Synthesis, biological evaluation, and molecular docking studies of 1,3,4-thiadiazol-2-amide derivatives as novel anticancer agents

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 9, 2012, Pages 2789-2795

  Yang, Xian Hui ^a   Xiang, Lu ^a   Li, Xi ^a   Zhao, Ting Ting ^a   Zhang, Hui ^a   Zhou, Wen Ping ^a   Wang, Xiao Ming ^a   Gong, Hai Bin ^b   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

^b XUZHOU CENTRAL HOSPITAL   (China)

Author keywords

1,3,4 Thiadiazol 2 amide derivatives; Focal adhesion kinase; Molecular docking; Structure activity relationship

Indexed keywords

1,3,4 THIAZOL 2 AMIDE DERIVATIVE; 2 HYDROXY N [5 (4 METHOXYPHENYL) 1,3,4 THIADIAZOL 2 YL] 2 BENZAMIDE; 2 HYDROXY N [5 (P TOLYL) 1,3,4 THIADIAZOL 2 YL]BENZAMIDE; 5 BROMO 2 HYDROXY N (5 PHENYL 1,3,4 THIAZOL 2 YL)BENZAMIDE; 5 BROMO N [5 (4 CHLOROPHENYL) 1,3,4 THIADIAZOL 2 YL] 2 HYDROXYBENZAMIDE; 5 BROMO N [5 (4 FLUOROPHENYL) 1,3,4 THIADIAZOL 2 YL] 2 HYDROXYBENZAMIDE; 5 CHLORO N [5 (4 CHLOROPHENYL) 1,3,4 THIADIAZOL 2 YL] 2 HYDROXYBENZAMIDE; 5 CHLORO N [5 (4 FLUOROPHENYL) 1,3,4 THIADIAZOL 2 YL] 2 HYDROXYBENZAMIDE; ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; N [5 (4 CHLOROPHENYL) 1,3,4 THIADIAZOL 2 YL] 2 HYDROXYBENZAMIDE; N [5 (4 FLUOROPHENYL) 1,3,4 THIADIAZOL 2 YL] 2 HYDROXYBENZAMIDE; N [5 (P TOLYL) 1,3,4 THIADIAZOL 2 YL]NICOTINAMIDE; STAUROSPORINE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BINDING SITE; CELL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

AMIDES; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTER SIMULATION; DRUG SCREENING ASSAYS, ANTITUMOR; FOCAL ADHESION KINASE 1; HUMANS; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES;

EID: 84859908319     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.03.040     Document Type: Article

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