Assessment on pollution of ochratoxin a in grain in China and its apoptosis effect on vitro-cultured human tubular kidney cells

Journal of Biochemical and Molecular Toxicology

Volumn 26, Issue 4, 2012, Pages 139-146

  Li, Zengning ^a   Zhang, Xianghong ^a   Cui, Jinfeng ^a   Kang, Weijun ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; C Jun NH 2 Terminal Kinase; Mitogen Activated Protein Kinase; Ochratoxin A; Signaling Pathway

Indexed keywords

CASPASE 3; OCHRATOXIN; PROTEIN BAX; PROTEIN BCL 2; STRESS ACTIVATED PROTEIN KINASE;

APOPTOSIS; ARTICLE; BARLEY; CHINA; CONTROLLED STUDY; FLOW CYTOMETRY; GRAIN; HUMAN; HUMAN CELL; KIDNEY TUBULE CELL; POLLUTION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION; WHEAT;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELLS, CULTURED; CEREALS; CHINA; ENVIRONMENTAL POLLUTANTS; FOOD CONTAMINATION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KIDNEY TUBULES; MAP KINASE SIGNALING SYSTEM; OCHRATOXINS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 84859874533     PISSN: 10956670     EISSN: 10990461     Source Type: Journal    
DOI: 10.1002/jbt.20420     Document Type: Article

References (34)

