE; FLUVOXAMINE; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; HYPERICUM PERFORATUM EXTRACT; LAMOTRIGINE; NEFAZODONE; OMEPRAZOLE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PLACEBO; RIFABUTIN; RIFAMPICIN; SERTRALINE; TICLOPIDINE; TOPIRAMATE; VALPROIC ACID;

EID: 84860283336     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/ern.12.14     Document Type: Article
Times cited : (7)

References (99)
  • 1
    • 0018142477 scopus 로고
    • Exceptional and unrecognized antiepileptic properties of a commercial anxiolytic: Clobazam [in French]
    • Gastaut H. Exceptional and unrecognized antiepileptic properties of a commercial anxiolytic: Clobazam [in French]. Concours Med. 100, 3697-3701 (1978).
    • (1978) Concours Med. , vol.100 , pp. 3697-3701
    • Gastaut, H.1
  • 2
    • 0018365803 scopus 로고
    • Antiepileptic properties of clobazam, a 1-5 benzodiazepine, in man
    • Gastaut H, Low MD. Antiepileptic properties of clobazam, a 1-5 benzodiazepine, in man. Epilepsia 20(4), 437-446 (1979). (Pubitemid 9208031)
    • (1979) Epilepsia , vol.20 , Issue.4 , pp. 437-446
    • Gastaut, H.1    Low, M.D.2
  • 3
    • 0020318272 scopus 로고
    • A review of the animal pharmacology of clobazam: An update
    • Fielding S, Lal H. A review of the animal pharmacology of clobazam: An update. Drug Dev. Res. 2(S1), 17-21 (1982). (Pubitemid 12020506)
    • (1982) Drug Development Research , vol.2 , Issue.SUPPL. 1 , pp. 17-21
    • Fielding, S.1    Lal, H.2
  • 4
    • 0025826618 scopus 로고
    • Clobazam in treatment of refractory epilepsy: The Canadian experience. A retrospective study
    • Canadian Clobazam Cooperative Group
    • Canadian Clobazam Cooperative Group. Clobazam in treatment of refractory epilepsy: The Canadian experience. A retrospective study. Epilepsia 32(3), 407-416 (1991).
    • (1991) Epilepsia , vol.32 , Issue.3 , pp. 407-416
  • 5
    • 0018174317 scopus 로고
    • Anticonvulsant action of a 1,5-benzodiazepine, clobazam, in reflex epilepsy
    • Chapman AG, Horton RW, Meldrum BS. Anticonvulsant action of a 1,5-benzodiazepine, clobazam, in reflex epilepsy. Epilepsia 19(3), 293-299 (1978). (Pubitemid 8367462)
    • (1978) Epilepsia , vol.19 , Issue.3 , pp. 293-299
    • Chapman, A.G.1    Horton, R.W.2    Meldrum, B.S.3
  • 6
    • 33846194260 scopus 로고    scopus 로고
    • Clobazam
    • DOI 10.1016/j.nurt.2006.11.002, PII S1933721306001814, New Antiepileptic Drugs: Discovery, Development, and Update
    • Ng YT, Collins SD. Clobazam. Neurotherapeutics 4(1), 138-144 (2007). (Pubitemid 46107321)
    • (2007) Neurotherapeutics , vol.4 , Issue.1 , pp. 138-144
    • Ng, Y.-t.1    Collins, S.D.2
  • 7
    • 10644225186 scopus 로고    scopus 로고
    • Clobazam as a new antiepileptic drug and clorazepate dipotassium as an alternative antiepileptic drug in Japan
    • Sugai K. Clobazam as a new antiepileptic drug and clorazepate dipotassium as an alternative antiepileptic drug in Japan. Epilepsia 45(Suppl. 8), 20-25 (2004). (Pubitemid 39648264)
    • (2004) Epilepsia , vol.45 , Issue.SUPPL. 8 , pp. 20-25
    • Sugai, K.1
  • 8
    • 84856905846 scopus 로고    scopus 로고
    • GABA(A) receptor physiology and its relationship to the mechanism of action of the 1,5-benzodiazepine clobazam
    • Sankar R. GABA(A) receptor physiology and its relationship to the mechanism of action of the 1,5-benzodiazepine clobazam. CNS Drugs 26(3), 229-244 (2012).
    • (2012) CNS Drugs , vol.26 , Issue.3 , pp. 229-244
    • Sankar, R.1
  • 9
    • 27944439764 scopus 로고    scopus 로고
    • +++-induced epileptic rats
    • DOI 10.1016/j.molbrainres.2005.09.010, PII S0169328X05003700
    • Doi T, Ueda Y, Tokumaru J, Willmore LJ. Molecular regulation of glutamate and GABA transporter proteins by clobazam during epileptogenesis in Fe(+++)-induced epileptic rats. Brain Res. Mol. Brain Res. 142(2), 91-96 (2005). (Pubitemid 41681276)
    • (2005) Molecular Brain Research , vol.142 , Issue.2 , pp. 91-96
    • Doi, T.1    Ueda, Y.2    Tokumaru, J.3    Willmore, L.J.4
  • 10
    • 54049137689 scopus 로고    scopus 로고
    • International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: Classification on the basis of subunit composition, pharmacology, and function. Update
    • Olsen RW, Sieghart W. International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: Classification on the basis of subunit composition, pharmacology, and function. Update. Pharmacol. Rev. 60(3), 243-260 (2008).
