The prevalence and etiology of anemia among HIV-infected children in India

European Journal of Pediatrics

Volumn 171, Issue 3, 2012, Pages 531-540

  Shet, Anita ^a   Arumugam, Karthika ^a   Rajagopalan, Nirmala ^b   Dinakar, Chitra ^a   Krishnamurthy, Shubha ^a   Mehta, Saurabh ^c   Shet, Arun S ^a  

^a ST JOHN'S NATIONAL ACADEMY OF HEALTH SCIENCES   (India)

^b Freedom Foundation   (India)

^c Department of Obstetrics Gynecology   (United States)

Author keywords

Anemia; Anemia of inflammation; Children; HIV; India; Iron; Resource limited

Indexed keywords

C REACTIVE PROTEIN; CYANOCOBALAMIN; EFAVIRENZ; FERRITIN; FOLIC ACID; FOLIC ACID DERIVATIVE; HEMOGLOBIN; LAMIVUDINE; NEVIRAPINE; PROTEINASE INHIBITOR; STAVUDINE; TENOFOVIR; TONOFERON; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANEMIA; ARTICLE; CD4 LYMPHOCYTE COUNT; CHILD; CHILDHOOD DISEASE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; FEMALE; FERRITIN BLOOD LEVEL; FOLIC ACID BLOOD LEVEL; HEALTH CARE QUALITY; HEMOGLOBIN BLOOD LEVEL; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INDIA; IRON BLOOD LEVEL; IRON DEFICIENCY; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; SCHOOL CHILD; STUNTING; UNDERWEIGHT; VIRUS LOAD; VITAMIN BLOOD LEVEL; VITAMIN DEFICIENCY;

ANEMIA; ANTI-RETROVIRAL AGENTS; CHILD; CHILD, PRESCHOOL; DIETARY SUPPLEMENTS; FEMALE; HIV INFECTIONS; HUMANS; INDIA; IRON; LINEAR MODELS; MALE; PILOT PROJECTS; PREVALENCE; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 84860276925     PISSN: 03406199     EISSN: 14321076     Source Type: Journal    
DOI: 10.1007/s00431-011-1599-y     Document Type: Article

References (52)

