Determination and modelling of stereoselective interactions of ligands with drug transporters: A key dimension in the understanding of drug disposition

Xenobiotica

Volumn 38, Issue 7-8, 2008, Pages 656-675

  Bhatia, P ^a   Kolinski, M ^b   Moaddel, R ^a   Jozwiak, K ^c   Wainer, I W ^a,d  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Poland)

^c MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^d NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Cellular membrane affinity chromatography; Chirality; Enantioselectivity; Organic cation transporter; P glycoprotein; Pharmacophore modelling; Quantitative structure activity relationship (QSAR)

Indexed keywords

ATENOLOL; DISOPYRAMIDE; DOMPERIDONE; DOXORUBICIN; DRUG CARRIER; FELODIPINE; FENOTEROL; FEXOFENADINE; FLUPENTIXOL; GLYCOPROTEIN P; IMIPRAMINE; ISOPRENALINE; ISRADIPINE; KETOCONAZOLE; LABETALOL; LORATADINE; NICARDIPINE; NIGULDIPINE; NITRENDIPINE; ORGANIC CATION TRANSPORTER; PRAZOSIN; PROPRANOLOL; PSEUDOEPHEDRINE; QUINIDINE; QUININE; RITONAVIR; SMALL MOLECULE TRANSPORT AGENT; VERAPAMIL; VINBLASTINE;

AFFINITY CHROMATOGRAPHY; CELL MEMBRANE; CHIRALITY; DRUG DETERMINATION; DRUG DISPOSITION; HUMAN; PHARMACOPHORE; REVIEW; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; DRUG DESIGN; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; P-GLYCOPROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP; XENOBIOTICS;

EID: 48749114912     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250802109207     Document Type: Review

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