메뉴 건너뛰기




Volumn 6, Issue 2, 2012, Pages 166-175

Detection of metabolites in the white matter of frontal lobes and hippocampus with proton in first-episode treatment-naïve schizophrenia patients

Author keywords

Frontal lobe; Hippocampus; Laterality index; Magnetic resonance spectroscopy; Schizophrenia; White matter

Indexed keywords

CHOLINE DERIVATIVE; CREATINE; CREATINE PHOSPHATE; INOSITOL; N ACETYLASPARTIC ACID; PROTON;

EID: 84859927262     PISSN: 17517885     EISSN: 17517893     Source Type: Journal    
DOI: 10.1111/j.1751-7893.2011.00291.x     Document Type: Article
Times cited : (14)

References (54)
  • 3
    • 1342285559 scopus 로고    scopus 로고
    • N-acetylaspartate synthase is bimodally expressed in microsomes and mitochondria of brain
    • Lu ZH, Chakraborty G, Ledeen RW, Yahya D, Wu G. N-acetylaspartate synthase is bimodally expressed in microsomes and mitochondria of brain. Mol Brain Res 2004; 122: 71-8.
    • (2004) Mol Brain Res , vol.122 , pp. 71-78
    • Lu, Z.H.1    Chakraborty, G.2    Ledeen, R.W.3    Yahya, D.4    Wu, G.5
  • 4
    • 0035476825 scopus 로고    scopus 로고
    • Reduced NAA in the thalamus and altered membrane and glial metabolism in schizophrenic patients detected by 1H-MRS and tissue segmentation
    • Auer DP, Wilke M, Grabner A, Heidenreich JO, Bronisch T, Wetter TC. Reduced NAA in the thalamus and altered membrane and glial metabolism in schizophrenic patients detected by 1H-MRS and tissue segmentation. Schizophr Res 2001; 52: 87-99.
    • (2001) Schizophr Res , vol.52 , pp. 87-99
    • Auer, D.P.1    Wilke, M.2    Grabner, A.3    Heidenreich, J.O.4    Bronisch, T.5    Wetter, T.C.6
  • 7
    • 13644268949 scopus 로고    scopus 로고
    • Bipolar disorder and myo-inositol: a review of the magnetic resonance spectroscopy findings
    • Silverstone PH, McGrath BM, Kim H. Bipolar disorder and myo-inositol: a review of the magnetic resonance spectroscopy findings. Bipolar Disord 2005; 7: 1-10.
    • (2005) Bipolar Disord , vol.7 , pp. 1-10
    • Silverstone, P.H.1    McGrath, B.M.2    Kim, H.3
  • 9
    • 77953962508 scopus 로고    scopus 로고
    • White matter volume abnormalities and associations with symptomatology in schizophrenia
    • Makris N, Seidman LJ, Ahern T etal. White matter volume abnormalities and associations with symptomatology in schizophrenia. Psychiatry Res 2010; 183: 21-9.
    • (2010) Psychiatry Res , vol.183 , pp. 21-29
    • Makris, N.1    Seidman, L.J.2    Ahern, T.3
  • 10
    • 62349095315 scopus 로고    scopus 로고
    • Recent advances in postmortem pathology and neurochemistry in schizophrenia
    • Dean B, Boer S, Gibbons A, Money T, Scarr E. Recent advances in postmortem pathology and neurochemistry in schizophrenia. Curr Opin Psychiatry 2009; 22: 154-60.
    • (2009) Curr Opin Psychiatry , vol.22 , pp. 154-160
    • Dean, B.1    Boer, S.2    Gibbons, A.3    Money, T.4    Scarr, E.5
  • 11
    • 0037839787 scopus 로고    scopus 로고
    • Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia
    • Hof PR, Haroutunian V, Friedrich VL. Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia. Biol Psychiatry 2003; 53: 1075-85.
    • (2003) Biol Psychiatry , vol.53 , pp. 1075-1085
    • Hof, P.R.1    Haroutunian, V.2    Friedrich, V.L.3
  • 13
    • 74449086366 scopus 로고    scopus 로고
    • Reduced cortical thickness in first episode schizophrenia
    • Schultz CC, Koch K, Wagner G etal. Reduced cortical thickness in first episode schizophrenia. Schizophr Res 2009; 116: 204-9.
