Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomas

International Journal of Radiation Oncology Biology Physics

Volumn 81, Issue 4, 2011, Pages 1081-1090

  Yoon, Sam S ^a,d   Duda, Dan G ^a   Karl, Daniel L ^a   Kim, Tae Min ^b   Kambadakone, Avinash R ^a   Chen, Yen Lin ^a   Rothrock, Courtney ^a   Rosenberg, Andrew E ^a   Nielsen, G Petur ^a   Kirsch, David G ^c   Choy, Edwin ^a   Harmon, David C ^a   Hornicek, Francis J ^a   Dreyfuss, Jonathan ^b   Ancukiewicz, Marek ^a   Sahani, Dushyant V ^a   Park, Peter J ^b   Jain, Rakesh K ^a   Delaney, Thomas F ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Harvard Medical School Center for Biomedical Informatics   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Angiogenesis inhibitors; Bevacizumab; Biomarkers; Radiotherapy; Sarcoma

Indexed keywords

ANGIOGENESIS INHIBITORS; BEVACIZUMAB; BLOOD FLOW; BLOOD VOLUMES; CIRCULATING PROGENITOR CELLS; COMBINATION THERAPY; COMPUTED TOMOGRAPHY SCAN; EXPLORATORY STUDIES; GENE EXPRESSION MICROARRAY; GENE EXPRESSION PROFILES; LOCAL RECURRENCE; MICROVESSEL DENSITY; NEOADJUVANT TREATMENT; PATHOLOGIC RESPONSE; PHASE II; PRECLINICAL STUDIES; SARCOMA; SOFT TISSUE SARCOMA; SURFACE AREA; SURGICAL RESECTION; TREATMENT RESPONSE; TUMOR SAMPLES; TUMOR SIZE;

BLOOD; BLOOD VESSELS; CELL DEATH; CELL PROLIFERATION; COMPUTERIZED TOMOGRAPHY; GENE EXPRESSION; HEMODYNAMICS; PATHOLOGY; RADIOTHERAPY; TOMOGRAPHY;

TUMORS;

BEVACIZUMAB; BIOLOGICAL MARKER; CD133 ANTIGEN; CD31 ANTIGEN; CD34 ANTIGEN; FIBROBLAST GROWTH FACTOR 2; INTERLEUKIN 6; INTERLEUKIN 8; PLACENTAL GROWTH FACTOR; STEM CELL FACTOR; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ADULT; AGED; ANOREXIA; APOPTOSIS; ARTICLE; BLOOD FLOW; BLOOD SAMPLING; BLOOD VOLUME; CANCER ADJUVANT THERAPY; CANCER RADIOTHERAPY; CANCER RISK; CANCER SURVIVAL; CELL MEMBRANE PERMEABILITY; CELL PROLIFERATION; CLINICAL ARTICLE; COMPUTER ASSISTED RADIOTHERAPY; COMPUTER ASSISTED TOMOGRAPHY; CONSTIPATION; CONTROLLED STUDY; DEHYDRATION; DIARRHEA; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; EPISTAXIS; FATIGUE; FEMALE; FLOW CYTOMETRY; FOLLOW UP; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; HYPERTENSION; INTENSITY MODULATED RADIATION THERAPY; LEIOMYOSARCOMA; LIPOSARCOMA; LIVER FUNCTION TEST; MALE; MICROARRAY ANALYSIS; MICROVASCULATURE; NAUSEA; OSTEOSARCOMA; OVERALL SURVIVAL; PELVIS TUMOR; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; RADIATION DERMATITIS; RANDOMIZED CONTROLLED TRIAL; RECURRENT CANCER; RETROPERITONEAL TUMOR; SIDE EFFECT; SOFT TISSUE SARCOMA; STEM CELL; SURFACE PROPERTY; TREATMENT RESPONSE; TUMOR VOLUME; ULCER; VOMITING;

ADULT; AGED; ANGIOGENESIS INHIBITORS; ANTIBODIES, MONOCLONAL, HUMANIZED; CELL PROLIFERATION; FEMALE; GENE EXPRESSION PROFILING; HUMANS; MALE; MICROVESSELS; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM RECURRENCE, LOCAL; POSTOPERATIVE COMPLICATIONS; RADIOTHERAPY DOSAGE; SARCOMA; SOFT TISSUE NEOPLASMS; TREATMENT OUTCOME; TUMOR BURDEN; TUMOR MARKERS, BIOLOGICAL;

EID: 80255141849     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2010.07.024     Document Type: Article

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