14-3-3 Interacts with LKB1 via recognizing phosphorylated threonine 336 residue and suppresses LKB1 kinase function

FEBS Letters

Volumn 586, Issue 8, 2012, Pages 1111-1119

  Bai, Yu ^a   Zhou, Tao ^a   Fu, Haian ^b   Sun, Hanyan ^a   Huang, Bei ^a  

^a ANHUI UNIVERSITY   (China)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

14 3 3; AMPK; Kinase function; LKB1; Phosphorylation

Indexed keywords

ADENYLATE KINASE; AMP DEPENDENT PROTEIN KINASE; PROTEIN 14 3 3; PROTEIN KINASE; PROTEIN KINASE LKB1; THREONINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CATALYSIS; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL STRAIN COS7; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; HELA CELL; PLASMID; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; REGULATORY MECHANISM;

14-3-3 PROTEINS; AMP-ACTIVATED PROTEIN KINASES; G1 PHASE CELL CYCLE CHECKPOINTS; HELA CELLS; HUMANS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; THREONINE;

EID: 84859898726     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.03.018     Document Type: Article

References (30)

1. A. Hemminki A serine/threonine kinase gene defective in Peutz-Jeghers syndrome Nature 391 1998 184 187 (Pubitemid 28092478)
2. D.E. Jenne Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinase Nat. genet. 18 1998 38 43 (Pubitemid 28027876)
3. P. Karuman The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death Mol. Cell 7 2001 1307 1319 (Pubitemid 32607363)
4. W. Qiu, F. Schonleben, H.M. Thaker, M. Goggins, and G.H. Su A novel mutation of STK11/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinoma Oncogene 25 2006 2937 2942 (Pubitemid 43739244)
5. M. Tiainen, A. Ylikorkala, and T.P. Makela Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest Proc. Natl. Acad. Sci. USA 96 1999 9248 9251 (Pubitemid 29374740)
6. P.Y. Zeng, and S.L. Berger LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation Cancer Res. 66 2006 10701 10708 (Pubitemid 44876965)
7. S.P. Hong, F.C. Leiper, A. Woods, D. Carling, and M. Carlson Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases Proc. Natl. Acad. Sci. USA 100 2003 8839 8843 (Pubitemid 36899185)
8. R.J. Shaw, M. Kosmatka, N. Bardeesy, R.L. Hurley, L.A. Witters, R.A. DePinho, and L.C. Cantley The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress Proc. Natl. Acad. Sci. USA 101 2004 3329 3335 (Pubitemid 38338195)
9. A.S. Green The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation Blood 116 2010 4262 4273
10. D.A. Guertin, and D.M. Sabatini Defining the role of mTOR in cancer Cancer Cell 12 2007 9 22 (Pubitemid 47001784)
11. M.K. Holz, B.A. Ballif, S.P. Gygi, and J. Blenis MTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events Cell 123 2005 569 580 (Pubitemid 41608461)
12. J. Liang The energy sensing LKB1-MPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis Nat. Cell Biol. 9 2007 218 224 (Pubitemid 46420865)
13. S. Wullschleger, R. Loewith, and M.N. Hall TOR signaling in growth and metabolism Cell 124 2006 471 484 (Pubitemid 43199434)
14. J. Nezu, A. Oku, and M. Shimane Loss of cytoplasmic retention ability of mutant LKB1 found in Peutz-Jeghers syndrome patients Biochem. Biophys. Res. Commun. 261 1999 750 755 (Pubitemid 29408129)
15. C.M. Smith, E. Radzio-Andzelm, Madhusudan, P. Akamine, and S.S. Taylor The catalytic subunit of cAMP-dependent protein kinase: prototype for an extended network of communication Prog. Biophys. Mol. Biol. 71 1999 313 341 (Pubitemid 29156305)
16. M. Tiainen, K. Vaahtomeri, A. Ylikorkala, and T.P. Makela Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1) Hum. Mol. Genet. 11 2002 1497 1504 (Pubitemid 34679250)
17. A.F. Baas, J. Boudeau, G.P. Sapkota, L. Smit, R. Medema, N.A. Morrice, D.R. Alessi, and H.C. Clevers Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD EMBO J. 22 2003 3062 3072 (Pubitemid 36758626)
18. S. Fogarty, and D.G. Hardie C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest J. Biol. Chem. 284 2009 77
19. P. Song, Z. Xie, Y. Wu, J. Xu, Y. Dong, and M.H. Zou Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells J. Biol. Chem. 283 2008 12446 12455
20. Z. Xie Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells J. Biol. Chem. 281 2006 6366 6375 (Pubitemid 43847568)
21. G.P. Sapkota, J. Boudeau, M. Deak, A. Kieloch, N. Morrice, and D.R. Alessi Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome Biochem. J. 362 2002 481 490 (Pubitemid 34214492)
22. H. Fu, R.R. Subramanian, and S.C. Masters 14-3-3 proteins: structure, function, and regulation Annu. Rev. Pharmacol. Toxicol. 40 2000 617 647 (Pubitemid 30340695)
23. M.B. Yaffe The structural basis for 14-3-3:phosphopeptide binding specificity Cell 91 1997 961 971 (Pubitemid 28027829)
24. M.K. Dougherty, and D.K. Morrison Unlocking the code of 14-3-3 J. Cell Sci. 117 2004 1875 1884 (Pubitemid 38745122)
25. R.R. Subramanian, H. Zhang, H. Wang, H. Ichijo, T. Miyashita, and H. Fu Interaction of apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins Exp. Cell Res. 294 2004 581 591 (Pubitemid 38326754)
26. J. Boudeau MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm EMBO J. 22 2003 5102 5114 (Pubitemid 37222030)
27. A.K. Al-Hakim, O. Goransson, M. Deak, R. Toth, D.G. Campbell, N.A. Morrice, A.R. Prescott, and D.R. Alessi 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK J. Cell Sci. 118 2005 5661 5673 (Pubitemid 43079304)
28. U. Bajpai, R. Sharma, T. Kausar, S. Dattagupta, T.K. Chattopadhayay, and R. Ralhan Clinical significance of 14-3-3 zeta in human esophageal cancer Int. J. Biol. Markers 23 2008 231 237
29. Z. Li Down-regulation of 14-3-3zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation Proc. Natl. Acad. Sci. USA 105 2008 162 167
30. Y. Liu, R.F. Tian, Y.M. Li, W.P. Liu, L. Cao, X.L. Yang, W.D. Cao, and X. Zhang The expression of seven 14-3-3 isoforms in human meningioma Brain Res. 1336 2010 98 102