Interactions between modulators of the GABAA receptor: Stiripentol and benzodiazepines

European Journal of Pharmacology

Volumn 654, Issue 2, 2011, Pages 160-165

  Fisher, Janet L ^a  

^a UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Anti convulsant; Clobazam; Clonazepam; Diazepam; Dravet syndrome; Electrophysiology; Norclobazam; Patch clamp; Recombinant

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CLOBAZAM; CLONAZEPAM; DIAZEPAM; NORCLOBAZAM; STIRIPENTOL;

ARTICLE; CELL STRAIN HEK293; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; DRUG RESPONSE; EMBRYO; HUMAN; HUMAN CELL; MONOTHERAPY; PRIORITY JOURNAL;

ANTI-ANXIETY AGENTS; ANTICONVULSANTS; BENZODIAZEPINES; CELL LINE; DIOXOLANES; DRUG INTERACTIONS; HEK293 CELLS; HUMANS; PATCH-CLAMP TECHNIQUES; PLASMIDS; RECEPTORS, GABA-A; TRANSFECTION;

EID: 79551594584     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.12.037     Document Type: Article

References (33)

1. A receptors: form, pharmacology and function J. Neurosci. 29 2009 12757 12763
2. R.N. Brogden, R.C. Heel, T.M. Speight, and G.S. Avery Clobazam: a review of its pharmacological properties and therapeutic use in anxiety Drugs 20 1980 161 178
3. W.A. Catterall, S. Dib-Hajj, M.H. Meisler, and D. Pietrobon Inherited neuronal ion channelopathies: new windows on complex neurological diseases J. Neurosci. 28 2008 11768 11777
4. J.D. Chesnut, A.R. Baytan, M. Russell, M.P. Chang, A. Bernard, I.H. Maxwell, and J.P. Hoeffler Selective isolation of transiently transfected cells from a mammalian cell population with vectors expressing a membrane anchored single-chain antibody J. Immunol. Meth. 193 1996 17 27
5. C. Chiron Stiripentol Neurotherapeutics 4 2007 123 125
6. C. Chiron, M.C. Marchand, A. Tran, E. Rey, P. d'Athis, J. Vincent, O. Dulac, and G. Pons Stiripentol in severe myoclonic epilepsy in infancy: a randomized placebo-controlled syndrome-dedicated trial, STICLO study group Lancet 356 2000 1638 1642
7. A receptor as a positive allosteric modulator Neuropharmaceutics 56 2009 190 197
8. J.A. French, and E. Faught Rational polytherapy Epilepsia 50 2009 63 68
9. C. Giraud, J.-M. Treluyer, E. Rey, C. Chiron, J. Vincent, G. Pons, and A. Tran In vitro and in vivo inhibitory effect of stiripentol on clobazam metabolism Drug Metab. Dispos. 34 2006 608 611
10. J.R. Haigh, T. Pullar, J.P. Gent, C. Dailley, and M. Feely N-desmethylclobazam: a possible alternative to clobazam in the treatment of refractory epilepsy Br. J. Clin. Pharmacol. 23 1987 213 218
11. Y. Inoue, Y. Ohtsuka, H. Oguni, J. Tohyama, H. Baba, K. Fukushima, H. Ohtani, Y. Takahashi, and S. Ikeda Stiripentol open study in Japanese patients with Dravet syndrome Epilepsia 50 2009 2362 2368
12. B. Kassaï, C. Chiron, S. Augier, M. Cucherat, E. Rey, F. Gueyffier, R. Guerrini, J. Vincent, O. Dulac, and G. Pons Severe myoclonic epilepsy in infancy: a systematic review and meta-analysis of individual patient data Epilepsia 49 2008 343 348
13. M. Kinoshita, A. Ikeda, T. Begum, K. Terada, and H. Shibasaki Efficacy of low-dose, add-on therapy of clobazam (CLB) is produced by its major metabolite N-desmethyl-CLB J. Neurol. Sci. 263 2007 44 48
14. A receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development J. Neurosci. 12 1992 4151 4172
15. J.J. Luszczki, M.K. Trojnar, N. Ratnaraj, P.N. Patsalos, and S.J. Czuczwar Interactions of stiripentol with clobazam and valproate in the mouse maximal electroshock-induced seizure model Epilepsy Res. 90 2010 188 198
16. F. Nakamura, S. Suzuki, S. Nishimura, K. Yagi, and M. Seino Effects of clobazam and its active metabolite on GABA-activated currents in rat cerebral neurons in culture Epilepsia 37 1996 728 735
17. Y. Ng, and S.D. Collins Clobazam Neurotherapeutics 4 2007 138 144
18. J. Perez, C. Chiron, C. Musial, E. Rey, H. Blehaut, P. d'Athis, J. Vincent, and O. Dulac Stiripentol: efficacy and tolerability in children with epilepsy Epilepsia 40 1999 1618 1626
19. - currents Mol. Pharmacol. 39 1991 691 696
20. A-receptor channels Epilepsia 47 2006 704 716
21. E. Rey, A. Tran, P. d'Athis, C. Chiron, O. Dulac, J. Vincent, and G. Pons Stiripentol potentiates clobazam in childhood epilepsy: a pharmacological study Epilepsia 40 1999 112 113
22. A receptor activation in human recombinant receptors Eur. J. Pharm. 314 1996 151 156
23. A receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates Proc. Natl Acad. Sci. 102 2005 915 920
24. A receptor subtype functions Curr. Opin. Pharmacol. 6 2006 18 23
25. A receptor subtypes: dissecting their pharmacological functions Trends Pharm. Sci. 22 2001 188 194
26. D.D. Shen, R.H. Levy, J.L. Savitch, A.V. Boddy, F. Tombret, and F. Lepage Comparative anticonvulsant potency and pharmacokinetics of (+)- and (-)-entantiomers of stiripentol Epilepsy Res. 12 1992 29 36
27. E.K. St. Louis Truly "rational" polytherapy: maximizing efficacy and minimizing drug interactions, drug load, and adverse effects Curr. Neuropharm. 7 2009 96 105
28. A. Tran, E. Rey, G. Pons, M. Rouseau, P. d'Athis, G. Olive, G.G. Mahter, F.E. Bishop, C.J. Wurden, R. Labroo, W.F. Trager, K.L. Kunze, K.E. Thummel, J.C. Vincent, J.-M. Gillardin, F. Lepage, and R.H. Levy Influence of stiripentol on cytochrome P450-mediated metabolic pathways in humans: in vitro and in vivo comparison and calculation of in vivo inhibition constants Clin. Pharmacol. Ther. 62 1997 490 504
29. M.K. Trojnar, K. Wojtal, M.P. Trojnar, and S.J. Czuczwar Stiripentol. A novel antiepileptic drug Pharm. Rep. 57 2005 154 160
30. T.A. Verdoorn Formation of heteromeric γ-aminobutyric acid type A receptors containing two different α subunits Mol. Pharm. 45 1994 475 480
31. P.J. Whiting GABA-A receptors: a viable target for novel anxiolytics? Curr. Opin. Pharmacol. 6 2006 24 29
32. M. Wolff, C. Cassé-Perrot, and C. Dravet Severe myoclonic epilepsy of infants (Dravet syndrome): natural history and neuropsychological findings Epilepsia 47 2006 45 48
33. A receptors: functional and binding studies Br. J. Pharmacol. 121 1997 1392 1396