Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemia/reperfusion injury in rats

Transplantation

Volumn 90, Issue 12, 2010, Pages 1344-1351

  Kawamura, Tomohiro ^a,b   Huang, Chien Sheng ^a,c   Tochigi, Naobumi ^a   Lee, Sungsoo ^a   Shigemura, Norihisa ^a   Billiar, Timothy R ^a   Okumura, Meinoshin ^b   Nakao, Atsunori ^a   Toyoda, Yoshiya ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b OSAKA UNIVERSITY   (Japan)

^c TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Apoptosis; Experimental model; Hydrogen gas; Ischemia reperfusion; Lung transplantation

Indexed keywords

DEXTRAN; HYDROGEN; POTASSIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; B CELL LYMPHOMA; CONTROLLED STUDY; EPITHELIUM; GAS EXCHANGE; GRAFT RECIPIENT; ISCHEMIA; LEWIS RAT; LIPID PEROXIDATION; LUNG TRANSPLANTATION; MALE; MEDIATOR; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

ADMINISTRATION, INHALATION; ANIMALS; ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; GENES, BCL-2; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HYDROGEN; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-1BETA; INTERLEUKIN-6; LUNG TRANSPLANTATION; MALE; MALONDIALDEHYDE; RATS; RATS, INBRED LEW; REPERFUSION; REPERFUSION INJURY; RESPIRATION, ARTIFICIAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRACHEOTOMY; TRANSPLANTATION, ISOGENEIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 78650813355     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181fe1357     Document Type: Article

References (46)

