Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: Is there a structure-activity relationship?

Chemico-Biological Interactions

Volumn 187, Issue 1-3, 2010, Pages 215-219

  Aurbek, Nadine ^a   Herkert, Nadja M ^a   Koller, Marianne ^a   Thiermann, Horst ^a   Worek, Franz ^a  

^a BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

Author keywords

AChE; Organophosphorus compounds; Oximes; Reactivation; Structure activity relationship

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ACETYLCHOLINESTERASE; ETHYL N DI N PROPYLPHOSPHORAMIDOCYANIDATE; ETHYL N DIETHYLPHOSPHOROFLUORIDATE; ETHYL N DIISOPROPYLPHOSPHOROFLUORIDATE; ETHYL N MONO N PROPYLPHOSPHOROFLUORIDATE; ETHYL N MONOETHYLPHOSPHOROFLUORIDATE; ETHYL N MONOMETHYLPHOSPHOROFLUORIDATE; ETHYLSARIN; ISOPENTYLSARIN; METHYLSARIN; N BUTYLSARIN; N PENTYLSARIN; N PROPYLSARIN; NEOPENTYLSARIN; OBIDOXIME; ORGANOPHOSPHATE; OXIME DERIVATIVE; SARIN; SECPENTYLSARIN; TABUN; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL INTERACTION; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; DEACETYLATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME REACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION;

EID: 77955515068     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.01.035     Document Type: Article

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