    • (2009) Schizophr Res , vol.116 , pp. 204-209
    • Schultz, C.C.1    Koch, K.2    Wagner, G.3
  • 14
    • 0024108858 scopus 로고    scopus 로고
    • Post-mortem neurochemistry of schizophrenia
    • Reynolds GP. Post-mortem neurochemistry of schizophrenia. Psychol Med 2009; 18: 793-7.
    • (2009) Psychol Med , vol.18 , pp. 793-797
    • Reynolds, G.P.1
  • 15
    • 68149160821 scopus 로고    scopus 로고
    • Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia
    • Minzenberg MJ, Laird AR, Thelen S, Carter CS, Glahn DC. Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia. Arch Gen Psychiatry 2009; 66: 811-22.
    • (2009) Arch Gen Psychiatry , vol.66 , pp. 811-822
    • Minzenberg, M.J.1    Laird, A.R.2    Thelen, S.3    Carter, C.S.4    Glahn, D.C.5
  • 16
    • 29644433776 scopus 로고    scopus 로고
    • Anomalies of asymmetry of pyramidal cell density and structure in dorsolateral prefrontal cortex in schizophrenia
    • Cullen TJ, Walker MA, Eastwood SL, Esiri MM, Harrison PJ, Crow TJ. Anomalies of asymmetry of pyramidal cell density and structure in dorsolateral prefrontal cortex in schizophrenia. Br J Psychiatry 2006; 188: 26-31.
    • (2006) Br J Psychiatry , vol.188 , pp. 26-31
    • Cullen, T.J.1    Walker, M.A.2    Eastwood, S.L.3    Esiri, M.M.4    Harrison, P.J.5    Crow, T.J.6
  • 17
    • 0014832532 scopus 로고
    • A classification of hand preference by association analysis
    • Annett M. A classification of hand preference by association analysis. Br J Psychol 1970; 61: 303-21.
    • (1970) Br J Psychol , vol.61 , pp. 303-321
    • Annett, M.1
  • 20
    • 0035028756 scopus 로고    scopus 로고
    • Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging
    • Schuff N, Ezekiel F, Gamst AC etal. Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging. Magn Reson Med 2001; 45: 899-907.
    • (2001) Magn Reson Med , vol.45 , pp. 899-907
    • Schuff, N.1    Ezekiel, F.2    Gamst, A.C.3
  • 21
    • 33645874180 scopus 로고    scopus 로고
    • Grey and white matter differences in brain energy metabolism in first episode schizophrenia: 31P-MRS chemical shift imaging at 4 Tesla
    • Jensen JE, Miller J, Williamson PC etal. Grey and white matter differences in brain energy metabolism in first episode schizophrenia: 31P-MRS chemical shift imaging at 4 Tesla. Psychiatry Res 2006; 146: 127-35.
    • (2006) Psychiatry Res , vol.146 , pp. 127-135
    • Jensen, J.E.1    Miller, J.2    Williamson, P.C.3
  • 22
    • 0034657022 scopus 로고    scopus 로고
    • Hippocampal pathology in schizophrenia: magnetic resonance imaging and spectroscopy studies
    • Kegeles LS, Shungu DC, Anjilvel S etal. Hippocampal pathology in schizophrenia: magnetic resonance imaging and spectroscopy studies. Psychiatry Res: Neuroimaging 2000; 98: 163-75.
    • (2000) Psychiatry Res: Neuroimaging , vol.98 , pp. 163-175
    • Kegeles, L.S.1    Shungu, D.C.2    Anjilvel, S.3
  • 24
    • 43649084927 scopus 로고    scopus 로고
    • Memory and executive impairment in schizophrenia: comparison with frontal and temporal brain damage
    • Ornstein TJ, Sahakian BJ, McKenna PJ. Memory and executive impairment in schizophrenia: comparison with frontal and temporal brain damage. Psychol Med 2008; 38: 833-42.