    • (2008) Pharmacol. Rev. , vol.60 , Issue.3 , pp. 243-260
    • Olsen, R.W.1    Sieghart, W.2
  • 11
    • 0034896836 scopus 로고    scopus 로고
    • A pharmacological profile of clobazam (Mystan®), a new antiepileptic drug
    • DOI 10.1254/fpj.118.117
    • Nakajima H. A pharmacological profile of clobazam (Mystan), a new antiepileptic drug [In Japanese]. Nippon Yakurigaku Zasshi 118(2), 117-122 (2001). (Pubitemid 32734656)
    • (2001) Folia Pharmacologica Japonica , vol.118 , Issue.2 , pp. 117-122
    • Nakajima, H.1
  • 12
    • 84856879304 scopus 로고    scopus 로고
    • A review of the pharmacological properties of the benzodiazepine anxiolytics
    • Trimble MR, Hindmarch I (Eds). Wrightson Biomedical Publishing Inc., Petersfield, UK
    • Leonard B. A review of the pharmacological properties of the benzodiazepine anxiolytics. In:Benzodiazepines . Trimble MR, Hindmarch I (Eds). Wrightson Biomedical Publishing Inc., Petersfield, UK, 1-16 (2000).
    • (2000) Benzodiazepines , pp. 1-16
    • Leonard, B.1
  • 13
    • 35648994906 scopus 로고    scopus 로고
    • Efficacy of low-dose, add-on therapy of clobazam (CLB) is produced by its major metabolite, N-desmethyl-CLB
    • DOI 10.1016/j.jns.2007.05.025, PII S0022510X0700384X
    • Kinoshita M, Ikeda A, Begum T, Terada K, Shibasaki H. Efficacy of low-dose, add-on therapy of clobazam (CLB) is produced by its major metabolite, N-desmethyl-CLB. J. Neurol. Sci. 263(1-2), 44-48 (2007). (Pubitemid 350029828)
    • (2007) Journal of the Neurological Sciences , vol.263 , Issue.1-2 , pp. 44-48
    • Kinoshita, M.1    Ikeda, A.2    Begum, T.3    Terada, K.4    Shibasaki, H.5
  • 14
    • 0026648378 scopus 로고
    • Interactions between clobazam and standard antiepileptic drugs in patients with epilepsy
    • Sennoune S, Mesdjian E, Bonneton J, Genton P, Dravet C, Roger J. Interactions between clobazam and standard antiepileptic drugs in patients with epilepsy. Ther. Drug Monit. 14(4), 269-274 (1992).
    • (1992) Ther. Drug Monit. , vol.14 , Issue.4 , pp. 269-274
    • Sennoune, S.1    Mesdjian, E.2    Bonneton, J.3    Genton, P.4    Dravet, C.5    Roger, J.6
  • 15
    • 0032750843 scopus 로고    scopus 로고
    • Effect of felbamate on clobazam and its metabolite kinetics in patients with epilepsy
    • Contin M, Riva R, Albani F, Baruzzi AA. Effect of felbamate on clobazam and its metabolite kinetics in patients with epilepsy. Ther. Drug Monit. 21(6), 604-608 (1999).
    • (1999) Ther. Drug Monit. , vol.21 , Issue.6 , pp. 604-608
    • Contin, M.1    Riva, R.2    Albani, F.3    Baruzzi, A.A.4
  • 16
    • 0018426182 scopus 로고
    • Pharmacology of anti-anxiety drugs with special reference to clobazam
    • Fielding S, Hoffmann I. Pharmacology of anti-anxiety drugs with special reference to clobazam. Br. J. Clin. Parmacol. 7(S1), 7S-15S (1979). (Pubitemid 9153373)
    • (1979) British Journal of Clinical Pharmacology , vol.7 , Issue.SUPPL. 1
    • Fielding, S.1    Hoffmann, I.2
  • 18
    • 0023178394 scopus 로고
    • N-desmethylclobazam: A possible alternative to clobazam in the treatment of refractory epilepsy?
    • Haigh, JR, Pullar, T, Gent, JP, Dailley C, Feely M. N-desmethylclobazam: A possible alternative to clobazam in the treatment of refractory epilepsy. Br. J. Clin. Pharmacol. 23(2), 213-218 (1987). (Pubitemid 17113499)
    • (1987) British Journal of Clinical Pharmacology , vol.23 , Issue.2 , pp. 213-218
    • Haigh, J.R.M.1    Pullar, T.2    Gent, J.P.3
  • 19
    • 0029793917 scopus 로고    scopus 로고
    • Effects of clobazam and its active metabolite on GABA-activated currents in rat cerebral neurons in culture
    • Nakamura F, Suzuki S, Nishimura S, Yagi K, Seino M. Effects of clobazam and its active metabolite on GABA-activated currents in rat cerebral neurons in culture. Epilepsia 37(8), 728-735 (1996). (Pubitemid 26276940)
    • (1996) Epilepsia , vol.37 , Issue.8 , pp. 728-735
    • Nakamura, F.1    Suzuki, S.2    Nishimura, S.3    Yagi, K.4    Seino, M.5
  • 20
    • 79551594584 scopus 로고    scopus 로고
    • Interactions between modulators of the GABAA receptor: Stiripentol and benzodiazepines
    • Demonstrated the action of clobazam and norclobazam on the recombinant GABAA receptor, and led to a better understanding of their mechanism of action.
    • Fisher JL. Interactions between modulators of the GABAA receptor: Stiripentol and benzodiazepines. Eur. J. Pharmacol. 654(2), 160-165 (2011). Demonstrated the action of clobazam and norclobazam on the recombinant GABAA receptor, and led to a better understanding of their mechanism of action.
