Influence of flow rate and scaffold pore size on cell behavior during mechanical stimulation in a flow perfusion bioreactor

Biotechnology and Bioengineering

Volumn 109, Issue 6, 2012, Pages 1583-1594

  Mccoy, R J ^a,b   Jungreuthmayer, C ^c,d   O'Brien, F J ^a,b  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c AIT AUSTRIAN INSTITUTE OF TECHNOLOGY   (Austria)

^d AUSTRIAN CENTRE OF INDUSTRIAL BIOTECHNOLOGY   (Austria)

Author keywords

Cell detachment; Computational fluid dynamics; Finite element analysis; Perfusion bioreactor; Pore size; Shear stress

Indexed keywords

BONE GRAFT SUBSTITUTES; CELL ATTACHMENTS; CELL BEHAVIORS; CELL DEFORMATION; CELL DETACHMENT; CELL DIFFERENTIATION; COMPUTATIONAL MODELING; CRITICAL THRESHOLD; EXPERIMENTAL APPROACHES; EXPOSURE TIME; FLOW PERFUSION; FLOW PERFUSION BIOREACTOR; MEAN PORE SIZE; MECHANICAL STIMULATION; OPERATING CONDITION; PERFUSION BIOREACTOR; THEORETICAL MODELS;

BIOCONVERSION; BIOREACTORS; CELLS; COMPUTATIONAL FLUID DYNAMICS; CYTOLOGY; DEFORMATION; FINITE ELEMENT METHOD; FLOW RATE; MORPHOLOGY; PORE SIZE; SHEAR STRESS;

SCAFFOLDS (BIOLOGY);

COLLAGEN; MOLECULAR SCAFFOLD;

ARTICLE; BIOREACTOR; CELL FUNCTION; CELL STRUCTURE; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED STUDY; FLOW PERFUSION BIOREACTOR; FLOW RATE; FLUID FLOW; MECHANICAL STIMULATION; OSTEOBLAST; PERFUSION; PORE SIZE; SHEAR STRESS; WEIGHT, MASS AND SIZE;

ANIMALS; BIOREACTORS; CELL ADHESION; MICE; MODELS, THEORETICAL; ORGAN CULTURE TECHNIQUES; OSTEOBLASTS; TISSUE SCAFFOLDS;

EID: 84859898611     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.24424     Document Type: Article

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