    • (2008) Psychol Med , vol.38 , pp. 833-842
    • Ornstein, T.J.1    Sahakian, B.J.2    McKenna, P.J.3
  • 25
    • 0842300435 scopus 로고    scopus 로고
    • Proton magnetic resonance spectroscopy in first episode psychosis and ultra high-risk individuals
    • Wood SJ, Berger G, Velakoulis D etal. Proton magnetic resonance spectroscopy in first episode psychosis and ultra high-risk individuals. Schizophr Bull 2003; 29: 831-43.
    • (2003) Schizophr Bull , vol.29 , pp. 831-843
    • Wood, S.J.1    Berger, G.2    Velakoulis, D.3
  • 26
    • 11844304922 scopus 로고    scopus 로고
    • Evidence for glutamatergic neuronal dysfunction in the prefrontal cortex in chronic but not in first-episode patients with schizophrenia: a proton magnetic resonance spectroscopy study
    • Ohrmann P, Siegmund A, Suslow T etal. Evidence for glutamatergic neuronal dysfunction in the prefrontal cortex in chronic but not in first-episode patients with schizophrenia: a proton magnetic resonance spectroscopy study. Schizophr Res 2005; 73: 153-7.
    • (2005) Schizophr Res , vol.73 , pp. 153-157
    • Ohrmann, P.1    Siegmund, A.2    Suslow, T.3
  • 27
    • 63449138812 scopus 로고    scopus 로고
    • Duration of untreated psychosis and proton magnetic resonance spectroscopy (1H-MRS) findings in first-episode schizophrenia
    • Galinska B, Szulc A, Tarasow E etal. Duration of untreated psychosis and proton magnetic resonance spectroscopy (1H-MRS) findings in first-episode schizophrenia. Med Sci Monit 2009; 15: CR82-88.
    • (2009) Med Sci Monit , vol.15
    • Galinska, B.1    Szulc, A.2    Tarasow, E.3
  • 28
    • 0347624156 scopus 로고    scopus 로고
    • Clinical and neuropsychological correlates of proton magnetic resonance spectroscopy detected metabolites in brains of first-episode and schizophrenic patients
    • Szulc A, Galinska B, Tarasow E etal. Clinical and neuropsychological correlates of proton magnetic resonance spectroscopy detected metabolites in brains of first-episode and schizophrenic patients. Psychiatr Pol 2003; 37: 977-88.
    • (2003) Psychiatr Pol , vol.37 , pp. 977-988
    • Szulc, A.1    Galinska, B.2    Tarasow, E.3
  • 29
    • 0242380353 scopus 로고    scopus 로고
    • Selective deficit of hippocampal N-acetylaspartate in antipsychotic-naive patients with schizophrenia
    • Fannon D, Simmons A, Tennakoon L etal. Selective deficit of hippocampal N-acetylaspartate in antipsychotic-naive patients with schizophrenia. Biol Psychiatry 2003; 54: 587-98.
    • (2003) Biol Psychiatry , vol.54 , pp. 587-598
    • Fannon, D.1    Simmons, A.2    Tennakoon, L.3
  • 30
    • 69249217769 scopus 로고    scopus 로고
    • MR spectroscopic evaluation of N-acetylaspartate's T2 relaxation time and concentration corroborates white matter abnormalities in schizophrenia
    • Tunc-Skarka N, Weber-Fahr W, Hoerst M, Meyer-Lindenberg A, Zink M, Ende G. MR spectroscopic evaluation of N-acetylaspartate's T2 relaxation time and concentration corroborates white matter abnormalities in schizophrenia. Neuroimage 2009; 48: 525-31.
    • (2009) Neuroimage , vol.48 , pp. 525-531
    • Tunc-Skarka, N.1    Weber-Fahr, W.2    Hoerst, M.3    Meyer-Lindenberg, A.4    Zink, M.5    Ende, G.6
  • 32
    • 67349264885 scopus 로고    scopus 로고
    • Short-echo-time magnetic resonance spectroscopy of single voxel with arbitrary shape in the living human brain using segmented two-dimensional selective radiofrequency excitations based on a blipped-planar trajectory
    • Weber-Fahr W, Busch MG, Finsterbusch J. Short-echo-time magnetic resonance spectroscopy of single voxel with arbitrary shape in the living human brain using segmented two-dimensional selective radiofrequency excitations based on a blipped-planar trajectory. Magn Reson Imaging 2009; 27: 664-71.