1. Coronel MB, Sanchis V, Ramos AJ, Marin S. Assessment of the exposureto ochratoxin A in the province of Lleida, Spain. Food Chem Toxicol. 2009;47:2847-2852.
2. Aoudia N, Tangni EK, Larondelle Y. Distribution of ochratoxin A in plasma and tissues of rats fed a naturally contaminated diet amended with micronized wheat fibres: Effectiveness of mycotoxin sequestering activity. Food Chem Toxicol. 2008;46:871-878.
3. Duarte SC, Bento J, Pena A, Lino CM, Delerue-Matos C, Oliveira MBPP, Alves, MR, Pereira JA. Influencing factors on bread-derived exposure to ochratoxin A: Type, origin and composition. Food Chem Toxicol. 2010;48:2139-2147.
4. Kabak B. Ochratoxin A in cereal-derived products in Turkey: occurrence and exposure assessment. Food Chem Toxicol 2009;47:348-352.
5. Viswanath P, Kavitha S, Ayesha F, Appaiah KM. A survey of ochartoxin A in wheat and barley in India. J Food Safety. 2007;27:111-123.
6. Rached E, Hoffmann D, Blumbach K. Evaluation of putative biomarkers of nephrotoxicity after exposure to ochratoxin a in vivo and in vitro. Toxicol Sci. 2008;103(2):371-381.
7. Gagliano N, Donne ID, Torri C. Early cytotoxic effects of ochratoxin A in rat liver: A morphological, biochemical and molecular study. Toxicology. 2006;225(2-3):214-224.
8. Assaf H, Azouri H, Pallardy M. Ochratoxin A induces apoptosis in human lymphocytes through down regulation of Bcl-xL. Toxicol Sci 2004;79(2):335-344.
9. Mantle P, Kulinskaya E, Nestler S. Renal tumourigenesis in male rats in response to chronic dietary ochratoxin A. Food Addit Contam Suppl 2005;1:58-64.
10. Wangikar PB, Dwivedi P, Sinha N. Teratogenic effects in rabbits of simultaneous exposure to ochratoxin A and aflatoxin B1 with special reference to microscopic effects. Toxicology. 2005;215(1-2):37-47.
11. Vrabcheva T, Petkova-bocharova T, Grosso F. Analysis of ochratoxin A in foods consumed by inhabitants from an area with Balkan endemic nephropathy: A 1 month follow-up study. J Agric Food Chem. 2004;52(8):2404-2410.
12. Abarca ML, Bragulat MR, Castella G. Ochratoxin A production by strains of Aspergillus niger var. niger. Appl Environ Microbiol. 1994;60(7):2650-2652.
13. Grosse Y, Baudrimont I, Castegnaro M, Betbeder AM, Creppy EE, Dirheimer G, Pfohl-Leszkowicz A. Formation of ochratoxin A metabolites and DNA-adducts in monkey kidney cells. Chem Biol Interact. 1995;95(1-2):175-187.
14. Muller G, Burkert B, Rosner H, Kohler H. Effects of the mycotoxin ochratoxin A and some of its metabolites on human kidney cell lines. Toxicol In Vitro. 2003;17(4):441-448.
15. Heussner AH, Dietrich DR, O'Brien E. In vitro investigation of individual and combined cytotoxic effects of ochratoxin A and other selected mycotoxins on renal cells. Toxicol In Vitro. 2006;20(3):332-341.
16. Paulsen JE, Namork E, Alexander J. Scanning electron microscopy of colonic lesions in 1, 2-dimethylhydrazine-treated rats. Anticancer Res. 2005;25(6B):3883-3888.
17. Yuki K, Takahashi A, Ota I, Ohnishi K, Yasumoto J, Yane K, Kanata H, Okamoto N, Hosoi H, Ohnishi T. Sensitization by glycerol for CDDP-therapy against human cultured cancer cells and tumors bearing mutated p53 gene. Apoptosis. 2004;9(6):853-859.
18. Li ZN, Cui JF, Zhang XH, Kang WJ. Aflatoxin G1 reduces the molecular expression of HLA-I, TAP-1 and LMP-2 of adult esophageal epithelial cells in vitro. Toxicol Lett. 2010;195(2-3):169-173.
19. Hurst WJ, Martin RA. High-performance liquid chromatographic determination of ochratoxin A in artificially contaminated cocoa beans using automated sample clean-up. J Chromatogr A. 1998;810(1-2):89-94.
20. Plestina R. Nephrotoxicity of ochratoxin A. Food Addit Contam 1996;13 (Suppl):49-50.
21. Malekinejad H, Farshid AA, Mirzakhani N. Liquorice plant extract reduces ochratoxin A-induced nephrotoxicity in rats. Exp Toxicol Pathol. 2011;63(1-2):125-130.
22. Mally A, Hard GC, Dekant W. Ochratoxin A as a potential etiologic factor in endemic nephropathy: lessons from toxicity studies in rats. Food Chem Toxico. 2007;45(11):2254-2260.
23. Kumar M, Dwivedi P, Sharma AK, Singh ND, Patil RD. Ochratoxin A and citrinin nephrotoxicity in New Zealand White rabbits: an ultrastructural assessment. Mycopathologia. 2007;163(1):21-30.
24. Rumora L, Grubisic TZ. A journey through mitogen-activated protein kinase and ochratoxin A interactions. Arh Hig Rada Toksiko. 2009;60(4):449-456.
25. Sharma N, Suzuki H, He Q. Tumor necrosis factor alpha-mediated activation of c-Jun NH(2)-terminal kinase as a mechanism for fumonisin B(1) induced apoptosis in murine primary hepatocytes. J Biochem Mol Toxicol. 2005;19(6):359-367.
26. Yang GH, Jarvis BB, Chung YJ. Apoptosis induction by the satratoxins and other trichothecene mycotoxins: relationship to ERK, p38 MAPK, and APK/JNK activation. Toxicol Appl Pharmacol. 2000;164(2):149-160.
27. Tournier C, Hess P, Yang, DD. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science. 2000;288(5467):870- 874.
28. Tournier C, Dong C, Turner TK. MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. Genes Dev. 2001;15(2):1419-1426.
29. Bonni A, Brunet A, West AE. Cell survival promoted by the Ras-MAPK signaling pathway by the dependent and independent mechanisms. Science. 1999;286(5443):1358-1362.
30. Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell. 2000;103(2):239-252.
31. Walker R. Risk assessment of ochratoxin: current views of the European Scientific Committee on Food, the JECFA and the Codex Committee on Food Additives and Contaminants. Adv Exp Med Biol. 2002;504:249-255.
32. O'Brien E and Dietrich DR. Ochratoxin A: The continuing enigma. Crit Rev Toxicol. 2005;35(1):33-60.
33. Gagliano N, Torri C, Donetti E. Ochratoxin A-induced renal cortex fibrosis and epithelial-to-mesenchymal transition: molecular mechanisms of ochratoxin A-injury and potential effects of red wine. Mol Med. 2005;11(1-12):30-38.
34. Marin-Kuan M, Nestler S, Verguet C. A toxicogenomics approach to identify new plausible epigenetic mechanisms of ochratoxin a carcinogenicity in rat. Toxicol Sci. 2006;89(1):120-134.