In vivo nitric oxide synthesis, insulin sensitivity, and asymmetric dimethylarginine in obese subjects without and with metabolic syndrome

Metabolism: Clinical and Experimental

Volumn 61, Issue 5, 2012, Pages 680-688

  Siervo, Mario ^a   Bluck, Les J C ^a  

^a MRC HUMAN NUTRITION RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; DIMETHYLARGININASE; GLUCOSE; HIGH DENSITY LIPOPROTEIN; INSULIN; NITRIC OXIDE; TRIACYLGLYCEROL;

ADULT; ARTICLE; BIOSYNTHESIS; BLOOD PRESSURE; BODY COMPOSITION; BODY MASS; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENDOTHELIUM; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; MALE; METABOLIC SYNDROME X; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; ARGININE; BLOOD GLUCOSE; BLOOD PRESSURE; CHOLESTEROL, HDL; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN RESISTANCE; MALE; METABOLIC SYNDROME X; NITRATES; NITRIC OXIDE; OBESITY; SALIVA; TRIGLYCERIDES; WAIST CIRCUMFERENCE;

EID: 84860237899     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2011.10.003     Document Type: Article

References (55)

1. D.W. Haslam, and W.P.T. James Obesity Lancet 366 2005 1197 1209
2. J.P. Despres, I. Lemieux, J. Bergeron, P. Pibarot, P. Mathieu, and E. Larose Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk Arterioscler Thromb Vasc Biol 28 2008 1039 1049
3. D. Guh, W. Zhang, N. Bansback, Z. Amarsi, C.L. Birmingham, and A. Anis The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis BMC Public Health 9 2009 88
4. A. Garg Regional adiposity and insulin resistance J Clin Endocrinol Metab 89 2004 4206 4210
5. G. Sesti Pathophysiology of insulin resistance Best Pract Res Clin Endocrinol Metab 20 2006 665 679
6. S.E. Kahn The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes Diabetologia 46 2003 3 19
7. W.F. Ganong Review of medical physiology 1999 Appleton & Lange Stamford
8. R. Muniyappa, M. Montagnani, K.K. Koh, and M.J. Quon Cardiovascular actions of insulin Endocr Rev 28 2007 463 491
9. E. Barrett, E. Eggleston, A. Inyard, H. Wang, G. Li, and W. Chai The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action Diabetologia 52 2009 752 764
10. J.A. Kim, M. Montagnani, K.K. Koh, and M.J. Quon Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms Circulation 113 2006 1888 1904
11. L.H. Clerk, M.A. Vincent, L.A. Jahn, Z. Liu, J.R. Lindner, and E.J. Barrett Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle Diabetes 55 2006 1436 1442
12. G. Reyes-Soffer, S. Holleran, M.R. Di Tullio, S. Homma, B. Boden-Albala, and R. Ramakrishnan Endothelial function in individuals with coronary artery disease with and without type 2 diabetes mellitus Metabolism 59 2010 1365 1371
13. M. Siervo, M. Corander, S. Stranges, and L. Bluck Post-challenge hyperglycaemia, nitric oxide production and endothelial dysfunction: the putative role of asymmetric dimethylarginine (ADMA) Nutr Metab Cardiovasc Dis 21 2011 1 10
14. G. Riccardi, P. Aggett, F. Brighenti, N. Delzenne, K. Frayn, and A. Nieuwenhuizen PASSCLAIM-body weight regulation, insulin sensitivity and diabetes risk Eur J Nutr 43 Suppl 2 2004 II7 II46
15. R.H. Eckel, S.M. Grundy, and P.Z. Zimmet The metabolic syndrome Lancet 365 2005 1415 1428
16. J.S. Yudkin Inflammation, obesity, and the metabolic syndrome Horm Metab Res 39 2007 707 709
17. S.B. Wheatcroft, I.L. Williams, A.M. Shah, and M.T. Kearney Pathophysiological implications of insulin resistance on vascular endothelial function Diabet Med 20 2003 255 268
18. M. Siervo, S.J. Jackson, and L.J.C. Bluck In vivo nitric oxide synthesis is reduced in obese subjects with metabolic syndrome: application of a novel stable isotopic method J of Hypertension 29 2011 1515 1527
19. K.G.M.M. Alberti, R.H. Eckel, S.M. Grundy, P.Z. Zimmet, J.I. Cleeman, and K.A. Donato Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity Circulation 120 2009 1640 1645
