Biosynthetic pathway toward carbohydrate-like moieties of alnumycins contains unusual steps for C-C bond formation and cleavage

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 16, 2012, Pages 6024-6029

  Oja, Terhi ^a   Klika, Karel D ^a   Appassamy, Laura ^a   Sinkkonen, Jari ^a   Mäntsälä, Pekka ^a   Niemi, Jarmo ^a   Metsä Ketelä, Mikko ^a  

^a UNIVERSITY OF TURKU   (Finland)

Author keywords

Biosynthesis; Natural product; Ribose 5 phosphate; Streptomyces

Indexed keywords

1,3 DIOXOLANE; ALNA PROTEIN; ALNB PROTEIN; ALNUMYCIN B; ALNUMYCIN C; ALNUMYCIN D; BICYCLO[3.3.0]2',4',6' TRIOXAOCTAN 3' BETA OL; CARBOHYDRATE; CARBON 13; DIOXANE; GLYCOSIDASE; HALOACID; POLYKETIDE; PSEUDOURIDINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RIBOSE 5 PHOSPHATE; UNCLASSIFIED DRUG;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ARTICLE; BIOSYNTHESIS; CHEMICAL REACTION; CONTROLLED STUDY; DEPHOSPHORYLATION; ENZYME STRUCTURE; ENZYME SYNTHESIS; GENE INACTIVATION; MICHAEL ADDITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE;

BACTERIAL PROTEINS; BIOSYNTHETIC PATHWAYS; CARBOHYDRATES; CARBON; CARBON ISOTOPES; DIOXANES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLYCOSIDE HYDROLASES; HYDROGEN PEROXIDE; HYDROLASES; HYDROXYLATION; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; NAPHTHOQUINONES; OXYGEN; PSEUDOURIDINE; RIBOSE; RIBOSEMONOPHOSPHATES; STREPTOMYCES;

STREPTOMYCES;

EID: 84860012599     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1201530109     Document Type: Article

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