DCLK1 variants are associated across schizophrenia and attention deficit/hyperactivity disorder

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Håvik, Bjarte ^a,b   Degenhardt, Franziska A ^c   Johansson, Stefan ^a,b   Fernandes, Carla P D ^a   Hinney, Anke ^d   Scherag, André ^d   Lybæk, Helle ^b   Djurovic, Srdjan ^e   Christoforou, Andrea ^a,b   Ersland, Kari M ^a,b   Giddaluru, Sudheer ^a,b   O'Donovan, Michael C ^f   Owen, Michael J ^f   Craddock, Nick ^f   Mühleisen, Thomas W ^c   Mattheisen, Manuel ^c   Schimmelmann, Benno G ^g   Renner, Tobias ^h   Warnke, Andreas ^h   Herpertz Dahlmann, Beate ⁱ   Sinzig, Judith ^j,k   Albayrak, Özgür ^d   Rietschel, Marcella ^c   Nöthen, Markus M ^c,l   Bramham, Clive R ^a   Werge, Thomas ^m   Hebebrand, Johannes ^d   Haavik, Jan ^a,b   Andreassen, Ole A ^e,n   Cichon, Sven ^a,c,o   Steen, Vidar M ^a,b   Le Hellard, Stéphanie ^a,b   more..

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF BONN   (Germany)

^d UNIVERSITY OF DUISBURG ESSEN   (Germany)

^e UNIVERSITY OF OSLO   (Norway)

^f CARDIFF UNIVERSITY   (United Kingdom)

^g UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^h UNIVERSITY OF WÜRZBURG   (Germany)

ⁱ UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^j UNIVERSITY OF COLOGNE   (Germany)

^k LVR Klinik Bonn   (Germany)

^l GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^m Mental Health Services CPH   (Denmark)

ⁿ OSLO UNIVERSITY HOSPITAL   (Norway)

^o FORSCHUNGSZENTRUM JÜLICH   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLECORTIN AND CALMODULIN LIKE KINASE 1; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG; DCLK1 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE;

3' UNTRANSLATED REGION; ARTICLE; ATTENTION DEFICIT DISORDER; BIPOLAR DISORDER; CONTROLLED STUDY; DCLK1 GENE; GENE; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; INTRON; MAJOR CLINICAL STUDY; PHENOTYPE; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; METABOLISM; RISK;

ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BIPOLAR DISORDER; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; INTRONS; ODDS RATIO; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN-SERINE-THREONINE KINASES; SCHIZOPHRENIA;

EID: 84860003144     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035424     Document Type: Article

References (60)

