메뉴 건너뛰기




Volumn 19, Issue 3, 2012, Pages 170-180

New therapeutic targets in soft tissue sarcoma

Author keywords

molecular mechanisms; soft tissue sarcoma; targeted therapy

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 6 ACETYL 8 CYCLOPENTYL 5 METHYL 2 [5 (1 PIPERAZINYL) 2 PYRIDINYLAMINO] 8H PYRIDO[2,3 D]PYRIMIDIN 7 ONE; ANTINEOPLASTIC AGENT; AZD 8055; BEVACIZUMAB; BRIVANIB; CABOZANTINIB; CEDIRANIB; CRIZOTINIB; DEFEROLIMUS; DULAMNERMIN; FIGITUMUMAB; GANETESPIB; GSK 1059615; IMATINIB; ISPINESIB; MK 2206; N ACETYLSARCOSYLGLYCYLVALYL DEXTRO ALLOISOLEUCYLTHREONYLNORVALYLISOLEUCYLARGINYLPROLINE ETHYLAMIDE; OBLIMERSEN; PANOBINOSTAT; PAZOPANIB; R 1507; RAPAMYCIN; RETASPIMYCIN; RG 7112; SELUMETINIB; SUNITINIB; TEMSIROLIMUS; TIVANTINIB; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84860007065     PISSN: 10724109     EISSN: 15334031     Source Type: Journal    
DOI: 10.1097/PAP.0b013e318253462f     Document Type: Review
Times cited : (43)

References (160)
  • 1
    • 0142191283 scopus 로고    scopus 로고
    • Soft tissue tumours: Epidemiology clinical features histopathological typing and grading
    • Fletcher CDM Unni KK Mertens F eds. World Health Organization Classification of Tumours Lyon: IARC Press;
    • Fletcher CDM, Rydholm A, Singer S, et al. Soft tissue tumours: epidemiology, clinical features, histopathological typing and grading. In: Fletcher CDM, Unni KK, Mertens F, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press; 2002:9-18.
    • (2002) Pathology and Genetics of Tumours of Soft Tissue and Bone , pp. 9-18
    • Fletcher, C.D.M.1    Rydholm, A.2    Singer, S.3
  • 5
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • Siegel R, Ward E, Brawley O, et al. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin. 2011;61:212-236.
    • (2011) CA Cancer J. Clin. , vol.61 , pp. 212-236
    • Siegel, R.1    Ward, E.2    Brawley, O.3
  • 6
    • 13144272331 scopus 로고
    • US Pub. L No 97-414.
    • Orphan Drug Act. US Pub. L No 97-414. 1983.
    • (1983) Orphan Drug Act
  • 7
    • 32044463568 scopus 로고    scopus 로고
    • Adopting orphan drugs - Two dozen years of treating rare diseases
    • DOI 10.1056/NEJMp058317
    • Haffner ME. Adopting orphan drugs-two dozen years of treating rare diseases. N Engl J Med. 2006;354:445-447. (Pubitemid 43200295)
    • (2006) New England Journal of Medicine , vol.354 , Issue.5 , pp. 445-447
    • Haffner, M.E.1
  • 8
    • 34248204234 scopus 로고    scopus 로고
    • Uncommon tumors and exceptional therapies: Paradox or paradigm?
    • DOI 10.1158/1535-7163.MCT-06-0674
    • Braiteh F, Kurzrock R. Uncommon tumors and exceptional therapies: paradox or paradigm? Mol Cancer Ther. 2007;6: 1175-1179. (Pubitemid 46711980)
    • (2007) Molecular Cancer Therapeutics , vol.6 , Issue.4 , pp. 1175-1179
    • Braiteh, F.1    Kurzrock, R.2
  • 9
    • 80355142264 scopus 로고    scopus 로고
    • Clinicopathologic considerations: How can we fine tune our approach to sarcoma
    • Demicco EG, Lazar AJ. Clinicopathologic considerations: how can we fine tune our approach to sarcoma. Semin Oncol. 2011;38:S3-S18.
    • (2011) Semin. Oncol. , vol.38
    • Demicco, E.G.1    Lazar, A.J.2
  • 10
    • 79961076378 scopus 로고    scopus 로고
    • Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing
    • Ducimetiere F, Lurkin A, Ranchere-Vince D, et al. Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing. PLoS One. 2011;6:e20294.
    • (2011) PLoS One. , vol.6
    • Ducimetiere, F.1    Lurkin, A.2    Ranchere-Vince, D.3
  • 11
    • 0034125650 scopus 로고    scopus 로고
    • Recurrent chromosome aberrations in cancer
    • DOI 10.1016/S1383-5742(00)00006-5, PII S1383574200000065
    • Mitelman F. Recurrent chromosome aberrations in cancer. Mutat Res. 2000;462:247-253. (Pubitemid 30190232)
    • (2000) Mutation Research - Reviews in Mutation Research , vol.462 , Issue.2-3 , pp. 247-253
    • Mitelman, F.1
  • 12
    • 77950361837 scopus 로고    scopus 로고
    • Soft tissue sarcomas with non-EWS translocations: Molecular genetic features and pathologic and clinical correlations
    • Fisher C. Soft tissue sarcomas with non-EWS translocations: molecular genetic features and pathologic and clinical correlations. Virchows Arch. 2010;456:153-166.
    • (2010) Virchows Arch. , vol.456 , pp. 153-166
    • Fisher, C.1
  • 13
    • 77950365088 scopus 로고    scopus 로고
    • Soft tissue tumors associated with EWSR1 translocation
    • Romeo S, Dei Tos AP. Soft tissue tumors associated with EWSR1 translocation. Virchows Arch. 2010;456:219-234.
    • (2010) Virchows. Arch. , vol.456 , pp. 219-234
    • Romeo, S.1    Dei Tos, A.P.2
  • 15
    • 78249289103 scopus 로고    scopus 로고
    • Consistent MYC and FLT4 gene amplification in radiation-induced angiosarcoma but not in other radiation-associated atypical vascular lesions
    • Guo T, Zhang L, Chang NE, et al. Consistent MYC and FLT4 gene amplification in radiation-induced angiosarcoma but not in other radiation-associated atypical vascular lesions. Genes Chromosomes Cancer. 2011;50:25-33.
    • (2011) Genes. Chromosomes. Cancer , vol.50 , pp. 25-33
    • Guo, T.1    Zhang, L.2    Chang, N.E.3
  • 16
    • 0032417124 scopus 로고    scopus 로고
    • N-myc gene amplification in rhabdomyosarcoma detected by fluorescence in situ hybridization: Its correlation with histologic features
    • Hachitanda Y, Toyoshima S, Akazawa K, et al. N-myc gene amplification in rhabdomyosarcoma detected by fluorescence in situ hybridization: its correlation with histologic features. Mod Pathol. 1998;11:1222-1227. (Pubitemid 29009333)
    • (1998) Modern Pathology , vol.11 , Issue.12 , pp. 1222-1227
    • Hachitanda, Y.1    Toyoshima, S.2    Akazawa, K.3    Tsuneyoshi, M.4
  • 17
    • 0031398432 scopus 로고    scopus 로고
    • Amplification of the MYC gene in osteosarcoma secondary to Paget's disease of bone
    • DOI 10.1080/13577149778209
    • Ueda T, Healey JH, Huvos AG, et al. Amplification of the MYC gene in osteosarcoma secondary to Paget's disease of bone. Sarcoma. 1997;1:131-134. (Pubitemid 28267180)
    • (1997) Sarcoma , vol.1 , Issue.3-4 , pp. 131-134
    • Ueda, T.1    Healey, J.H.2    Huvos, A.G.3    Ladanyi, M.4
  • 18
    • 0028147592 scopus 로고
    • Amplification of the c-myc proto-oncogene in soft tissue sarcomas
    • Barrios C, Castresana JS, Ruiz J, et al. Amplification of the cmyc proto-oncogene in soft tissue sarcomas. Oncology. 1994;51:13-17. (Pubitemid 24008633)
    • (1994) Oncology , vol.51 , Issue.1 , pp. 13-17
    • Barrios, C.1    Castresana, J.S.2    Ruiz, J.3    Kreicbergs, A.4
  • 19
    • 77749279644 scopus 로고    scopus 로고
    • Myc proteins as therapeutic targets
    • Gustafson WC, Weiss WA. Myc proteins as therapeutic targets. Oncogene. 2010;29:1249-1259.