    • (2011) Eur. J. Pharmacol. , vol.654 , Issue.2 , pp. 160-165
    • Fisher, J.L.1
  • 21
    • 0019131276 scopus 로고
    • Clobazam: A review of its pharmacological properties and therapeutic use in anxiety
    • Brogden RN, Heel RC, Speight TM, Avery GS. Clobazam: A review of its pharmacological properties and therapeutic use in anxiety. Drugs 20(3), 161-178 (1980). (Pubitemid 11233588)
    • (1980) Drugs , vol.20 , Issue.3 , pp. 161-178
    • Brogden, R.N.1    Heel, R.C.2    Speight, T.M.3    Avery, G.S.4
  • 22
    • 0018383221 scopus 로고
    • Pharmacokinetics of single and multiple doses of clobazam in humans
    • Rupp W, Badian M, Christ O et al. Pharmacokinetics of single and multiple doses of clobazam in humans. Br. J. Clin. Pharmacol. 7(S1), 51S-57S (1979). (Pubitemid 9154215)
    • (1979) British Journal of Clinical Pharmacology , vol.7 , Issue.SUPPL. 1
    • Rupp, W.1    Badian, M.2    Christ, O.3
  • 23
    • 42049100573 scopus 로고    scopus 로고
    • Benzodiazepines: Chemistry, biotransformation, and pharmacokinetics
    • Levy RH, Mattson RH, Meldrum BS, Peracca E (Eds). Lippincott Williams & Wilkins, PA, USA
    • Anderson GD, Miller JW. Benzodiazepines: Chemistry, biotransformation, and pharmacokinetics. In:Antiepileptic Drugs. Levy RH, Mattson RH, Meldrum BS, Peracca E (Eds). Lippincott Williams & Wilkins, PA, USA, 187-205 (2002).
    • (2002) Antiepileptic Drugs. , pp. 187-205
    • Anderson, G.D.1    Miller, J.W.2
  • 24
    • 0020043306 scopus 로고
    • Clobazam kinetics: Intrasubject variability and effect of food on absorption
    • Divoll M, Greenblatt DJ, Ciraulo DA, Puri SK, Ho I, Shader RI. Clobazam kinetics: Intrasubject variability and effect of food on adsorption. J. Clin. Pharmacol. 22(1), 69-73 (1982). (Pubitemid 12185379)
    • (1982) Journal of Clinical Pharmacology , vol.22 , Issue.1 , pp. 69-73
    • Divoll, M.1    Greenblatt, D.J.2    Ciraulo, D.A.3
  • 26
    • 0036890616 scopus 로고    scopus 로고
    • Evidence of polymorphic CYP2C19 involvement in the human metabolism of N-desmethylclobazam
    • DOI 10.1097/00007691-200212000-00009
    • Contin M, Sangiorgi S, Riva R, Parmeggiani A, Albani F, Baruzzi A. Evidence of polymorphic CYP2C19 involvement in the human metabolism of N-desmethylclobazam. Ther. Drug Monit. 24(6), 737-741 (2002). (Pubitemid 35379527)
    • (2002) Therapeutic Drug Monitoring , vol.24 , Issue.6 , pp. 737-741
    • Contin, M.1    Sangiorgi, S.2    Riva, R.3    Parmeggiani, A.4    Albani, F.5    Baruzzi, A.6
  • 27
    • 0029073698 scopus 로고
    • The place of clobazam in the treatment of epilepsy: An update
    • Robertson MM. The place of clobazam in the treatment of epilepsy: An update. Hum. Psychopharmacol. 10(Suppl. 1), S43-S63 (1995).
    • (1995) Hum. Psychopharmacol. , vol.10 , Issue.SUPPL. 1
    • Robertson, M.M.1
  • 28
    • 84860315752 scopus 로고    scopus 로고
    • Oral pharmacokinetics of clobazam in normal subjects
    • Los Angeles, CA, USA, 8-12 November, One of the most recent studies on clobazam pharmacokinetics.
    • Tolbert DS, Reid M, Walzer A et al. Oral pharmacokinetics of clobazam in normal subjects. AAPS Annual Meeting and Exposition, Los Angeles, CA, USA, 8-12 November 2009. One of the most recent studies on clobazam pharmacokinetics.
    • (2009) AAPS Annual Meeting and Exposition
    • Tolbert, D.S.1    Reid, M.2    Walzer, A.3
  • 29
    • 0019797875 scopus 로고
    • Clobazam plasma concentrations: Pharmacokinetic study in healthy volunteers and data in epileptic patients
    • Tedeschi G, Riva R, Baruzzi A. Clobazam plasma concentrations: Pharmacokinetic study in healthy volunteers and data in epileptic patients. Br. J. Clin. Pharmacol. 11(6), 619-622 (1981). (Pubitemid 11112445)
    • (1981) British Journal of Clinical Pharmacology , vol.11 , Issue.6 , pp. 619-622
    • Tedeschi, G.1    Riva, R.2    Baruzzi, A.3
  • 30
    • 0008894748 scopus 로고
    • Clobazam (Frisium) for the treatment of complications of epilepsy [in German]
    • Meeting of the German Section of the International League Against Epilepsy in Berlin. Remschmidt H, Rentz R, Jungmann JE (Eds). Georg Thieme, Stuttgart, Germany
    • Dehnerdt M, Boenigk H. Clobazam (Frisium) for the treatment of complications of epilepsy [in German]. In: Epilepsy: Psychological Aspects, Post-traumatic Epilepsy, Drug Treatment, Diagnostic Methods. Meeting of the German Section of the International League Against Epilepsy in Berlin. Remschmidt H, Rentz R, Jungmann JE (Eds). Georg Thieme, Stuttgart, Germany, 172-175 (1980).