1. Gur RE, Calkins ME, Gur RC, Horan WP, Nuechterlein KH, et al. (2007) The Consortium on the Genetics of Schizophrenia: neurocognitive endophenotypes. Schizophr Bull 33: 49-68.
2. Heinrichs RW, Zakzanis KK, (1998) Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology 12: 426-445.
3. Kalkstein S, Hurford I, Gur RC, (2010) Neurocognition in schizophrenia. Curr Top Behav Neurosci 4: 373-390.
4. Kuntsi J, McLoughlin G, Asherson P, (2006) Attention deficit hyperactivity disorder. Neuromolecular Med 8: 461-484.
5. McIntyre R, (2009) Bipolar disorder and ADHD: Clinical concerns. CNS Spectr 14: 8-9; discussion 13-14.
6. Yatham LN, Torres IJ, Malhi GS, Frangou S, Glahn DC, et al. (2010) The International Society for Bipolar Disorders-Battery for Assessment of Neurocognition (ISBD-BANC). Bipolar Disord 12: 351-363.
7. Savitz JB, Solms M, Ramesar RS, (2005) Neurocognitive function as an endophenotype for genetic studies of bipolar affective disorder. Neuromolecular Med 7: 275-286.
8. Gottesman II, Gould TD, (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160: 636-645.
9. Hasler G, Drevets WC, Gould TD, Gottesman II, Manji HK, (2006) Toward constructing an endophenotype strategy for bipolar disorders. Biol Psychiatry 60: 93-105.
10. Chubb JE, Bradshaw NJ, Soares DC, Porteous DJ, Millar JK, (2008) The DISC locus in psychiatric illness. Mol Psychiatry 13: 36-64.
11. Esslinger C, Walter H, Kirsch P, Erk S, Schnell K, et al. (2009) Neural Mechanisms of a Genome-Wide Supported Psychosis Variant. Science 324: 605-605.
12. Hariri AR, Goldberg TE, Mattay VS, Kolachana BS, Callicott JH, et al. (2003) Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J Neurosci 23: 6690-6694.
13. Prathikanti S, Weinberger DR, (2005) Psychiatric genetics-the new era: genetic research and some clinical implications. Br Med Bull 73-74: 107-122.
14. Bramham CR, Messaoudi E, (2005) BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis. Progress in Neurobiology 76: 99-125.
15. Wibrand K, Messaoudi E, Havik B, Steenslid V, Lovlie R, et al. (2006) Identification of genes co-upregulated with Arc during BDNF-induced long-term potentiation in adult rat dentate gyrus in vivo. European Journal of Neuroscience 23: 1501-1511.
16. Le Hellard S, Havik B, Espeseth T, Breilid H, Lovlie R, et al. (2009) Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are associated with memory and general cognitive abilities. PLoS One 4: e7534.
17. Burgess HA, Reiner O, (2002) Alternative splice variants of doublecortin-like kinase are differentially expressed and have different kinase activities. J Biol Chem 277: 17696-17705.
18. Lin PT, Gleeson JG, Corbo JC, Flanagan L, Walsh CA, (2000) DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization. Journal of Neuroscience 20: 9152-9161.
19. Tanaka T, Koizumi H, Gleeson JG, (2006) The doublecortin and doublecortin-like kinase 1 genes cooperate in murine hippocampal development. Cerebral Cortex 16: I69-I73.
20. Vreugdenhil E, Kolk SM, Boekhoorn K, Fitzsimons CP, Schaaf M, et al. (2007) Doublecortin-like, a microtubule-associated protein expressed in radial glia, is crucial for neuronal precursor division and radial process stability. European Journal of Neuroscience 25: 635-648.
21. Pedotti P, t Hoen PA, Vreugdenhil E, Schenk GJ, Vossen RH, et al. (2008) Can subtle changes in gene expression be consistently detected with different microarray platforms? BMC Genomics 9: 124.
22. Schenk GJ, Veldhuisen B, Wedemeier O, McGown CC, Schouten TG, et al. (2010) Over-expression of deltaC-DCLK-short in mouse brain results in a more anxious behavioral phenotype. Physiol Behav 101: 541-548.
23. Schenk GJ, Vreugdenhil E, Hubens CJ, Veldhuisen B, de Kloet ER, et al. (2011) Hippocampal CARP over-expression solidifies consolidation of contextual fear memories. Physiol Behav 102: 323-331.
24. Green MJ, Matheson SL, Shepherd A, Weickert CS, Carr VJ, (2011) Brain-derived neurotrophic factor levels in schizophrenia: a systematic review with meta-analysis. Mol Psychiatry 16: 960-972.
25. Rybakowski JK, (2008) BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia. Pharmacogenomics 9: 1589-1593.
26. Banaschewski T, Becker K, Scherag S, Franke B, Coghill D, (2010) Molecular genetics of attention-deficit/hyperactivity disorder: an overview. Eur Child Adolesc Psychiatry 19: 237-257.
27. Chen ZY, Bath K, McEwen B, Hempstead B, Lee F, (2008) Impact of genetic variant BDNF (Val66Met) on brain structure and function. Novartis Found Symp 289: 180-188; discussion 188-195.
28. O'Donovan MC, Craddock NJ, Owen MJ, (2009) Genetics of psychosis; insights from views across the genome. Hum Genet 126: 3-12.
29. Sharp SI, McQuillin A, Gurling HM, (2009) Genetics of attention-deficit hyperactivity disorder (ADHD). Neuropharmacology 57: 590-600.
30. Cichon S, Muhleisen TW, Degenhardt FA, Mattheisen M, Miro X, et al. (2011) Genome-wide Association Study Identifies Genetic Variation in Neurocan as a Susceptibility Factor for Bipolar Disorder. Am J Hum Genet 88: 372-381.