    • (2010) Oncogene , vol.29 , pp. 1249-1259
    • Gustafson, W.C.1    Weiss, W.A.2
  • 20
    • 0033551374 scopus 로고    scopus 로고
    • MYC oncogenes and human neoplastic disease
    • DOI 10.1038/sj.onc.1202746
    • Nesbit CE, Tersak JM, Prochownik EV. MYC oncogenes and human neoplastic disease. Oncogene. 1999;18:3004-3016. (Pubitemid 29276540)
    • (1999) Oncogene , vol.18 , Issue.19 , pp. 3004-3016
    • Nesbit, C.E.1    Tersak, J.M.2    Prochownik, E.V.3
  • 21
    • 0032731758 scopus 로고    scopus 로고
    • Detection of COL1A1-PDGFB fusion transcripts in dermatofibrosarcoma protuberans by reverse transcription-polymerase chain reaction using archival formalin-fixed, paraffin-embedded tissues
    • DOI 10.1097/00019606-199909000-00002
    • Wang J, Hisaoka M, Shimajiri S, et al. Detection of COL1A1- PDGFB fusion transcripts in dermatofibrosarcoma protuberans by reverse transcription- polymerase chain reaction using archival formalin-fixed, paraffin-embedded tissues. Diagn Mol Pathol. 1999;8:113-119. (Pubitemid 29521901)
    • (1999) Diagnostic Molecular Pathology , vol.8 , Issue.3 , pp. 113-119
    • Wang, J.1    Hisaoka, M.2    Shimajiri, S.3    Morimitsu, Y.4    Hashimoto, H.5
  • 22
    • 79751475654 scopus 로고    scopus 로고
    • Treatment of advanced dermatofibrosarcoma protuberans with imatinib mesylate with or without surgical resection
    • Rutkowski P, Debiec-Rychter M, Nowecki Z, et al. Treatment of advanced dermatofibrosarcoma protuberans with imatinib mesylate with or without surgical resection. J Eur Acad Dermatol Venereol. 2011;25:264-270.
    • (2011) J. Eur. Acad. Dermatol. Venereol. , vol.25 , pp. 264-270
    • Rutkowski, P.1    Debiec-Rychter, M.2    Nowecki, Z.3
  • 23
  • 24
    • 0034989396 scopus 로고    scopus 로고
    • ALK1 and p80 expression and chromosomal rearrangements involving 2p23 in inflammatory myofibroblastic tumor
    • DOI 10.1038/modpathol.3880352
    • Coffin CM, Patel A, Perkins S, et al. ALK1 and p80 expression and chromosomal rearrangements involving 2p23 in inflammatory myofibroblastic tumor. Mod Pathol. 2001;14: 569-576. (Pubitemid 32554081)
    • (2001) Modern Pathology , vol.14 , Issue.6 , pp. 569-576
    • Coffin, C.M.1    Patel, A.2    Perkins, S.3    Elenitoba-Johnson, K.S.J.4    Perlman, E.5    Griffin, C.A.6
  • 26
    • 78049428879 scopus 로고    scopus 로고
    • Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor
    • Butrynski JE, D'Adamo DR, Hornick JL, et al. Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor. N Engl J Med. 2010;363:1727-1733.
    • (2010) N. Engl. J. Med. , vol.363 , pp. 1727-1733
    • Butrynski, J.E.1    D'Adamo, D.R.2    Hornick, J.L.3
  • 29
    • 79958807634 scopus 로고    scopus 로고
    • Treatment of tenosynovial giant cell tumor and pigmented villonodular synovitis
    • Ravi V, Wang WL, Lewis VO. Treatment of tenosynovial giant cell tumor and pigmented villonodular synovitis. Curr Opin Oncol. 2011;23:361-366.
    • (2011) Curr. Opin. Oncol. , vol.23 , pp. 361-366
    • Ravi, V.1    Wang, W.L.2    Lewis, V.O.3
  • 30
    • 0030882823 scopus 로고    scopus 로고
    • Oncogenic transformation and inhibition of adipocytic conversion of preadipocytes by TLS/FUS-CHOP type II chimeric protein
    • Kuroda M, Ishida T, Takanashi M, et al. Oncogenic transformation and inhibition of adipocytic conversion of preadipocytes by TLS/FUS-CHOP type II chimeric protein. Am J Pathol. 1997;151:735-744. (Pubitemid 27385605)
    • (1997) American Journal of Pathology , vol.151 , Issue.3 , pp. 735-744
    • Kuroda, M.1    Ishida, T.2    Takanashi, M.3    Satoh, M.4    Machinami, R.5    Watanabe, T.6
  • 31
    • 74549213797 scopus 로고    scopus 로고
    • DDIT3/CHOP and the sarcoma fusion oncoprotein FUS-DDIT3/TLS-CHOP bind cyclin-dependent kinase 2
    • Bento C, Andersson MK, Aman P. DDIT3/CHOP and the sarcoma fusion oncoprotein FUS-DDIT3/TLS-CHOP bind cyclin-dependent kinase 2. BMC Cell Biol. 2009;10:89.
    • (2009) BMC Cell Biol. , vol.10 , pp. 89
    • Bento, C.1    Andersson, M.K.2    Aman, P.3
  • 32
    • 60849129809 scopus 로고    scopus 로고
    • Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors
    • Forni C, Minuzzo M, Virdis E, et al. Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors. Mol Cancer Ther. 2009;8:449-457.
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 449-457
    • Forni, C.1    Minuzzo, M.2    Virdis, E.3
  • 33
    • 69449106265 scopus 로고    scopus 로고
    • Trabectedin in myxoid liposarcomas (MLS): A long-term analysis of a singleinstitution series
    • Grosso F, Sanfilippo R, Virdis E, et al. Trabectedin in myxoid liposarcomas (MLS): a long-term analysis of a singleinstitution series. Ann Oncol. 2009;20:1439-1444.
    • (2009) Ann. Oncol. , vol.20 , pp. 1439-1444
    • Grosso, F.1    Sanfilippo, R.2    Virdis, E.3
  • 34
    • 0030695913 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts
    • DOI 10.1074/jbc.272.49.30822
    • Toretsky JA, Kalebic T, Blakesley V, et al. The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts. J Biol Chem. 1997;272:30822-30827. (Pubitemid 27527522)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.49 , pp. 30822-30827
    • Toretsky, J.A.1    Kalebic, T.2    Blakesley, V.3    LeRoith, D.4    Helman, L.J.5
  • 35
    • 0025461112 scopus 로고
    • Insulin-like growth factor II acts as an autocrine growth and motility factor in human rhabdomyosarcoma tumors
    • El-Badry OM, Minniti C, Kohn EC, et al. Insulin-like growth factor II acts as an autocrine growth and motility factor in human rhabdomyosarcoma tumors. Cell Growth Differ. 1990;1:325-331.
    • (1990) Cell Growth Differ. , vol.1 , pp. 325-331
    • El-Badry, O.M.1    Minniti, C.2    Kohn, E.C.3
  • 36
    • 0025632981 scopus 로고
    • Insulin-like growth factor I expression by tumors of neuroectodermal origin with the t(11;22) chromosomal translocation. A potential autocrine growth factor
    • Yee D, Favoni RE, Lebovic GS, et al. Insulin-like growth factor I expression by tumors of neuroectodermal origin with the t(11;22) chromosomal translocation. A potential autocrine growth factor. J Clin Invest. 1990;86:1806-1814.