    • (1980) Epilepsy: Psychological Aspects, Post-traumatic Epilepsy, Drug Treatment, Diagnostic Methods , pp. 172-175
    • Dehnerdt, M.1    Boenigk, H.2
  • 31
    • 0025036304 scopus 로고
    • Effects of age and antiepileptic drugs on plasma levels and kinetics of clobazam and N-desmethylclobazam
    • Bun H, Monjanel-Mouterde S, Noel F, Durand A, Cano JP. Effects of age and antiepileptic drugs on plasma levels and kinetics of clobazam and N-desmethylclobazam. Pharmacol. Toxicol. 67(2), 136-140 (1990). (Pubitemid 20354494)
    • (1990) Pharmacology and Toxicology , vol.67 , Issue.2 , pp. 136-140
    • Bun, H.1    Monjanel-Mouterde, S.2    Noel, F.3    Durand, A.4    Cano, J.-P.5
  • 32
    • 0038331241 scopus 로고
    • The effects of clobazam on the blood levels of sodium valproate
    • Hindmarch I, Stonier PD, Trimble MR (Eds). Royal Society of Medicine, London, UK
    • Cocks A, Critchley EMR, Hayward HW. The effects of clobazam on the blood levels of sodium valproate. In: Clobazam: Human Psychopharmacology and Clinical Applications. Hindmarch I, Stonier PD, Trimble MR (Eds). Royal Society of Medicine, London, UK, 155-157 (1985).
    • (1985) Clobazam: Human Psychopharmacology and Clinical Applications , pp. 155-157
    • Cocks, A.1    Critchley, E.M.R.2    Hayward, H.W.3
  • 33
    • 0028936914 scopus 로고
    • Open clinical trials of NH-15 (clobazam) in refractory epilepsies: Early Phase II study and long-term study
    • Yagi K, Seino M, Takeda A, et al. Open clinical trials of NH-15 (clobazam) in refractory epilepsies: Early Phase II study and long-term study. Jpn. J. Neuropsychopharmacol. 17, 161-173 (1995).
    • (1995) Jpn. J. Neuropsychopharmacol. , vol.17 , pp. 161-173
    • Yagi, K.1    Seino, M.2    Takeda, A.3
  • 35
    • 77955058562 scopus 로고    scopus 로고
    • Interactions of stiripentol with clobazam and valproate in the mouse maximal electroshock-induced seizure model
    • Luszczki JJ, Trojnar MK, Ratnaraj N, Patsalos PN, Czuczwar SJ. Interactions of stiripentol with clobazam and valproate in the mouse maximal electroshock-induced seizure model. Epilepsy Res. 90(3), 188-198 (2010).
    • (2010) Epilepsy Res. , vol.90 , Issue.3 , pp. 188-198
    • Luszczki, J.J.1    Trojnar, M.K.2    Ratnaraj, N.3    Patsalos, P.N.4    Czuczwar, S.J.5
  • 36
    • 0038759981 scopus 로고    scopus 로고
    • Use of clobazam for the treatment of refractory complex partial seizures
    • DOI 10.1016/S1059-1311(02)00287-X
    • Shimizu H, Kawasaki J, Yuasa S, Tarao Y, Kumagai S, Kanemoto K. Use of clobazam for the treatment of refractory complex partial seizures. Seizure 12(5), 282-286 (2003). (Pubitemid 36806073)
    • (2003) Seizure , vol.12 , Issue.5 , pp. 282-286
    • Shimizu, H.1    Kawasaki, J.2    Yuasa, S.3    Tarao, Y.4    Kumagai, S.5    Kanemoto, K.6
  • 37
    • 0036220551 scopus 로고    scopus 로고
    • The importance of drug interactions in epilepsy therapy
    • DOI 10.1046/j.1528-1157.2002.13001.x
    • Patsalos PN, Fröscher W, Pisani F, van Rijn CM. The importance of drug interactions in epilepsy therapy. Epilepsia 43(4), 365-385 (2002). (Pubitemid 34297175)
    • (2002) Epilepsia , vol.43 , Issue.4 , pp. 365-385
    • Patsalos, P.N.1    Froscher, W.2    Pisani, F.3    Van Rijn, C.M.4
  • 38
    • 0025744745 scopus 로고
    • Monitoring of concentrations of clobazam and norclobazam in serum and saliva of children with epilepsy
    • Bardy AH, Seppälä T, Salokorpi T, Granström ML, Santavuori P. Monitoring of concentrations of clobazam and norclobazam in serum and saliva of children with epilepsy. Brain Dev. 13(3), 174-179 (1991).
    • (1991) Brain Dev. , vol.13 , Issue.3 , pp. 174-179
    • Bardy, A.H.1    Seppälä, T.2    Salokorpi, T.3    Granström, M.L.4    Santavuori, P.5
  • 40
    • 3543067463 scopus 로고    scopus 로고
    • Carbamazepine intoxication with negative myoclonus after the addition of clobazam
    • DOI 10.1111/j.1528-1157.1998.tb01299.x
    • Genton P, Nguyen VH, Mesdjian E. Carbamazepine intoxication with negative myoclonus after the addition of clobazam. Epilepsia 39(10), 1115-1118 (1998). (Pubitemid 28458044)
    • (1998) Epilepsia , vol.39 , Issue.10 , pp. 1115-1118
    • Genton, P.1    Nguyen, V.H.2    Mesdjian, E.3
  • 41
    • 0026019073 scopus 로고
    • Phenytoin toxicity due to interaction with clobazam
    • Zifkin B, Sherwin A, Andermann F. Phenytoin toxicity due to interaction with clobazam. Neurology 41(2 Pt 1), 313-314 (1991).
    • (1991) Neurology , vol.41 , Issue.2 PART 1 , pp. 313-314
    • Zifkin, B.1    Sherwin, A.2    Andermann, F.3
  • 42
    • 77953622492 scopus 로고    scopus 로고
    • Which factors have an impact on levetiracetam serum concentrations? An analysis in 163 patients with epilepsy [In German]
    • Bauer J, Pfeiffer C, Burr W. Which factors have an impact on levetiracetam serum concentrations? An analysis in 163 patients with epilepsy [In German]. Nervenarzt 81(4), 391-395 (2010).