31. Halmoy A, Halleland H, Dramsdahl M, Bergsholm P, Fasmer OB, et al. (2010) Bipolar symptoms in adult attention-deficit/hyperactivity disorder: a cross-sectional study of 510 clinically diagnosed patients and 417 population-based controls. J Clin Psychiatry 71: 48-57.
32. Hansen T, Olsen L, Lindow M, Jakobsen KD, Ullum H, et al. (2007) Brain expressed microRNAs implicated in schizophrenia etiology. PLoS One 2: e873.
33. Hinney A, Scherag A, Jarick I, Albaryrak O, Pütter C, et al. (2011) Genome-Wide Association Study in German Patients With Attention Deficit/Hyperactivity Disorder. American Journal of medical genetics in press.
34. O'Donovan MC, Craddock N, Norton N, Williams H, Peirce T, et al. (2008) Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet 40: 1053-1055.
35. Rietschel M, Mattheisen M, Degenhardt F, Kahn RS, Linszen DH, et al. (2011) Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe. Mol Psychiatry.
36. WTCCC (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447: 661-678.
37. Havik B, Le Hellard S, Rietschel M, Lybaek H, Djurovic S, et al. (2011) The Complement Control-Related Genes CSMD1 and CSMD2 Associate to Schizophrenia. Biol Psychiatry.
38. Baum AE, Akula N, Cabanero M, Cardona I, Corona W, et al. (2008) A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. Mol Psychiatry 13: 197-207.
39. International Hapmap consortium (2005) A haplotype map of the human genome. Nature 437: 1299-1320.
40. Neale BM, Lasky-Su J, Anney R, Franke B, Zhou K, et al. (2008) Genome-wide association scan of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 147B: 1337-1344.
41. Le Hellard S, Muhleisen TW, Djurovic S, Ferno J, Ouriaghi Z, et al. (2010) Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples. Mol Psychiatry 15: 463-472.
42. The (APA) APAAssociation AP, editor (1994) Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) Washington, D.C.
43. Hebebrand J, Dempfle A, Saar K, Thiele H, Herpertz-Dahlmann B, et al. (2006) A genome-wide scan for attention-deficit/hyperactivity disorder in 155 German sib-pairs. Mol Psychiatry 11: 196-205.
44. Schimmelmann BG, Friedel S, Dempfle A, Warnke A, Lesch KP, et al. (2007) No evidence for preferential transmission of common valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor gene (BDNF) in ADHD. J Neural Transm 114: 523-526.
45. Nyholt DR, (2004) A simple correction for multiple testing for SNPs in linkage disequilibrium with each other. Am J Hum Genet 74: 765-769.
46. Le Hellard S, Theisen FM, Haberhausen M, Raeder MB, Ferno J, et al. (2009) Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects? Mol Psychiatry 14: 308-317.
47. Ballas N, Mandel G, (2005) The many faces of REST oversee epigenetic programming of neuronal genes. Curr Opin Neurobiol 15: 500-506.
48. Xia K, Shabalin AA, Huang S, Madar V, Zhou YH, et al. (2012) seeQTL: a searchable database for human eQTLs. Bioinformatics 28: 451-452.
49. Millar JK, Wilson-Annan JC, Anderson S, Christie S, Taylor MS, et al. (2000) Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet 9: 1415-1423.
50. Palo OM, Antila M, Silander K, Hennah W, Kilpinen H, et al. (2007) Association of distinct allelic haplotypes of DISC1 with psychotic and bipolar spectrum disorders and with underlying cognitive impairments. Hum Mol Genet 16: 2517-2528.
51. Hennah W, Thomson P, McQuillin A, Bass N, Loukola A, et al. (2009) DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder. Mol Psychiatry 14: 865-873.
52. Cichon S, Craddock N, Daly M, Faraone SV, Gejman PV, et al. (2009) Genomewide association studies: history, rationale, and prospects for psychiatric disorders. Am J Psychiatry 166: 540-556.
53. Smith M, Woodroffe A, Smith R, Holguin S, Martinez J, et al. (2002) Molecular genetic delineation of a deletion of chromosome 13q12-q13 in a patient with autism and auditory processing deficits. Cytogenet Genome Res 98: 233-239.
54. Williams HJ, Craddock N, Russo G, Hamshere ML, Moskvina V, et al. (2011) Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries. Hum Mol Genet 20: 387-391.
55. Owen MJ, Craddock N, Jablensky A, (2007) The genetic deconstruction of psychosis. Schizophr Bull 33: 905-911.
56. de la Serna E, Baeza I, Toro J, Andres S, Puig O, et al. (2010) Relationship between clinical and neuropsychological characteristics in child and adolescent first degree relatives of subjects with schizophrenia. Schizophr Res 116: 159-167.
57. Maydell RJ, van der Walt C, Roos JL, Scribante L, Ladikos A, (2009) Clinical characteristics and premorbid variables in childhood-onset schizophrenia: a descriptive study of twelve cases from a schizophrenia founder population. Afr J Psychiatry (Johannesbg) 12: 144-148.
58. Williams NM, Zaharieva I, Martin A, Langley K, Mantripragada K, et al. (2010) Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis. Lancet 376: 1401-1408.
59. Bradley WE, Raelson JV, Dubois DY, Godin E, Fournier H, et al. (2010) Hotspots of large rare deletions in the human genome. PLoS One 5: e9401.
60. Ingason A, Rujescu D, Cichon S, Sigurdsson E, Sigmundsson T, et al. (2011) Copy number variations of chromosome 16p13.1 region associated with schizophrenia. Mol Psychiatry 16: 17-25.