    • (1990) J. Clin. Invest. , vol.86 , pp. 1806-1814
    • Yee, D.1    Favoni, R.E.2    Lebovic, G.S.3
  • 37
    • 3543026281 scopus 로고    scopus 로고
    • EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3
    • DOI 10.1128/MCB.24.16.7275-7283.2004
    • Prieur A, Tirode F, Cohen P, et al. EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Mol Cell Biol. 2004;24: 7275-7283. (Pubitemid 39014452)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.16 , pp. 7275-7283
    • Prieur, A.1    Tirode, F.2    Cohen, P.3    Delattre, O.4
  • 38
    • 0035242001 scopus 로고    scopus 로고
    • PDGC-C is an EWS/FLI induced transforming growth factor in Ewing family tumors
    • DOI 10.1038/sj.onc.1204133
    • Zwerner JP, May WA. PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors. Oncogene. 2001;20:626-633. (Pubitemid 32156187)
    • (2001) Oncogene , vol.20 , Issue.5 , pp. 626-633
    • Zwerner, J.P.1    May, W.A.2
  • 39
    • 0035728324 scopus 로고    scopus 로고
    • Transcriptional regulation of IGF-I receptor gene expression by the PAX3-FKHR oncoprotein
    • DOI 10.1054/ghir.2001.0244
    • Ayalon D, Glaser T, Werner H. Transcriptional regulation of IGF-I receptor gene expression by the PAX3-FKHR oncoprotein. Growth Horm IGF Res. 2001;11:289-297. (Pubitemid 34257726)
    • (2001) Growth Hormone and IGF Research , vol.11 , Issue.5 , pp. 289-297
    • Ayalon, D.1    Glaser, T.2    Werner, H.3
  • 40
    • 0032529257 scopus 로고    scopus 로고
    • Up-regulation of MET but not neural cell adhesion molecule expression by the PAX3-FKHR fusion protein in alveolar rhabdomyosarcoma
    • Ginsberg JP, Davis RJ, Bennicelli JL, et al. Up-regulation of MET but not neural cell adhesion molecule expression by the PAX3-FKHR fusion protein in alveolar rhabdomyosarcoma. Cancer Res. 1998;58:3542-3546. (Pubitemid 28376547)
    • (1998) Cancer Research , vol.58 , Issue.16 , pp. 3542-3546
    • Ginsberg, J.P.1    Davis, R.J.2    Bennicelli, J.L.3    Nauta, L.E.4    Barr, F.G.5
  • 41
    • 43049183354 scopus 로고    scopus 로고
    • Identification of PAX3-FKHR-regulated genes differentially expressed between alveolar and embryonal rhabdomyosarcoma: Focus on MYCN as a biologically relevant target
    • DOI 10.1002/gcc.20554
    • Mercado GE, Xia SJ, Zhang C, et al. Identification of PAX3- FKHR-regulated genes differentially expressed between alveolar and embryonal rhabdomyosarcoma: focus on MYCN as a biologically relevant target. Genes Chromosomes Cancer. 2008;47:510-520. (Pubitemid 351657186)
    • (2008) Genes Chromosomes and Cancer , vol.47 , Issue.6 , pp. 510-520
    • Mercado, G.E.1    Xia, S.J.2    Zhang, C.3    Ahn, E.H.4    Gustafson, D.M.5    Lae, M.6    Ladanyi, M.7    Barr, F.G.8
  • 42
    • 70849112399 scopus 로고    scopus 로고
    • Validation of potential therapeutic targets in alveolar soft part sarcoma: An immunohistochemical study utilizing tissue microarray
    • Lazar AJ, Lahat G, Myers SE, et al. Validation of potential therapeutic targets in alveolar soft part sarcoma: an immunohistochemical study utilizing tissue microarray. Histopathology. 2009;55:750-755.
    • (2009) Histopathology , vol.55 , pp. 750-755
    • Lazar, A.J.1    Lahat, G.2    Myers, S.E.3
  • 43
    • 33847066415 scopus 로고    scopus 로고
    • TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition
    • Tsuda M, Davis IJ, Argani P, et al. TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition. Cancer Res. 2007;67:919-929.
    • (2007) Cancer Res. , vol.67 , pp. 919-929
    • Tsuda, M.1    Davis, I.J.2    Argani, P.3
  • 44
    • 76549109409 scopus 로고    scopus 로고
    • Identification of the receptor tyrosine kinase c-Met and its ligand, hepatocyte growth factor, as therapeutic targets in clear cell sarcoma
    • Davis IJ, McFadden AW, Zhang Y, et al. Identification of the receptor tyrosine kinase c-Met and its ligand, hepatocyte growth factor, as therapeutic targets in clear cell sarcoma. Cancer Res. 2010;70:639-645.
    • (2010) Cancer Res. , vol.70 , pp. 639-645
    • Davis, I.J.1    McFadden, A.W.2    Zhang, Y.3
  • 45
    • 77950974697 scopus 로고    scopus 로고
    • A phase I study of weekly R1507, a human monoclonal antibody insulin-like growth factor-I receptor antagonist, in patients with advanced solid tumors
    • Kurzrock R, Patnaik A, Aisner J, et al. A phase I study of weekly R1507, a human monoclonal antibody insulin-like growth factor-I receptor antagonist, in patients with advanced solid tumors. Clin Cancer Res. 2010;16:2458-2465.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 2458-2465
    • Kurzrock, R.1    Patnaik, A.2    Aisner, J.3
  • 46
    • 73349099049 scopus 로고    scopus 로고
    • Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1
    • Tolcher AW, Sarantopoulos J, Patnaik A, et al. Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1. J Clin Oncol. 2009;27:5800-5807.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 5800-5807
    • Tolcher, A.W.1    Sarantopoulos, J.2    Patnaik, A.3
  • 47
    • 75249097799 scopus 로고    scopus 로고
    • Safety,pharmacokinetics, and preliminary activity of the anti-IGF- 1R antibody figitumumab (CP-751, 871) in patients with sarcoma and Ewing's sarcoma: A phase 1 expansion cohort study
    • Olmos D, Postel-Vinay S, Molife LR, et al. Safety, pharmacokinetics, and preliminary activity of the anti-IGF- 1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study. Lancet Oncol. 2010;11:129-135.
    • (2010) Lancet Oncol. , vol.11 , pp. 129-135
    • Olmos, D.1    Postel-Vinay, S.2    Molife, L.R.3
  • 54
    • 77951644822 scopus 로고    scopus 로고
    • Current treatment protocols have eliminated the prognostic advantage of type 1 fusions in Ewing sarcoma: A report from the children's oncology group
    • van Doorninck JA, Ji L, Schaub B, et al. Current treatment protocols have eliminated the prognostic advantage of type 1 fusions in Ewing sarcoma: a report from the Children's Oncology Group. J Clin Oncol. 2010;28:1989-1994.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 1989-1994
    • Van Doorninck, J.A.1    Ji, L.2    Schaub, B.3
  • 57
    • 79958841531 scopus 로고    scopus 로고
    • Prognostic value of PAX-FKHR fusion status in alveolar rhabdomyosarcoma: A report from the cooperative soft tissue sarcoma study group (CWS
    • Stegmaier S, Poremba C, Schaefer KL, et al. Prognostic value of PAX-FKHR fusion status in alveolar rhabdomyosarcoma: a report from the cooperative soft tissue sarcoma study group (CWS). Pediatr Blood Cancer. 2011;57:406-414.
    • (2011) Pediatr Blood Cancer , vol.57 , pp. 406-414
    • Stegmaier, S.1    Poremba, C.2    Schaefer, K.L.3
  • 60
    • 77953231024 scopus 로고    scopus 로고
    • Molecular mechanisms of secondary imatinib resistance in patients with gastrointestinal stromal tumors
    • Wang CM, Huang K, Zhou Y, et al. Molecular mechanisms of secondary imatinib resistance in patients with gastrointestinal stromal tumors. J Cancer Res Clin Oncol. 2010;136: 1065-1071.
    • (2010) J. Cancer Res. Clin. Oncol. , vol.136 , pp. 1065-1071
    • Wang, C.M.1    Huang, K.2    Zhou, Y.3
  • 63
    • 77950354811 scopus 로고    scopus 로고
    • Soft tissue sarcomas with complex genomic profiles
    • Guillou L, Aurias A. Soft tissue sarcomas with complex genomic profiles. Virchows Arch. 2010;456:201-217.
    • (2010) Virchows Arch. , vol.456 , pp. 201-217
    • Guillou, L.1    Aurias, A.2
  • 64
    • 77953161582 scopus 로고    scopus 로고
    • Telomere loss as a mechanism for chromosome instability in human cancer
    • Murnane JP. Telomere loss as a mechanism for chromosome instability in human cancer. Cancer Res. 2010;70:4255-4259.
    • (2010) Cancer Res. , vol.70 , pp. 4255-4259
    • Murnane, J.P.1
  • 65
    • 78650959663 scopus 로고    scopus 로고
    • Massive genomic rearrangement acquired in a single catastrophic event during cancer development
    • Stephens PJ, Greenman CD, Fu B, et al. Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell. 2011;144:27-40.
