Structure of the Complex between HER2 and an Antibody Paratope Formed by Side Chains from Tryptophan and Serine

Journal of Molecular Biology

Volumn 402, Issue 1, 2010, Pages 217-229

  Fisher, Robert D ^a,b   Ultsch, Mark ^a,c   Lingel, Andreas ^a   Schaefer, Gabriele ^a   Shao, Lily ^a   Birtalan, Sara ^a   Sidhu, Sachdev S ^a,d,e   Eigenbrot, Charles ^a  

^a GENENTECH INC   (United States)

^b Takeda San Francisco   (United States)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^d Department of Molecular Genetics ^*  (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

Antibody sequence diversity; Binary phage library; HER2; Receptor oligomer; X ray structure

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; SERINE; TRYPTOPHAN; ANTIBODY; ERBB2 PROTEIN, HUMAN; IMMUNOGLOBULIN F(AB) FRAGMENT;

ANTIBODY COMBINING SITE; ARTICLE; BACTERIOPHAGE; BINDING AFFINITY; CRYSTAL STRUCTURE; HUMAN; MOLECULAR LIBRARY; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STRUCTURE; X RAY; AMINO ACID SEQUENCE; CHEMISTRY; GENETICS; IMMUNOPRECIPITATION; METABOLISM; MOLECULAR GENETICS; WESTERN BLOTTING; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANTIBODIES; BINDING SITES, ANTIBODY; BLOTTING, WESTERN; CRYSTALLOGRAPHY, X-RAY; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOPRECIPITATION; MOLECULAR SEQUENCE DATA; RECEPTOR, ERBB-2; SERINE; TRYPTOPHAN;

EID: 77956181220     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.07.027     Document Type: Article

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