    • (2010) Nervenarzt , vol.81 , Issue.4 , pp. 391-395
    • Bauer, J.1    Pfeiffer, C.2    Burr, W.3
  • 43
  • 45
    • 0035201366 scopus 로고    scopus 로고
    • Rifampin is a selective, pleiotropic inducer of drug metabolism genes in human hepatocytes: Studies with cDNA and oligonucleotide expression arrays
    • Rae JM, Johnson MD, Lippman ME, Flockhart DA. Rifampin is a selective, pleiotropic inducer of drug metabolism genes in human hepatocytes: Studies with cDNA and oligonucleotide expression arrays. J. Pharmacol. Exp. Ther. 299(3), 849-857 (2001). (Pubitemid 33104951)
    • (2001) Journal of Pharmacology and Experimental Therapeutics , vol.299 , Issue.3 , pp. 849-857
    • Rae, J.M.1    Johnson, M.D.2    Lippman, M.E.3    Flockhart, D.A.4
  • 47
    • 0012960193 scopus 로고    scopus 로고
    • Clinically significant P450 drug interactions
    • Goshman L, Fish J, Roller K. Clinically significant P450 drug interactions. J. Pharm. Soc. Wis. 1999, 23-38 (1999).
    • (1999) J. Pharm. Soc. Wis. , vol.1999 , pp. 23-38
    • Goshman, L.1    Fish, J.2    Roller, K.3
  • 49
    • 65549123702 scopus 로고    scopus 로고
    • Clobazam in the treatment of Lennox-Gastaut syndrome
    • Phase II (prospective, double-blind, dosage-ranging) study on the effect of clobazam on Lennox-Gastaut syndrome.
    • Conry JA, Ng YT, Paolicchi JM et al. Clobazam in the treatment of Lennox-Gastaut syndrome. Epilepsia 50(5), 1158-1166 (2009). Phase II (prospective, double-blind, dosage-ranging) study on the effect of clobazam on Lennox-Gastaut syndrome.
    • (2009) Epilepsia , vol.50 , Issue.5 , pp. 1158-1166
    • Conry, J.A.1    Ng, Y.T.2    Paolicchi, J.M.3
  • 52
    • 0022486822 scopus 로고
    • Clobazam for refractory focal epilepsy. A controlled trial
    • Schmidt D, Rohde M, Wolf P, Roeder-Wanner U. Clobazam for refractory focal epilepsy: A controlled trial. Arch. Neurol. 43(8), 824-826 (1986). (Pubitemid 16034233)
    • (1986) Archives of Neurology , vol.43 , Issue.8 , pp. 824-826
    • Schmidt, D.1    Rohde, M.2    Wolf, P.3    Roeder-Wanner, U.4
  • 53
    • 0025124844 scopus 로고
    • Clobazam as an add-on drug in the treatment of refractory epilepsy of childhood
    • Keene DL, Whiting S, Humphreys P. Clobazam as an add-on drug in the treatment of refractory epilepsy of childhood. Can. J. Neurol. Sci. 17(3), 317-319 (1990). (Pubitemid 20254758)
    • (1990) Canadian Journal of Neurological Sciences , vol.17 , Issue.3 , pp. 317-319
    • Keene, D.L.1    Whiting, S.2    Humphreys, P.3
  • 55
    • 0020533697 scopus 로고
    • Clobazam as adjunctive treatment in refractory epilepsy
    • Allen JW, Oxley J, Robertson MM, Trimble MR, Richens A, Jawad SS. Clobazam as adjunctive treatment in refractory epilepsy. Br. Med. J. 186(6373), 1246-1247 (1983). (Pubitemid 13112080)
    • (1983) British Medical Journal , vol.286 , Issue.6373 , pp. 1246-1247
    • Allen, J.W.1    Oxley, J.2    Robertson, M.M.3
  • 56
    • 82955235708 scopus 로고    scopus 로고
    • Randomized, Phase III study results of clobazam for seizures associated with Lennox-Gastaut syndrome
    • This Phase III multicenter, double-blind, placebo-controlled study is the largest study conducted in Lennox-Gastaut syndrome.
    • Ng YT, Conry JA, Drummond R et al. Randomized, Phase III study results of clobazam for seizures associated with Lennox-Gastaut syndrome. Neurology 77(15), 1473-1481 (2011).This Phase III multicenter, double-blind, placebo-controlled study is the largest study conducted in Lennox-Gastaut syndrome.
    • (2011) Neurology , vol.77 , Issue.15 , pp. 1473-1481
    • Ng, Y.T.1    Conry, J.A.2    Drummond, R.3
  • 57
    • 0027230541 scopus 로고
    • Clobazam in the treatment of epilepsy: Prospective follow-up to 8 years
    • Buchanan N. Clobazam in the treatment of epilepsy: Prospective follow-up to 8 years. J. R. Soc. Med. 86(7), 378-380 (1993). (Pubitemid 23196171)
    • (1993) Journal of the Royal Society of Medicine , vol.86 , Issue.7 , pp. 378-380
    • Buchanan, N.1
  • 58
    • 0036212920 scopus 로고    scopus 로고
    • Clinical study of a new antiepileptic drug, clobazam, on efficacy and resistance in refractory epilepsies
    • Watanabe M, Yagi K, Ohtahara S, Seino M. Clinical study of a new antiepileptic drug, clobazam, on efficacy and resistance in refractory epilepsies. J. Jpn. Epil. Soc. 20(1), 11-18 (2002). (Pubitemid 34288974)
    • (2002) Journal of the Japan Epilepsy Society , vol.20 , Issue.1 , pp. 11-18
    • Watanabe, M.1    Yagi, K.2    Ohtahara, S.3    Seino, M.4
  • 61
    • 0029102310 scopus 로고
    • Clobazam in long-term epilepsy treatment: Sustained responders versus those developing tolerance
    • Singh A, Guberman AH, Boisvert D. Clobazam in long-term epilepsy treatment: Sustained responders versus those developing tolerance. Epilepsia 36(8), 798-803 (1995).
