Nature versus nurture in glioblastoma: Microenvironment and genetics can both drive mesenchymal transcriptional signature

American Journal of Pathology

Volumn 180, Issue 5, 2012, Pages 1768-1771

  Orr, Brent A ^a   Eberhart, Charles G ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; CCAAT ENHANCER BINDING PROTEIN BETA; HEXOKINASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MESSENGER RNA; MICRORNA; STAT3 PROTEIN;

ANGIOGENESIS; CANCER PROGNOSIS; CELL INFILTRATION; CHROMATIN IMMUNOPRECIPITATION; COPY NUMBER VARIATION; GENE EXPRESSION; GENETICS; GLIOBLASTOMA; HIGH THROUGHPUT SEQUENCING; HISTOPATHOLOGY; HUMAN; MACROPHAGE; MESENCHYME; NOTE; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; THROMBOSIS; TUMOR MICROENVIRONMENT; TUMOR NECROSIS;

GLIOBLASTOMA; HUMANS; TUMOR MICROENVIRONMENT;

EID: 84860262036     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2012.03.001     Document Type: Note

References (23)

1. R. McLendon, A. Friedman, D. Bigner, E.G. Van Meir, D.J. Brat, G.M. Mastrogianakis Cancer Genome Atlas Research Network: Comprehensive genomic characterization defines human glioblastoma genes and core pathways Nature 455 2008 1061 1068
2. S. Madhavan, J.C. Zenklusen, Y. Kotliarov, H. Sahni, H.A. Fine, K. Buetow Rembrandt: helping personalized medicine become a reality through integrative translational research Mol Cancer Res 7 2009 157 167
3. H. Yan, D.W. Parsons, G. Jin, R. McLendon, B.A. Rasheed, W. Yuan, I. Kos, I. Batinic-Haberle, S. Jones, G.J. Riggins, H. Friedman, A. Friedman, D. Reardon, J. Herndon, K.W. Kinzler, V.E. Velculescu, B. Vogelstein, D.D. Bigner IDH1 and IDH2 mutations in gliomas N Engl J Med 360 2009 765 773
4. R.G. Verhaak, K.A. Hoadley, E. Purdom, V. Wang, Y. Qi, M.D. Wilkerson, C.R. Miller, L. Ding, T. Golub, J.P. Mesirov, G. Alexe, M. Lawrence, M. O'Kelly, P. Tamayo, B.A. Weir, S. Gabriel, W. Winckler, S. Gupta, L. Jakkula, H.S. Feiler, J.G. Hodgson, C.D. James, J.N. Sarkaria, C. Brennan, A. Kahn, P.T. Spellman, R.K. Wilson, T.P. Speed, J.W. Gray, M. Meyerson, G. Getz, C.M. Perou, D.N. Hayes Cancer Genome Atlas Research Network: Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1 Cancer Cell 17 2010 98 110
5. H. Noushmehr, D.J. Weisenberger, K. Diefes, H.S. Phillips, K. Pujara, B.P. Berman, F. Pan, C.E. Pelloski, E.P. Sulman, K.P. Bhat, R.G. Verhaak, K.A. Hoadley, D.N. Hayes, C.M. Perou, H.K. Schmidt, L. Ding, R.K. Wilson, D. Van Den Berg, H. Shen, H. Bengtsson, P. Neuvial, L.M. Cope, J. Buckley, J.G. Herman, S.B. Baylin, P.W. Laird, K. Aldape Cancer Genome Atlas Research Network: Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma Cancer Cell 17 2010 510 522
6. H.S. Phillips, S. Kharbanda, R. Chen, W.F. Forrest, R.H. Soriano, T.D. Wu, A. Misra, J.M. Nigro, H. Colman, L. Soroceanu, P.M. Williams, Z. Modrusan, B.G. Feuerstein, K. Aldape Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis Cancer Cell 9 2006 157 173
7. P. Kleihues, F. Soylemezoglu, B. Schuble, B.W. Scheithauer, P.C. Burger Histopathology, classification, and grading of gliomas Glia 15 1995 211 221
8. D.N. Louis, H. Ohgaki, O.D. Wiestler, W.K. Cavenee WHO Classification of Tumours of the Central Nervous System ed 4. 2007 IARC Press Lyon