    • (2011) Cell , vol.144 , pp. 27-40
    • Stephens, P.J.1    Greenman, C.D.2    Fu, B.3
  • 66
    • 71949126268 scopus 로고    scopus 로고
    • Telomeres and telomerase in sarcomas
    • Matsuo T, Shimose S, Kubo T, et al. Telomeres and telomerase in sarcomas. Anticancer Res. 2009;29:3833-3836.
    • (2009) Anticancer Res. , vol.29 , pp. 3833-3836
    • Matsuo, T.1    Shimose, S.2    Kubo, T.3
  • 67
    • 77952991499 scopus 로고    scopus 로고
    • Prognostic relevance of ALT-associated markers in liposarcoma: A comparative analysis
    • Venturini L, Motta R, Gronchi A, et al. Prognostic relevance of ALT-associated markers in liposarcoma: a comparative analysis. BMC Cancer. 2010;10:254.
    • (2010) BMC Cancer , vol.10 , pp. 254
    • Venturini, L.1    Motta, R.2    Gronchi, A.3
  • 68
    • 70350692066 scopus 로고    scopus 로고
    • A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT
    • Lafferty-Whyte K, Cairney CJ, Will MB, et al. A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT. Oncogene. 2009;28:3765-3774.
    • (2009) Oncogene , vol.28 , pp. 3765-3774
    • Lafferty-Whyte, K.1    Cairney, C.J.2    Will, M.B.3
  • 69
    • 79953326730 scopus 로고    scopus 로고
    • Preclinical evaluation of telomerase-specific oncolytic virotherapy for human bone and soft tissue sarcomas
    • Sasaki T, Tazawa H, Hasei J, et al. Preclinical evaluation of telomerase-specific oncolytic virotherapy for human bone and soft tissue sarcomas. Clin Cancer Res. 2011;17:1828-1838.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 1828-1838
    • Sasaki, T.1    Tazawa, H.2    Hasei, J.3
  • 70
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100:57-70. (Pubitemid 30046295)
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 71
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 72
    • 30344477367 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
    • DOI 10.1038/nrc1779
    • Minucci S, Pelicci PG. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer. 2006;6:38-51. (Pubitemid 43054973)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.1 , pp. 38-51
    • Minucci, S.1    Pelicci, P.G.2
  • 73
    • 79953659370 scopus 로고    scopus 로고
    • Autophagy blockade enhances HDAC inhibitors' pro-apoptotic effects: Potential implications for the treatment of a therapeutic-resistant malignancy
    • Lopez G, Torres K, Lev D. Autophagy blockade enhances HDAC inhibitors' pro-apoptotic effects: potential implications for the treatment of a therapeutic-resistant malignancy. Autophagy. 2011;7:440-441.
    • (2011) Autophagy , vol.7 , pp. 440-441
    • Lopez, G.1    Torres, K.2    Lev, D.3
  • 74
    • 78651390321 scopus 로고    scopus 로고
    • Autophagic survival in resistance to histone deacetylase inhibitors: Novel strategies to treat malignant peripheral nerve sheath tumors
    • Lopez G, Torres K, Liu J, et al. Autophagic survival in resistance to histone deacetylase inhibitors: novel strategies to treat malignant peripheral nerve sheath tumors. Cancer Res. 2011;71:185-196.
    • (2011) Cancer Res. , vol.71 , pp. 185-196
    • Lopez, G.1    Torres, K.2    Liu, J.3
  • 76
    • 19444376494 scopus 로고    scopus 로고
    • Significant growth suppression of synovial sarcomas by the histone deacetylase inhibitor FK228 in vitro and in vivo
    • DOI 10.1016/j.canlet.2004.10.030, PII S0304383504008122
    • Ito T, Ouchida M, Morimoto Y, et al. Significant growth suppression of synovial sarcomas by the histone deacetylase inhibitor FK228 in vitro and in vivo. Cancer Lett. 2005;224: 311-319. (Pubitemid 40725851)
    • (2005) Cancer Letters , vol.224 , Issue.2 , pp. 311-319
    • Ito, T.1    Ouchida, M.2    Morimoto, Y.3    Yoshida, A.4    Jitsumori, Y.5    Ozaki, T.6    Sonobe, H.7    Inoue, H.8    Shimizu, K.9
  • 77
    • 79951904594 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor vorinostat selectively sensitizes fibrosarcoma cells to chemotherapy
    • Sampson ER, Amin V, Schwarz EM, et al. The histone deacetylase inhibitor vorinostat selectively sensitizes fibrosarcoma cells to chemotherapy. J Orthop Res. 2011;29: 623-632.
    • (2011) J. Orthop. Res. , vol.29 , pp. 623-632
    • Sampson, E.R.1    Amin, V.2    Schwarz, E.M.3
  • 78
    • 70149091271 scopus 로고    scopus 로고
    • Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors
    • Muhlenberg T, Zhang Y, Wagner AJ, et al. Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors. Cancer Res. 2009;69:6941-6950.
    • (2009) Cancer Res. , vol.69 , pp. 6941-6950
    • Muhlenberg, T.1    Zhang, Y.2    Wagner, A.J.3
  • 79
    • 77951237809 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo
    • Hrzenjak A, Moinfar F, Kremser ML, et al. Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo. Mol Cancer. 2010;9:49.
    • (2010) Mol. Cancer , vol.9 , pp. 49
    • Hrzenjak, A.1    Moinfar, F.2    Kremser, M.L.3
  • 80
    • 84856807056 scopus 로고    scopus 로고
    • Frequent alterations and epigenetic silencing of differentiation pathway genes in structurally rearranged liposarcomas
    • Taylor BS, DeCarolis PL, Angeles CV, et al. Frequent alterations and epigenetic silencing of differentiation pathway genes in structurally rearranged liposarcomas. Cancer Discovery. 2011;1:587-597.
    • (2011) Cancer Discovery , vol.1 , pp. 587-597
    • Taylor, B.S.1    DeCarolis, P.L.2    Angeles, C.V.3
  • 82
    • 33845743957 scopus 로고    scopus 로고
    • Aurora kinases: New targets for cancer therapy
    • DOI 10.1158/1078-0432.CCR-06-1405
    • Carvajal RD, Tse A, Schwartz GK. Aurora kinases: new targets for cancer therapy. Clin Cancer Res. 2006;12:6869-6875. (Pubitemid 44974478)
    • (2006) Clinical Cancer Research , vol.12 , Issue.23 , pp. 6869-6875
    • Carvajal, R.D.1    Tse, A.2    Schwartz, G.K.3
  • 83
    • 57749101153 scopus 로고    scopus 로고
    • EWS-Fli1 upregulates expression of the Aurora A and aurora b kinases
    • Wakahara K, Ohno T, Kimura M, et al. EWS-Fli1 upregulates expression of the Aurora A and Aurora B kinases. Mol Cancer Res. 2008;6:1937-1945.
    • (2008) Mol. Cancer Res. , vol.6 , pp. 1937-1945
    • Wakahara, K.1    Ohno, T.2    Kimura, M.3
  • 84
    • 80054000380 scopus 로고    scopus 로고
    • An integrated chemical biology approach identifies specific vulnerability of Ewing's sarcoma to combined inhibition of Aurora kinases A and B
    • Winter GE, Rix U, Lissat A, et al. An integrated chemical biology approach identifies specific vulnerability of Ewing's sarcoma to combined inhibition of Aurora kinases A and B. Mol Cancer Ther. 2011;10:1846-1856.
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 1846-1856
    • Winter, G.E.1    Rix, U.2    Lissat, A.3
  • 85
    • 82455192242 scopus 로고    scopus 로고
    • Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer
    • Carol H, Boehm I, Reynolds CP, et al. Efficacy and pharmacokinetic/ pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer. Cancer Chemother Pharmacol. 2011;68: 1291-1304.
    • (2011) Cancer Chemother. Pharmacol. , vol.68 , pp. 1291-1304
    • Carol, H.1    Boehm, I.2    Reynolds, C.P.3
  • 86
    • 78449300379 scopus 로고    scopus 로고
    • The role of kinesin family proteins in tumorigenesis and progression: Potential biomarkers and molecular targets for cancer therapy
    • Yu Y, Feng YM. The role of kinesin family proteins in tumorigenesis and progression: potential biomarkers and molecular targets for cancer therapy. Cancer. 2010;116: 5150-5160.