    • (2009) Magn Reson Imaging , vol.27 , pp. 664-671
    • Weber-Fahr, W.1    Busch, M.G.2    Finsterbusch, J.3
  • 33
    • 30744443492 scopus 로고    scopus 로고
    • Measurement of brain metabolites by 1H magnetic resonance spectroscopy in patients with schizophrenia: a systematic review and meta-analysis
    • Steen RG, Hamer RM, Lieberman JA. Measurement of brain metabolites by 1H magnetic resonance spectroscopy in patients with schizophrenia: a systematic review and meta-analysis. Neuropsychopharmacology 2005; 30: 1949-62.
    • (2005) Neuropsychopharmacology , vol.30 , pp. 1949-1962
    • Steen, R.G.1    Hamer, R.M.2    Lieberman, J.A.3
  • 34
    • 71849110853 scopus 로고    scopus 로고
    • Specific metabolites in the medial prefrontal cortex are associated with the neurocognitive deficits in schizophrenia: a preliminary study
    • Shirayama Y, Obata T, Matsuzawa D etal. Specific metabolites in the medial prefrontal cortex are associated with the neurocognitive deficits in schizophrenia: a preliminary study. Neuroimage 2009; 49: 2783-90.
    • (2009) Neuroimage , vol.49 , pp. 2783-2790
    • Shirayama, Y.1    Obata, T.2    Matsuzawa, D.3
  • 35
    • 62749132256 scopus 로고    scopus 로고
    • Proton magnetic resonance spectroscopy of the frontal, cingulate and perirolandic cortices and its relationship to skin conductance in patients with schizophrenia
    • Sanches RF, Crippa JA, Hallak JE etal. Proton magnetic resonance spectroscopy of the frontal, cingulate and perirolandic cortices and its relationship to skin conductance in patients with schizophrenia. Braz J Med Biol Res 2008; 41: 1132-41.
    • (2008) Braz J Med Biol Res , vol.41 , pp. 1132-1141
    • Sanches, R.F.1    Crippa, J.A.2    Hallak, J.E.3
  • 36
    • 34547207179 scopus 로고    scopus 로고
    • Correlations between Diffusion Tensor Imaging (DTI) and Magnetic Resonance Spectroscopy (1H MRS) in schizophrenic patients and normal controls
    • Tang CY, Friedman J, Shungu D etal. Correlations between Diffusion Tensor Imaging (DTI) and Magnetic Resonance Spectroscopy (1H MRS) in schizophrenic patients and normal controls. BMC Psychiatry 2007; 7: 25.
    • (2007) BMC Psychiatry , vol.7 , pp. 25
    • Tang, C.Y.1    Friedman, J.2    Shungu, D.3
  • 37
    • 33745202049 scopus 로고    scopus 로고
    • Comparison of right thalamus and temporal cortex metabolite levels of drug-naive first-episode psychotic and chronic schizophrenia in patients
    • Basoglu C, Cetin M, Oner O etal. Comparison of right thalamus and temporal cortex metabolite levels of drug-naive first-episode psychotic and chronic schizophrenia in patients. Turk Psikiyatri Derg 2006; 17: 85-91.
    • (2006) Turk Psikiyatri Derg , vol.17 , pp. 85-91
    • Basoglu, C.1    Cetin, M.2    Oner, O.3
  • 38
    • 77951903563 scopus 로고    scopus 로고
    • Proton magnetic resonance spectroscopic imaging of the hippocampus in schizophrenia patients before and after surgery
    • Chang HM, Qi ST, Yang KJ, Wang KW, Guo ZW, Wang H. Proton magnetic resonance spectroscopic imaging of the hippocampus in schizophrenia patients before and after surgery. Nan Fang Yi Ke Da Xue Xue Bao 2009; 29: 996-8.