1. Christie JD, Kotloff RM, Ahya VN, et al. The effect of primary graft dysfunction on survival after lung transplantation. Am J Respir Crit Care Med 2005; 171: 1312.
2. de Perrot M, Liu M, Waddell TK, et al. Ischemia-reperfusion-induced lung injury. Am J Respir Crit Care Med 2003; 167: 490.
3. Serrick C, Giaid A, Reis A, et al. Prolonged ischemia is associated with more pronounced rejection in the lung allograft. Ann Thorac Surg 1997; 63: 202.
4. Eppinger MJ, Deeb GM, Bolling SF, et al. Mediators of ischemia-reperfusion injury of rat lung. Am J Pathol 1997; 150: 1773.
5. Fischer S, Maclean AA, Liu M, et al. Dynamic changes in apoptotic and necrotic cell death correlate with severity of ischemia-reperfusion injury in lung transplantation. Am J Respir Crit Care Med 2000; 162: 1932.
6. Fischer S, Cassivi SD, Xavier AM, et al. Cell death in human lung transplantation: Apoptosis induction in human lungs during ischemia and after transplantation. Ann Surg 2000; 231: 424.
7. Daud SA, Yusen RD, Meyers BF, et al. Impact of immediate primary lung allograft dysfunction on bronchiolitis obliterans syndrome. Am J Respir Crit Care Med 2007; 175: 507.
8. Ohsawa I, Ishikawa M, Takahashi K, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 2007; 13: 688.
9. Hayashida K, Sano M, Ohsawa I, et al. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun 2008; 373: 30.
10. Buchholz BM, Kaczorowski DJ, Sugimoto R, et al. Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. Am J Transplant 2008; 8: 2015.
11. Huang C, Kawamura T, Toyoda Y, et al. Recent advances in hydrogen research as a therapeutic medical gas. Free Rad Res 2010; 44: 971.
12. NASA. Safety standard for hydrogen and hydrogen systems. National Aeronautics and Space Administration 2005.
13. Kohmoto J, Nakao A, Stolz DB, et al. Carbon monoxide protects rat lung transplants from ischemia-reperfusion injury via a mechanism involving p38 MAPK pathway. Am J Transplant 2007; 7: 2279.
14. Zhao M, Fernandez LG, Doctor A, et al. Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol 2006; 291: L1018.
15. Fiser SM, Tribble CG, Long SM, et al. Pulmonary macrophages are involved in reperfusion injury after lung transplantation. Ann Thorac Surg 2001; 71: 1134.
16. Song R, Kubo M, Morse D, et al. Carbon monoxide induces cytoprotection in rat orthotopic lung transplantation via anti-inflammatory and anti-apoptotic effects. Am J Pathol 2003; 163: 231.
17. Cooke DT, Hoyt EG, Robbins RC. Overexpression of human Bcl-2 in syngeneic rat donor lungs preserves posttransplant function and reduces intragraft caspase activity and interleukin-1beta production. Transplantation 2005; 79: 762.
18. Buccellato LJ, Tso M, Akinci OI, et al. Reactive oxygen species are required for hyperoxia-induced Bax activation and cell death in alveolar epithelial cells. J Biol Chem 2004; 279: 6753.
19. Land WG. The role of postischemic reperfusion injury and other nonantigen- dependent inflammatory pathways in transplantation. Transplantation 2005; 79: 505.
20. Nakao A, Sugimoto R, Billiar TR, et al. Therapeutic antioxidant medical gas. J Clin Biochem Nutr 2009; 44: 1.
21. Itoh T, Fujita Y, Ito M, et al. Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells. Biochem Biophys Res Commun 2009; 389: 651.
22. George JF, Agarwal A. Hydrogen: Another gas with therapeutic potential. Kidney Int 2010; 77: 85.
23. Pirnia F, Schneider E, Betticher DC, et al. Mitomycin C induces apoptosis and caspase-8 and -9 processing through a caspase-3 and Fasindependent pathway. Cell Death Differ 2002; 9: 905.
24. Ng CS, Wan S, Yim AP. Pulmonary ischaemia-reperfusion injury: Role of apoptosis. Eur Respir J 2005; 25: 356.
25. Abraini JH, Gardette-Chauffour MC, Martinez E, et al. Psychophysiological reactions in humans during an open sea dive to 500 m with a hydrogen-helium-oxygen mixture. J Appl Physiol 1994; 76: 1113.
26. Suzuki Y, Sano M, Hayashida K, et al. Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract? FEBS Lett 2009; 583: 2157.
27. Katz A, Gentile MA, Craig DM, et al. Heliox improves gas exchange during high-frequency ventilation in a pediatric model of acute lung injury. Am J Respir Crit Care Med 2001; 164: 260.
28. Nawab US, Touch SM, Irwin-Sherman T, et al. Heliox attenuates lung inflammation and structural alterations in acute lung injury. Pediatr Pulmonol 2005; 40: 524.
29. Pagel PS, Krolikowski JG, Shim YH, et al. Noble gases without anesthetic properties protect myocardium against infarction by activating prosurvival signaling kinases and inhibiting mitochondrial permeability transition in vivo. Anesth Analg 2007; 105: 562.
30. Cai J, Kang Z, Liu WW, et al. Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci Lett 2008; 441: 167.
31. Avlonitis VS, Wigfield CH, Golledge HD, et al. Early hemodynamic injury during donor brain death determines the severity of primary graft dysfunction after lung transplantation. Am J Transplant 2007; 7: 83.
32. Avlonitis VS, Wigfield CH, Kirby JA, et al. The hemodynamic mechanisms of lung injury and systemic inflammatory response following brain death in the transplant donor. Am J Transplant 2005; 5(4 pt 1): 684.
33. Date H, Triantafillou AN, Trulock EP, et al. Inhaled nitric oxide reduces human lung allograft dysfunction. J Thorac Cardiovasc Surg 1996; 111: 913.
34. Pinsky DJ, Naka Y, Chowdhury NC, et al. The nitric oxide/cyclic GMP pathway in organ transplantation: Critical role in successful lung preservation. Proc Natl Acad Sci USA 1994; 91: 12086.
35. Takashima S, Date H, Aoe M, et al. Short-term inhaled nitric oxide in canine lung transplantation from non-heart-beating donor. Ann Thorac Surg 2000; 70: 1679.
36. Bhabra MS, Hopkinson DN, Shaw TE, et al. Low-dose nitric oxide inhalation during initial reperfusion enhances rat lung graft function. Ann Thorac Surg 1997; 63: 339.
37. George I, Xydas S, Topkara VK, et al. Clinical indication for use and outcomes after inhaled nitric oxide therapy. Ann Thorac Surg 2006; 82: 2161.
38. Perrin G, Roch A, Michelet P, et al. Inhaled nitric oxide does not prevent pulmonary edema after lung transplantation measured by lung water content: A randomized clinical study. Chest 2006; 129: 1024.
39. Meade MO, Granton JT, Matte-Martyn A, et al. A randomized trial of inhaled nitric oxide to prevent ischemia-reperfusion injury after lung transplantation. Am J Respir Crit Care Med 2003; 167: 1483.
40. Nakao A, Kaczorowski DJ, Wang Y, et al. Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both. J Heart Lung Transplant 2010; 29: 544.
41. Kohmoto J, Nakao A, Kaizu T, et al. Low-dose carbon monoxide inhalation prevents ischemia/reperfusion injury of transplanted rat lung grafts. Surgery 2006; 140: 179.
42. Sugimoto R, Nakao A, Nagahiro I, et al. Experimental orthotopic lung transplantation model in rats with cold storage. Surg Today 2009; 39: 641.
43. Mizuta T, Kawaguchi A, Nakahara K, et al. Simplified rat lung transplantation using a cuff technique. J Thorac Cardiovasc Surg 1989; 97: 578.
44. Nakao A, Kimizuka K, Stolz DB, et al. Carbon monoxide inhalation protects rat intestinal grafts from ischemia/reperfusion injury. Am J Pathol 2003; 163: 1587.
45. Itoh T, Itoh A, Pleasure D. Bcl-2-related protein family gene expression during oligodendroglial differentiation. J Neurochem 2003; 85: 1500.
46. Hirschburger M, Zakrzewicz A, Kummer W, et al. Nicotine attenuates macrophage infiltration in rat lung allografts. J Heart Lung Transplant 2009; 28: 493.