    • (2010) Cancer , vol.116 , pp. 5150-5160
    • Yu, Y.1    Feng, Y.M.2
  • 87
    • 70449728074 scopus 로고    scopus 로고
    • Initial testing (stage 1) of the kinesin spindle protein inhibitor ispinesib by the pediatric preclinical testing program
    • Carol H, Lock R, Houghton PJ, et al. Initial testing (stage 1) of the kinesin spindle protein inhibitor ispinesib by the pediatric preclinical testing program. Pediatr Blood Cancer. 2009;53:1255-1263.
    • (2009) Pediatr. Blood Cancer , vol.53 , pp. 1255-1263
    • Carol, H.1    Lock, R.2    Houghton, P.J.3
  • 88
    • 78049278014 scopus 로고    scopus 로고
    • A pediatric phase I trial and pharmacokinetic study of ispinesib: A children's oncology group phase i consortium study
    • Souid AK, Dubowy RL, Ingle AM, et al. A pediatric phase I trial and pharmacokinetic study of ispinesib: a Children's Oncology Group phase I consortium study. Pediatr Blood Cancer. 2010;55:1323-1328.
    • (2010) Pediatr. Blood Cancer , vol.55 , pp. 1323-1328
    • Souid, A.K.1    Dubowy, R.L.2    Ingle, A.M.3
  • 89
    • 77950352242 scopus 로고    scopus 로고
    • Soft tissue sarcomas: Introduction to the Virchows Archiv review issue
    • Guillou L, Hogendoorn PC, Bosman FT. Soft tissue sarcomas: introduction to the Virchows Archiv review issue. Virchows Arch. 2010;456:107-109.
    • (2010) Virchows Arch. , vol.456 , pp. 107-109
    • Guillou, L.1    Hogendoorn, P.C.2    Bosman, F.T.3
  • 90
    • 77952087785 scopus 로고    scopus 로고
    • Characterization of the 12q15 mdm2 and 12q13-14 cdk4 amplicons and clinical correlations in osteosarcoma
    • Mejia-Guerrero S, Quejada M, Gokgoz N, et al. Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma. Genes Chromosomes Cancer. 2010;49:518-525.
    • (2010) Genes. Chromosomes Cancer , vol.49 , pp. 518-525
    • Mejia-Guerrero, S.1    Quejada, M.2    Gokgoz, N.3
  • 91
    • 70450196419 scopus 로고    scopus 로고
    • Targeting sarcomas: Novel biological agents and future perspectives
    • Mahalingam D, Mita A, Sankhala K, et al. Targeting sarcomas: novel biological agents and future perspectives. Curr Drug Targets. 2009;10:937-949.
    • (2009) Curr. Drug Targets. , vol.10 , pp. 937-949
    • Mahalingam, D.1    Mita, A.2    Sankhala, K.3
  • 92
    • 0033590604 scopus 로고    scopus 로고
    • Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas
    • DOI 10.1038/sj.onc.1202346
    • Wunder JS, Eppert K, Burrow SR, et al. Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas. Oncogene. 1999;18:783-788. (Pubitemid 29080336)
    • (1999) Oncogene , vol.18 , Issue.3 , pp. 783-788
    • Wunder, J.S.1    Eppert, K.2    Burrow, S.R.3    Gogkoz, N.4    Bell, R.S.5    Andrulis, I.L.6
  • 93
    • 34250020728 scopus 로고    scopus 로고
    • Treatment of patients with advanced soft tissue sarcoma: Disappointment or challenge?
    • DOI 10.1097/CCO.0b013e32812143ef, PII 0000162220070700000009
    • Kasper B, Gil T, Awada A. Treatment of patients with advanced soft tissue sarcoma: disappointment or challenge? Curr Opin Oncol. 2007;19:336-340. (Pubitemid 46883522)
    • (2007) Current Opinion in Oncology , vol.19 , Issue.4 , pp. 336-340
    • Kasper, B.1    Gil, T.2    Awada, A.3
  • 94
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science. 1998;281:1305-1308. (Pubitemid 28406815)
    • (1998) Science , vol.281 , Issue.5381 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 95
    • 77956792568 scopus 로고    scopus 로고
    • Platelet-derived growth factor receptor beta inhibition increases tumor necrosis factorrelated apoptosis-inducing ligand (TRAIL) sensitivity: Imatinib and TRAIL dual therapy
    • Wang Y, Mandal D, Wang S, et al. Platelet-derived growth factor receptor beta inhibition increases tumor necrosis factorrelated apoptosis-inducing ligand (TRAIL) sensitivity: imatinib and TRAIL dual therapy. Cancer. 2010;116:3892-3902.
    • (2010) Cancer , vol.116 , pp. 3892-3902
    • Wang, Y.1    Mandal, D.2    Wang, S.3
  • 96
    • 77956414973 scopus 로고    scopus 로고
    • Phase I doseescalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancer
    • Herbst RS, Eckhardt SG, Kurzrock R, et al. Phase I doseescalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancer. J Clin Oncol. 2010;28:2839-2846.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 2839-2846
    • Herbst, R.S.1    Eckhardt, S.G.2    Kurzrock, R.3
  • 97
    • 27644466759 scopus 로고    scopus 로고
    • Autophagy and signaling: Their role in cell survival and cell death
    • DOI 10.1038/sj.cdd.4401751, PII 4401751
    • Codogno P, Meijer AJ. Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ. 2005; 12(suppl 2):1509-1518. (Pubitemid 41553987)
    • (2005) Cell Death and Differentiation , vol.12 , Issue.SUPPL. 2 , pp. 1509-1518
    • Codogno, P.1    Meijer, A.J.2
  • 98
    • 77956282607 scopus 로고    scopus 로고
    • Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST
    • Gupta A, Roy S, Lazar AJ, et al. Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST). Proc Natl Acad Sci USA. 2010;107:14333-14338.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 14333-14338
    • Gupta, A.1    Roy, S.2    Lazar, A.J.3
  • 99
    • 33751203833 scopus 로고    scopus 로고
    • Heat shock proteins 27 and 70: Anti-apoptotic proteins with tumorigenic properties
    • Garrido C, Brunet M, Didelot C, et al. Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties. Cell Cycle. 2006;5:2592-2601. (Pubitemid 44785803)
    • (2006) Cell Cycle , vol.5 , Issue.22 , pp. 2592-2601
    • Garrido, C.1    Brunet, M.2    Didelot, C.3    Zermati, Y.4    Schmitt, E.5    Kroemer, G.6
  • 100
    • 33749461709 scopus 로고    scopus 로고
    • Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor
    • DOI 10.1158/0008-5472.CAN-06-0165
    • Bauer S, Yu LK, Demetri GD, et al. Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor. Cancer Res. 2006;66:9153-9161. (Pubitemid 44521135)
    • (2006) Cancer Research , vol.66 , Issue.18 , pp. 9153-9161
    • Bauer, S.1    Yu, L.K.2    Demetri, G.D.3    Fletcher, J.A.4
  • 101
    • 79958788978 scopus 로고    scopus 로고
    • Treatment of gastrointestinal stromal tumor after imatinib and sunitinib
    • Montemurro M, Bauer S. Treatment of gastrointestinal stromal tumor after imatinib and sunitinib. Curr Opin Oncol. 2011;23:367-372.
    • (2011) Curr. Opin. Oncol. , vol.23 , pp. 367-372
    • Montemurro, M.1    Bauer, S.2
  • 102
    • 77953915105 scopus 로고    scopus 로고
    • Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma/solitary fibrous tumor
    • Park MS, Ravi V, Araujo DM. Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma/solitary fibrous tumor. Curr Opin Oncol. 2010;22:351-355.
    • (2010) Curr. Opin. Oncol. , vol.22 , pp. 351-355
    • Park, M.S.1    Ravi, V.2    Araujo, D.M.3
  • 103
    • 60749109846 scopus 로고    scopus 로고
    • Cell cycle CDKs and cancer: A changing paradigm
    • Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer. 2009;9:153-166.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 153-166
    • Malumbres, M.1    Barbacid, M.2
  • 104
    • 77955090106 scopus 로고    scopus 로고
    • Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy
    • Barretina J, Taylor BS, Banerji S, et al. Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nat Genet. 2010;42:715-721.
    • (2010) Nat. Genet. , vol.42 , pp. 715-721
    • Barretina, J.1    Taylor, B.S.2    Banerji, S.3
  • 105
    • 84856543023 scopus 로고    scopus 로고
    • Involvement of the PI3K/Akt pathway in myxoid/round cell liposarcoma
    • Demicco EG, Torres KE, Ghadimi MP, et al. Involvement of the PI3K/Akt pathway in myxoid/round cell liposarcoma. Mod Pathol. 2012;25:212-221.