    • (2009) Nan Fang Yi Ke Da Xue Xue Bao , vol.29 , pp. 996-998
    • Chang, H.M.1    Qi, S.T.2    Yang, K.J.3    Wang, K.W.4    Guo, Z.W.5    Wang, H.6
  • 40
    • 34047185227 scopus 로고    scopus 로고
    • Cognitive impairment and in vivo metabolites in first-episode neuroleptic-naive and chronic medicated schizophrenic patients: a proton magnetic resonance spectroscopy study
    • Ohrmann P, Siegmund A, Suslow T etal. Cognitive impairment and in vivo metabolites in first-episode neuroleptic-naive and chronic medicated schizophrenic patients: a proton magnetic resonance spectroscopy study. J Psychiatr Res 2007; 41: 625-34.
    • (2007) J Psychiatr Res , vol.41 , pp. 625-634
    • Ohrmann, P.1    Siegmund, A.2    Suslow, T.3
  • 41
    • 34447534557 scopus 로고    scopus 로고
    • First and second generation antipsychotics and morphological and neurochemical brain changes in schizophrenia. Review of magnetic resonance imaging and proton spectroscopy findings
    • Szulc A. First and second generation antipsychotics and morphological and neurochemical brain changes in schizophrenia. Review of magnetic resonance imaging and proton spectroscopy findings. Psychiatr Pol 2007; 41: 329-38.
    • (2007) Psychiatr Pol , vol.41 , pp. 329-338
    • Szulc, A.1
  • 42
    • 46249097673 scopus 로고    scopus 로고
    • A 1H-MRS investigation of the medial temporal lobe in antipsychotic-naive and early-treated first episode psychosis
    • Wood SJ, Berger GE, Wellard RM etal. A 1H-MRS investigation of the medial temporal lobe in antipsychotic-naive and early-treated first episode psychosis. Schizophr Res 2008; 102: 163-70.
    • (2008) Schizophr Res , vol.102 , pp. 163-170
    • Wood, S.J.1    Berger, G.E.2    Wellard, R.M.3
  • 43
    • 76649145089 scopus 로고    scopus 로고
    • Reduced laterality as a trait marker of schizophrenia - evidence from structural and functional neuroimaging
    • Oertel V, Knochel C, Rotarska-Jagiela A etal. Reduced laterality as a trait marker of schizophrenia - evidence from structural and functional neuroimaging. J Neurosci 2010; 30: 2289-99.
    • (2010) J Neurosci , vol.30 , pp. 2289-2299
    • Oertel, V.1    Knochel, C.2    Rotarska-Jagiela, A.3
  • 45
    • 33646699354 scopus 로고    scopus 로고
    • Quantitative magnetic resonance spectroscopy of schizophrenia: relationship between decreased N-acetylaspartate and frontal lobe dysfunction
    • Tanaka Y, Obata T, Sassa T etal. Quantitative magnetic resonance spectroscopy of schizophrenia: relationship between decreased N-acetylaspartate and frontal lobe dysfunction. Psychiatry Clin Neurosci 2006; 60: 365-72.
    • (2006) Psychiatry Clin Neurosci , vol.60 , pp. 365-372
    • Tanaka, Y.1    Obata, T.2    Sassa, T.3
  • 46
    • 0141679200 scopus 로고    scopus 로고
    • Frontal lobe N-acetylaspartate correlates with psychopathology in schizophrenia: a proton magnetic resonance spectroscopy study
    • Sigmundsson T, Maier M, Toone BK etal. Frontal lobe N-acetylaspartate correlates with psychopathology in schizophrenia: a proton magnetic resonance spectroscopy study. Schizophr Res 2003; 64: 63-71.
    • (2003) Schizophr Res , vol.64 , pp. 63-71
    • Sigmundsson, T.1    Maier, M.2    Toone, B.K.3
  • 47
    • 0022196667 scopus 로고    scopus 로고
    • Acetylation of L-aspartate in the nervous system: differential distribution of a specific enzyme
    • Truckenmiller ME, Namboodiri MAA, Brownstein MJ, N NJH. Acetylation of L-aspartate in the nervous system: differential distribution of a specific enzyme. J Neurochem 2006; 45: 1658-62.