    • (1995) Epilepsia , vol.36 , Issue.8 , pp. 798-803
    • Singh, A.1    Guberman, A.H.2    Boisvert, D.3
  • 62
    • 0031931727 scopus 로고    scopus 로고
    • The use of clobazam, midazolam, and nitrazepam in epilepsy
    • Shorvon SD. The use of clobazam, midazolam, and nitrazepam in epilepsy. Epilepsia 39(Suppl. 1), S15-S23 (1998). (Pubitemid 28063387)
    • (1998) Epilepsia , vol.39 , Issue.SUPPL. 1
    • Shorvon, S.D.1
  • 66
    • 79955683025 scopus 로고    scopus 로고
    • Retention rate of clobazam, topiramate and lamotrigine in children with intractable epilepsies at 1 year
    • Mills JK, Lewis TG, Mughal K, Ali I, Ugur A, Whitehouse WP. Retention rate of clobazam, topiramate and lamotrigine in children with intractable epilepsies at 1 year. Seizure 20(5), 402-405 (2011).
    • (2011) Seizure , vol.20 , Issue.5 , pp. 402-405
    • Mills, J.K.1    Lewis, T.G.2    Mughal, K.3    Ali, I.4    Ugur, A.5    Whitehouse, W.P.6
  • 67
    • 59849128869 scopus 로고    scopus 로고
    • Efficacy of clobazam as add-on therapy for refractory epilepsy: Experience at a US epilepsy center
    • Montenegro MA, Arif H, Nahm EA, Resor SR Jr, Hirsch LJ. Efficacy of clobazam as add-on therapy for refractory epilepsy: Experience at a US epilepsy center. Clin. Neuropharmacol. 31(6), 333-338 (2008).
    • (2008) Clin. Neuropharmacol. , vol.31 , Issue.6 , pp. 333-338
    • Montenegro, M.A.1    Arif, H.2    Nahm, E.A.3    Resor Jr., S.R.4    Hirsch, L.J.5
  • 68
    • 0022922480 scopus 로고
    • Current status of the 1,4- and 1,5-benzodiazepines in the treatment of epilepsy: The place of clobazam
    • Robertson MM. Current status of the 1,4- and 1,5- benzodiazepines in the treatment of epilepsy: The place of clobazam. Epilepsia 27(Suppl. 1), S27-S41 (1986). (Pubitemid 16027711)
    • (1986) Epilepsia , vol.27 , Issue.SUPPL. 1
    • Robertson, M.M.1
  • 69
    • 0008764296 scopus 로고
    • Clobazam in resistant epilepsy: A retrospective survey
    • Hindmarch I, Stonier PD, Trimble MR (Eds). Royal Society of Medicine, London, UK
    • Dalby MA. Clobazam in resistant epilepsy: A retrospective survey. In:Clobazam: Human Psychopharmacology and Clinical Applications . Hindmarch I, Stonier PD, Trimble MR (Eds). Royal Society of Medicine, London, UK, 189 (1985).
    • (1985) Clobazam: Human Psychopharmacology and Clinical Applications , vol.189
    • Dalby, M.A.1
  • 70
    • 0038331240 scopus 로고
    • An open clinical trial of a newly developed antiepileptic drug, clobazam, on treatment-resistant epileptic seizures [In Japanese]
    • Watanabe M, Yagi K, Seino M. An open clinical trial of a newly developed antiepileptic drug, clobazam, on treatment-resistant epileptic seizures [In Japanese]. Saishin Igaku 34, 757-766 (1992).
    • (1992) Saishin Igaku , vol.34 , pp. 757-766
    • Watanabe, M.1    Yagi, K.2    Seino, M.3
  • 71
    • 17144474677 scopus 로고    scopus 로고
    • Clobazam has equivalent efficacy to carbamazepine and phenytoin as monotherapy for childhood epilepsy
    • Canadian Study Group for Childhood Epilepsy
    • Canadian Study Group for Childhood Epilepsy. Clobazam has equivalent efficacy to carbamazepine and phenytoin as monotherapy for childhood epilepsy. Epilepsia 39(9), 952-959 (1998).
    • (1998) Epilepsia , vol.39 , Issue.9 , pp. 952-959
  • 72
    • 0023912950 scopus 로고
    • Factors relating to dramatic response to clobazam in refractory epilepsy
    • Heller AJ, Ring HA, Reynolds EH. Factors relating to dramatic response to clobazam in refractory epilepsy. Epilepsy Res. 2(4), 276-280 (1988).
    • (1988) Epilepsy Res. , vol.2 , Issue.4 , pp. 276-280
    • Heller, A.J.1    Ring, H.A.2    Reynolds, E.H.3
  • 73
    • 85047679199 scopus 로고
    • Disappointing results of increasing benzodiazepine dose after the development of anticonvulsant tolerance
    • Haigh JR, Gent JP, Garratt JC et al. Disappointing results of increasing benzodiazepine dose after the development of anticonvulsant tolerance. J Neurol. Neurosurg. Psychiatry 51(7), 1008-1009 (1988).