    • (2012) Mod. Pathol. , vol.25 , pp. 212-221
    • Demicco, E.G.1    Torres, K.E.2    Ghadimi, M.P.3
  • 108
    • 77950516284 scopus 로고    scopus 로고
    • Epithelioid sarcoma expresses epidermal growth factor receptor but gene amplification and kinase domain mutations are rare
    • Cascio MJ, O'Donnell RJ, Horvai AE. Epithelioid sarcoma expresses epidermal growth factor receptor but gene amplification and kinase domain mutations are rare. Mod Pathol. 2010;23:574-580.
    • (2010) Mod. Pathol. , vol.23 , pp. 574-580
    • Cascio, M.J.1    O'Donnell, R.J.2    Horvai, A.E.3
  • 109
    • 80052833534 scopus 로고    scopus 로고
    • Combining EGFR and mTOR blockade for the treatment of epithelioid sarcoma
    • Xie X, Ghadimi MP, Young ED, et al. Combining EGFR and mTOR blockade for the treatment of epithelioid sarcoma. Clin Cancer Res. 2011;17:5901-5912.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 5901-5912
    • Xie, X.1    Ghadimi, M.P.2    Young, E.D.3
  • 110
    • 62849105383 scopus 로고    scopus 로고
    • The insulin-like growth factor system and sarcomas
    • Rikhof B, de Jong S, Suurmeijer AJ, et al. The insulin-like growth factor system and sarcomas. J Pathol. 2009;217: 469-482.
    • (2009) J. Pathol. , vol.217 , pp. 469-482
    • Rikhof, B.1    De Jong, S.2    Suurmeijer, A.J.3
  • 111
    • 79958820840 scopus 로고    scopus 로고
    • Phase 1 clinical trials for sarcomas: The cutting edge
    • Subbiah V, Kurzrock R. Phase 1 clinical trials for sarcomas: the cutting edge. Curr Opin Oncol. 2011;23:352-360.
    • (2011) Curr. Opin. Oncol. , vol.23 , pp. 352-360
    • Subbiah, V.1    Kurzrock, R.2
  • 112
    • 79959226237 scopus 로고    scopus 로고
    • Activated MET is a molecular prognosticator and potential therapeutic target for malignant peripheral nerve sheath tumors
    • Torres KE, Zhu QS, Bill K, et al. Activated MET is a molecular prognosticator and potential therapeutic target for malignant peripheral nerve sheath tumors. Clin Cancer Res. 2011;17:3943-3955.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 3943-3955
    • Torres, K.E.1    Zhu, Q.S.2    Bill, K.3
  • 113
    • 76749121298 scopus 로고    scopus 로고
    • Preliminary results from a phase II study of ARQ 197 in patients with microphthalmia transcription factor family (MiT)-associated tumors
    • abstract 10502
    • Goldberg J, Demetri GD, Choy E, et al. Preliminary results from a phase II study of ARQ 197 in patients with microphthalmia transcription factor family (MiT)-associated tumors. J Clin Oncol. 2009;27(suppl):abstract 10502.
    • (2009) J. Clin. Oncol. , vol.27 , Issue.SUPPL.
    • Goldberg, J.1    Demetri, G.D.2    Choy, E.3
  • 114
    • 66849131261 scopus 로고    scopus 로고
    • Dual targeting of AKT and mammalian target of rapamycin: A potential therapeutic approach for malignant peripheral nerve sheath tumor
    • Zou CY, Smith KD, Zhu QS, et al. Dual targeting of AKT and mammalian target of rapamycin: a potential therapeutic approach for malignant peripheral nerve sheath tumor. Mol Cancer Ther. 2009;8:1157-1168.
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 1157-1168
    • Zou, C.Y.1    Smith, K.D.2    Zhu, Q.S.3
  • 115
    • 33947538050 scopus 로고    scopus 로고
    • Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism
    • DOI 10.1038/sj.onc.1209990, PII 1209990
    • Wan X, Harkavy B, Shen N, et al. Rapamycin induces feedback activation of Akt signaling through an IGF-1Rdependent mechanism. Oncogene. 2007;26:1932-1940. (Pubitemid 46474636)
    • (2007) Oncogene , vol.26 , Issue.13 , pp. 1932-1940
    • Wan, X.1    Harkavy, B.2    Shen, N.3    Grohar, P.4    Helman, L.J.5
  • 116
    • 84855556875 scopus 로고    scopus 로고
    • Phase II study of the mammalian target of rapamycin inhibitor ridaforolimus in patients with advanced bone and soft tissue sarcomas
    • Chawla SP, Staddon AP, Baker LH, et al. Phase II study of the mammalian target of rapamycin inhibitor ridaforolimus in patients with advanced bone and soft tissue sarcomas. J Clin Oncol. 2012;30:78-84.
    • (2012) J. Clin. Oncol. , vol.30 , pp. 78-84
    • Chawla, S.P.1    Staddon, A.P.2    Baker, L.H.3
  • 117
    • 77649215630 scopus 로고    scopus 로고
    • Clinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors: Targeting the pathogenic activation of mTORC1 in tumors
    • Wagner AJ, Malinowska-Kolodziej I, Morgan JA, et al. Clinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors: targeting the pathogenic activation of mTORC1 in tumors. J Clin Oncol. 2010;28:835-840.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 835-840
    • Wagner, A.J.1    Malinowska-Kolodziej, I.2    Morgan, J.A.3
  • 118
    • 80053312080 scopus 로고    scopus 로고
    • The expression of c-Met pathway components in unclassified pleomorphic sarcoma/ malignant fibrous histiocytoma (UPS/MFH): A tissue microarray study
    • Lahat G, Zhang P, Zhu QS, et al. The expression of c-Met pathway components in unclassified pleomorphic sarcoma/ malignant fibrous histiocytoma (UPS/MFH): a tissue microarray study. Histopathology. 2011;59:556-561.
    • (2011) Histopathology , vol.59 , pp. 556-561
    • Lahat, G.1    Zhang, P.2    Zhu, Q.S.3
  • 119
    • 79953235832 scopus 로고    scopus 로고
    • The role of MAPK pathway in bone and soft tissue tumors
    • Sasaki K, Hitora T, Nakamura O, et al. The role of MAPK pathway in bone and soft tissue tumors. Anticancer Res. 2011;31:549-553.
    • (2011) Anticancer Res. , vol.31 , pp. 549-553
    • Sasaki, K.1    Hitora, T.2    Nakamura, O.3
  • 120
    • 50249152932 scopus 로고    scopus 로고
    • Novel V600E BRAF mutations in imatinib-naive and imatinib-resistant gastrointestinal stromal tumors
    • Agaram NP, Wong GC, Guo T, et al. Novel V600E BRAF mutations in imatinib-naive and imatinib-resistant gastrointestinal stromal tumors. Genes Chromosomes Cancer. 2008; 47:853-859.
    • (2008) Genes. Chromosomes Cancer , vol.47 , pp. 853-859
    • Agaram, N.P.1    Wong, G.C.2    Guo, T.3
  • 121
    • 78649663490 scopus 로고    scopus 로고
    • Sorafenib induces growth inhibition and apoptosis of human chondrosarcoma cells by blocking the RAF/ERK/MEK pathway
    • Lu X, Tang X, Guo W, et al. Sorafenib induces growth inhibition and apoptosis of human chondrosarcoma cells by blocking the RAF/ERK/MEK pathway. J Surg Oncol. 2010; 102:821-826.
    • (2010) J. Surg. Oncol. , vol.102 , pp. 821-826
    • Lu, X.1    Tang, X.2    Guo, W.3
  • 123
    • 72449133456 scopus 로고    scopus 로고
    • Sorafenib induces growth inhibition and apoptosis in human synovial sarcoma cells via inhibiting the RAF/MEK/ERK signaling pathway
    • Peng CL, Guo W, Ji T, et al. Sorafenib induces growth inhibition and apoptosis in human synovial sarcoma cells via inhibiting the RAF/MEK/ERK signaling pathway. Cancer Biol Ther. 2009;8:1729-1736.