    • (2006) J Neurochem , vol.45 , pp. 1658-1662
    • Truckenmiller, M.E.1    Namboodiri, M.A.A.2    Brownstein, M.J.3    N, N.J.H.4
  • 48
    • 3242773654 scopus 로고    scopus 로고
    • White matter lesions impair frontal lobe function regardless of their location
    • Tullberg M, Fletcher E, DeCarli C etal. White matter lesions impair frontal lobe function regardless of their location. Neurology 2004; 63: 246.
    • (2004) Neurology , vol.63 , pp. 246
    • Tullberg, M.1    Fletcher, E.2    DeCarli, C.3
  • 49
    • 0037362598 scopus 로고    scopus 로고
    • Working memory deficits and levels of N-acetylaspartate in patients with schizophreniform disorder
    • Bertolino A, Sciota D, Brudaglio F etal. Working memory deficits and levels of N-acetylaspartate in patients with schizophreniform disorder. Am J Psychiatry 2003; 160: 483-9.
    • (2003) Am J Psychiatry , vol.160 , pp. 483-489
    • Bertolino, A.1    Sciota, D.2    Brudaglio, F.3
  • 50
    • 0028904153 scopus 로고    scopus 로고
    • Central nervous system trans-synaptic effects of acute axonal injury: a 1H magnetic resonance spectroscopy study
    • Rango M, Spagnoli D, Tomei G, Bamonti F, Scarlato G, Zetta L. Central nervous system trans-synaptic effects of acute axonal injury: a 1H magnetic resonance spectroscopy study. Magn Reson Med 2005; 33: 595-600.
    • (2005) Magn Reson Med , vol.33 , pp. 595-600
    • Rango, M.1    Spagnoli, D.2    Tomei, G.3    Bamonti, F.4    Scarlato, G.5    Zetta, L.6
  • 51
    • 0035986127 scopus 로고    scopus 로고
    • Sequential proton MRS study of brain metabolite changes monitored during a complete pathological cycle of demyelination and remyelination in a lysophosphatidyl choline (LPC)-induced experimental demyelinating lesion model
    • Degaonkar MN, Khubchandhani M, Dhawan JK, Jayasundar R, Jagannathan NR. Sequential proton MRS study of brain metabolite changes monitored during a complete pathological cycle of demyelination and remyelination in a lysophosphatidyl choline (LPC)-induced experimental demyelinating lesion model. NMR Biomed 2002; 15: 293-300.
    • (2002) NMR Biomed , vol.15 , pp. 293-300
    • Degaonkar, M.N.1    Khubchandhani, M.2    Dhawan, J.K.3    Jayasundar, R.4    Jagannathan, N.R.5
  • 52
    • 0029882536 scopus 로고    scopus 로고
    • Observation of metabolic changes in chronic schizophrenia after neuroleptic treatment by in vivo hydrogen magnetic resonance spectroscopy
    • Choe BY, Suh TS, Shinn KS, Lee CW, Lee C, Paik IH. Observation of metabolic changes in chronic schizophrenia after neuroleptic treatment by in vivo hydrogen magnetic resonance spectroscopy. Invest Radiol 1996; 31: 345-52.
    • (1996) Invest Radiol , vol.31 , pp. 345-352
    • Choe, B.Y.1    Suh, T.S.2    Shinn, K.S.3    Lee, C.W.4    Lee, C.5    Paik, I.H.6
  • 53
    • 57349134532 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy of the brain: review of metabolites and clinical applications
    • Soares DP, Law M. Magnetic resonance spectroscopy of the brain: review of metabolites and clinical applications. Clin Radiol 2009; 64: 12-21.
    • (2009) Clin Radiol , vol.64 , pp. 12-21
    • Soares, D.P.1    Law, M.2
  • 54
    • 0033818216 scopus 로고    scopus 로고
    • Role of phospholipase A2 on the variations of the choline signal intensity observed by 1H magnetic resonance spectroscopy in brain diseases1
    • Boulanger Y, Labelle M, Khiat A. Role of phospholipase A2 on the variations of the choline signal intensity observed by 1H magnetic resonance spectroscopy in brain diseases1. Brain Res Rev 2000; 33: 380-9.
    • (2000) Brain Res Rev , vol.33 , pp. 380-389
    • Boulanger, Y.1    Labelle, M.2    Khiat, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.