Radiofluorinated histamine H 3 receptor antagonist as a potential probe for in vivo PET imaging: Radiosynthesis and pharmacological evaluation

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 9, 2012, Pages 2889-2896

  Selivanova, Svetlana V ^a   Honer, Michael ^a   Combe, Francine ^a   Isensee, Kathleen ^b   Stark, Holger ^b   Krämer, Stefanie D ^a   Schubiger, P August ^a   Ametamey, Simon M ^a  

^a ETH ZURICH   (Switzerland)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

CNS; H 3R; Histamine H 3 receptor; Neurological disorders; PET imaging

Indexed keywords

GLYCOPROTEIN P; HISTAMINE H3 RECEPTOR; HISTAMINE H3 RECEPTOR ANTAGONIST; MESYLIC ACID; NUCLEOPHILE; RADIOPHARMACEUTICAL AGENT; ST 889; ST 889 F 18; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BRAIN CORTEX; CONTROLLED STUDY; CORPUS STRIATUM; DRUG STABILITY; DRUG SYNTHESIS; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; LIVER MICROSOME; MALE; NEUROIMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; RADIOCHEMISTRY; RAT;

ANIMALS; BRAIN; CELL LINE; DOGS; DRUG STABILITY; FLUORINE RADIOISOTOPES; HISTAMINE H3 ANTAGONISTS; HUMANS; ISOTOPE LABELING; MALE; MICROSOMES, LIVER; P-GLYCOPROTEIN; PIPERIDINES; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, HISTAMINE H3;

RATTUS;

EID: 84859889899     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.03.024     Document Type: Article

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