Semisynthetic neoclerodanes as kappa opioid receptor probes

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 9, 2012, Pages 3100-3110

  Lovell, Kimberly M ^a   Vasiljevik, Tamara ^a   Araya, Juan J ^a   Lozama, Anthony ^b   Prevatt Smith, Katherine M ^a   Day, Victor W ^a   Dersch, Christina M ^c   Rothman, Richard B ^c   Butelman, Eduardo R ^d   Kreek, Mary Jeanne ^d   Prisinzano, Thomas E ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c DHHS   (United States)

^d ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Furan; Hallucinogen; Kappa opioid receptor; Natural product; Salvia divinorum; Salvinorin A

Indexed keywords

BORONIC ACID; CARBON; CENTRAL NERVOUS SYSTEM AGENTS; KAPPA OPIATE RECEPTOR; KETONE DERIVATIVE; METHYL 9 ACETOXY 2 (2 HYDROZYBENZOYL) 6A,10B DIMETHYL 4,10 DIOXODODECAHYDRO 1H BENZO[F]ISOCHROMENE 7 CARBOXYLIC ACID; METHYL 9 ACETOXY 2 (2 METHOXYBENZOYL) 6A,10B DIMETHYL 4,10 DIOXODODECAHYDRO 1H BENZO[F]ISOCHROMENE 7 CARBOXYLIC ACID; METHYL 9 ACETOXY 2 (3 CARBAMOYLBENZOYL) 6A,10B DIMETHYL 4,10 DIOXODODECAHYDRO 1H BENZO[F]ISOCHROMENE 7 CARBOXYLIC ACID; METHYL 9 ACETOXY 2 (3 CYANOBENZOYL) 6A,10B DIMETHYL 4,10 DIOXODODECAHYDRO 1H BENZO[F]ISOCHROMENE 7 CARBOXYLIC ACID; METHYL 9 ACETOXY 2 (3 HYDROZYBENZOYL) 6A,10B DIMETHYL 4,10 DIOXODODECAHYDRO 1H BENZO[F]ISOCHROMENE 7 CARBOXYLIC ACID; METHYL 9 ACETOXY 2 (3 METHOXYBENZOYL) 6A,10B DIMETHYL 4,10 DIOXODODECAHYDRO 1H BENZO[F]ISOCHROMENE 7 CARBOXYLIC ACID; METHYL 9 ACETOXY 2 (4 HYDROZYBENZOYL) 6A,10B DIMETHYL 4,10 DIOXODODECAHYDRO 1H BENZO[F]ISOCHROMENE 7 CARBOXYLIC ACID; METHYL 9 ACETOXY 2 (4 METHOXYBENZOYL) 6A,10B DIMETHYL 4,10 DIOXODODECAHYDRO 1H BENZO[F]ISOCHROMENE 7 CARBOXYLIC ACID; METHYL 9 ACETOXY 2 (BENZO(B)THIOPHENE 2 CARBONYL) 6A,10B DIMETHYL 4,10 DIOXODODECAHYDRO 1H BENZO[F]ISOCHROMENE 7 CARBOXYLIC ACID; METHYL 9 ACETOXY 2 (BENZOFURAN 2 CARBONYL) 6A,10B DIMETHYL 4,10 DIOXODODECAHYDRO 1H BENZO[F]ISOCHROMENE 7 CARBOXYLIC ACID; METHYL 9 ACETOXY 2 (FURAN 2 CARBONYL) 6A,10B DIMETHYL 4,10 DIOXODODECAHYDRO 1H BENZO[F]ISOCHROMENE 7 CARBOXYLIC ACID; METHYL 9 ACETOXY 2 (FURAN 2 YL) 6A,10B DIMETHYL 4,10 DI OXODODECAHYDRO 1H BENZO[F]ISOCHROMENE 7 CARBOXYLIC ACID; METHYL 9 ACETOXY 2 (FURAN 3 YL) 6A,10B DIMETHYL 4,10 DIOXODODECAHYDRO 1H BENZO[F]ISOCHROMENE 7 CARBOXYLIC ACID; METHYL 9 ACETOXY 2 [2 (FURAN 3 YL)VINYL] 6A,10B DIMETHYL 4,10 DIOXODODECAHYDRO 1H BENZO[F]ISOCHROMENE 7 CARBOXYLIC ACID; METHYL 9 ACETOXY 2 BENZOYL 6A,10B DIMETHYL 4,10 DIOXO DODECAHYDRO 1H BENZO[F]ISOCHROMENE 7 CARBOXYLIC ACID; METHYL 9 ACETOXY 6A,10B DIMETHYL 4,10 DIOXO 2 (PHENYLTHIOCARBONYL)DODECAHYDRO 1H BENZO[F]ISOCHROMENE 7 CARBOXYLIC ACID; METHYL 9 ACETOXY 6A,10B DIMETHYL 4,10 DIOXO 2 (THIOPHENE 2 CARBONYL)DODECAHYDRO 1H BENZO[F]ISOCHROMENE 7 CARBOXYLIC ACID; METHYL 9 ACETOXY 6A,10B DIMETHYL 4,10 DIOXO 2 (THIOPHENE 3 CARBONYL)DODECAHYDRO 1H BENZO[F]ISOCHROMENE 7 CARBOXYLIC ACID; METHYL 9 ACETOXY 6A,10B DIMETHYL 4,10 DIOXO 2 [3 (TRIFLUOROMETHOXY)BENZOYL]DODECAHYDRO 1H BENZO[F]ISOCHROMENE 7 CARBOXYLIC ACID; METHYL 9 ACETOXY 6A,10B DIMETHYL 4,10 DIOXO 2 [3 (TRIFLUOROMETHYL)BENZOYL]DODECAHYDRO 1H BENZO[F]ISOCHROMENE 7 CARBOXYLIC ACID; NEOCLERODANE DERIVATIVE; PALLADIUM; SALIVINORIN A; THIOESTER; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHEMICAL BINDING; CHO CELL; CONTROLLED STUDY; CROSS COUPLING REACTION; DRUG ACTIVITY; DRUG ANALYSIS; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENVIRONMENTAL TEMPERATURE; LIEBESKIND SROGL REACTION; MACACA MULATTA; MALE; NONHUMAN; PH;

ANIMALS; BIOLOGICAL MARKERS; DITERPENES; DITERPENES, CLERODANE; HUMANS; MACACA MULATTA; MALE; MICROWAVES; NEURONS; PROTEIN BINDING; RECEPTORS, OPIOID, KAPPA; SALVIA; STRUCTURE-ACTIVITY RELATIONSHIP;

SALVIA DIVINORUM;

EID: 84859893566     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.02.040     Document Type: Article

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