    • (2009) Cancer Biol. Ther. , vol.8 , pp. 1729-1736
    • Peng, C.L.1    Guo, W.2    Ji, T.3
  • 124
    • 79959219259 scopus 로고    scopus 로고
    • Activity of sorafenib against desmoid tumor/deep fibromatosis
    • Gounder MM, Lefkowitz RA, Keohan ML, et al. Activity of sorafenib against desmoid tumor/deep fibromatosis. Clin Cancer Res. 2011;17:4082-4090.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 4082-4090
    • Gounder, M.M.1    Lefkowitz, R.A.2    Keohan, M.L.3
  • 125
    • 67650293850 scopus 로고    scopus 로고
    • Phase II study of sorafenib in patients with metastatic or recurrent sarcomas
    • Maki RG, D'Adamo DR, Keohan ML, et al. Phase II study of sorafenib in patients with metastatic or recurrent sarcomas. J Clin Oncol. 2009;27:3133-3140.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 3133-3140
    • Maki, R.G.1    D'Adamo, D.R.2    Keohan, M.L.3
  • 126
    • 39149133664 scopus 로고    scopus 로고
    • Is B-Raf a good therapeutic target for melanoma and other malignancies?
    • DOI 10.1158/0008-5472.CAN-07-2038
    • Madhunapantula SV, Robertson GP. Is B-Raf a good therapeutic target for melanoma and other malignancies? Cancer Res. 2008;68:5-8. (Pubitemid 351380097)
    • (2008) Cancer Research , vol.68 , Issue.1 , pp. 5-8
    • Madhunapantula, S.V.1    Robertson, G.P.2
  • 127
    • 66449129841 scopus 로고    scopus 로고
    • MEK/ERK inhibitor U0126 affects in vitro and in vivo growth of embryonal rhabdomyosarcoma
    • Marampon F, Bossi G, Ciccarelli C, et al.MEK/ERK inhibitor U0126 affects in vitro and in vivo growth of embryonal rhabdomyosarcoma. Mol Cancer Ther. 2009;8:543-551.
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 543-551
    • Marampon, F.1    Bossi, G.2    Ciccarelli, C.3
  • 130
    • 27244450145 scopus 로고    scopus 로고
    • Phase II study of doxorubicin and bevacizumab for patients with metastatic soft-tissue sarcomas
    • D'Adamo DR, Anderson SE, Albritton K, et al. Phase II study of doxorubicin and bevacizumab for patients with metastatic soft-tissue sarcomas. J Clin Oncol. 2005;23:7135-7142.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 7135-7142
    • D'Adamo, D.R.1    Anderson, S.E.2    Albritton, K.3
  • 131
    • 57149111052 scopus 로고    scopus 로고
    • Randomized, phase II study of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 in patients with advanced soft tissue sarcoma
    • Baker LH, Rowinsky EK, Mendelson D, et al. Randomized, phase II study of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 in patients with advanced soft tissue sarcoma. J Clin Oncol. 2008;26:5583-5588.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 5583-5588
    • Baker, L.H.1    Rowinsky, E.K.2    Mendelson, D.3
  • 132
  • 133
    • 79551717942 scopus 로고    scopus 로고
    • Notch pathway inhibition significantly reduces rhabdomyosarcoma invasiveness and mobility in vitro
    • Roma J, Masia A, Reventos J, et al. Notch pathway inhibition significantly reduces rhabdomyosarcoma invasiveness and mobility in vitro. Clin Cancer Res. 2011;17: 505-513.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 505-513
    • Roma, J.1    Masia, A.2    Reventos, J.3
  • 134
    • 49649103793 scopus 로고    scopus 로고
    • Critical role of notch signaling in osteosarcoma invasion and metastasis
    • Zhang P, Yang Y, Zweidler-McKay PA, et al. Critical role of notch signaling in osteosarcoma invasion and metastasis. Clin Cancer Res. 2008;14:2962-2969.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 2962-2969
    • Zhang, P.1    Yang, Y.2    Zweidler-McKay, P.A.3
  • 135
    • 84869079889 scopus 로고    scopus 로고
    • Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21(Cip1) expression and hampers tumour cell growth in vitro and in vivo
    • Epub ahead of print]
    • Raimondi L, Ciarapica R, De Salvo M, et al. Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21(Cip1) expression and hampers tumour cell growth in vitro and in vivo. Cell Death Differ. 2011 [Epub ahead of print].
    • (2011) Cell Death Differ.
    • Raimondi, L.1    Ciarapica, R.2    De Salvo, M.3
  • 136
    • 82555173147 scopus 로고    scopus 로고
    • Inhibition of the notch-hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis
    • Belyea BC, Naini S, Bentley RC, et al. Inhibition of the notch-hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis. Clin Cancer Res. 2011;17:7324-7336.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 7324-7336
    • Belyea, B.C.1    Naini, S.2    Bentley, R.C.3
  • 137
    • 80054720133 scopus 로고    scopus 로고
    • Notch signalling is off and is uncoupled from HES1 expression in Ewing's sarcoma
    • Bennani-Baiti IM, Aryee DN, Ban J, et al. Notch signalling is off and is uncoupled from HES1 expression in Ewing's sarcoma. J Pathol. 2011;225:353-363.
    • (2011) J. Pathol. , vol.225 , pp. 353-363
    • Bennani-Baiti, I.M.1    Aryee, D.N.2    Ban, J.3
  • 138
    • 29744463531 scopus 로고    scopus 로고
    • Deregulation of the hedgehog signalling pathway: A possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development
    • DOI 10.1002/path.1882
    • Tostar U, Malm CJ, Meis-Kindblom JM, et al. Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development. J Pathol. 2006;208: 17-25. (Pubitemid 43025700)
    • (2006) Journal of Pathology , vol.208 , Issue.1 , pp. 17-25
    • Tostar, U.1    Malm, C.J.2    Meis-Kindblom, J.M.3    Kindblom, L.-G.4    Toftgard, R.5    Unden, A.B.6
  • 139
    • 80052655551 scopus 로고    scopus 로고
    • Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: A report from the children's oncology group
    • Pressey JG, Anderson JR, Crossman DK, et al. Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2011;57:930-938.
    • (2011) Pediatr. Blood Cancer , vol.57 , pp. 930-938
    • Pressey, J.G.1    Anderson, J.R.2    Crossman, D.K.3
  • 140
    • 79952820588 scopus 로고    scopus 로고
    • Reduction of human embryonal rhabdomyosarcoma tumor growth by inhibition of the hedgehog signaling pathway
    • Tostar U, Toftgard R, Zaphiropoulos PG, et al. Reduction of human embryonal rhabdomyosarcoma tumor growth by inhibition of the hedgehog signaling pathway. Genes Cancer. 2010;1:941-951.
    • (2010) Genes. Cancer , vol.1 , pp. 941-951
    • Tostar, U.1    Toftgard, R.2    Zaphiropoulos, P.G.3
  • 141
    • 79955627111 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in a subset of patients with advanced soft tissue sarcoma from a phase II randomized discontinuation trial
    • Pacey S, Ratain MJ, Flaherty KT, et al. Efficacy and safety of sorafenib in a subset of patients with advanced soft tissue sarcoma from a phase II randomized discontinuation trial. Invest New Drugs. 2011;29:481-488.
    • (2011) Invest. New Drugs , vol.29 , pp. 481-488
    • Pacey, S.1    Ratain, M.J.2    Flaherty, K.T.3
  • 142
    • 83255163333 scopus 로고    scopus 로고
    • R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory ewing sarcoma family of tumors: Results of a phase ii sarcoma alliance for research through collaboration study
    • Pappo AS, Patel SR, Crowley J, et al. R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II Sarcoma Alliance for Research through Collaboration study. J Clin Oncol. 2011;29:4541-4547.
    • (2011) J. Clin. Oncol. , vol.29 , pp. 4541-4547
    • Pappo, A.S.1    Patel, S.R.2    Crowley, J.3
  • 143
    • 79951816312 scopus 로고    scopus 로고
    • Combination mTOR and IGF-1R inhibition: Phase I trial of everolimus and figitumumab in patients with advanced sarcomas and other solid tumors
    • Quek R, Wang Q, Morgan JA, et al. Combination mTOR and IGF-1R inhibition: phase I trial of everolimus and figitumumab in patients with advanced sarcomas and other solid tumors. Clin Cancer Res. 2010;17:871-879.