9. D.J. Brat, R.A. Prayson, T.C. Ryken, J.J. Olson Diagnosis of malignant glioma: role of neuropathology J Neurooncol 89 2008 287 311
10. L.A.D. Cooper, D.A. Gutman, C. Chisolm, C. Appin, J. Kong, Y. Rong, T. Kurc, E.G. Van Meir, J.H. Saltz, C.S. Moreno, D.J. Brat The tumor microenvironment strongly impacts master transcriptional regulators and gene expression class of glioblastoma Am J Pathol 180 2012 2108 2119
11. M.S. Carro, W.K. Lim, M.J. Alvarez, R.J. Bollo, X. Zhao, E.Y. Snyder, E.P. Sulman, S.L. Anne, F. Doetsch, H. Colman, A. Lasorella, K. Aldape, A. Califano, A. Iavarone The transcriptional network for mesenchymal transformation of brain tumours Nature 463 2010 318 325
12. J. Kong, L. Cooper, C. Moreno, F. Wang, T. Kurc, J. Saltz, D. Brat In silico analysis of nuclei in glioblastoma using large-scale microscopy images improves prediction of treatment response Conf Proc IEEE Eng Med Biol Soc 2011 2011 87 90
13. L.A. Cooper, J. Kong, F. Wang, T. Kurc, C.S. Moreno, D.J. Brat, J.H. Saltz Morphological Signatures and Genomic Correlates in Glioblastoma Proc IEEE Int Symp Biomed Imaging 1624 2011
14. H. Chang, G.V. Fontenay, J. Han, G. Cong, F.L. Baehner, J.W. Gray, P.T. Spellman, B. Parvin Morphometic analysis of TCGA glioblastoma multiforme BMC Bioinformatics 12 2011 484
15. D.J. Brat, A.A. Castellano-Sanchez, S.B. Hunter, M. Pecot, C. Cohen, E.H. Hammond, S.N. Devi, B. Kaur, E.G. Van Meir Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population Cancer Res 64 2004 920 927
16. D.J. Brat, E.G. Van Meir Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia, necrosis, and accelerated growth in glioblastoma Lab Invest 84 2004 397 405
17. Z. Li, S. Bao, Q. Wu, H. Wang, C. Eyler, S. Sathornsumetee, Q. Shi, Y. Cao, J. Lathia, R.E. McLendon, A.B. Hjelmeland, J.N. Rich Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells Cancer Cell 15 2009 501 513
18. E.E. Bar, A. Lin, V. Mahairaki, W. Matsui, C.G. Eberhart Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres Am J Pathol 177 2010 1491 1502
19. B. Keith, R.S. Johnson, M.C. Simon HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression Nat Rev Cancer 12 2011 9 22
20. M. Hirata, F. Kugimiya, A. Fukai, T. Saito, F. Yano, T. Ikeda, A. Mabuchi, B.R. Sapkota, T. Akune, N. Nishida, N. Yoshimura, T. Nakagawa, K. Tokunaga, K. Nakamura, U.I. Chung, H. Kawaguchi c/EBPbeta and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2alpha as the inducer in chondrocytes Hum Mol Genet 21 2012 1111 1123
21. S. Banerjee, J.N. Byrd, S.M. Gianino, S.E. Harpstrite, F.J. Rodriguez, R.G. Tuskan, K.M. Reilly, D.R. Piwnica-Worms, D.H. Gutmann The neurofibromatosis type 1 tumor suppressor controls cell growth by regulating signal transducer and activator of transcription-3 activity in vitro and in vivo Cancer Res 70 2010 1356 1366
22. M.J. Gray, J. Zhang, L.M. Ellis, G.L. Semenza, D.B. Evans, S.S. Watowich, G.E. Gallick HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas Oncogene 24 2005 3110 3120
23. Q. Xu, J. Briggs, S. Park, G. Niu, M. Kortylewski, S. Zhang, T. Gritsko, J. Turkson, H. Kay, G.L. Semenza, J.Q. Cheng, R. Jove, H. Yu Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways Oncogene 24 2005 5552 5560