Conformational transition and energy landscape of ErbB4 activated by neuregulin1ar dynamics simulations

Journal of the American Chemical Society

Volumn 134, Issue 15, 2012, Pages 6720-6731

  Du, Yun ^a   Yang, Huaiyu ^a   Xu, Yechun ^a   Cang, Xiaohui ^a   Luo, Cheng ^a   Mao, Yanyan ^a   Wang, Yuanyuan ^a   Qin, Guangrong ^a   Luo, Xiaomin ^a   Jiang, Hualiang ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION PROCESS; ATOMIC MECHANISM; CONFORMATIONAL CHANGE; CONFORMATIONAL TRANSITIONS; DYNAMICS SIMULATION; ENERGY LANDSCAPE; EXPERIMENTAL VALUES; EXTRACELLULAR REGION; LIGAND BINDING; MD SIMULATION; MOLECULAR DYNAMICS SIMULATIONS; RECEPTOR TYROSINE KINASE;

AMINO ACIDS; BINDING ENERGY; LIGANDS; MOLECULAR DYNAMICS; PRINCIPAL COMPONENT ANALYSIS;

BIOACTIVITY;

EPIDERMAL GROWTH FACTOR RECEPTOR 4; NEU DIFFERENTIATION FACTOR; NEUREGULIN 1 BETA; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; DIMERIZATION; ENERGY; EXTRACELLULAR SPACE; FORCE; LIGAND BINDING; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; PRINCIPAL COMPONENT ANALYSIS; PROTEIN BINDING; SIMULATION;

LIGANDS; MOLECULAR DYNAMICS SIMULATION; NEUREGULIN-1; PHASE TRANSITION; PROTEIN CONFORMATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; THERMODYNAMICS;

EID: 84859984291     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja211941d     Document Type: Article

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