20. R.N. Bergman, Y.Z. Ider, C.R. Bowden, and C. Cobelli Quantitative estimation of insulin sensitivity Am J Physiol Endocrinol Metab 236 1979 E667 E677
21. S. Jackson, M. Siervo, E. Persson, L.M. McKenna, and L.J.C. Bluck A novel derivative for the assessment of urinary and salivary nitrate using gas chromatography/mass spectrometry Rapid Commun Mass Spectrom 22 2008 4158 4164
22. S.J. Jackson, J.S. Waterhouse, and L.J.C. Bluck A single glucose derivative suitable for gas chromatography/mass spectrometry and gas chromatography/combustion/isotope ratio mass spectrometry Rapid Commun Mass Spectrom 21 2007 3123 3128
23. D.R. Matthews, J.P. Hosker, A.S. Rudenski, B.A. Naylor, D.F. Treacher, and R.C. Turner Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 1985 412 419
24. W.J. Conover, and R.L. Iman Analysis of covariance using the rank transformation Biometrics 38 1982 715 724
25. P. Forte, M. Copland, L.M. Smith, E. Milne, J. Sutherland, and N. Benjamin Basal nitric oxide synthesis in essential hypertension Lancet 349 1997 837 842
26. L.H. Clerk, S. Rattigan, and M.G. Clark Lipid infusion impairs physiologic insulin-mediated capillary recruitment and muscle glucose uptake in vivo Diabetes 51 2002 1138 1145
27. P.D. O'Kane, G. Jackson, and A. Ferro Whole body nitric oxide production is not decreased in patients with coronary atherosclerosis but is inversely related to plasma homocysteine Atherosclerosis 196 2008 574 579
28. L.M. Title, E. Lonn, F. Charbonneau, M. Fung, K.J. Mather, and S. Verma Relationship between brachial artery flow-mediated dilatation, hyperemic shear stress, and the metabolic syndrome Vasc Med 13 2008 263 270
29. I. Wendelhag, B. Fagerberg, J. Hulthe, L. Bokemark, and J. Wikstrand Endothelium-dependent flow-mediated vasodilatation, insulin resistance and the metabolic syndrome in 60-year-old men J Intern Med 252 2002 305 313
30. N.M. Hamburg, M.G. Larson, J.A. Vita, R.S. Vasan, M.J. Keyes, and M.E. Widlansky Metabolic syndrome, insulin resistance, and brachial artery vasodilator function in Framingham Offspring participants without clinical evidence of cardiovascular disease Am J Cardiol 101 2008 82 88
31. A. Avogaro, G. Toffolo, E. Kiwanuka, S.V. de Kreutzenberg, P. Tessari, and C. Cobelli L-arginine-nitric oxide kinetics in normal and type 2 diabetic subjects: a stable-labelled 15N arginine approach Diabetes 52 2003 795 802
32. J.A. Beckman, A.B. Goldfine, A. Dunaif, M. Gerhard-Herman, and M.A. Creager Endothelial function varies according to insulin resistance disease type Diabetes Care 30 2007 1226 1232
33. B.M. Balletshofer, K. Rittig, M.D. Enderle, A. Volk, E. Maerker, and S. Jacob Endothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with type 2 diabetes in association with insulin resistance Circulation 101 2000 1780 1784
34. N.M. Hamburg, M.J. Keyes, M.G. Larson, R.S. Vasan, R. Schnabel, and M.M. Pryde Cross-sectional relations of digital vascular function to cardiovascular risk factors in the Framingham Heart Study Circulation 117 2008 2467 2474
35. A.J. Pope, K. Karuppiah, and A.J. Cardounel Role of the PRMT-DDAH-ADMA axis in the regulation of endothelial nitric oxide production Pharmacol Res 2009
36. R. Maas, E. Schwedhelm, L. Kahl, H. Li, R. Benndorf, and N. Luneburg Simultaneous assessment of endothelial function, nitric oxide synthase activity, nitric oxide-mediated signaling, and oxidative stress in individuals with and without hypercholesterolemia Clin Chem 54 2008 292 300
37. M.I. Yilmaz, A. Sonmez, M. Saglam, A.R. Qureshi, J.J. Carrero, and K. Caglar ADMA levels correlate with proteinuria, secondary amyloidosis, and endothelial dysfunction J Am Soc Nephrol 19 2008 388 395
38. L. Sibal, S. Agarwal, E. Schwedhelm, N. Luneburg, R. Boger, and P. Home A study of endothelial function and circulating asymmetric dimethylarginine levels in people with type 1 diabetes without macrovascular disease or microalbuminuria Cardiovasc Diabetol 8 2009 27