    • (1988) J Neurol. Neurosurg. Psychiatry , vol.51 , Issue.7 , pp. 1008-1009
    • Haigh, J.R.1    Gent, J.P.2    Garratt, J.C.3
  • 74
    • 0021715853 scopus 로고
    • TRAITEMENT DE CERTAINS ETATS DE MAL PAR INGESTION D'UNE DOSE UNIQUE DE CLOBAZAM
    • DOI 10.1016/S0370-4475(84)80005-2
    • Gastaut H, Tinuper P, Aguglia U, Lugaresi E. Treatment of certain forms of status epilepticus by means of single dose of clobazam [In French]. Rev. Electroencephalogr. Neurophysiol. 14(3), 203-206 (1984). (Pubitemid 15198627)
    • (1984) Revue d'E.E.G. et de Neuro-Physiologie Clinique , vol.14 , Issue.3 , pp. 203-206
    • Gastaut, H.1    Tinuper, P.2    Aguglia, U.3    Lugaresi, E.4
  • 75
    • 0027152087 scopus 로고
    • Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984
    • Hauser WA, Annegers JF, Kurland LT. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia 34(3), 453-468 (1993). (Pubitemid 23184580)
    • (1993) Epilepsia , vol.34 , Issue.3 , pp. 453-468
    • Hauser, W.A.1    Annegers, J.F.2    Kurland, L.T.3
  • 76
    • 1642498346 scopus 로고    scopus 로고
    • Lennox-Gastaut Syndrome (Childhood Epileptic Encephalopathy)
    • DOI 10.1097/00004691-200311000-00005
    • Markand ON. Lennox-Gastaut syndrome (childhood epileptic encephalopathy). J. Clin. Neurophysiol. 20(6), 426-441 (2003). (Pubitemid 38133970)
    • (2003) Journal of Clinical Neurophysiology , vol.20 , Issue.6 , pp. 426-441
    • Markand, O.N.1
  • 77
    • 0002168137 scopus 로고
    • The Lennox- Gastaut syndrome
    • (2nd Edition) Roger J, Bureau M, Dravet CH, Dreifuss FE, Perret AWP (Eds). John Libbey Eurotext, London, UK
    • Beaumanoir A, Darvet C. The Lennox- Gastaut syndrome. In:Epileptic Syndromes in Infancy, Childhood and Adolescence (2nd Edition) . Roger J, Bureau M, Dravet CH, Dreifuss FE, Perret AWP (Eds). John Libbey Eurotext, London, UK, 115-132 (1992).
    • (1992) Epileptic Syndromes in Infancy, Childhood and Adolescence , pp. 115-132
    • Beaumanoir, A.1    Darvet, C.2
  • 78
    • 0036242654 scopus 로고    scopus 로고
    • Lennox-gastaut syndrome
    • Crumrine PK. Lennox-Gastaut syndrome. J. Child Neurol. 17(Suppl. 1), S70-S75 (2002). (Pubitemid 34460814)
    • (2002) Journal of Child Neurology , vol.17 , Issue.SUPPL. 1
    • Crumrine, P.K.1
  • 79
    • 4043123446 scopus 로고    scopus 로고
    • Nonpharmacologic treatment of the catastrophic epilepsies of childhood
    • Wheless JW. Nonpharmacologic treatment of the catastrophic epilepsies of childhood. Epilepsia 45(Suppl. 5), 17-22 (2004). (Pubitemid 39060665)
    • (2004) Epilepsia , vol.45 , Issue.SUPPL. 5 , pp. 17-22
    • Wheless, J.W.1
  • 80
    • 0007105701 scopus 로고
    • Double-blind clinical study of clobazam in refractory epilepsy
    • Hindmarch I, Stonier PD (Eds). Royal Society of Medicine, London, UK
    • Critchley EMR, Vakil SD, Hayward HW, Owen MV, Cocks A. Double-blind clinical study of clobazam in refractory epilepsy. In:Clobazam. Hindmarch I, Stonier PD (Eds). Royal Society of Medicine, London, UK, 159-163 (1981).
    • (1981) Clobazam , pp. 159-163
    • Critchley, E.M.R.1    Vakil, S.D.2    Hayward, H.W.3    Owen, M.V.4    Cocks, A.5
  • 81
    • 0021710051 scopus 로고
    • Intermittent clobazam for catamenial epilepsy: Tolerance avoided
    • Feely M, Gibson J. Intermittent clobazam for catamenial epilepsy: Tolerance avoided. J. Neurol. Neurosurg. Psychiatry 47(12), 1279-1282 (1984). (Pubitemid 15178747)
    • (1984) Journal of Neurology Neurosurgery and Psychiatry , vol.47 , Issue.12 , pp. 1279-1282
    • Feely, M.1    Gibson, J.2
  • 82
    • 0021216529 scopus 로고
    • Clobazam as adjunctive treatment in drug resistant epilepsy. Report on an open prospective study
    • Callaghan N, Goggin T. Clobazam as adjunctive treatment in drug resistant epilepsy - report on an open prospective study. Ir. Med. J. 77(8), 240-244 (1984). (Pubitemid 14000775)
    • (1984) Irish Medical Journal , vol.77 , Issue.8 , pp. 240-244
    • Callaghan, N.1    Goggin, T.2
  • 83
    • 73949110692 scopus 로고    scopus 로고
    • A prospective, open, controlled and randomised study of clobazam versus carbamazepine in patients with frequent episodes of Rolandic epilepsy [In Spanish]
    • Andrade R, García-Espinosa A, Machado- Rojas A, García-González ME, Trápaga- Quincoses O, Morales-Chacón LM. A prospective, open, controlled and randomised study of clobazam versus carbamazepine in patients with frequent episodes of Rolandic epilepsy [In Spanish]. Rev. Neurol. 49(11), 581-586 (2009).
    • (2009) Rev. Neurol. , vol.49 , Issue.11 , pp. 581-586
    • Andrade, R.1    García-Espinosa, A.2    Machado- Rojas, A.3    García-González, M.E.4    Trápaga- Quincoses, O.5    Morales-Chacón, L.M.6
  • 84
    • 0033913299 scopus 로고    scopus 로고
    • Clobazam for the treatment of intractable childhood epilepsy
    • Jan MM, Shaabat AO. Clobazam for the treatment of intractable childhood epilepsy. Saudi Med. J. 21(7), 622-624 (2000). (Pubitemid 30490668)
    • (2000) Saudi Medical Journal , vol.21 , Issue.7 , pp. 622-624
    • Jan, M.M.1    Shaabat, A.O.2
  • 86
    • 0021529070 scopus 로고
    • Clobazam in refractory epilepsies of children [In Spanish]
    • Figueroa D, Adlerstein L, Manterola A. Clobazam in refractory epilepsies of children [In Spanish]. Rev. Chil. Pediatr. 55(6), 401-405 (1984).
