Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model

Brain Research

Volumn 1256, Issue , 2009, Pages 129-137

  Cai, Jianmei ^a,b   Kang, Zhimin ^a   Liu, Kan ^a   Liu, WenWu ^a   Li, RunPing ^a   Zhang, John H ^c   Luo, Xu ^b   Sun, Xuejun ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b Qingdao Medical University   (China)

^c LOMA LINDA UNIVERSITY   (United States)

Author keywords

Caspase; Hydrogen; Hypoxia ischemia; Iba 1; Neurobehavioral function

Indexed keywords

CASPASE 3; HYDROGEN; TRIPHENYLTETRAZOLIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; BRAIN HYPOXIA; BRAIN ISCHEMIA; CAROTID ARTERY LIGATION; CELL DEATH; CONTROLLED STUDY; DRUG EFFECT; INFLAMMATION; LOCOMOTION; MAZE TEST; NEUROPROTECTION; NEWBORN; NICK END LABELING; NISSL STAINING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SENSORIMOTOR FUNCTION;

ANIMALS; ANIMALS, NEWBORN; BODY WEIGHT; BRAIN; CALCIUM-BINDING PROTEINS; CASPASE 3; CELL DEATH; DISEASE MODELS, ANIMAL; HYDROGEN; HYPOXIA-ISCHEMIA, BRAIN; INFLAMMATION; MALONDIALDEHYDE; MAZE LEARNING; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; POSTURE; RATS; RECOVERY OF FUNCTION; SODIUM CHLORIDE;

RATTUS;

EID: 59649110496     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.11.048     Document Type: Article

References (21)

1. Bona E., Johansson B.B., and Hagberg H. Sensorimotor function and neuropathology five to six weeks after hypoxia-ischemia in seven-day-old rats. Pediatr. Res. 42 (1997) 678-683
2. Cai J., Kang Z., Liu W.W., Luo X., Qiang S., Zhang J.H., Ohta S., Sun X., Xu W., Tao H., and Li R. Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci. Lett. 441 (2008) 167-172
3. Dedon P.C., and Tannenbaum S.R. Reactive nitrogen species in the chemical biology of inflammation. Arch. Biochem. Biophys. 423 (2004) 12-22
4. Deininger M.H., Meyermann R., and Schluesener H.J. The allograft inflammatory factor-1 family of proteins. FEBS Lett. 514 (2002) 115-121
5. Fukuda K., Asoh S., Ishikawa M., Yamamoto Y., Ohsawa I., and Ohta S. Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem. Biophys. Res. Commun. 361 (2007) 670-674
6. Hayashida K., Sano M., Ohsawa I., Shinmura K., Tamaki K., Kimura K., Endo J., Katayama T., Kawamura A., Kohsaka S., Makino S., Ohta S., Ogawa S., and Fukuda K. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem. Biophys. Res. Commun. 373 (2008) 30-35
7. Ito D., Imai Y., Ohsawa K., Nakajima K., Fukuuchi Y., and Kohsaka S. Microglia-specific localisation of a novel calcium binding protein, Iba1. Brain Res. Mol. Brain Res. 57 (1998) 1-9
8. Ito D., Tanaka K., Suzuki S., Dembo T., and Fukuuchi Y. Enhanced expression of Iba1, ionized calcium-binding adapter molecule 1, after transient focal cerebral ischemia in rat brain. Stroke 32 (2001) 1208-1215
9. Kriz J. Inflammation in ischemic brain injury: timing is important. Crit. Rev. Neurobiol. 18 (2006) 145-157
10. Martin L.J., Blue M.E., and Johnston M.V. Apoptosis has a prolonged role in the neurodegeneration after hypoxic ischemia in the newborn rat. J. Neurosci. 20 (2000) 7994-8004
11. Nagata, K., Nakashima-Kamimura, N., Mikami, T., Ohsawa, I., Ohta, S., 2008. Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice. Neuropsychopharmacology (2008). doi:10.1038/213npp.2008.95.214.
12. Northington F.J., Ferriero D.M., Flock D.L., and Martin L.J. Delayed neurodegeneration in neonatal rat thalamus after hypoxia-ischemia is apoptosis. J. Neurosci. 21 (2001) 1931-1938
13. Ohsawa I., Ishikawa M., Takahashi K., Watanabe M., Nishimaki K., Yamagata K., Katsura K., Katayama Y., Asoh S., and Ohta S. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat. Med. 13 (2007) 688-694
14. Perlman J.M. Intervention strategies for neonatal hypoxic-ischemic cerebral injury. Clin. Ther. 28 (2006) 1353-1365
15. Postler E., Rimner A., Beschorner R., Schluesener H.J., and Meyermann R. Allograft-inflammatory-factor-1 is upregulated in microglial cells in human cerebral infarctions. J. Neuroimmunol. 108 (2000) 244-250
16. Pulera M.R., Adams L.M., Liu H., Santos D.G., Nishimura R.N., Yang F., Cole G.M., and Wasterlain C.G. Apoptosis in a neonatal rat model of cerebral hypoxia-ischemia. Stroke 29 (1998) 2622-2630
17. Reed T.M., Repaske D.R., Snyder G.L., Greengard P., and Vorhees C.V. Phosphodiesterase 1B knock-out mice exhibit exaggerated locomotor hyperactivity and DARPP-32 phosphorylation in response to dopamine agonists and display impaired spatial learning. J. Neurosci. 22 (2002) 5188-5197
18. Stoll G., Jander S., and Schroeter M. Inflammation and glial responses in ischemic brain lesions. Prog. Neurobiol. 56 (1998) 149-171
19. Tanaka S., Suzuki K., Watanabe M., Matsuda A., Tone S., and Koike T. Upregulation of a new microglial gene, mrf-1, in response to programmed neuronal cell death and degeneration. J. Neurosci. 18 (1998) 6358-6369
20. Valko M., Leibfritz D., Moncol J., Cronin M.T., Mazur M., and Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol. 39 (2007) 44-84
21. Vannucci R.C., and Vannucci S.J. A model of perinatal hypoxic-ischemic brain damage. Ann. N. Y. Acad. Sci. 835 (1997) 234-249