    • (2010) Clin. Cancer Res. , vol.17 , pp. 871-879
    • Quek, R.1    Wang, Q.2    Morgan, J.A.3
  • 144
    • 80054052236 scopus 로고    scopus 로고
    • Results of a phase II trial of sirolimus (S) and cyclophosphamide (C) in advanced sarcoma
    • suppl):abstract 10003
    • Schuetze S, Zhao L, Chugh R, et al. Results of a phase II trial of sirolimus (S) and cyclophosphamide (C) in advanced sarcoma. J Clin Oncol. 2011;29(suppl):abstract 10003.
    • (2011) J. Clin. Oncol. , pp. 29
    • Schuetze, S.1    Zhao, L.2    Chugh, R.3
  • 145
    • 79960698959 scopus 로고    scopus 로고
    • A phase 2 study of temsirolimus (CCI-779) in patients with soft tissue sarcomas: A study of the Mayo phase 2 consortium (P2C
    • Okuno S, Bailey H, Mahoney MR, et al. A phase 2 study of temsirolimus (CCI-779) in patients with soft tissue sarcomas: a study of the Mayo phase 2 consortium (P2C). Cancer. 2011;117:3468-3475.
    • (2011) Cancer , vol.117 , pp. 3468-3475
    • Okuno, S.1    Bailey, H.2    Mahoney, M.R.3
  • 146
    • 83455253885 scopus 로고    scopus 로고
    • Initial testing (stage 1) of the mTOR kinase inhibitor AZD8055 by the pediatric preclinical testing program
    • Houghton PJ, Gorlick R, Kolb EA, et al. Initial testing (stage 1) of the mTOR kinase inhibitor AZD8055 by the pediatric preclinical testing program. Pediatr Blood Cancer. 2011;58:191-199.
    • (2011) Pediatr. Blood Cancer , vol.58 , pp. 191-199
    • Houghton, P.J.1    Gorlick, R.2    Kolb, E.A.3
  • 147
    • 68249093818 scopus 로고    scopus 로고
    • Targeting the phosphoinositide 3-kinase pathway in cancer
    • Liu P, Cheng H, Roberts TM, et al. Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov. 2009;8:627-644.
    • (2009) Nat. Rev. Drug. Discov. , vol.8 , pp. 627-644
    • Liu, P.1    Cheng, H.2    Roberts, T.M.3
  • 148
    • 74549164751 scopus 로고    scopus 로고
    • NVP-BEZ235 as a new therapeutic option for sarcomas
    • Manara MC, Nicoletti G, Zambelli D, et al. NVP-BEZ235 as a new therapeutic option for sarcomas. Clin Cancer Res. 2010;16:530-540.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 530-540
    • Manara, M.C.1    Nicoletti, G.2    Zambelli, D.3
  • 149
    • 84863870086 scopus 로고    scopus 로고
    • Testing of the Akt/ PKB inhibitor MK-2206 by the pediatric preclinical testing program
    • Epub ahead of print]
    • Gorlick R, Maris JM, Houghton PJ, et al. Testing of the Akt/ PKB inhibitor MK-2206 by the pediatric preclinical testing program. Pediatr Blood Cancer. 2011 [Epub ahead of print].
    • (2011) Pediatr. Blood Cancer
    • Gorlick, R.1    Maris, J.M.2    Houghton, P.J.3
  • 151
    • 80255141849 scopus 로고    scopus 로고
    • Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomas
    • Yoon SS, Duda DG, Karl DL, et al. Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomas. Int J Radiat Oncol Biol Phys. 2011;81:1081-1090.
    • (2011) Int. J. Radiat. Oncol. Biol. Phys. , vol.81 , pp. 1081-1090
    • Yoon, S.S.1    Duda, D.G.2    Karl, D.L.3
  • 152
    • 67650337802 scopus 로고    scopus 로고
    • Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: A phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043
    • Sleijfer S, Ray-Coquard I, Papai Z, et al. Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043). J Clin Oncol. 2009;27:3126-3132.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 3126-3132
    • Sleijfer, S.1    Ray-Coquard, I.2    Papai, Z.3
  • 153
    • 79951865371 scopus 로고    scopus 로고
    • A phase 1 trial and pharmacokinetic study of cediranib, an orally bioavailable pan-vascular endothelial growth factor receptor inhibitor, in children and adolescents with refractory solid tumors
    • Fox E, Aplenc R, Bagatell R, et al. A phase 1 trial and pharmacokinetic study of cediranib, an orally bioavailable pan-vascular endothelial growth factor receptor inhibitor, in children and adolescents with refractory solid tumors. J Clin Oncol. 2010;28:5174-5181.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 5174-5181
    • Fox, E.1    Aplenc, R.2    Bagatell, R.3
  • 154
    • 84855541297 scopus 로고    scopus 로고
    • Brivanib (BMS- 582664) in advanced soft-tissue sarcoma (STS): Biomarker and subset results of a phase II randomized discontinuation trial
    • suppl):abstract 10000
    • Schwartz GK, Maki RG, Ratain MJ, et al. Brivanib (BMS- 582664) in advanced soft-tissue sarcoma (STS): biomarker and subset results of a phase II randomized discontinuation trial. J Clin Oncol. 2011;29(suppl):abstract 10000.
    • (2011) J. Clin. Oncol. , vol.29
    • Schwartz, G.K.1    Maki, R.G.2    Ratain, M.J.3
  • 155
    • 80054075229 scopus 로고    scopus 로고
    • Neoadjuvant MDM2 antagonist RG7112 for well-differentiated and dedifferentiated liposarcomas (WD/DD LPS): A pharmacodynamic (PD) biomarker study
    • suppl): abstract 10007b
    • Ray-Coquard IL, Blay J, Italiano A, et al. Neoadjuvant MDM2 antagonist RG7112 for well-differentiated and dedifferentiated liposarcomas (WD/DD LPS): a pharmacodynamic (PD) biomarker study. J Clin Oncol. 2011;29(suppl): abstract 10007b.
    • (2011) J. Clin. Oncol. , vol.29
    • Ray-Coquard, I.L.1    Blay, J.2    Italiano, A.3
  • 156
    • 34248157136 scopus 로고    scopus 로고
    • Phase I trial of G3139, a bcl-2 antisense oligonucleotide, combined with doxorubicin and cyclophosphamide in children with relapsed solid tumors: A Children's Oncology Group study
    • DOI 10.1200/JCO.2006.09.5125
    • Rheingold SR, Hogarty MD, Blaney SM, et al. Phase I trial of G3139, a bcl-2 antisense oligonucleotide, combined with doxorubicin and cyclophosphamide in children with relapsed solid tumors: a Children's Oncology Group Study. J Clin Oncol. 2007;25:1512-1518. (Pubitemid 46733077)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.12 , pp. 1512-1518
    • Rheingold, S.R.1    Hogarty, M.D.2    Blaney, S.M.3    Zwiebel, J.A.4    Sauk-Schubert, C.5    Chandula, R.6    Krailo, M.D.7    Adamson, P.C.8
  • 157
    • 84859975229 scopus 로고    scopus 로고
    • October 25, Available at: Accessed January 2012
    • PD0332991 in patients with advanced or metastatic liposarcoma. October 25, 2011. Available at: http://clinicaltrials. gov/ct2/show/NCT01209598. Accessed January 21, 2012.
    • (2011) PD0332991 in Patients with Advanced or Metastatic Liposarcoma , vol.21
  • 159
    • 84859981704 scopus 로고    scopus 로고
    • A phase II consortium trial of vorinostat and bortezomib for advanced soft tissue sarcomas
    • suppl):abstract 10075
    • Attia S,MahoneyMR, Okuno SH, et al. A phase II consortium trial of vorinostat and bortezomib for advanced soft tissue sarcomas. J Clin Oncol. 2011;29(suppl):abstract 10075.
    • (2011) J. Clin. Oncol. , vol.29
    • Attia, S.1    Mahoney, M.R.2    Okuno, S.H.3
  • 160
    • 84859998674 scopus 로고    scopus 로고
    • A phase I doseescalation study of azacitidine in combination with temozolamide in patients with soft tissue sarcomas
    • suppl):abstract 10073
    • Mtushansky I, Coakley KE, Uldrick TS, et al. A phase I doseescalation study of azacitidine in combination with temozolamide in patients with soft tissue sarcomas. J Clin Oncol. 2011;29(suppl):abstract 10073.
    • (2011) J. Clin. Oncol. , vol.29
    • Mtushansky, I.1    Coakley, K.E.2    Uldrick, T.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.