    • (1984) Rev. Chil. Pediatr. , vol.55 , Issue.6 , pp. 401-405
    • Figueroa, D.1    Adlerstein, L.2    Manterola, A.3
  • 88
    • 0000350924 scopus 로고
    • The effect of benzodiazepines on chronic epilepsy in man (with particular reference to clobazam)
    • Hindmarch I, Stonier P (Eds). Royal Society of Medicine, London, UK
    • Gastaut H. The effect of benzodiazepines on chronic epilepsy in man (with particular reference to clobazam). In:Clobazam. Hindmarch I, Stonier P (Eds). Royal Society of Medicine, London, UK, 141-150 (1981).
    • (1981) Clobazam , pp. 141-150
    • Gastaut, H.1
  • 89
    • 0018661344 scopus 로고
    • The anti-epileptic properties of a diazepine drug (clobazam). Preliminary results. [In Italian]
    • Bravaccio F, D'Ambrosio G, De Rosa A, Tata MR, Volpe E. The anti-epileptic properties of a diazepine drug (clobazam). Preliminary results. [In Italian]. Acta. Neurol. Quad. 39, 58-64 (1979).
    • (1979) Acta. Neurol. Quad. , vol.39 , pp. 58-64
    • Bravaccio, F.1    D'Ambrosio, G.2    De Rosa, A.3    Tata, M.R.4    Volpe, E.5
  • 90
    • 0019432345 scopus 로고
    • UTILISATION DU CLOBAZAM COMME ANTI-EPILEPTIQUE DANS LE SYNDROME DE LENNOX ET GASTAUT
    • Pechadre JC, Beudin P, Devoize JL, Gibert J. [Anti-epileptic effect of clobazam in Lennox-Gastaut syndrome]. Encephale 7(2), 181-190 (1981). (Pubitemid 11096092)
    • (1981) Encephale , vol.7 , Issue.2 , pp. 181-190
    • Pechadre, J.C.1    Beudin, P.2    Devoize, J.L.3    Gibert, J.4
  • 93
    • 0346099113 scopus 로고    scopus 로고
    • Parachute use to prevent death and major trauma related to gravitational challenge: Systematic review of randomised controlled trials
    • Smith GC, Pell JP. Parachute use to prevent death and major trauma related to gravitational challenge: Systematic review of randomised controlled trials. BMJ 327(7429), 1459-1461 (2003). (Pubitemid 38045824)
    • (2003) British Medical Journal , vol.327 , Issue.7429 , pp. 1459-1461
    • Smith, G.C.S.1    Pell, J.P.2
  • 94
    • 0032976081 scopus 로고    scopus 로고
    • A double-blind, randomized trial of topiramate in Lennox-Gastaut syndrome
    • Sachdeo RC, Glauser TA, Ritter F, Reife R, Lim P, Pledger G. A double-blind, randomized trial of topiramate in Lennox- Gastaut syndrome. Topiramate YL Study Group. Neurology 52(9), 1882-1887 (1999). (Pubitemid 29260904)
    • (1999) Neurology , vol.52 , Issue.9 , pp. 1882-1887
    • Sachdeo, R.C.1    Glauser, T.A.2    Ritter, F.3    Reife, R.4    Lim, P.5    Pledger, G.6
  • 95
    • 0027530628 scopus 로고
    • Felbamate Study Group in Lennox- Gastaut Syndrome. Efficacy of felbamate in childhood epileptic encephalopathy (Lennox-Gastaut syndrome
    • Felbamate Study Group in Lennox- Gastaut Syndrome. Efficacy of felbamate in childhood epileptic encephalopathy (Lennox-Gastaut syndrome). N. Engl. J. Med. 328(1), 29-33 (1993).
    • (1993) N. Engl. J. Med. , vol.328 , Issue.1 , pp. 29-33
  • 96
    • 0031453973 scopus 로고    scopus 로고
    • Lamotrigine for generalized seizures associated with the Lennox-Gastaut syndrome
    • DOI 10.1056/NEJM199712183372504
    • Motte J, Trevathan E, Arvidsson JF, Barrera MN, Mullens EL, Manasco P. Lamotrigine for generalized seizures associated with the Lennox-Gastaut syndrome. Lamictal Lennox-Gastaut Study Group. N. Engl. J. Med. 337(25), 1807-1812 (1997). (Pubitemid 28006785)
    • (1997) New England Journal of Medicine , vol.337 , Issue.25 , pp. 1807-1812
    • Motte, J.1    Trevathan, E.2    Arvidsson, J.F.V.3    Barrera, M.N.4    Mullens, E.L.5    Manasco, P.6
  • 97
    • 44949184519 scopus 로고    scopus 로고
    • Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome
    • Glauser T, Kluger G, Sachdeo R, Krauss G, Perdomo C, Arroyo S. Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome. Neurology 70(21), 1950-1958 (2008).
    • (2008) Neurology , vol.70 , Issue.21 , pp. 1950-1958
    • Glauser, T.1    Kluger, G.2    Sachdeo, R.3    Krauss, G.4    Perdomo, C.5    Arroyo, S.6
  • 98
    • 77952479116 scopus 로고    scopus 로고
    • A case of symptomatic, lesional epilepsy (hypothalamic hamartoma) masquerading as a generalized epilepsy with Lennox-Gastaut syndrome
    • Ng YT. A case of symptomatic, lesional epilepsy (hypothalamic hamartoma) masquerading as a generalized epilepsy with Lennox-Gastaut syndrome. Sem. Pediatr. Neurol. 17(1), 13-15 (2010).
    • (2010) Sem. Pediatr. Neurol. , vol.17 , Issue.1 , pp. 13-15
    • Ng, Y.T.1


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