CYP450-Dependent biotransformation of the insecticide fipronil into fipronil sulfone can mediate fipronil-induced thyroid disruption in rats

Toxicological Sciences

Volumn 127, Issue 1, 2012, Pages 29-41

  Roques, Béatrice B ^a,b   Lacroix, Marlène Z ^a,b   Puel, Sylvie ^a,b   Gayrard, Véronique ^a,b   Picard Hagen, Nicole ^a,b   Jouanin, Isabelle ^a,b   Perdu, Elisabeth ^a,b   Martin, Pascal G ^a,b   Viguié, Catherine ^a,b  

^a CEMAGREF   (France)

^b TOXALIM RESEARCH CENTRE IN FOOD TOXICOLOGY   (France)

Author keywords

Clearance; Fipronil; Fipronil sulfone; Metabolism; Rat; Thyroid disruption

Indexed keywords

BIOLOGICAL MARKER; CYTOCHROME P450; CYTOCHROME P450 2B2; CYTOCHROME P450 3A1; FIPRONIL; FIPRONIL SULFONE; GLUCURONOSYLTRANSFERASE 1A1; INSECTICIDE; LIOTHYRONINE; LIOTRIX; MESSENGER RNA; PHENAZONE; SULFOTRANSFERASE; THYROXINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG TRANSFORMATION; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; GENE EXPRESSION; IMMUNOREACTIVITY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT; THYROID DISEASE; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 84860209046     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs094     Document Type: Article

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