1. Angeles Vazquez Lopez M, Molinos FL, Carmona ML, Morales AC, Munoz Vico FJ, Munoz JL, Munoz Hoyos A (2006) Serum transferrin receptor in children: usefulness for determinating the nature of anemia in infection. J Pediatr Hematol Oncol 28 (12):809-815 (Pubitemid 44967676)
2. Bal AM, Lakhashe SK, Thakar MR, Tripathy SP, Paranjape RS (2005) Dysregulation of proinflammatory and regulatory cytokines in HIV infected persons with active tuberculosis. Cytokine 30(5):275-281 (Pubitemid 40775847)
3. Bharathi AV, Kurpad AV, Thomas T, Yusuf S, Saraswathi G, Vaz M (2008) Development of food frequency questionnaires and a nutrient database for the Prospective Urban and Rural Epidemiological (PURE) pilot study in South India: methodological issues. Asia Pac J Clin Nutr 17(1):178-185
4. Boelaert JR, Weinberg GA, Weinberg ED (1996) Altered iron metabolism in HIV infection: mechanisms, possible consequences, and proposals for management. Infect Agents Dis 5(1):36-46 (Pubitemid 26038608)
5. Calis JC, van Hensbroek MB, de Haan RJ, Moons P, Brabin BJ, Bates I (2008) HIV-associated anemia in children: a systematic review from a global perspective. AIDS 22(10):1099-1112
6. Clark TD, Mmiro F, Ndugwa C, Perry RT, Jackson JB, Melikian G, Semba RD (2002) Risk factors and cumulative incidence of anaemia among human immunodeficiency virus-infected children in Uganda. Ann Trop Paediatr 22(1):11-17 (Pubitemid 34240340)
7. de Monye C, Karcher DS, Boelaert JR, Gordeuk VR (1999) Bone marrow macrophage iron grade and survival of HIV-seropositive patients. AIDS 13(3):375-380 (Pubitemid 29095100)
8. Ekiz C, Agaoglu L, Karakas Z, Gurel N, Yalcin I (2005) The effect of iron deficiency anemia on the function of the immune system. Hematol J 5(7):579-583 (Pubitemid 40309623)
9. Eley BS, Sive AA, Shuttleworth M, Hussey GD (2002) A prospective, cross-sectional study of anaemia and peripheral iron status in antiretroviral naive, HIV-1 infected children in Cape Town, South Africa. BMC Infect Dis 2(1):3
10. Ellaurie M, Burns ER, Rubinstein A (1990) Hematologic manifestations in pediatric HIV infection: severe anemia as a prognostic factor. Am J Pediatr Hematol Oncol 12(4):449-453
11. Fawzi WW, Msamanga GI, Spiegelman D, Wei R, Kapiga S, Villamor E, Mwakagile D, Mugusi F, Hertzmark E, Essex M, Hunter DJ (2004) A randomized trial of multivitamin supplements and HIV disease progression and mortality. N Engl J Med 351 (1):23-32 (Pubitemid 38857244)
12. Georgiou NA, van der Bruggen T, Oudshoorn M, Nottet HS, Marx JJ, van Asbeck BS (2000) Inhibition of human immunodeficiency virus type 1 replication in human mononuclear blood cells by the iron chelators deferoxamine, deferiprone, and bleomycin. J Infect Dis 181(2):484-490 (Pubitemid 30131814)
13. Gopalan C, Rama Sastri BV, Balasubramanian SC SC, Narasinga Rao BS, Deosthale YG, Pant KC (1996) Nutritive value of Indian foods. National Institute of Nutrition (ICMR), Hyderabad
14. Hilgartner M (1991) Guidelines for the care of children and adolescents with HIV infection. Hematologic manifestations in HIV-infected children. J Pediatr 119(1 Pt 2):S47-S49
15. Indian Council of Medical Research (ICMR) (2000) Iron absorption and its implications on strategies to control iron deficiency anaemia. ICMR Bull 30(2). Available at http://icmr. nic.in/bufeb00.pdf
16. Kapur D, Sharma S, Agarwal KN (2005) Dietary intake and growth pattern of children 9-36 months of age in an urban slum in Delhi. Indian Pediatr 42(4):351-356 (Pubitemid 40663693)
17. Kupka R, Msamanga GI, Mugusi F, Petraro P, Hunter DJ, Fawzi WW (2007) Iron status is an important cause of anemia in HIVinfected Tanzanian women but is not related to accelerated HIV disease progression. J Nutr 137(10):2317-2323 (Pubitemid 47529596)
18. Lee EJ, Oh EJ, Park YJ, Lee HK, Kim BK (2002) Soluble transferrin receptor (sTfR), ferritin, and sTfR/log ferritin index in anemic patients with nonhematologic malignancy and chronic inflammation. Clin Chem 48(7):1118-1121
19. Malik ZA, Abadi J, Sansary J, Rosenberg M (2009) Elevated levels of vitamin B12 and folate in vertically infected children with HIV-1. AIDS 23(3):403-407
20. Merchant RH, Oswal JS, Bhagwat RV, Karkare J (2001) Clinical profile of HIV infection. Indian Pediatr 38(3):239-246 (Pubitemid 33611230)
21. Mildvan D, Creagh T, Leitz G (2007) Prevalence of anemia and correlation with biomarkers and specific antiretroviral regimens in 9690 human-immunodeficiency-virus-infected patients: findings of the Anemia Prevalence Study. Curr Med Res Opin 23(2):343-355 (Pubitemid 46333383)
22. Ministry of Health and Family Welfare, Government of India (2007) National Family Health Survey (NFHS-3) 2005-06: key findings. International Institute for Population Sciences, Mumbai. http://www.measuredhs.com/pubs/pdf/ SR128/SR128.pdf. Accessed on 17 November 2008
23. Mocroft A, Kirk O, Barton SE, Dietrich M, Proenca R, Colebunders R, Pradier C, dArminio Monforte A, Ledergerber B, Lundgren JD (1999) Anaemia is an independent predictive marker for clinical prognosis in HIV-infected patients from across Europe. EuroSIDA study group. AIDS 13(8):943-950 (Pubitemid 29240189)
24. Muthayya S, Thankachan P, Zimmermann MB, Andersson M, Eilander A, Misquith D, Hurrell RF, Kurpad AV (2007) Low anemia prevalence in school-aged children in Bangalore, South India: possible effect of school health initiatives. Eur J Clin Nutr 61(7):865-869 (Pubitemid 47040309)
25. National AIDS Control Organization (2006) Guidelines for HIV Care and treatment in infants and children. Available at http://www. nacoonline.org/ Quick-Links/Publication/Treatment-Care-Support/ Operational-Technical- guidelines-and-policies/Guidelines- for-HIV-Care-and-Treatment/