39. D. Ardigo, M. Stuehlinger, L. Franzini, S. Valtuena, P.M. Piatti, and O. Pachinger ADMA is independently related to flow-mediated vasodilation in subjects at low cardiovascular risk Eur J Clin Invest 37 2007 263 269
40. S. Doshi, I. McDowell, J. Goodfellow, S. Stabler, R. Boger, and R. Allen Relationship between S-adenosylmethionine, S-adenosylhomocysteine, asymmetric dimethylarginine, and endothelial function in healthy human subjects during experimental hyper- and hypohomocysteinemia Metabolism 54 2005 351 360
41. P.E. Gates, M.L. Boucher, A.E. Silver, K.D. Monahan, and D.R. Seals Impaired flow-mediated dilation with age is not explained by l-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression J Appl Physiol 102 2007 63 71
42. M. Juonala, J.S. Viikari, G. Alfthan, J. Marniemi, M. Kahonen, and L. Taittonen Brachial artery flow-mediated dilation and asymmetrical dimethylarginine in the cardiovascular risk in young Finns study Circulation 116 2007 1367 1373
43. A.S. Kelly, A.M. Thelen, D.R. Kaiser, J.M. Gonzalez-Campoy, and A.J. Bank Rosiglitazone improves endothelial function and inflammation but not asymmetric dimethylarginine or oxidative stress in patients with type 2 diabetes mellitus Vasc Med 12 2007 311 318
44. L.J. Moran, S.K. Hutchison, C. Meyer, S. Zoungas, and H.J. Teede A comprehensive assessment of endothelial function in overweight women with and without polycystic ovary syndrome Clin Sci (Lond) 116 2009 761 770
45. C. Antoniades, C. Shirodaria, P. Leeson, A. Antonopoulos, N. Warrick, and T. Van-Assche Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis Eur Heart J 30 2009 1142 1150
46. R.H. Boger, S.R. Lentz, S.M. Bode-Boger, H.R. Knapp, and W.G. Haynes Elevation of asymmetrical dimethylarginine may mediate endothelial dysfunction during experimental hyperhomocyst(e)inaemia in humans Clin Sci (Lond) 100 2001 161 167
47. A. Fard, C.H. Tuck, J.A. Donis, R. Sciacca, M.R. Di Tullio, and H.D. Wu Acute elevations of plasma asymmetric dimethylarginine and impaired endothelial function in response to a high-fat meal in patients with type 2 diabetes Arterioscler Thromb Vasc Biol 20 2000 2039 2044
48. M.D. Savvidou, A.D. Hingorani, D. Tsikas, J.C. Frolich, P. Vallance, and K.H. Nicolaides Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia Lancet 361 2003 1511 1517
49. H.M.A. Eid, H. Arnesen, E.M. Hjerkinn, T. Lyberg, T. Lyberg, and I. Seljeflot Relationship between obesity, smoking, and the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine Metabolism 53 2004 1574 1579
50. J.P.J. Halcox, A.E. Donald, E. Ellins, D.R. Witte, M.J. Shipley, and E.J. Brunner Endothelial function predicts progression of carotid intima-media thickness Circulation 119 2009 1005 1012
51. R. Campuzano, J.L. Moya, A. Garcia-Lleda, J.P. Tomas, S. Ruiz, and A. Megas Endothelial dysfunction, intima-media thickness and coronary reserve in relation to risk factors and Framingham score in patients without clinical atherosclerosis J Hypertens 24 2006 1581 1588
52. R. Cui, H. Iso, J. Pi, Y. Kumagai, K. Yamagishi, and T. Tanigawa Metabolic syndrome and urinary cGMP excretion in general population Atherosclerosis 190 2007 423 428
53. V.A. Gomes, A. Casella-Filho, A.C. Chagas, and J.E. Tanus-Santos Enhanced concentrations of relevant markers of nitric oxide formation after exercise training in patients with metabolic syndrome Nitric Oxide 19 2008 345 350
54. M. Olszanecka-Glinianowicz, B. Zahorska-Markiewicz, J. Janowska, and A. Zurakowski Serum concentrations of nitric oxide, tumor necrosis factor (TNF)-α and TNF soluble receptors in women with overweight and obesity Metabolism 53 2004 1268 1273
55. S. Zahedi Asl, A. Ghasemi, and F. Azizi Serum nitric oxide metabolites in subjects with metabolic syndrome Clin Biochem 41 2008 1342 1347