26. National AIDS Control Organization (2010). HIV/AIDS estimates, 2010 http://www.nacoonline.org
27. Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T (2004) IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 113(9):1271-1276 (Pubitemid 39069926)
28. Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T (2003) Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 101 (7):2461-2463 (Pubitemid 36857598)
29. Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard X, Devaux I, Beaumont C, Kahn A, Vaulont S (2002) The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 110(7):1037-1044
30. Osei A, Houser R, Bulusu S, Joshi T, Hamer D (2010) Nutritional status of primary schoolchildren in Garhwali Himalayan villages of India. Food Nutr Bull 31(2):221-233
31. Pasricha SR, Black J, Muthayya S, Shet A, Bhat V, Nagaraj S, Prashanth NS, Sudarshan H, Biggs BA, Shet AS (2010) Determinants of anemia among young children in rural India. Pediatrics 126(1):e140-e149
32. Pfeiffer CM, Johnson CL, Jain RB, Yetley EA, Picciano MF, Rader JI, Fisher KD, Mulinare J, Osterloh JD (2007) Trends in blood folate and vitamin B-12 concentrations in the United States, 1988 2004. Am J Clin Nutr 86(3):718-727 (Pubitemid 47435840)
33. Punnonen K, Irjala K, Rajamaki A (1997) Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood 89(3):1052-1057 (Pubitemid 27121300)
34. Rajasekaran S, Jeyaseelan L, Ravichandran N, Gomathi C, Thara F, Chandrasekar C (2009) Efficacy of antiretroviral therapy program in children in India: prognostic factors and survival analysis. J Trop Pediatr 55(4):225-232
35. Rawat R, Humphrey JH, Ntozini R, Mutasa K, Iliff PJ, Stoltzfus RJ (2009) Elevated iron stores are associated with HIV disease severity and mortality among postpartum women in Zimbabwe. Public Health Nutr 12(9):1321-1329
36. Ray A, Ndugwa C, Mmirot F, Ricks MO, Semba RD (2007) Soluble transferrin receptor as an indicator of iron deficiency in HIV-infected infants. Ann Trop Paediatr 27(1):11-16 (Pubitemid 47628956)
37. Salhi Y, Costagliola D, Rebulla P, Dessi C, Karagiorga M, Lena- Russo D, de Montalembert M, Girot R (1998) Serum ferritin, desferrioxamine, and evolution of HIV-1 infection in thalassemic patients. J Acquir Immune Defic Syndr Hum Retrovirol 18 (5):473-478
38. Sappey C, Boelaert JR, Legrand-Poels S, Forceille C, Favier A, Piette J (1995) Iron chelation decreases NF-kappa B and HIV type 1 activation due to oxidative stress. AIDS Res Hum Retroviruses 11(9):1049-1061
39. Semba RD (2003) Iron-deficiency anemia and the cycle of poverty among human immunodeficiency virus-infected women in the inner city. Clin Infect Dis 37(Suppl 2):S105-S111 (Pubitemid 37107441)
40. Semba RD, Broadhead R, Taha TE, Totin D, Ricks MO, Kumwenda N (2001) Erythropoietin response to anemia among human immunodeficiency virus-infected infants in Malawi. Haematologica 86(11):1221-1222 (Pubitemid 33063870)
41. Semba RD, Gray GE (2001) Pathogenesis of anemia during human immunodeficiency virus infection. J Investig Med 49 (3):225-239 (Pubitemid 32479161)
42. Shah SR, Tullu MS, Kamat JR (2005) Clinical profile of pediatric HIV infection from India. Arch Med Res 36(1):24-31 (Pubitemid 40386344)
43. Shet A, Mehta S, Rajagopalan N, Dinakar C, Ramesh E, Samuel NM, Indumathi CK, Fawzi WW, Kurpad AV (2009) Anemia and growth failure among HIV-infected children in India: a retrospective analysis. BMC Pediatr 9:37
44. Stoltzfus R, Dreyfus ML (1998) In: INACG, WHO, UNICEF (eds) Guidelines for the use of iron supplements to prevent and treat iron deficiency anemia. Washington, IUNACG
45. Sullivan PS, Hanson DL, Chu SY, Jones JL, Ward JW (1998) Epidemiology of anemia in human immunodeficiency virus (HIV)- infected persons: results from the multistate adult and adolescent spectrum of HIV disease surveillance project. Blood 91(1):301-308 (Pubitemid 28018758)
46. Taneja S, Bhandari N, Strand TA, Sommerfelt H, Refsum H, Ueland PM, Schneede J, Bahl R, Bhan MK (2007) Cobalamin and folate status in infants and young children in a low-to-middle income community in India. Am J Clin Nutr 86(5):1302-1309 (Pubitemid 350126231)
47. Totin D, Ndugwa C, Mmiro F, Perry RT, Jackson JB, Semba RD (2002) Iron deficiency anemia is highly prevalent among human immunodeficiency virus-infected and uninfected infants in Uganda. J Nutr 132(3):423-429 (Pubitemid 34208744)
48. van Lettow M, van der Meer JW, West CE, van Crevel R, Semba RD (2005) Interleukin-6 and human immunodeficiency virus load, but not plasma leptin concentration, predict anorexia and wasting in adults with pulmonary tuberculosis in Malawi. J Clin Endocrinol Metab 90(8):4771-4776 (Pubitemid 41159370)
49. Weinstein DA, Roy CN, Fleming MD, Loda MF, Wolfsdorf JI, Andrews NC (2002) Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood 100(10):3776-3781 (Pubitemid 35303951)
50. Weiss G, Goodnough LT (2005) Anemia of chronic disease. N Engl J Med 352(10):1011-1023
51. WHO (2001) Iron deficiency anaemia assessment, prevention, and control. A guide for programme managers. WHO/NHD/01.3. World Health Organization, Geneva. Accessible at http://www.who. int/nutrition/publications/micronutrients/anaemia- iron-deficiency/ WHO-NHD-01.3/en/index.html
52. WHO (2004) Iron supplementation of young children in regions where malaria transmission is intense and infectious disease highly prevalent. Report of the meeting to review results of the zinc/iron supplementation trials conducted in Nepal and Tanzania-Zanzibar, Tanzania, 30 April-1 May 2004. WHO Statement. http://www.who.int/childadolescenthealth/- New-Publications/CHILD- HEALTH/WHO-FCH- CAH-06.2.pdf